LOCUS       NM_152781               1970 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens HEAT repeat containing 9 (HEATR9), transcript variant
            1, mRNA.
ACCESSION   NM_152781
VERSION     NM_152781.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Stairiker,C.J., van Meurs,M., Leon,L.G., Brouwers-Haspels,A.A.,
            Rijsbergen,L., Mueller,Y.M. and Katsikis,P.D.
  TITLE     Heatr9 is an infection responsive gene that affects cytokine
            production in alveolar epithelial cells
  JOURNAL   PLoS One 15 (7), e0236195 (2020)
   PUBMED   32678841
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057392.1, BC033734.1, BX114438.1 and DB090576.1.
            
            On May 17, 2019 this sequence version replaced NM_152781.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057392.1, BC132681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000604834.6/ ENSP00000473941.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-813               AK057392.1         1-813
            814-1587            BC033734.1         1448-2221
            1588-1969           BX114438.1         75-456
            1970-1970           DB090576.1         30-30               c
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1970
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /note="HEAT repeat containing 9"
                     /db_xref="GeneID:256957"
                     /db_xref="HGNC:HGNC:26548"
     exon            1..237
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1862
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /note="isoform 1 is encoded by transcript variant 1; HEAT
                     repeat-containing protein 9; protein HEATR9"
                     /codon_start=1
                     /product="protein HEATR9 isoform 1"
                     /protein_id="NP_689994.2"
                     /db_xref="CCDS:CCDS11299.1"
                     /db_xref="GeneID:256957"
                     /db_xref="HGNC:HGNC:26548"
                     /translation="MAYEKSTDISDVSRSMFLYPWLEYPDKTKELRKAMAPVHLPLSC
                     YQMPKEEFPPSPECWRQHPSKPNSVPYCYFKKPEIYTHWHDLYDQREEREAEKMLRKM
                     RDDCRYIKEVHQTHIKMFHLPMSKLTIKSEMRSRPLEPTQDPLKWQRLRELTKSLESP
                     REDEQFYAAQALGCLRISDKFVMEALQQVAQTGPEKVKYEAYRTLAILGCLNKHVIRA
                     LIKQLKEKNEGQRMETLTGLRMALNSWAAVSKDKRTQVGDEGKLVPVLQTLIKKSSSE
                     ASLEAALCLGFLRPCSNMVQEFLLQCLCQGLKTQRMKALRMLVKVMHVHSAPVIKAIL
                     DQLCSSSVLEDRFEATQMLKTIGLEQIQAQGLEELTFNLLRRKTHNEPFLAVRQAVAQ
                     TVEELKLKPTMMNLVEAQLMNPDATARQEAVISLGVLGIRSPQVFHLLLDLLDAENHQ
                     AVKKSLQETLILCASIDPWIQNKLKNKVLSVYEAPKTNVKAEPTRFQKEPENPEELTI
                     QDFRLAKLNPLFIAKSITKVGQKKTPAFPPCCSKPRKHRPQVIGPWQPRIKKQLRVLA
                     EIAK"
     exon            238..287
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            288..469
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            470..602
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            603..659
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            660..716
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            717..774
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            775..905
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1088
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1181
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1301
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1375
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1427
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1514
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1970
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1951..1956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /note="hexamer: AATAAA"
     polyA_site      1970
                     /gene="HEATR9"
                     /gene_synonym="C17orf66"
                     /note="major polyA site"
ORIGIN      
        1 acttggaagc ttctacctcc agaagtccag acacctcccc tgtacctctc gtaccacaga
       61 ggacaggtct cctccagctg tgcccccact cccctaaaag ccttgtattc ccccctgcag
      121 gttccctctg gccccaccag gagaagaaga tggcctatga aaaatcaact gatatctctg
      181 atgtctccag gtcaatgttc ctgtacccat ggctggaata tccagacaag accaaagaac
      241 tcagaaaagc catggctcct gttcatctgc ccttgtcctg ctaccagatg ccaaaggaag
      301 agtttccccc aagtccagag tgctggaggc agcatccgag caagccaaac tcagtcccgt
      361 actgctactt caagaaacct gagatctaca cgcactggca cgacctgtat gatcagcgag
      421 aggaaaggga ggctgagaag atgttgagga aaatgagaga tgactgtagg tacatcaaag
      481 aggtacatca aacccacatc aaaatgttcc atctcccaat gagcaagctg actataaaat
      541 ctgagatgcg atccaggccc ttagagccta cccaggaccc cctgaagtgg caaagattaa
      601 gggaactcac aaaaagcctg gaatctccca gagaggatga gcagttctat gcagcacagg
      661 ctctgggatg cttacgcatc agtgacaagt ttgtcatgga ggcactacag caggtggccc
      721 aaactggtcc agagaaagtg aagtacgagg cctaccgaac cctggccatc ctgggttgcc
      781 tgaataagca tgtgatccgg gctctcatca aacagctgaa ggagaaaaat gagggtcaaa
      841 ggatggagac tttgacgggg ctacgaatgg ctcttaactc ctgggctgct gtctctaaag
      901 acaagaggac tcaagtcggg gatgagggca agctggtgcc tgtactacag acactgatca
      961 agaagtcgtc cagtgaagca tctctggagg cagccctgtg cctgggtttc ctgaggcctt
     1021 gcagcaacat ggtccaagag ttcttgttgc agtgcctgtg ccaaggactc aagacccagc
     1081 ggatgaaggc acttaggatg ctggtcaagg tgatgcacgt gcactcagcc ccagtcatca
     1141 aggccatcct agaccagctg tgttcttcca gtgtccttga ggaccgcttt gaagccaccc
     1201 aaatgctcaa gaccattggg ctggaacaga tccaggcaca ggggctagag gaactcacat
     1261 ttaacctgct caggaggaag acgcataatg aacccttcct tgctgtgagg caggctgtgg
     1321 ctcaaactgt ggaagagctc aagttgaagc ctacgatgat gaacttggtg gaggcacaac
     1381 tgatgaaccc agatgccact gcacgccagg aagcagtcat ctctttgggt gtcctgggga
     1441 tccgcagtcc acaagtgttc cacttgctcc tggacttact agatgcagaa aaccaccagg
     1501 ctgtgaagaa gagtctacaa gaaacattaa tcctttgtgc ctcaattgat ccctggatcc
     1561 aaaacaagct gaaaaacaag gttctctctg tatatgaggc acctaagacc aatgtgaagg
     1621 cagagcccac aaggttccag aaagagcctg agaacccaga agagttaact attcaagact
     1681 ttcgacttgc aaagctgaac cccttgttta ttgcaaagtc catcaccaaa gtaggccaaa
     1741 agaaaacgcc tgctttccca ccgtgctgct cgaaaccacg aaaacatagg ccacaggtca
     1801 tagggccctg gcagccaagg atcaagaaac agctccgggt ccttgctgaa attgccaaat
     1861 aagtcaattc tttgggccta ctccccgact ccctccctga agatgcttct caggctccca
     1921 tgagaaaaca atctatactt atcttccgtg aataaacaag tgtcactcta
//
