LOCUS       NM_014320              10010 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens heme binding protein 2 (HEBP2), transcript variant 2,
            mRNA.
ACCESSION   NM_014320
VERSION     NM_014320.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10010)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 10010)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10010)
  AUTHORS   Mikasa,T., Kugo,M., Nishimura,S., Taketani,S., Ishijima,S. and
            Sagami,I.
  TITLE     Thermodynamic Characterization of the Ca2+-Dependent Interaction
            Between SOUL and ALG-2
  JOURNAL   Int J Mol Sci 19 (12), 3802 (2018)
   PUBMED   30501057
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10010)
  AUTHORS   Qin,J., Yang,Y., Gao,S., Liu,Y., Yu,F., Zhou,Y., Lyu,R., Liu,M.,
            Liu,X., Li,D. and Zhou,J.
  TITLE     Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and
            mitotic spindle behavior to stimulate cancer development
  JOURNAL   J Cell Physiol 232 (11), 3067-3076 (2017)
   PUBMED   28004381
  REMARK    GeneRIF: The gene copy numbers and mRNA levels for both ALG-2 and
            HEBP2 are significantly upregulated in breast and lung cancer.
            Coexpression of ALG-2 and HEBP2 markedly increases the cytoplasmic
            pool of ALG-2 and alters the subcellular distribution of HEBP2.
            Abnormalities in the ALG-2/HEBP2 interaction impairs spindle
            orientation and positioning during mitosis.
REFERENCE   5  (bases 1 to 10010)
  AUTHORS   Ma,J., Zhang,X., Feng,Y., Zhang,H., Wang,X., Zheng,Y., Qiao,W. and
            Liu,X.
  TITLE     Structural and Functional Study of Apoptosis-linked
            Gene-2.Heme-binding Protein 2 Interactions in HIV-1 Production
  JOURNAL   J Biol Chem 291 (52), 26670-26685 (2016)
   PUBMED   27784779
REFERENCE   6  (bases 1 to 10010)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 10010)
  AUTHORS   Szigeti,A., Bellyei,S., Gasz,B., Boronkai,A., Hocsak,E., Minik,O.,
            Bognar,Z., Varbiro,G., Sumegi,B. and Gallyas,F. Jr.
  TITLE     Induction of necrotic cell death and mitochondrial permeabilization
            by heme binding protein 2/SOUL
  JOURNAL   FEBS Lett 580 (27), 6447-6454 (2006)
   PUBMED   17098234
  REMARK    GeneRIF: SOUL promotes necrotic cell death by inducing
            mitochondrial permeability transition
REFERENCE   8  (bases 1 to 10010)
  AUTHORS   Liu,L. and McKeehan,W.L.
  TITLE     Sequence analysis of LRPPRC and its SEC1 domain interaction
            partners suggests roles in cytoskeletal organization, vesicular
            trafficking, nucleocytosolic shuttling, and chromosome activity
  JOURNAL   Genomics 79 (1), 124-136 (2002)
   PUBMED   11827465
REFERENCE   9  (bases 1 to 10010)
  AUTHORS   Zylka,M.J. and Reppert,S.M.
  TITLE     Discovery of a putative heme-binding protein family (SOUL/HBP) by
            two-tissue suppression subtractive hybridization and database
            searches
  JOURNAL   Brain Res Mol Brain Res 74 (1-2), 175-181 (1999)
   PUBMED   10640688
REFERENCE   10 (bases 1 to 10010)
  AUTHORS   Bohn,H. and Winckler,W.
  TITLE     Isolation and characterization of five new soluble placental tissue
            proteins (PP22, PP23, PP24, PP25, PP26)
  JOURNAL   Arch Gynecol Obstet 248 (3), 111-115 (1991)
   PUBMED   2018407
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF974311.1, AF117616.1,
            AK057928.1 and AL391669.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014320.2.
            
            Summary: The protein encoded by this gene is found predominately in
            the cytoplasm, where it plays a role in the collapse of
            mitochondrial membrane potential (MMP) prior to necrotic cell
            death. The encoded protein enhances outer and inner mitochondrial
            membrane permeabilization, especially under conditions of oxidative
            stress. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057928.1, AF117616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000607197.6/ ENSP00000475750.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               BF974311.1         25-535
            512-1135            AF117616.1         514-1137
            1136-1258           AK057928.1         1075-1197
            1259-10010          AL391669.11        224-8975
FEATURES             Location/Qualifiers
     source          1..10010
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..10010
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="heme binding protein 2"
                     /db_xref="GeneID:23593"
                     /db_xref="HGNC:HGNC:15716"
                     /db_xref="MIM:605825"
     exon            1..375
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..891
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="isoform 2 is encoded by transcript variant 2;
                     placental protein 23"
                     /codon_start=1
                     /product="heme-binding protein 2 isoform 2"
                     /protein_id="NP_055135.1"
                     /db_xref="CCDS:CCDS5191.1"
                     /db_xref="GeneID:23593"
                     /db_xref="HGNC:HGNC:15716"
                     /db_xref="MIM:605825"
                     /translation="MAEPLQPDPGAAEDAAAQAVETPGWKAPEDAGPQPGSYEIRHYG
                     PAKWVSTSVESMDWDSAIQTGFTKLNSYIQGKNEKEMKIKMTAPVTSYVEPGSGPFSE
                     STITISLYIPSEQQFDPPRPLESDVFIEDRAEMTVFVRSFDGFSSAQKNQEQLLTLAS
                     ILREDGKVFDEKVYYTAGYNSPVKLLNRNNEVWLIQKNEPTKENE"
     exon            376..511
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /inference="alignment:Splign:2.1.0"
     exon            512..692
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /inference="alignment:Splign:2.1.0"
     exon            693..10010
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="hexamer: AGTAAA"
     polyA_site      967
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="major polyA site"
     regulatory      1242..1247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="hexamer: AATAAA"
     polyA_site      1259
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="hexamer: AACAAA"
     polyA_site      3396
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
     regulatory      8631..8636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="hexamer: AATAAA"
     polyA_site      8652
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
     regulatory      9910..9915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="hexamer: ATTAAA"
     polyA_site      9933
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
     regulatory      9988..9993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
                     /note="hexamer: ATTAAA"
     polyA_site      10010
                     /gene="HEBP2"
                     /gene_synonym="C6orf34; C6ORF34B; PP23; SOUL"
ORIGIN      
        1 ccctgtcgcc gcggaggggc gggggcagga cgcgcaactc cggccggagc tgtccggggt
       61 cgtgagccgg ccccgccttg gtggcggcgc cccctcgcgg tccagaggca gacgcatcgg
      121 gtgggctcgg gtctccagcc cggccgggag gagggaccgg gtctgcggag cggggactcg
      181 gggcctcggc ggggcgcgca cacgcaggcg gggcggcccg gggtgcgggg cctctgcgcg
      241 gctgaccagg ctcccagagc gtcagcgccg cccatggccg agccgctcca gccagacccc
      301 ggggcggccg aggacgcggc ggcccaagct gtggagacgc cgggctggaa ggccccggag
      361 gacgccggcc cccagcccgg aagttatgag atccgacact atggaccagc caagtgggtc
      421 agcacgtccg tggagtctat ggactgggat tcagccatcc agacgggctt tacgaaactg
      481 aacagctaca ttcaaggcaa aaacgagaaa gagatgaaaa taaagatgac agctccagtg
      541 acaagctacg tggagcctgg ttcaggtcct tttagtgagt ctaccattac catttccctg
      601 tatattccct ctgaacagca atttgatcca cccaggcctt tagagtcaga tgtcttcatt
      661 gaagatagag ccgaaatgac tgtgtttgta cggtctttcg atggattttc tagtgcccaa
      721 aagaatcaag aacaactttt gacattagca agcattttaa gggaagatgg aaaagttttc
      781 gatgagaagg tttactacac tgcaggctac aacagtcctg tcaaattgct taatagaaat
      841 aatgaagtgt ggttgattca aaaaaatgaa cccaccaaag aaaacgaatg agaaaaatga
      901 aaggaagttc tgctgtcaga ggcaaaacat ctgtttatca tagacatcaa catgacctat
      961 aagtaaagtg cgtgtctagt gtcttctatt gagagtacta ctattaatta agcttatttc
     1021 caatgtgcct ttttaatgct tgaagtttta tctacataca caggtaacag aggacagtag
     1081 tctgtaaaca tataaatcgg tcataactat cgtggtcttt atttctgtga ggatctaggg
     1141 aaatttcatg tcacttccct ccttcactgc atcacaatca tattcccttt tttttttctt
     1201 ggatttgtgt cagttggatg atatcccctc cagatagtat caataaaatg ttaaaattat
     1261 ttatcttgtg tggaacccct aggctgtcag gcccggagag gtgaaattca gctggacaca
     1321 aaaatcaaat tgtcttttgt ggctgccacc attacattct ctgttgtatg tattactttc
     1381 cctcctgcat cctcccactg ccccactgca caagaatact ccatgtaact ccatttaaat
     1441 gtaatgaatt cattcctttc tttctggtct ccacttaacc ccctaaaaat cttgcttttt
     1501 cccctaaaca tttccctgaa ctgtcacgta ttttcattca ttctttaact cattgtaggg
     1561 agtccctgct atgttccaag cactctgcta aggactggga ggtggtggta agaaaacctg
     1621 tgtcccaagc ccctcatcac tgacttcctc ttcactaact ccaacaacat ctttccacct
     1681 ccttaactat ttcattcacc ctcccactgt gaacaccaca gacaaggccc ctggcctcat
     1741 ggagtttaca ttctagaggg tgagggagtt caacacaaat aagatgcttg aaattggcaa
     1801 gtgtgatgaa gaacagaata gggcagtggg gtagagtgtg gttaggtagg gtgtggtgga
     1861 catcacataa ggtggtcagc aaaggcctct caagagacag ttgagacttg aatgacgagg
     1921 atgagtcaga tgaaagccag gggcagaggt gaggggagca tcttgggcag aggtgacagt
     1981 gttaaaggga gaggccacgt tcagtaccca gaacaaaaag ctgcacacac tgcttgctga
     2041 gcaagagagc actgctcttg tagggcacgg tctctcggat aaagaaaact gcggacctta
     2101 tgcagggttt taggaaggat taacagactt tcaaaagcat ttaggagtcg agggagcttt
     2161 agttgtgggg atgcagttac cagagtgagg ccgctgctga ttagcatgat ttagaagcct
     2221 agtttggagg tgaggttact gatgggaaat tgtcattgat tgtttctggt acttaattgc
     2281 tactgtggcc aaaggatggt cagttttatt caggatttga agtggtggca gacaacgtga
     2341 ggtgtgccac tcaaattcac cttcaagaaa gtaccagccg cccagctgtg aggggtgtgg
     2401 ttcgccgaca gtctccccgt taccgtcttc agggtccacg ccagatttca agataaggac
     2461 acactattct gtgggagaga gggacctagt ctacaactga gcaaggcagt ggtagctgac
     2521 agcatgcttt tttctggcaa ttcccagcca ataactgagc aaggtggtgg tataagacct
     2581 agccatttag gccaggtgca gtggctcaca gctgtaattc cagcactttg ggaggctaag
     2641 gtgggaggat tgcttgagcc cagaagttca agacgagtca tggcaaccta gtgagactgt
     2701 ctgtccaaaa aataaaaaat tagccaagcg tggtggcaca cgcctgtatt cctagctcct
     2761 gaggtgaaag gattgcttga gctcgggagg cggaggttgc agtgagtcct gatcatgcca
     2821 ctgcactcca gcctgggtga cagagcaaga tcctgtctca gaaagaaaaa aaaaagtcct
     2881 agtcatttct accaactcga aagccctcta ataagcagtc tctgctctgg agctttttgg
     2941 tgggctgcta gagactttgt tagatcctac cgttcctctg ctcaatcctg cttttccctt
     3001 ttcctttcag agatgtcact tcaccagttt tgtactccta actccatctc agcctaaaat
     3061 tggcacaatt ggtaccagtg gcccacgaac gtaggtggta agacagcatt tgcaggctga
     3121 gtgactcact gtctggctgg ctcggaggcc cccatccctg gtggataggt ggcacagaca
     3181 gtccctggca caagaaggct gtccagtgat gaagacttca gatgaaatgg catgctggtg
     3241 caggggaacg caatgactgg tgggtgattt gggtgtctca aatatgggaa gggtggataa
     3301 aagagacaag gacagtgggc ttccatggtt attgctgagt tggattgacg tcctgcaagt
     3361 ggataatgaa aagctgaggt caattaacaa acaaaactaa gtgtgagccg cagagtctct
     3421 gtggtagctt gccaacaatc ctcatctcat gctgtagcca agcagagcaa gctgaaggcc
     3481 aagcacagga tttgatggta aaagtagcta acagccaaca aatactcaac caagccaggt
     3541 ctgttagatc aaggttggaa tcaaacttgg gatcccaaaa catgggatgg gagcatttag
     3601 tggatctccc caaccatctg cctccctaga aaactccctg aatattcaca tccttcagaa
     3661 gaggcccacc cttccccatg aagagctgga actaccctcc cttcctgcct cttccctaac
     3721 acaagggaag acagtgtcca aggtctttcc ccatgaagca aaaggtgtcc ctcaggactg
     3781 gtccctcccc ttctcctggc taccaggcct ataacgagac ttaagtcaca acataactga
     3841 ttgcggctga ggggtctgat gagggagaaa tgggatctat gccagaggag ccacctaacc
     3901 tggcagcatg tactgcaggg gccaggggcg tactcttggg actggatcct gagggtgctt
     3961 ggtcaaaggg gctgggttta tacaactaga taaaggagag ggtatattga cttggggctc
     4021 tcaggataga ggatttcaca ccatgagaaa aatgccagga gataatacag actcactgct
     4081 ctagggcagc ttggtagaag cctagaaaga gtgatcaaaa tgttgaaatg cctgaatggc
     4141 tgggacaaac aatagagaaa ggaatgagaa ggctcaggga agggagcatg ccagcatgga
     4201 tatatgaggc aaggtgaccc atcagacaat tatgttccac gggaaggccc aggggaccca
     4261 tccttcagca aggctgctgg gaatgcactg ataagcgggc ttgggcatca taaaggagct
     4321 cagcggtggc tctcctcggc aggctggggc tggcaggaag ggctgtgatg gaacttcact
     4381 tgctgagagc aatgtggatg atgatgagac cttgaagagc ccaggtggca gtgccagcca
     4441 cagaagccag ggtgccatca gtatcctgtt aaccactaag ctccaaatgg cagccgaggg
     4501 gtcctgacct gtaaagtctc atggaaatag ttggtagaac aaggcattcc tagggacaaa
     4561 agagctgact aatcaacaag ggtaaggctt tatatataat caaaagtgag caagaattga
     4621 tgagcagggg actgagagag atcactccaa ttaaaaaaca aaaacatgat tccttgccag
     4681 tttctagttc agttttctga cctagagctc attaattgca gaggtgactg tatcctaggg
     4741 gaaagtttcc tgcaacattt cagcaggtgt acacagtaat gatcccctca ttctttttct
     4801 aaaggatcta tggccattta ctcaggtggc tctaccctgg ggaaagagga atacctggat
     4861 acgtcagggt ccaagttaac gtctgatacc cagaaaccca aagagtcatt acagttcctc
     4921 ctcctcccat taaaatggga gcatacagag gttagaaagt aaacgtagtt ctaatcaaag
     4981 tttggcttac agcagatctc ctgggcctgc aggttatctg cctaatccct gaatgtataa
     5041 ttgagactga catccttggc aggcagaata acccctacat ttgttccttg acctgtgggg
     5101 aaagagtata agcttctaaa ctccctctcc tccaatcagg gcagtaaacc ataataaata
     5161 ttgccttgaa cagtattttt taagcacctc gggtgaacat ctgcttctgg ccatgatgat
     5221 gaattgggaa cccaatttac ctgtccctct taaacaacta aaagcccaga caaaatatat
     5281 gaaacaatgg ttttcagaca ctgaaagttc atagtacagg actgtgatct ctgcgagaag
     5341 ggggaataat gaggtgagtc cagtgattgc tcaggcgaat ggcctggagg cagtttctag
     5401 gcagcaaagc agggagaggg aagccagaga ccagtggtcc tgctgtgttg aggagatgga
     5461 gatcagtgtc accggaggcc aaggtgagta agtgagagga gaggaggcag cagcacacag
     5521 acagagagtg ctgtagatct gcagtgggtc ccctggagtc cttggttgag tgaaggtgtt
     5581 agaagaaact acttaagcca agaaatgagt aactggaaat tagtagagca aataatttac
     5641 agatcatcta tggggctggg aaaagtttgt gtttccacta gccagagtag aaataactca
     5701 taatgcatgg gtcatcaggt ggagtcctcc aacaggtgtt gccttagtac tgaggtcaaa
     5761 ttgtccctag accaaaggct tctttggact tcccctaaca aagcttaaag acaagccttg
     5821 gaaggatcaa actaatttca agaaacttaa ctgtgaatca gaataaaacc caataccatt
     5881 tataggaata taacaaaatc catcaacaaa caacataaca ctcataatta ccaacattca
     5941 gtaaaaaatt actggaaaca gagaaatata aattatggcc cataattagg aaaaaagggt
     6001 aatcattaga agtagaacca gaagtgacag atatgaagaa attagcagct tgaattatgt
     6061 gatgtggcag atcttatgta ttggaggtag ggggaaagaa gatgcagtgt ggaatagatg
     6121 acaaggccca atgagagaat cacagtgcag gtccctgggg ccctgaagga aggtggttct
     6181 aaccacagga gaggatcata tgctttttga aaaacagcct ctgctgtgct actgggccct
     6241 ggtagacacg gaactttgag acccagtgat gctgtatcca gaactgctca tcttaactag
     6301 gtcctgtggg aagcactaag tcataagcta gtaggatcgg cagcagccca ttggaagatg
     6361 gaaatgatat gtacaggagc agttccaagc cagaccagag gacataagca aactgcaaga
     6421 gcaattactc caaccgccat gtctgcacag tggcacctac atcccccctc cctgtggttg
     6481 ttggaggacc tgtatgatcc actgaaggaa gaggaatgct tgggcttggt ttattgatta
     6541 gttatcttct gtagttgcaa gctgaaaatg gaccttcact caaaggtgac attgaaaaac
     6601 gggaaaaaaa ttgcaatctt cctgcaaaaa ctgggcagaa ttttttgagg tacactggat
     6661 cattcacctt gtgagggagg acaggtaaaa tatttatgga agtggcagaa aatggcctgc
     6721 cagctgatca ggagtttggg aggaaaaaaa catggattag gaggtctggg gtagaggcat
     6781 gtggatgggc atatggagtg aacacagaag ttgaaaaact gtatcacatg ttaatgccca
     6841 ctagatagca cccaccagag aagaggcact aaacaaccaa gtagatgaaa tgacttagcc
     6901 tgttctatta gcttttgcca gtgcccacct cagtgctggt aaaatgcaca cataaagtgg
     6961 cagtggtggc aaagatggag gctatggatg gaacccacca acatgggctc ccacttacca
     7021 aggccaactt agacactgct cactgtgact atccaacctg cctgcaacaa ataccaatgc
     7081 tgagaccctg atgaggctgt gaagaccaac tggtcgcttg atagcaaatt cactatggta
     7141 ggctcattct ttcctagaag caccagcagt ttattcacac aaggacagac ttcctattct
     7201 aggtatgtgg ttcctttcgg gcctacaggg tcctgaacac aatctaagga cttacaaaac
     7261 atctgaactg tcagcgtaga tttgctgaat acgtgatcta tacatgttaa cacccaatca
     7321 gggagagttc gccagcggtc ataggatcca ctgctcctat cacatactgc gccacctaga
     7381 agctgctaga ctgatggaat gttggcatgg cctgctttag tgccaggtgg gagacaatac
     7441 cctgccaaga tgtgccaccg tctcctgcac acagtatact tattgaatca gaaagcctgt
     7501 atgatgctgt gtctacaaca ggaatatata gatttcagaa ccaaggagtg gaggcaggag
     7561 tgaccccact taccatcgca cccaacgaac cactgaggga cttagtactt cccatgccca
     7621 caactccagg ttctacagca tcagaagtcc tagttctcag agactgtata ccttctctag
     7681 gcaatattgc aagaatccca ttgaactaca gtctgctgct actatgtggg cactttggac
     7741 tctgtgttca gggaccagta ggcaagaagt caccatctag tcaagggtaa ttgaccctga
     7801 actgcaggag gaggcaagcc tgctgtcaga ggatagtggc gagagcaatg tgtgtggaac
     7861 ttagcggacc cactggaggc accctctgta ctccttgccc agttgtaact gaatggacta
     7921 gtgcagcaac cctggtctga gaagggtttg gctcccagga gctcaggacc ctcaggaatg
     7981 agagcttggt ttatactatc aaaaaagcca ccaagaccag caaagatgac agttgtgggt
     8041 gaggggaatt tagaatgaag cagggagtaa tgaggaccag ttgtggttcc aaaaccattt
     8101 gcaggaaggt gctatagttg gtcctaccaa actcctcttt caacatttat cctcaggaag
     8161 agaggtccat tggcgccctg aaacagtcac tctctgcgtg tttttgggaa aatggatcca
     8221 cataggcaag gggtggacca tggcaggcat agagcggtgc cacttagatc ccccttcaag
     8281 acaagatatg ccatccagct gcaaggagtg tgggtagctg gcagccacca gctgctactt
     8341 caccaggatc caccttagct ttcaagctga ggtcacgcta ttctcaagac aggaggggtt
     8401 ggtggccaat gatttcacta aattatggaa attgagagca tgcttttctg agggggccct
     8461 cttgccaaag accaagcaag gccatggtac aaggacctaa ctgtttcagt ccaacacagg
     8521 actcctccaa tgagtgacct ttttcccaga gttcccctgg gatggcagct cgcctgctct
     8581 ccctgcctcg tcctgcttcc tcttttcctt tcaaaggtgc ttactccaat aataaatcct
     8641 ttggtattct aactgtctac ttcttgaaga atctaaactg gcagtaggat catgcccctc
     8701 actgatagct caaccacgtt ttctatcttt gggcctcctt gtctttacct agcacatgag
     8761 aagcatttat taggactttt tttcccccat tgctgaacaa atgactacag attgctctac
     8821 ctcttgttct gtgaataaag gctggccgct gtggaaggta ggtcagagca ggcaactgag
     8881 agaaactgta ttacagttac cgagtggctt attaaggaaa gtggcgcaac aatcaggtcc
     8941 atgtttcatt caaatgaccc tccattcccc caacaacatc ctcacatctg ccaaagcaaa
     9001 ttatgctgct gtgctcattt gatgatggaa tcagcatcgc atgcaggctg aacccctact
     9061 acggcagaac caagaaagcc actctttccc ctctcctcct aagatgccac cacagagcag
     9121 ggtgccagtg gtgggtgggg agaaagacgg agacacagaa acgtctcctt ttcactgtga
     9181 ttctcctaag gaatatacag tcacccccac aggaaaagca agagttcaat caagattctt
     9241 cagaaatagt aggatggcag aaagcagatc gcattgaggt tgtttccaac tgacagacca
     9301 agcagtaatt tgtttctctc cccactgata gtaaaaataa agtggaaata atttagggct
     9361 ggggcttctg tgattatctg gaacttaaag tatgagggta tgagagccat cagatctacc
     9421 cctgtggagc tttttaagat gcggtccata acagaagcgg gccccaagga gtagagtagc
     9481 cacatggaag gtgccatgtt tcagggatga gtctcgattc ttctctccct gtatttcatc
     9541 catgcctgta agaagttctc acgtctctcc acatgccacg tcatctgaac cgccaggcga
     9601 taggttattc gtattttatt ccaaagtcca taggacacga tgtggacttg tttttccacg
     9661 tgcccttgta gatggtgcca tccagtgtct gtgatgttcc acctcctctg ttgggttgtc
     9721 acctccccca gagaccttct ggtctcactg cttttctgtt tgtatccagc aaaacactca
     9781 acaattctgt ataagaacac ctatctcatt attcaaaaaa aatgcatgta taaacaaaaa
     9841 gaaatatttc aaatatttac tttacaattg ttttattcaa aggaaattaa atacaaatgt
     9901 atatttttca ttaaaaatgg ggatttaaaa atagttttat aattagtgtt atgttgcttt
     9961 atcttatctt tgcataaatt atgtattatt aaaggtttct gatatccata
//
