LOCUS       NM_001289074            3047 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens helicase, lymphoid specific (HELLS), transcript
            variant 9, mRNA.
ACCESSION   NM_001289074
VERSION     NM_001289074.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3047)
  AUTHORS   Consiglio,A., Venturin,M., Briguglio,S., Rossi,C., Grillo,G.,
            Bellosta,S., Cattaneo,M.G., Licciulli,F. and Battaglia,C.
  TITLE     Lost in HELLS: Disentangling the mystery of SALNR existence in
            senescence cellular models
  JOURNAL   PLoS One 18 (5), e0286104 (2023)
   PUBMED   37252915
  REMARK    GeneRIF: Lost in HELLS: Disentangling the mystery of SALNR
            existence in senescence cellular models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3047)
  AUTHORS   Peixoto,E., Khan,A., Lewis,Z.A., Contreras-Galindo,R. and Czaja,W.
  TITLE     The Chromatin Remodeler HELLS: A New Regulator in DNA Repair,
            Genome Maintenance, and Cancer
  JOURNAL   Int J Mol Sci 23 (16), 9313 (2022)
   PUBMED   36012581
  REMARK    GeneRIF: The Chromatin Remodeler HELLS: A New Regulator in DNA
            Repair, Genome Maintenance, and Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3047)
  AUTHORS   Liang,X., Li,L. and Fan,Y.
  TITLE     Diagnostic, Prognostic, and Immunological Roles of HELLS in
            Pan-Cancer: A Bioinformatics Analysis
  JOURNAL   Front Immunol 13, 870726 (2022)
   PUBMED   35774795
  REMARK    GeneRIF: Diagnostic, Prognostic, and Immunological Roles of HELLS
            in Pan-Cancer: A Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3047)
  AUTHORS   He,C. and Liu,L.
  TITLE     Hsa_circ_0072008 regulates cell proliferation, migration, and
            invasion in cervical squamous cell carcinoma via miR-1305/helicase,
            lymphoid specific (HELLS) axis
  JOURNAL   Bioengineered 13 (4), 8311-8322 (2022)
   PUBMED   35311456
  REMARK    GeneRIF: Hsa_circ_0072008 regulates cell proliferation, migration,
            and invasion in cervical squamous cell carcinoma via
            miR-1305/helicase, lymphoid specific (HELLS) axis.
REFERENCE   5  (bases 1 to 3047)
  AUTHORS   Chen,X., Li,Y., Rubio,K., Deng,B., Li,Y., Tang,Q., Mao,C., Liu,S.,
            Xiao,D., Barreto,G. and Tao,Y.
  TITLE     Lymphoid-specific helicase in epigenetics, DNA repair and cancer
  JOURNAL   Br J Cancer 126 (2), 165-173 (2022)
   PUBMED   34493821
  REMARK    GeneRIF: Lymphoid-specific helicase in epigenetics, DNA repair and
            cancer.
            Review article
REFERENCE   6  (bases 1 to 3047)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 3047)
  AUTHORS   Sun,L.Q., Lee,D.W., Zhang,Q., Xiao,W., Raabe,E.H., Meeker,A.,
            Miao,D., Huso,D.L. and Arceci,R.J.
  TITLE     Growth retardation and premature aging phenotypes in mice with
            disruption of the SNF2-like gene, PASG
  JOURNAL   Genes Dev 18 (9), 1035-1046 (2004)
   PUBMED   15105378
REFERENCE   8  (bases 1 to 3047)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   9  (bases 1 to 3047)
  AUTHORS   Lee,D.W., Zhang,K., Ning,Z.Q., Raabe,E.H., Tintner,S., Wieland,R.,
            Wilkins,B.J., Kim,J.M., Blough,R.I. and Arceci,R.J.
  TITLE     Proliferation-associated SNF2-like gene (PASG): a SNF2 family
            member altered in leukemia
  JOURNAL   Cancer Res 60 (13), 3612-3622 (2000)
   PUBMED   10910076
REFERENCE   10 (bases 1 to 3047)
  AUTHORS   Geiman,T.M., Durum,S.K. and Muegge,K.
  TITLE     Characterization of gene expression, genomic structure, and
            chromosomal localization of Hells (Lsh)
  JOURNAL   Genomics 54 (3), 477-483 (1998)
   PUBMED   9878251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC423372.1, BC105606.1,
            AB102722.1, BC111789.1 and BC015477.1.
            
            On May 31, 2019 this sequence version replaced NM_001289074.1.
            
            Summary: This gene encodes a lymphoid-specific helicase. Other
            helicases function in processes involving DNA strand separation,
            including replication, repair, recombination, and transcription.
            This protein is thought to be involved with cellular proliferation
            and may play a role in leukemogenesis. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (9) uses an alternate splice site
            and lacks an alternate exon in the 5' coding region, and uses a
            downstream translation start codon, compared to variant 1. The
            encoded protein (isoform 9) has a shorter and distinct N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB102722.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN03267750,
                                           SAMN03267752 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC423372.1         444-471
            29-134              BC105606.1         2-107
            135-364             AB102722.1         1-230
            365-594             BC111789.1         310-539
            595-2570            AB102722.1         461-2436
            2571-3047           BC015477.1         956-1432
FEATURES             Location/Qualifiers
     source          1..3047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3047
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="helicase, lymphoid specific"
                     /db_xref="GeneID:3070"
                     /db_xref="HGNC:HGNC:4861"
                     /db_xref="MIM:603946"
     exon            1..165
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            166..287
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            288..410
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..467
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            468..504
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            505..569
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            570..611
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            612..839
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1022
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1070
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1085
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1282
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             1137..2570
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="isoform 9 is encoded by transcript variant 9;
                     SWI/SNF2-related, matrix-associated, actin-dependent
                     regulator of chromatin, subfamily A, member 6;
                     proliferation-associated SNF2-like protein; Senescence
                     Associated Long Non-coding RNA"
                     /codon_start=1
                     /product="lymphoid-specific helicase isoform 9"
                     /protein_id="NP_001276003.1"
                     /db_xref="GeneID:3070"
                     /db_xref="HGNC:HGNC:4861"
                     /db_xref="MIM:603946"
                     /translation="MKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVF
                     DDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPK
                     REVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKI
                     DDFPNELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEY
                     PIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHL
                     RDFNFSRLDGSMSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSD
                     WNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFK
                     GGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSREKVISDKDLELLLDRSDLIDQMN
                     ASGPIKEKMGIFKILENSEDSSPECLF"
     exon            1283..1379
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1541
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1681
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1820
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1904
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2024
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2141
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2301
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2398
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2475
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..3047
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3025..3030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="hexamer: AATAAA"
     polyA_site      3047
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="major polyA site"
ORIGIN      
        1 gaaggagaag cgcgcttttt tccctggcgg gggatttggc tagaaggctg ggccggcagc
       61 ggttgtgagg agttagctcg cggcattgca ggctctgaga ggaggggacc cggttcccgg
      121 gtgagtgtcc aggcatgcca gcggaacggc ccgcgggcag cggcggctcg gaggctccag
      181 caatggttga acaactggac actgctgtga ttaccccggc catgctagaa gaggaagaac
      241 agcttgaagc tgctggacta gagagagagc ggaagatgct ggaaaaggct cgcatgtctt
      301 gggatagaga gtcgacagaa attcggtacc gtagacttca acatttgctt gaaaaaagca
      361 atatatactc caaattttta ttgacgaaaa tggaacagca acaattagag gaacagaaga
      421 agaaagaaaa attggagaga aaaaaggagt ctttaaaagt taaaaagggt aaaaattcaa
      481 ttgatgcaag tgaagagaag ccagttatga ggaaaaaaag aggaagagaa gatgaatcat
      541 acaatatttc agaggtcatg tcaaaagagg aaattttgtc tgtggctaaa aaaaataaaa
      601 aggagaatga ggatgaaaac tcctcctcta ctaatctctg tgtggaagat cttcagaaaa
      661 ataaagattc gaatagtata attaaagata gattgtctga aacggttagg cagaatacta
      721 aattcttttt tgacccagtc cggaagtgta atggtcagcc agtacctttt caacaaccaa
      781 agcacttcac tggaggagtg atgcgatggt accaagtaga aggcatggaa tggcttagga
      841 tgctttggga aaatggaatt aatggcattt tagcagatga aatgggattg ggtaagacag
      901 ttcagtgcat tgctactatt gcattgatga ttcagagagg agtaccagga ccttttcttg
      961 tctgtggccc tttgtctaca cttcctaact ggatggctga attcaaaaga tttacaccag
     1021 atatccctac aatgttatat catggaaccc aggaggaacg tcaaaaattg atatatttgt
     1081 gacagcattg ctattggaaa tacttaatag tagatgaagg acacaggatt aagaatatga
     1141 agtgccgtct aatcagggag ttaaaacgat tcaatgctga taacaaactt cttttgactg
     1201 gtactccctt gcaaaacaat ttatcagaac tttggtcatt gctaaacttt ttgttgccag
     1261 atgtatttga tgacttgaaa agctttgagt cttggtttga catcactagt ctttctgaaa
     1321 ctgctgaaga tattattgct aaagaaagag aacagaatgt attgcatatg ctgcaccaga
     1381 ttttaacacc tttcttattg agaagactga agtctgatgt tgctcttgaa gttcctccta
     1441 aacgagaagt agtcgtttat gctccacttt caaagaagca ggagatcttt tatacagcca
     1501 ttgtgaaccg tacaattgca aacatgtttg gatccagtga gaaagaaaca attgagttaa
     1561 gtcctactgg tcgaccaaaa cgacgaacta gaaaatcaat aaattacagc aaaatagatg
     1621 atttccctaa tgaattggaa aaactgatca gtcaaataca gccagaggtg gaccgagaaa
     1681 gagctgttgt ggaagtgaat atccctgtag aatctgaagt taatctgaag ctgcagaata
     1741 taatgatgct acttcgtaaa tgttgtaatc atccatattt gattgaatat cctatagacc
     1801 ctgttacaca agaatttaag atcgatgaag aattggtaac aaattctggg aagttcttga
     1861 ttttggatcg aatgctgcca gaactaaaaa aaagaggtca caaggtgctg cttttttcac
     1921 aaatgacaag catgttggac attttgatgg attactgcca tctcagagat ttcaacttca
     1981 gcaggcttga tgggtccatg tcttactcag agagagaaaa aaacatgcac agcttcaaca
     2041 cggatccaga ggtgtttatc ttcttagtga gtacacgagc tggtggcctg ggcattaatc
     2101 tgactgcagc agatacagtt atcatttatg atagtgattg gaacccccag tcggatcttc
     2161 aggcccagga tagatgtcat agaattggtc agacaaagcc agttgttgtt tatcgccttg
     2221 ttacagcaaa tactatcgat cagaaaattg tggaaagagc agctgctaaa aggaaactgg
     2281 aaaagttgat catccataaa aatcatttca aaggtggtca gtctggatta aatctgtcta
     2341 agaatttctt agatcctaag gaattaatgg aattattaaa atctagagat tatgaaaggg
     2401 aaataaaagg atcaagagag aaggtcatta gtgataaaga tctagagttg ttgttagatc
     2461 gaagtgatct tattgatcaa atgaatgctt caggaccaat taaagagaag atggggatat
     2521 tcaagatatt agaaaattct gaagattcca gtcctgaatg tttgttttaa agtggagctc
     2581 aagaatagct tttaaaagtt cttatttaca tctagtgatt tccctgtatt gggtttgaaa
     2641 tactgattgt ccacttcacc ttttttatta tatcagttga catgtaacta gtaccatgcg
     2701 tacttaaata gatggtaatt ttctgagcct taccaagaac aaagaagtat ccatattaag
     2761 tttagatttt cagttaattt ttgagactga gtagtattct tggatacagg ctgatgtgta
     2821 cttaaccact tccagattta tacagtcttc ctgtggaagt ttagtaaatg tctttttccc
     2881 tcctttcttc tagtaatgca gttcatgggc tttaggtact tcagttatga agtaggcttt
     2941 tcatggggag agattgggat tatgctctct gttgtttaag aaactgtttg attttagagt
     3001 ctatttctat gagatagttt accaaataaa tgttccttat aagatga
//
