LOCUS       NM_016217               5646 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens hdc homolog, cell cycle regulator (HECA), mRNA.
ACCESSION   NM_016217
VERSION     NM_016217.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5646)
  AUTHORS   Li,T., Wu,Y., Chen,W.C., Xue,X., Suo,M.J., Li,P., Sheng,W. and
            Huang,G.Y.
  TITLE     Functional analysis of HECA variants identified in congenital heart
            disease in the Chinese population
  JOURNAL   J Clin Lab Anal 36 (9), e24649 (2022)
   PUBMED   35949005
  REMARK    GeneRIF: Functional analysis of HECA variants identified in
            congenital heart disease in the Chinese population.
REFERENCE   2  (bases 1 to 5646)
  AUTHORS   Son,H.J., Choi,E.J., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational and expressional alterations of a candidate tumor
            suppressor HECA gene in gastric and colorectal cancers
  JOURNAL   Pathol Res Pract 216 (5), 152896 (2020)
   PUBMED   32088090
  REMARK    GeneRIF: Mutational and expressional alterations of a candidate
            tumor suppressor HECA gene in gastric and colorectal cancers.
REFERENCE   3  (bases 1 to 5646)
  AUTHORS   Dowejko,A., Bauer,R., Bauer,K., Muller-Richter,U.D. and
            Reichert,T.E.
  TITLE     The human HECA interacts with cyclins and CDKs to antagonize
            Wnt-mediated proliferation and chemoresistance of head and neck
            cancer cells
  JOURNAL   Exp Cell Res 318 (5), 489-499 (2012)
   PUBMED   22100912
  REMARK    GeneRIF: HECA expression is markedly decreased in oral squamous
            cell carcinoma (OSCC) compared to controls and is associated with
            decreased sensitivity to cisplatin in OSCC cell lines
REFERENCE   4  (bases 1 to 5646)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 5646)
  AUTHORS   Dowejko,A., Bauer,R.J., Muller-Richter,U.D. and Reichert,T.E.
  TITLE     The human homolog of the Drosophila headcase protein slows down
            cell division of head and neck cancer cells
  JOURNAL   Carcinogenesis 30 (10), 1678-1685 (2009)
   PUBMED   19643820
  REMARK    GeneRIF: Human HECA slows down cell division of oral squamous cell
            carcinoma cells and may therefore act as a tumor suppressor in head
            and neck cancer.
REFERENCE   6  (bases 1 to 5646)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5646)
  AUTHORS   Chien,C.C., Chang,C.C., Yang,S.H., Chen,S.H. and Huang,C.J.
  TITLE     A homologue of the Drosophila headcase protein is a novel tumor
            marker for early-stage colorectal cancer
  JOURNAL   Oncol Rep 15 (4), 919-926 (2006)
   PUBMED   16525680
  REMARK    GeneRIF: Data show that HECA may be an early-stage classifier of
            colorectal cancer that can discriminate between late- and
            early-stage disease.
REFERENCE   8  (bases 1 to 5646)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 5646)
  AUTHORS   Makino,N., Yamato,T., Inoue,H., Furukawa,T., Abe,T., Yokoyama,T.,
            Yatsuoka,T., Fukushige,S., Orikasa,S., Takahashi,T. and Horii,A.
  TITLE     Isolation and characterization of the human gene homologous to the
            Drosophila headcase (hdc) gene in chromosome bands 6q23-q24, a
            region of common deletion in human pancreatic cancer
  JOURNAL   DNA Seq 11 (6), 547-553 (2001)
   PUBMED   11696983
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031772.6, BC070068.1 and
            AB033492.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016217.2.
            
            Summary: This gene encodes the homolog of the Drosophila headcase
            protein, a highly basic, cytoplasmic protein that regulates the
            re-entry of imaginal cells into the mitotic cycle during adult
            morphogenesis. In Drosophila, the encoded protein also inhibits
            terminal branching of neighboring cells during tracheal
            development. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070068.1, SRR1803614.7220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367658.3/ ENSP00000356630.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL031772.6         68934-68965
            33-454              BC070068.1         9-430
            455-2881            AB033492.1         423-2849
            2882-5646           AL031772.6         111892-114656
FEATURES             Location/Qualifiers
     source          1..5646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..5646
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /note="hdc homolog, cell cycle regulator"
                     /db_xref="GeneID:51696"
                     /db_xref="HGNC:HGNC:21041"
                     /db_xref="MIM:607977"
     exon            1..588
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1949
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /note="headcase homolog"
                     /codon_start=1
                     /product="headcase protein homolog"
                     /protein_id="NP_057301.1"
                     /db_xref="CCDS:CCDS5194.1"
                     /db_xref="GeneID:51696"
                     /db_xref="HGNC:HGNC:21041"
                     /db_xref="MIM:607977"
                     /translation="MPNPKNSKGGRKNKRANSSGDEQENGAGALAAAGAAGAAAGGAL
                     AAAAGCGAAAAGAPGAGGAAGAGGAGTGAANAAAAAGAAAAGDAKNEAPCATPLICSF
                     GRPVDLEKDDYQKVVCNNEHCPCSTWMHLQCFYEWESSILVQFNCIGRARSWNEKQCR
                     QNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTGRPPGEA
                     AEEAKKCRPPNKPQKGPSHDLPRRHSMDRQNSQEKAVGAAAYGARSPGGSPGQSPPTG
                     YSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMAGGHVFRNAHFDYSPAGLAVHRG
                     GHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASH
                     RNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHLQGRLMHLYAVCVDC
                     LEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIGM
                     QYFSEYSNVQQCPHCGNLDYHFVKPFSSFKVLEAY"
     exon            589..1629
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1784
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..5646
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5627..5632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /note="hexamer: AATAAA"
     polyA_site      5646
                     /gene="HECA"
                     /gene_synonym="dJ225E12.1; HDC; HDCL; HHDC"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagccg aatcaaaaca agccggagac ccgccttttc cctccggctc gggagcgtct
       61 cgcttgcgcc ccgggcccgc ggcgcccgcg cggctgcgag cctcgggtgg ccgcgtgccg
      121 gctccaggaa gccggagagg gcgcggcggc caggatggcg cggcacgggc cgtgcggcta
      181 gacgggagcc gagggaaccg ccggctcgcg ccctccgttc tttcccggag ccggcttcac
      241 gcagggccgg gaacggccgt gcctctggga tccgccttcg ctgacgccgg gcacctacct
      301 ggacgcgagc gagcgagatg cccaacccca aaaacagcaa aggcggccgc aaaaacaagc
      361 gcgccaacag cagcggcgac gagcaggaaa atggagccgg ggccctggca gcggcgggcg
      421 cggcgggagc ggcggccggg ggggccctgg cggcggcggc cggttgcggg gcggcggcgg
      481 cgggcgcgcc gggcgccgga ggcgcggcgg gcgccggagg cgcggggact ggcgccgcga
      541 acgctgcggc cgccgcgggg gctgcggccg cgggcgatgc caaaaacgaa gccccatgtg
      601 ccactcccct gatctgcagc ttcggtaggc cggtggacct ggagaaggac gactaccaga
      661 aggtggtgtg caacaacgag cactgcccct gcagcacctg gatgcacctg cagtgcttct
      721 acgagtggga gagcagcatc ctcgtccagt tcaactgcat cggccgcgcg cgcagctgga
      781 acgagaagca atgccgccag aacatgtgga caaagaaggg ctacgacctg gccttccgct
      841 tctgctcttg ccgctgtggc cagggccact tgaagaagga cacagactgg tatcaggtga
      901 agcggatgca ggacgagaaa aagaagaagt ctggctccga gaagaacaca gggaggcctc
      961 ctggtgaggc ggcggaggag gcaaaaaagt gcaggccccc aaataagccc cagaaaggcc
     1021 caagccacga cctcccccgc cggcattcca tggaccggca gaactcccag gagaaggcag
     1081 tgggtgccgc agcctacggt gcccgttccc ccggtggctc cccgggccag tccccaccca
     1141 cgggctactc catcctctct cctgcccact tcagcggccc ccgctcctcc agatacctcg
     1201 gggagttctt aaagaacgcc atccatctgg agcctcacaa gaaggccatg gctgggggcc
     1261 atgtgttcag aaatgcccac tttgattaca gccctgcggg gttggcagtt cacagggggg
     1321 gacacttcga cacccccgtg cagttccttc ggcggctgga cctctccgaa ctcctcactc
     1381 acatccccag gcataagctg aacactttcc acgtgcgcat ggaagacgat gcccaagtgg
     1441 gccaggggga agacttgcgg aagttcattc tggccgcgct cagtgccagc cacagaaacg
     1501 tggtaaactg tgccctgtgc caccgggcgc tcccggtgtt cgaacagttc ccactggtgg
     1561 atggaacttt gttcctaagc ccgtcgagac atgatgagat cgaatatgat gttccttgtc
     1621 accttcaagg gagactcatg catctgtatg ccgtgtgcgt ggactgcctg gaaggggttc
     1681 acaagatcat ctgcatcaag tgtaagtcac ggtgggatgg cagctggcac cagctgggca
     1741 ctatgtacac ctacgacatc ctggctgcct ctccatgttg tcaggcccgc ctgaactgta
     1801 agcactgtgg gaagccggtg atcgacgtga ggatcgggat gcagtacttc tccgaatata
     1861 gcaacgtcca gcagtgtcca cactgtggga acctggacta ccacttcgtg aagccatttt
     1921 cctccttcaa agttctcgaa gcttattgat gaaagctttg ctttagtaat agctatttta
     1981 ttgatattat tactttatta catatctttt atagggaaac attctgtgac attaatttcc
     2041 tttctaattt aaaggagagt tactttgttg tatgtgtgcc actaaaatag gggctgccct
     2101 tgccctgtct tgattcccga gtgttaatct gtggttttga ccagagccca gatgggtaat
     2161 cctgtgcatt tgggttgggg ttcactctta ccaagaatct ttgatgcagc tttaagatgg
     2221 tggggaggat ggggtgaatt taggaaagga atttgtggtt ataaactaag agcttgatag
     2281 gagttggaag gaaactctta ctaaaatgtt aactttctaa aaaccttctt ttagatcttc
     2341 cttgggcctt tggaaaaata tgtgacaagt gaatgtaagt ctgtgcctgg agagctaata
     2401 gtgcattagt ctatctcagc ctagtgttct gcagcacaca tgggcaggca gtttactcac
     2461 actgacaggt gacctgaaag tggcacaagt gctgtttcta tcactattgt aatttgccag
     2521 ttcatttttc atgctgaaag taatatccaa attgtaagac atatgaaaga tattagtgtt
     2581 gcaaatatgt ttaggtaaac tgacctataa cagaatatgt gaaatgaatt tggaaataat
     2641 gcaagaaggc agaactcaat catttaaatt gtgtctttga agttggtaat atagctttta
     2701 aggagaaccc atgaataacc tgatttgggc agtgatgatt tattacaggt tgcactgttg
     2761 aagtgtcatt tggtgtcagg ttcttctcac aggtaaatct ttcagccaca gaatctaact
     2821 ggtgagcttc agaaccaata attgccacat ttattgtcct caaaattgct tatggccatg
     2881 tataaccaat taattctgag tttccaaaat caaagatttg accttaagag ggaagggaaa
     2941 aaagtgtgaa aggatgatga agaaaataat tttactattt cttttaaaag tatgttttgg
     3001 aaaatcaatg attttaatgc atagcagtat gtttgaaaaa tagaccattc taaaaagccc
     3061 atgatacctt actgttgatg aaaaaggatg atcatatata tagaacttga ttagtcagag
     3121 cattgggcat tccaaaatac agcctttggt tcagtagatt ttaatgcttt aaatagactg
     3181 acgtcgcata cccttataga attggaatat gatttctcaa aaattaattt gataatttca
     3241 tgtatgatgt gcatatatgc taaaagaatg cagaaaatca ttttatgaat agccaaattt
     3301 ggggttgatg tgaacatttt atgttactca tttggtttat actttttttt tttttttttt
     3361 aactgtgtgg tttttctttt cagaagtatt taggcaatat tgcacgtgag tttcagttct
     3421 ttttttcttt tttttgagat ggagtctcac tcttgtcacc caggctggag tgcagtagtg
     3481 cgatctcagc tcactgcaac ctctgcctcc tggattcaag cgattctcct gtcccagcct
     3541 cccaggtagc tgggactata ggcacgtgcc accacacccg gctaattttt tgtattttta
     3601 gtagagacag cgtttcacca tgttagctag gatggtctag atctcctgac cttgtgatct
     3661 gcctgcctcg gcctcccaaa gtgctgggat tacaggcgtg agtcactgtg cctggccaag
     3721 tttcagttct atatgaagta tttgatgttt tgtttgaaac aatacagcat taaagaacca
     3781 atgttattca ctaatatcat tcatctttca gtttggatga tttggtttgc tgcatctagg
     3841 ttggtgtttg atcatctgaa aaaacatttc agtgggaaga aatgcataaa atgcctataa
     3901 gaagtagaaa gtcattgaac tgacagtgtt tgatgcaact aaaagaggat tgtaagacat
     3961 agctttctgc aaacttgtct ttaatgcaca aagctgtagt ggtgaattaa ctatctcctt
     4021 attgattctc tcctgtaccc agatgcaaaa agtgctaagt ttctcttgtc ctcgtaatac
     4081 catttggatt ttatttctga atttaaatag taaaatattt atgatgctga tctttaaccc
     4141 acctaaaatt ttatagtgaa acctgcttta tattgttgtt ctgaagctta caattgacct
     4201 atacattgca ttcagcaagc tcctgaattt agaactgccg tcagtgtagt gtatgctgtg
     4261 ttccatgttg cctttttaga tggctttcta ccccctgaac aataaatagg atgaggtttt
     4321 actgtaattg ggtaaagttt actcttggac attatttcga tgctaaagta aggattctgt
     4381 ggatgttact taaagagaaa agcataagag catgaagcat atctgggaat atcttttgcc
     4441 tttaagacga ttcattcttg tctagaggga aaatctggct gatttgggaa taaaatataa
     4501 tcgaatattc aacaccatga agataaatct tattttggaa atctactgac cttaataccc
     4561 caagcttgcc ctgaatactt tgattggaat tggaatatat caaaaaaggt tagtattttt
     4621 gttgtagtta ggatactaaa aggatattag ttacccaaga gatccaattt gtttttctga
     4681 tgaatagtgt tcagtaaaat gaagcagtct taagagtgac taataatttc aaagtgattt
     4741 ttcgtctatt cttaatattt tttaattatt tatttttaag agttttatac cttgagcaga
     4801 tacaatgatc tgctttagtg agaggacaat ttctgattga ttgttttctc ttcaggccat
     4861 ctcacctctt cattctcttg ttacatttga agcagttgat ataatgggtt tatactttaa
     4921 aagatagaca tggtgccatg aagttgggga gttgggtgaa ttatcccatt ctagttacag
     4981 aggagctttc cttaaatgcc ctttaacttc taggttttgt tcaagaagtt cattttctga
     5041 gtaaaaggta ttttcatata tgttggggga aaattaactc atctaaaaag aatcttatta
     5101 ggtatttgaa ctctaaaact aacagataag acagatatgt accttattag agcaccagaa
     5161 ctaatttgct aagtcttttg tttagtcctg caagactgat gcttaataca cagtctgttc
     5221 tcctgtgtct aggtcaggaa ctccagtttg cttttctgtt ttgtgtcctg gtagcagctg
     5281 ttgagtaact ttcattggag gttgggaagg aagtgaggag aaagtgttct tgtttagtgt
     5341 tttatttcct ataataggat gctgcctaac ccagttcatc tctatgtcct gttcactgaa
     5401 tattccgggt aattgaaaga aaatataatg gatgggctcc attaaaacca gctcaaaaat
     5461 aaattcttgt cagtaaagat ttcttgtcaa gatgtcttgg attgcacttt tgttgaggaa
     5521 agacagtgta aatagttaaa gaatgttgat aaaattgaaa catttggttg tggaattgtg
     5581 tgtggtttta gagggtttct gtttgtgaaa tgtatgtatt aaaaataata aaattccaga
     5641 aactaa
//
