LOCUS       NM_001289073            3063 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens helicase, lymphoid specific (HELLS), transcript
            variant 8, mRNA.
ACCESSION   NM_001289073
VERSION     NM_001289073.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3063)
  AUTHORS   Consiglio,A., Venturin,M., Briguglio,S., Rossi,C., Grillo,G.,
            Bellosta,S., Cattaneo,M.G., Licciulli,F. and Battaglia,C.
  TITLE     Lost in HELLS: Disentangling the mystery of SALNR existence in
            senescence cellular models
  JOURNAL   PLoS One 18 (5), e0286104 (2023)
   PUBMED   37252915
  REMARK    GeneRIF: Lost in HELLS: Disentangling the mystery of SALNR
            existence in senescence cellular models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3063)
  AUTHORS   Peixoto,E., Khan,A., Lewis,Z.A., Contreras-Galindo,R. and Czaja,W.
  TITLE     The Chromatin Remodeler HELLS: A New Regulator in DNA Repair,
            Genome Maintenance, and Cancer
  JOURNAL   Int J Mol Sci 23 (16), 9313 (2022)
   PUBMED   36012581
  REMARK    GeneRIF: The Chromatin Remodeler HELLS: A New Regulator in DNA
            Repair, Genome Maintenance, and Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3063)
  AUTHORS   Liang,X., Li,L. and Fan,Y.
  TITLE     Diagnostic, Prognostic, and Immunological Roles of HELLS in
            Pan-Cancer: A Bioinformatics Analysis
  JOURNAL   Front Immunol 13, 870726 (2022)
   PUBMED   35774795
  REMARK    GeneRIF: Diagnostic, Prognostic, and Immunological Roles of HELLS
            in Pan-Cancer: A Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3063)
  AUTHORS   He,C. and Liu,L.
  TITLE     Hsa_circ_0072008 regulates cell proliferation, migration, and
            invasion in cervical squamous cell carcinoma via miR-1305/helicase,
            lymphoid specific (HELLS) axis
  JOURNAL   Bioengineered 13 (4), 8311-8322 (2022)
   PUBMED   35311456
  REMARK    GeneRIF: Hsa_circ_0072008 regulates cell proliferation, migration,
            and invasion in cervical squamous cell carcinoma via
            miR-1305/helicase, lymphoid specific (HELLS) axis.
REFERENCE   5  (bases 1 to 3063)
  AUTHORS   Chen,X., Li,Y., Rubio,K., Deng,B., Li,Y., Tang,Q., Mao,C., Liu,S.,
            Xiao,D., Barreto,G. and Tao,Y.
  TITLE     Lymphoid-specific helicase in epigenetics, DNA repair and cancer
  JOURNAL   Br J Cancer 126 (2), 165-173 (2022)
   PUBMED   34493821
  REMARK    GeneRIF: Lymphoid-specific helicase in epigenetics, DNA repair and
            cancer.
            Review article
REFERENCE   6  (bases 1 to 3063)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 3063)
  AUTHORS   Sun,L.Q., Lee,D.W., Zhang,Q., Xiao,W., Raabe,E.H., Meeker,A.,
            Miao,D., Huso,D.L. and Arceci,R.J.
  TITLE     Growth retardation and premature aging phenotypes in mice with
            disruption of the SNF2-like gene, PASG
  JOURNAL   Genes Dev 18 (9), 1035-1046 (2004)
   PUBMED   15105378
REFERENCE   8  (bases 1 to 3063)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   9  (bases 1 to 3063)
  AUTHORS   Lee,D.W., Zhang,K., Ning,Z.Q., Raabe,E.H., Tintner,S., Wieland,R.,
            Wilkins,B.J., Kim,J.M., Blough,R.I. and Arceci,R.J.
  TITLE     Proliferation-associated SNF2-like gene (PASG): a SNF2 family
            member altered in leukemia
  JOURNAL   Cancer Res 60 (13), 3612-3622 (2000)
   PUBMED   10910076
REFERENCE   10 (bases 1 to 3063)
  AUTHORS   Geiman,T.M., Durum,S.K. and Muegge,K.
  TITLE     Characterization of gene expression, genomic structure, and
            chromosomal localization of Hells (Lsh)
  JOURNAL   Genomics 54 (3), 477-483 (1998)
   PUBMED   9878251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC423372.1, BC105606.1,
            AB102717.1, BC111789.1 and BC015477.1.
            
            On May 31, 2019 this sequence version replaced NM_001289073.1.
            
            Summary: This gene encodes a lymphoid-specific helicase. Other
            helicases function in processes involving DNA strand separation,
            including replication, repair, recombination, and transcription.
            This protein is thought to be involved with cellular proliferation
            and may play a role in leukemogenesis. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (8) lacks an alternate exon in the
            5' coding region and uses a downstream translation start codon,
            compared to variant 1. The encoded protein (isoform 8) has a
            shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB102717.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC423372.1         444-471
            29-134              BC105606.1         2-107
            135-364             AB102717.1         1-230
            365-504             BC111789.1         310-449
            505-2586            AB102717.1         371-2452
            2587-3063           BC015477.1         956-1432
FEATURES             Location/Qualifiers
     source          1..3063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3063
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="helicase, lymphoid specific"
                     /db_xref="GeneID:3070"
                     /db_xref="HGNC:HGNC:4861"
                     /db_xref="MIM:603946"
     exon            1..165
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            166..287
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            288..410
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..467
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            468..504
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             484..2586
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="isoform 8 is encoded by transcript variant 8;
                     SWI/SNF2-related, matrix-associated, actin-dependent
                     regulator of chromatin, subfamily A, member 6;
                     proliferation-associated SNF2-like protein; Senescence
                     Associated Long Non-coding RNA"
                     /codon_start=1
                     /product="lymphoid-specific helicase isoform 8"
                     /protein_id="NP_001276002.1"
                     /db_xref="GeneID:3070"
                     /db_xref="HGNC:HGNC:4861"
                     /db_xref="MIM:603946"
                     /translation="MQVKRSQEILSVAKKNKKENEDENSSSTNLCVEDLQKNKDSNSI
                     IKDRLSETVRQNTKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWEN
                     GINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPDIP
                     TMLYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFEIAMRDRNALQHCYWKYLIVDEG
                     HRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESW
                     FDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPL
                     SKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRPKRRTRKSINYSKIDDFPNELEK
                     LISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMMLLRKCCNHPYLIEYPIDPVTQEF
                     KIDEELVTNSGKFLILDRMLPELKKRGHKVLLFSQMTSMLDILMDYCHLRDFNFSRLD
                     GSMSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQA
                     QDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLNLS
                     KNFLDPKELMELLKSRDYEREIKGSREKVISDKDLELLLDRSDLIDQMNASGPIKEKM
                     GIFKILENSEDSSPECLF"
     exon            505..546
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            547..774
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            775..957
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1101
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1298
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1395
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1557
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1697
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1836
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1920
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2040
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2157
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2317
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2414
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2491
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..3063
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="hexamer: AATAAA"
     polyA_site      3063
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="major polyA site"
ORIGIN      
        1 gaaggagaag cgcgcttttt tccctggcgg gggatttggc tagaaggctg ggccggcagc
       61 ggttgtgagg agttagctcg cggcattgca ggctctgaga ggaggggacc cggttcccgg
      121 gtgagtgtcc aggcatgcca gcggaacggc ccgcgggcag cggcggctcg gaggctccag
      181 caatggttga acaactggac actgctgtga ttaccccggc catgctagaa gaggaagaac
      241 agcttgaagc tgctggacta gagagagagc ggaagatgct ggaaaaggct cgcatgtctt
      301 gggatagaga gtcgacagaa attcggtacc gtagacttca acatttgctt gaaaaaagca
      361 atatatactc caaattttta ttgacgaaaa tggaacagca acaattagag gaacagaaga
      421 agaaagaaaa attggagaga aaaaaggagt ctttaaaagt taaaaagggt aaaaattcaa
      481 ttgatgcaag tgaagagaag ccaggaaatt ttgtctgtgg ctaaaaaaaa taaaaaggag
      541 aatgaggatg aaaactcctc ctctactaat ctctgtgtgg aagatcttca gaaaaataaa
      601 gattcgaata gtataattaa agatagattg tctgaaacgg ttaggcagaa tactaaattc
      661 ttttttgacc cagtccggaa gtgtaatggt cagccagtac cttttcaaca accaaagcac
      721 ttcactggag gagtgatgcg atggtaccaa gtagaaggca tggaatggct taggatgctt
      781 tgggaaaatg gaattaatgg cattttagca gatgaaatgg gattgggtaa gacagttcag
      841 tgcattgcta ctattgcatt gatgattcag agaggagtac caggaccttt tcttgtctgt
      901 ggccctttgt ctacacttcc taactggatg gctgaattca aaagatttac accagatatc
      961 cctacaatgt tatatcatgg aacccaggag gaacgtcaaa aattggtaag aaatatttac
     1021 aaacggaaag ggactttgca gattcatcct gtggtaatca cgtcatttga aatagccatg
     1081 agagaccgaa atgcgttaca gcattgctat tggaaatact taatagtaga tgaaggacac
     1141 aggattaaga atatgaagtg ccgtctaatc agggagttaa aacgattcaa tgctgataac
     1201 aaacttcttt tgactggtac tcccttgcaa aacaatttat cagaactttg gtcattgcta
     1261 aactttttgt tgccagatgt atttgatgac ttgaaaagct ttgagtcttg gtttgacatc
     1321 actagtcttt ctgaaactgc tgaagatatt attgctaaag aaagagaaca gaatgtattg
     1381 catatgctgc accagatttt aacacctttc ttattgagaa gactgaagtc tgatgttgct
     1441 cttgaagttc ctcctaaacg agaagtagtc gtttatgctc cactttcaaa gaagcaggag
     1501 atcttttata cagccattgt gaaccgtaca attgcaaaca tgtttggatc cagtgagaaa
     1561 gaaacaattg agttaagtcc tactggtcga ccaaaacgac gaactagaaa atcaataaat
     1621 tacagcaaaa tagatgattt ccctaatgaa ttggaaaaac tgatcagtca aatacagcca
     1681 gaggtggacc gagaaagagc tgttgtggaa gtgaatatcc ctgtagaatc tgaagttaat
     1741 ctgaagctgc agaatataat gatgctactt cgtaaatgtt gtaatcatcc atatttgatt
     1801 gaatatccta tagaccctgt tacacaagaa tttaagatcg atgaagaatt ggtaacaaat
     1861 tctgggaagt tcttgatttt ggatcgaatg ctgccagaac taaaaaaaag aggtcacaag
     1921 gtgctgcttt tttcacaaat gacaagcatg ttggacattt tgatggatta ctgccatctc
     1981 agagatttca acttcagcag gcttgatggg tccatgtctt actcagagag agaaaaaaac
     2041 atgcacagct tcaacacgga tccagaggtg tttatcttct tagtgagtac acgagctggt
     2101 ggcctgggca ttaatctgac tgcagcagat acagttatca tttatgatag tgattggaac
     2161 ccccagtcgg atcttcaggc ccaggataga tgtcatagaa ttggtcagac aaagccagtt
     2221 gttgtttatc gccttgttac agcaaatact atcgatcaga aaattgtgga aagagcagct
     2281 gctaaaagga aactggaaaa gttgatcatc cataaaaatc atttcaaagg tggtcagtct
     2341 ggattaaatc tgtctaagaa tttcttagat cctaaggaat taatggaatt attaaaatct
     2401 agagattatg aaagggaaat aaaaggatca agagagaagg tcattagtga taaagatcta
     2461 gagttgttgt tagatcgaag tgatcttatt gatcaaatga atgcttcagg accaattaaa
     2521 gagaagatgg ggatattcaa gatattagaa aattctgaag attccagtcc tgaatgtttg
     2581 ttttaaagtg gagctcaaga atagctttta aaagttctta tttacatcta gtgatttccc
     2641 tgtattgggt ttgaaatact gattgtccac ttcacctttt ttattatatc agttgacatg
     2701 taactagtac catgcgtact taaatagatg gtaattttct gagccttacc aagaacaaag
     2761 aagtatccat attaagttta gattttcagt taatttttga gactgagtag tattcttgga
     2821 tacaggctga tgtgtactta accacttcca gatttataca gtcttcctgt ggaagtttag
     2881 taaatgtctt tttccctcct ttcttctagt aatgcagttc atgggcttta ggtacttcag
     2941 ttatgaagta ggcttttcat ggggagagat tgggattatg ctctctgttg tttaagaaac
     3001 tgtttgattt tagagtctat ttctatgaga tagtttacca aataaatgtt ccttataaga
     3061 tga
//
