LOCUS       NM_015987               1159 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens heme binding protein 1 (HEBP1), mRNA.
ACCESSION   NM_015987
VERSION     NM_015987.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Yagensky,O., Kohansal-Nodehi,M., Gunaseelan,S., Rabe,T., Zafar,S.,
            Zerr,I., Hartig,W., Urlaub,H. and Chua,J.J.
  TITLE     Increased expression of heme-binding protein 1 early in Alzheimer's
            disease is linked to neurotoxicity
  JOURNAL   Elife 8, e47498 (2019)
   PUBMED   31453805
  REMARK    GeneRIF: Taken together, these data highlight a role of Hebp1 in
            progressive neuronal loss during Alzheimer's disease progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Devosse,T., Dutoit,R., Migeotte,I., De Nadai,P., Imbault,V.,
            Communi,D., Salmon,I. and Parmentier,M.
  TITLE     Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist
            of formyl peptide receptor 3
  JOURNAL   J Immunol 187 (3), 1475-1485 (2011)
   PUBMED   21709160
  REMARK    GeneRIF: The functional activity of purified full-length HEBP1 has
            been evaluated on human formyl peptide receptor (FPR)3-expressing
            CHO-K1 cells
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Micaelo,N.M., Macedo,A.L., Goodfellow,B.J. and Felix,V.
  TITLE     Tetrapyrrole binding affinity of the murine and human p22HBP
            heme-binding proteins
  JOURNAL   J Mol Graph Model 29 (3), 396-405 (2010)
   PUBMED   20800521
  REMARK    GeneRIF: Results present a systematic molecular modeling study of
            the binding properties of murine and human p22HBP protein
            (heme-binding protein) with four tetrapyrrole ring systems
            belonging to the heme biosynthetic pathway.
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Lambert,N.A.
  TITLE     Dissociation of heterotrimeric g proteins in cells
  JOURNAL   Sci Signal 1 (25), re5 (2008)
   PUBMED   18577758
  REMARK    Review article
            Erratum:[Sci Signal. 2008 Jul 15;1(28):er3]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Gao,J.L., Guillabert,A., Hu,J., Le,Y., Urizar,E., Seligman,E.,
            Fang,K.J., Yuan,X., Imbault,V., Communi,D., Wang,J.M.,
            Parmentier,M., Murphy,P.M. and Migeotte,I.
  TITLE     F2L, a peptide derived from heme-binding protein, chemoattracts
            mouse neutrophils by specifically activating Fpr2, the low-affinity
            N-formylpeptide receptor
  JOURNAL   J Immunol 178 (3), 1450-1456 (2007)
   PUBMED   17237393
  REMARK    GeneRIF: mouse neutrophils, which like macrophages and dendritic
            cells express Fpr2, responded to human and mouse F2L in both
            calcium flux and chemotaxis assays
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Migeotte,I., Riboldi,E., Franssen,J.D., Gregoire,F., Loison,C.,
            Wittamer,V., Detheux,M., Robberecht,P., Costagliola,S., Vassart,G.,
            Sozzani,S., Parmentier,M. and Communi,D.
  TITLE     Identification and characterization of an endogenous chemotactic
            ligand specific for FPRL2
  JOURNAL   J Exp Med 201 (1), 83-93 (2005)
   PUBMED   15623572
  REMARK    GeneRIF: F2L is a chemoattractant peptide promoting calcium
            mobilization and chemotaxis in dendritic cells and monocytes. [F2L]
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Jacob Blackmon,B., Dailey,T.A., Lianchun,X. and Dailey,H.A.
  TITLE     Characterization of a human and mouse tetrapyrrole-binding protein
  JOURNAL   Arch Biochem Biophys 407 (2), 196-201 (2002)
   PUBMED   12413491
  REMARK    GeneRIF: Characterization as a tetrapyrrole-binding protein
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Zylka,M.J. and Reppert,S.M.
  TITLE     Discovery of a putative heme-binding protein family (SOUL/HBP) by
            two-tissue suppression subtractive hybridization and database
            searches
  JOURNAL   Brain Res Mol Brain Res 74 (1-2), 175-181 (1999)
   PUBMED   10640688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF126276.1, AC007688.15 and
            AW452041.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015987.4.
            
            Summary: The full-length protein encoded by this gene is an
            intracellular tetrapyrrole-binding protein. This protein includes a
            natural chemoattractant peptide of 21 amino acids at the
            N-terminus, which is a natural ligand for formyl peptide
            receptor-like receptor 2 (FPRL2) and promotes calcium mobilization
            and chemotaxis in monocytes and dendritic cells. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279873.4554.1,
                                           SRR3476690.869805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000014930.9/ ENSP00000014930.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-667               CF126276.1         46-712
            668-1141            AC007688.15        32033-32506
            1142-1159           AW452041.1         19-36               c
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.1"
     gene            1..1159
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /note="heme binding protein 1"
                     /db_xref="GeneID:50865"
                     /db_xref="HGNC:HGNC:17176"
                     /db_xref="MIM:605826"
     exon            1..229
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..721
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /note="p22HBP"
                     /codon_start=1
                     /product="heme-binding protein 1"
                     /protein_id="NP_057071.2"
                     /db_xref="CCDS:CCDS31749.1"
                     /db_xref="GeneID:50865"
                     /db_xref="HGNC:HGNC:17176"
                     /db_xref="MIM:605826"
                     /translation="MLGMIKNSLFGSVETWPWQVLSKGDKEEVAYEERACEGGKFATV
                     EVTDKPVDEALREAMPKVAKYAGGTNDKGIGMGMTVPISFAVFPNEDGSLQKKLKVWF
                     RIPNQFQSDPPAPSDKSVKIEEREGITVYSMQFGGYAKEADYVAQATRLRAALEGTAT
                     YRGDIYFCTGYDPPMKPYGRRNEIWLLKT"
     exon            230..368
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            369..549
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1159
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1132..1137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /note="hexamer: AATAAA"
     polyA_site      1159
                     /gene="HEBP1"
                     /gene_synonym="HBP; HEBP"
                     /note="major polyA site"
ORIGIN      
        1 ctcgccgtcc cgccgccttg ccgccctgcc accctgccgc cctgccgccc tgccgccctg
       61 ccgccctgcc gccggtggtc gctgcccgtg gtgctccgtc gcccccgcca cctcacgtcc
      121 tcccgtgcgt cgggagcgtc tcggctacaa catgttgggc atgatcaaga actcgctgtt
      181 cggaagcgta gagacgtggc cttggcaggt cctaagcaaa ggggacaagg aagaagttgc
      241 ctatgaagaa agggcctgtg aaggcggcaa atttgccaca gtagaagtga cagataagcc
      301 tgtggatgag gctctacggg aagcaatgcc caaggtcgca aagtatgcgg ggggcaccaa
      361 tgacaaggga attgggatgg ggatgacagt ccctatttcc tttgctgtgt tccccaatga
      421 agatggctct ctgcagaaga aattaaaagt ctggttccgg attccaaacc aatttcaaag
      481 cgacccacca gctcccagtg acaaaagcgt taagattgag gaacgggaag gcatcactgt
      541 ctattccatg cagtttggtg gttatgccaa ggaagcagac tacgtagcac aagccacccg
      601 tctgcgtgct gccctggagg gcacagccac ctaccggggg gacatctact tctgcacggg
      661 ttatgaccct cccatgaagc cctacggacg gcgcaatgag atctggctgt tgaagacatg
      721 agtgacccac tgaaccaaga acttactgga agtgtgcctc tgtgtctcct tcctcggggg
      781 taaggagggg acagtgcttc ccaagttcca gctgcaagtc caacttaacc aactttcctt
      841 caaagtcagt tactgccaat tttctgaaaa aagcatgttc catatactaa gtctcttttc
      901 tcacagtagg aaataataca gccaagatat gcagcatcct tctcattgat gtagaaaatt
      961 ctgcgataga ccagaaaaat cctggcagct tttctccagg catctgggtc actaaaaact
     1021 gattttctaa aattattgga tttgtatttt gttattaagg gggaaaatgt gatttgtgcc
     1081 tgatctttca tctgtgattc ttataagagc tttgtcttca gaaaaactaa aaataaaagg
     1141 cattgactta aacagctga
//
