LOCUS       NM_022070               6108 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens HEAT repeat containing 6 (HEATR6), mRNA.
ACCESSION   NM_022070
VERSION     NM_022070.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6108)
  AUTHORS   Liu,N., Meng,Q.X. and Wang,G.S.
  TITLE     [The relationship between the expression of amplified in breast
            cancer 1androgen receptor and tamoxifen resistance in breast
            cancer]
  JOURNAL   Zhonghua Yi Xue Za Zhi 103 (20), 1553-1559 (2023)
   PUBMED   37246005
  REMARK    GeneRIF: [The relationship between the expression of amplified in
            breast cancer 1androgen receptor and tamoxifen resistance in breast
            cancer].
REFERENCE   2  (bases 1 to 6108)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 6108)
  AUTHORS   Sinclair,C.S., Rowley,M., Naderi,A. and Couch,F.J.
  TITLE     The 17q23 amplicon and breast cancer
  JOURNAL   Breast Cancer Res Treat 78 (3), 313-322 (2003)
   PUBMED   12755490
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025048.8 and AC005702.1.
            
            On Aug 2, 2019 this sequence version replaced NM_022070.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX640819.1, AK127708.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000184956.11/ ENSP00000184956.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC025048.8         28100-28325         c
            227-334             AC025048.8         25534-25641         c
            335-475             AC025048.8         23150-23290         c
            476-591             AC025048.8         22568-22683         c
            592-706             AC025048.8         21619-21733         c
            707-808             AC025048.8         20110-20211         c
            809-946             AC025048.8         19115-19252         c
            947-1245            AC025048.8         16838-17136         c
            1246-1423           AC025048.8         15613-15790         c
            1424-1630           AC005702.1         5876-6082
            1631-1730           AC005702.1         6451-6550
            1731-2086           AC005702.1         8569-8924
            2087-2209           AC005702.1         9735-9857
            2210-2296           AC005702.1         10371-10457
            2297-2431           AC005702.1         14995-15129
            2432-2554           AC005702.1         16270-16392
            2555-2679           AC005702.1         17584-17708
            2680-2776           AC005702.1         18567-18663
            2777-2981           AC005702.1         19743-19947
            2982-6108           AC005702.1         21838-24964
FEATURES             Location/Qualifiers
     source          1..6108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..6108
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="HEAT repeat containing 6"
                     /db_xref="GeneID:63897"
                     /db_xref="HGNC:HGNC:24076"
     exon            1..226
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..3553
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="amplified in breast cancer 1; amplified in breast
                     cancer protein 1"
                     /codon_start=1
                     /product="HEAT repeat-containing protein 6"
                     /protein_id="NP_071353.4"
                     /db_xref="CCDS:CCDS11623.1"
                     /db_xref="GeneID:63897"
                     /db_xref="HGNC:HGNC:24076"
                     /translation="MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDD
                     SSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIH
                     HLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPE
                     LLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTIL
                     QSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPG
                     LNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEK
                     ESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWK
                     RVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDT
                     PELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPF
                     SVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQ
                     IKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPP
                     DWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTY
                     EPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELG
                     TGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSS
                     ILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVAD
                     AANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSA
                     IEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKV
                     RWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKR
                     EQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDL
                     PCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPT
                     GDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ"
     exon            227..334
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..475
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..591
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..706
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..808
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..946
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1245
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1423
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1630
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1730
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..2086
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2209
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2296
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2431
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2554
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2679
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2776
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2981
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..6108
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="hexamer: AATAAA"
     polyA_site      3922
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="major polyA site"
     regulatory      5731..5736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="hexamer: GATAAA"
     polyA_site      5752
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
     regulatory      5799..5804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="hexamer: AATAAA"
     polyA_site      5828
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
     regulatory      6070..6075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
                     /note="hexamer: AATAAA"
     polyA_site      6108
                     /gene="HEATR6"
                     /gene_synonym="ABC1"
ORIGIN      
        1 agaaaagatg gctgctgtgc aagttgtcgg ttcgtggcct tccgtgcagc cgcgggaggc
       61 accgcgggaa gcaatccctg agcgaggcaa tgggtttcgc ctcttgtctg ccaggctctg
      121 cgccctgcgc ccggatgaca gcagctccgc ccgcaccgag atccacctgc tcttcgatca
      181 gctcatctcc gagaactaca gcgagggcag tggcgtggcc ccggaggacg ttagtgctct
      241 tcttgtccag gcttgccgac tggtacctct taatcagaat catcttgtca gcaaagtgag
      301 ccagcttatc caccatttac ttaacagatt acaggtaatt gttgatgaac agcacttgga
      361 tttcctgttg gcatatacta tttcggctat tcatcagtgt agttcctgga cacacaggga
      421 aattcttcaa gccctggcag ctctggtgta ctgcaatggc tccaaatgtc aaaagtacct
      481 cccagagctg ctaggcaaca ccggactctt aatgaagttg agtgacttgg ctcagtctga
      541 tcctgaagtc aggagagctg cagtacattg tatggcaaac ttatgtctca gtgtgccagg
      601 acagccgtat ttggaggagc cctaccaaaa tgtctgtttc caagcttttc tgactatttt
      661 acagtctcca aaatcatctg atatggatga tatcacattt tgcatgttat tgcaaaatgc
      721 attaaaaggt atacagtcac ttctaaatgg tgggagaatg aaactaacac agactgatga
      781 acttggagca cttttagctg tgctaaagaa attcatgttt cacggactcc ctggactaaa
      841 catagagatg cccacggtgt tatacccaac tccgcttcct cagtatgatg ggcgaacacc
      901 tatcaaacca cagcaatcag aatccagtgc ttctcgacca actttgaata aaaagaaaaa
      961 atccaaagta aaaccaaaga aaatccagca aggagaggag gaggaaaagg aatccagtgg
     1021 tgaaatagag gcagccccag tcactggcac aggcagagtg aacctgcatg aagggaacac
     1081 ttggtgtccc tcctccctgg gtgtccagag tttgccttta gatggaagtg gagctgcaga
     1141 aaaagatgga gtctcctcat ccttcagttc ttccagttgg aaaagggtca gcagtagtga
     1201 gtcagacttt tctgatgctg aaggaggcat gcagagtaaa atgaggtctt accaagctaa
     1261 agttcgccaa ggagccttag tttgttttct ttctactata aaatcgatag aaaaaaaagt
     1321 tctttatggc tactggtcag cttttattcc tgatacgcct gaacttggca gcccacagtc
     1381 agtgtccttg atgactctta cattgaaaga cccttctcca aagacacgtg cctgtgctct
     1441 gcaagtttta tctgccatct tggaaggctc aaagcagttt ctttctgttg ctgaagatac
     1501 cagtgaccac agaagggctt ttaccccctt ctccgtaatg atcgcttgca gcattagaga
     1561 gttgcacaga tgtcttttgt tagctttggt ggcggagtca tcctcacaga ccgttactca
     1621 gataattaag tgccttgcaa atttagtatc aaatgcacct tatgatcgtc taaaactcag
     1681 cctgctgacc aaagtctgga accagataaa gccttatatt cgccacaaag atgttaatgt
     1741 tcgtgtgtca agtctcacac tcttgggagc tatagtgtcc acccacgcac ctttacctga
     1801 agtccaacta cttctgcaac agccatgttc ttctggactc ggtaatagca attcagcaac
     1861 ccctcacctc agccctcctg attggtggaa gaaagcccct gcaggaccct ctctggaaga
     1921 aacgtcagtt agctcaccta aggggtcttc agagccctgc tggctcattc gactctgcat
     1981 ttccattgtc gtactgccca aggaggattc ctgttcaggt agcgatgctg gctctgcagc
     2041 aggaagcacc tacgaaccat cccccatgcg actggaggcc ttacaggtat tgactcttct
     2101 ggcaaggggc tacttttcaa tgactcaagc ctacttgatg gagcttggag aggtgatttg
     2161 caagtgcatg ggggaagcag atccatccat tcagcttcat ggagcaaagc ttctggaaga
     2221 actgggcaca ggcttaatac agcagtataa accagactcc actgcagcac ctgatcagag
     2281 agcaccagtc ttcttggtgg tgatgttctg gactatgatg ctgaacggtc ctttacccag
     2341 agccctgcag aattcagaac acccaactct ccaggcgagc gcctgtgatg ccctgtcttc
     2401 catcttgcca gaggccttca gcaatctgcc gaatgacagg cagatgctgt gcatcacagt
     2461 gctgctcggg ctgaatgaca gcaagaatcg cttagtgaaa gctgcaactt cacgggccct
     2521 gggagtctat gtgctttttc cctgtctcag acaggatgtc atatttgttg cagacgcagc
     2581 aaatgcaata ttgatgtcac ttgaagacaa gtctctgaat gttcgagcca aagcagcctg
     2641 gtccctgggc aacctgacag acactctgat tgtcaacatg gaaacaccag acccaagttt
     2701 ccaggaagag ttctctggtc tcctgctctt gaaaatgtta cgatcagcta tagaagcatc
     2761 caaggataaa gacaaggtaa aaagcaatgc agtccgggcc cttggaaatt tgcttcattt
     2821 tctgcaaccc tctcatatag aaaaacccac atttgcagaa atcattgagg agtctatcca
     2881 ggccctaatt tctactgttc taacagaagc tgccatgaaa gtccgatgga atgcttgtta
     2941 tgcaatggga aatgtattta aaaatcctgc ccttccttta gggacagccc catggacctc
     3001 ccaggcctac aatgccctga catcggtcgt gacatcatgc aagaacttca aagtgcgcat
     3061 cagatctgca gctgcccttt ccgtcccggg gaagagagag cagtacgggt ctgttgacca
     3121 gtatgctcgg atctggaatg cattggtcac cgctttacag aagagtgaag acaccataga
     3181 ctttttggaa ttcaagtact gtgtcagcct acggacccaa atctgccagg cactgattca
     3241 cctcttgagc ttggccagtg cctcggacct cccttgtatg aaagaaaccc ttgaactgag
     3301 tgggaatatg gtccagtcct atattctaca gtttttaaaa tcaggagcag agggagatga
     3361 cactggagca ccccacagcc cacaggaaag agaccagatg gtcagaatgg cccttaaaca
     3421 catgggcagc atccaggcac caactggaga cacagccaga agggccatca tgggcttttt
     3481 agaagagatc ctggccgttt gttttgactc atctggatca caaggggcac tcccagggtt
     3541 aacaaatcag tgaagatccc accatacttt ctagatgtcg aaggcggcag taggaagacc
     3601 tgagcttgag cataagatct gtgggatttc atcttagggg cagaaacaat ccgttcacta
     3661 tttatttaga atgacttagc agccatttaa attttcacag agggctcaac cacctttgga
     3721 gtgactccat agcactggcc atggtcaggg ttgttggaac atctgacctg tgcatccagg
     3781 agccgaggag tcaggttgta atacaggcca agcagacggg ctttgagggc atttagtctc
     3841 agaaaaaaaa aatgtagaag gatttcggaa ttagaatttt gtgtattgta tctgtagttt
     3901 tgtaataaac taacgaaaaa tagtgtgtcc acaatctcct gttgttacca agttgtattt
     3961 ctagcaagct gcaagcagag ctgcagttca gccagtttgt cctggcccag ctgcacagga
     4021 tgcgaggatg ctgacagtgc ctcacagccg cacaggaccg aggatgctga cggtgcctca
     4081 cagccacaca ggacgcgagg atgctgacgg tgcctcacag ccacacagga cgcgaggatg
     4141 ctgacagtgc ctcacagcca cacaggacgc gaggatgctg acggtgcctc acagccgcac
     4201 aggaccgagg atgctgacgg tgcctcacag ccacacagga cgcgaggatg ctgacggtgc
     4261 ctcacagccg cacaggaccg aggatgctga cggtgcctca cagccacaca ggacgcgagg
     4321 atgctgacgg tgcctcacag ccacacagga cgcgaggatg ctgacggtgc ctcacagccg
     4381 cacaggacgc gaggatgctg acggtgcctc acagccacac aggacgcgag gatgctgaca
     4441 gtgcctcaca gccgcacagg acgcgaggat gctgacagtg cctcacagcc gcacaggacg
     4501 cgaggatgct gacagtgcct cacagccgca caggacgcga ggatgctgac ggtgcctcac
     4561 agccgcacag gacgcgagga tgctgacagt gcctcacagc cgcacaggac gcgaggatgc
     4621 tgacagtgcc tcacagccgc acaggacgcg aggatgctga cagtgcctca cagccgcaca
     4681 ggacgcgagg atgctgacag tgcctcacag ccgcacagga cgcgaggatg ctgacagtgc
     4741 ctcacagcca cacaggacgc aaggatgctg acggtgcctc acagctgatg agctgctgct
     4801 ccgagcttct ggagtgcccg tgttcccctg accaccttcc ctgccacacc tccccacaat
     4861 ccaataacca gagttaactc ccagcaagca gggccttcta acctaggcta caacattgac
     4921 ttctacctac atttcctgat gctctttagg agaatgtgat cccacacact aaatatatgg
     4981 ttgttttgcc accttttaat ttgtgccttt aagaaaagat catttggtta gttggttaca
     5041 aagaggggtt tccaattata ttttgataat gccccacaag ttatgaaggt aacttctact
     5101 gaatatatat atttaaattt tgcatttttc tactgagcac caacgattta ttggaattga
     5161 tttcaattag gaatttaggg atatataaga accaattaca gttgtccata cttatctttg
     5221 atgtgggaca attaagaagt tacaaaaaat gggtgttggt gatattttat catggttatt
     5281 tagcttaaaa tacacgtgta aaggcaggtg tcttccattt ttctcctttg ccttttagct
     5341 gctgttttcc tgcctctgac atgttggctg ctcagaaact gctctctggg cagtgattgg
     5401 ggaacagggt attcaagttc actaaaggct caattttcca ttgatagaat atcagtgtcc
     5461 acagaattaa gactgcaagc acagcaaaga cacccatatt gaatgttccc ttaaattgct
     5521 tttatttgga gacaattctg aacatgaagt gttatagagg gcccaggaaa ctaagttgag
     5581 cccacctgac cctgtgatga atcttggaac ttccgtctct tgaatacatt cttagtagta
     5641 gcttcttggc attttcaaaa aaggaaaaaa aaaatatggc atagacagct tattactgtg
     5701 attctttgag ttttctcagg tgagtttttt gataaaatat ttgtgaagtg gcctcatggt
     5761 ttcatttgat gattcactct tatcctttcc ttatcttgaa taaaatccca ttcattttct
     5821 ttttaaaact tcagcttctg taaaggtttc cagatcctga tgtggatgtt aatgttcatg
     5881 tgcaggaaaa caatgaaggc atagcacctc tagaaacttc agaaggcagt ggtacctgct
     5941 gtgtcccaac agtatgctga ttctcttctc tgcagcattg tgggtgtaca tacactaaag
     6001 gacagaagct cctcatatgc ctgggcacgt gcctccataa agctgctgtg gggaaaggaa
     6061 gccactgaca ataaagacaa cttaagctga tgaaaatcag cacacagc
//
