LOCUS       NM_019024               6937 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens HEAT repeat containing 5B (HEATR5B), mRNA.
ACCESSION   NM_019024 XM_042685
VERSION     NM_019024.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6937)
  AUTHORS   Marmorale,L.J., Jin,H., Reidy,T.G., Palomino-Alonso,B.,
            Zysnarski,C.J., Jordan-Javed,F., Lahiri,S. and Duncan,M.C.
  TITLE     Fast-evolving cofactors regulate the role of HEATR5 complexes in
            intra-Golgi trafficking
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38240799
  REMARK    GeneRIF: Fast-evolving cofactors regulate the role of HEATR5
            complexes in intra-Golgi trafficking.
REFERENCE   2  (bases 1 to 6937)
  AUTHORS   Ghosh,S.G., Breuss,M.W., Schlachetzki,Z., Chai,G., Ross,D.,
            Stanley,V., Sonmez,F.M., Topaloglu,H., Zaki,M.S., Hosny,H., Gad,S.
            and Gleeson,J.G.
  TITLE     Biallelic hypomorphic mutations in HEATR5B, encoding HEAT
            repeat-containing protein 5B, in a neurological syndrome with
            pontocerebellar hypoplasia
  JOURNAL   Eur J Hum Genet 29 (6), 957-964 (2021)
   PUBMED   33824466
  REMARK    GeneRIF: Biallelic hypomorphic mutations in HEATR5B, encoding HEAT
            repeat-containing protein 5B, in a neurological syndrome with
            pontocerebellar hypoplasia.
REFERENCE   3  (bases 1 to 6937)
  AUTHORS   Zysnarski,C.J., Lahiri,S., Javed,F.T., Martinez-Marquez,J.Y.,
            Trowbridge,J.W. and Duncan,M.C.
  TITLE     Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein
            Laa1 and its co-factor Laa2 in yeast
  JOURNAL   J Biol Chem 294 (4), 1410-1419 (2019)
   PUBMED   30523155
REFERENCE   4  (bases 1 to 6937)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6937)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6937)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6937)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6937)
  AUTHORS   Hirst,J., Borner,G.H., Harbour,M. and Robinson,M.S.
  TITLE     The aftiphilin/p200/gamma-synergin complex
  JOURNAL   Mol Biol Cell 16 (5), 2554-2565 (2005)
   PUBMED   15758025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007899.3, AV759566.1, AK096637.1, AB037835.1, BX538008.1,
            CA432330.1 and AC007404.4.
            
            On Nov 23, 2018 this sequence version replaced NM_019024.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.200923.1,
                                           SRR1660809.37106.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233099.6/ ENSP00000233099.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC007899.3         106833-106859
            28-195              AV759566.1         1-168
            196-383             AK096637.1         108-295
            384-384             AC007899.3         112005-112005
            385-2206            AK096637.1         297-2118
            2207-6494           AB037835.1         627-4914
            6495-6822           BX538008.1         5391-5718
            6823-6833           CA432330.1         15-25               c
            6834-6937           AC007404.4         92212-92315
FEATURES             Location/Qualifiers
     source          1..6937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..6937
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /note="HEAT repeat containing 5B"
                     /db_xref="GeneID:54497"
                     /db_xref="HGNC:HGNC:29273"
                     /db_xref="MIM:619627"
     exon            1..104
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            105..252
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..6342
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /codon_start=1
                     /product="HEAT repeat-containing protein 5B"
                     /protein_id="NP_061897.1"
                     /db_xref="CCDS:CCDS33181.1"
                     /db_xref="GeneID:54497"
                     /db_xref="HGNC:HGNC:29273"
                     /db_xref="MIM:619627"
                     /translation="MELAHSLLLNEEALAQITEAKRPVFIFEWLRFLDKVLVAANKTD
                     VKEKQKKLVEQLTGLISSSPGPPTRKLLAKNLAALYSIGDTFTVFQTLDKCNDIIRNK
                     DDTAAYLPTKLAAVACVGAFYEKMGRMLGSAFPETVNNLLKSLKSAESQGRSEILMSL
                     QKVLSGLGGAAASSHRDIYKNARSLLTDRSMAVRCAVAKCLLELQNEAVFMWTAELEN
                     IATLCFKALENSNYGVRVAVSKLLGTVMATALMPKQATVMRQNVKRATFDEVLELMAT
                     GFLRGGSGFLKSGGEMLKVGGSVNREVRVGVTQAYVVFVTTLGGQWLERSFATFLSHV
                     LDLVSHPRATQTHVEAVYSRRCVSFILRATVGSLLGEKAQIAAAKEICQAIGKQMKAV
                     EAVVNDTSGENKSGAADIAASQHVMVCALQELGSLVQSLNATASPLIQEASIGLLEIV
                     TSVLLHPSMAARLAAAWCLRCVAVALPFQLTPFLDRCAERLNNLKTSPEAVSGYSFAM
                     AALLGGVHQCPLGIPHAKGKMVVSIAEDLLRTAAQNSRLSLQRTQAGWLLLGALMTLG
                     PSVVRYHLPKMLLLWRNVFPRSLKELEAEKARGDSFTWQVTLEGRAGALCAMRSFVAH
                     CPELLTEDVIRKLMTPIECAMTMMSHIPSVMKAHGAHLKASAAMVRLRLYDILALLPP
                     KTYEGSFNALLRELVAEFTLTDNSANTTTSLLRSLCHYDDSVLLGSWLQETDHKSIED
                     QLQPNSASGSGALEHDPSSIYLRIPAGEAVPGPLPLGVSVIDASVALFGVVFPHVSYK
                     HRLQMLDHFAECVKQAKGVRQQAVQLNIFTAVLSALKGLAENKSTLGPEEVRKSALTL
                     VMGPLDNPNPILRCAAGEALGRMAQVVGEATFIARMAQYSFDKLKSARDVVSRTGHSL
                     ALGCLHRYVGGIGSGQHLKTSVSILLALAQDGTSPEVQTWSLHSLALIVDSSGPMYRG
                     YVEPTLSLVLTLLLTVPPSHTEVHQCLGRCLGAIITTVGPELQGNGATTSTIRSSCLV
                     GCAITQDHSDSLVQAAAISCLQQLHMFAPRHVNLSSLVPSLCVHLCSSHLLLRRAAVA
                     CLRQLAQREAAEVCEYAMSLAKNTGDKESSSANVSPFAPGVSSRTDIHCRHQGVNITE
                     TGLEGLLFGMLDRETDRKLCSDIHDTLGHMLSSLAVEKLSHWLMLCKDVLAASSDMST
                     ATLLSSGKDEEAEKKDEMDDDTMFTTLGEEDKSKPFVAPRWATRVFAADCLCRIINLC
                     ENADQAHFDLALARSAKLRNPTNDLLVLHLSDLIRMAFMAATDHSNQLRMAGLQALED
                     IIKKFASVPEPEFPGHVILEQYQANVGAALRPAFSQDTPSDIIAKACQVCSTWIGSGV
                     VSDLNDLRRVHNLLVSSLDKVQAGKGSSSQLYRESATTMEKLAVLKAWAEVYVVAMNI
                     KKEAESKPKRAIKNTDDDDDDCGTIDELPPDSLITLVQPELPTLSRLWLAALKDYALL
                     TLPAEFSSQLPPDGGAFYTPETIDTARLHYRNSWAPILHAVALWLNSTGFTCSESTEA
                     AAISGLQKRSTSVNLNQASGAVGSAKSLPEINKDRMHLILGVSIQFLCSPRPEEPIEH
                     VTACLQALHTLLDSPYARVHIAEDQLIGVELLSVLHRLLLTWNPSSVQLLVTGVVQQI
                     VRAAQDYLQEKRNTLNEDDMEKEACTVLGEGGDSGGLIPGKSLVFATMELLMFILVRH
                     MPHLSTKVSDSPSHIATKTRLSEESARLVAATVTILSDLPSLCSPAGCMTILPTILFL
                     IARILKDTAIKSADNQVPPPVSAALQGIKSIVTLSMAKTEAGVQKQWTALIRSTLACI
                     LEYSQPEDSVPTPDEVSMLTAIALFLWSASNEIIGVQSLQNGCMNRFKNALNSCDPWV
                     QAKCYQLLLSVFQHSNRALSTPYIHSLAPIVVEKLKAVERNRPASNIELLAVQEGIKV
                     LETLVALGEEQNRVQLLALLVPTLISYLLDENSFASASSASKDLHEFALQNLMHIGPL
                     YPHAFKTVMGAAPELKVRLETAVRASQASKAKAAARQPAPAIHSAPTIKLKTSFF"
     exon            253..464
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            465..573
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            574..723
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            724..895
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1053
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1303
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1459
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1710
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1822
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1975
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2075
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2185
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2349
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2525
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2631
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2822
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2982
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3172
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3342
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            3343..3487
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3727
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3979
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4161
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4230
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            4231..4410
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4648
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            4649..4903
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            4904..5031
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5176
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            5177..5443
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            5444..5671
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            5672..5823
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            5824..6037
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     exon            6038..6937
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6798..6803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /note="hexamer: AATAAA"
     polyA_site      6823
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /note="major polyA site"
     regulatory      6913..6918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
                     /note="hexamer: ATTAAA"
     polyA_site      6937
                     /gene="HEATR5B"
                     /gene_synonym="p200; p200a"
ORIGIN      
        1 cccttgtttc ctgcaggtag gagtgcggga ggtggggcat ccgggtctct tggtggctgc
       61 ttctaccccc ggagctcagc tgatcttccc ttccagacta cgaggtgtga atttcaaact
      121 tccgtaatgg agttagccca cagtttattg ctaaatgaag aagctttggc tcaaatcacc
      181 gaagcaaaaa gaccagtttt catctttgaa tggttgcgat ttcttgataa agtcttggtt
      241 gctgccaaca agaccgatgt aaaggaaaaa cagaaaaaac ttgttgaaca attaactgga
      301 ttaataagta gttcacctgg accacctaca cgaaaattat tagctaaaaa tctcgcagcc
      361 ctttatagca ttggggatac tttcacagtt tttcagacac ttgataaatg caatgacatt
      421 atcagaaata aagatgacac tgcggcctac ttaccaacaa aattggctgc ggtggcttgt
      481 gtcggagcat tttatgaaaa aatggggaga atgttgggca gcgcatttcc agaaacggta
      541 aataatctat tgaaatctct gaaaagtgca gagtctcaag ggcgaagtga aatcttaatg
      601 agtctacaga aagttctaag tggactgggt ggtgcagcag cttcctccca tcgtgatatt
      661 tacaagaatg ccaggtctct cttgactgat aggtcaatgg ctgttcgatg tgcagtggcc
      721 aagtgtctac tagaactaca gaatgaagct gtatttatgt ggactgctga actagaaaat
      781 atagccactc tctgctttaa ggctttggaa aactcaaatt atggggtacg agtggcagtg
      841 tctaaacttt taggaacagt catggccaca gcattaatgc caaaacaggc aacagtaatg
      901 cgtcagaatg tgaagcgagc aacatttgat gaagtcttag aactcatggc cacaggattt
      961 ctgcgtggag ggtcaggttt cttaaagagc ggtggagaaa tgttaaaagt tggagggtcc
     1021 gttaatcgtg aagtgagagt tggagttacg caggcgtatg ttgtttttgt gacaacattg
     1081 ggtggtcagt ggttggagcg cagctttgcc acgttcctgt cccatgtact tgatctggtt
     1141 tcccatcctc gggcaacaca aacacatgtg gaggctgtgt actccagacg atgtgtttcc
     1201 tttatcctaa gagctactgt gggcagtttg ctaggtgaaa aagcccagat tgcagctgcc
     1261 aaagaaatct gccaagctat tggaaaacaa atgaaagccg tagaagcagt agtgaatgac
     1321 acaagtggag aaaacaaatc tggcgcagca gacattgcag caagccagca tgtgatggtc
     1381 tgtgccctcc aggaactcgg gagcctggtg cagagcttga atgccaccgc atcccctctt
     1441 attcaagaag catctatagg gcttttggag attgtgactt cagtgctgct tcatccaagc
     1501 atggctgccc gacttgctgc tgcatggtgt ttgcgctgtg tggctgtggc attacctttc
     1561 cagctgacac catttctaga caggtgtgca gaacggctca acaacttgaa gacctcacca
     1621 gaagctgtca gtggatatag ttttgcaatg gctgctttgt taggtggagt acatcagtgt
     1681 cctttgggca ttcctcatgc caaaggaaag atggtagtta gtattgctga agatctttta
     1741 cgaactgctg cccaaaatag caggctatct ttacagcgca cccaagctgg ctggctttta
     1801 cttggagcac ttatgacttt aggaccatct gtcgttcgtt accatctgcc caagatgttg
     1861 ttattgtggc gaaatgtttt cccacgttcc ttaaaggaat tggaagctga gaaggcccga
     1921 ggcgattctt ttacctggca ggtaactttg gaaggtcgtg ctggagctct atgtgccatg
     1981 aggagcttcg ttgcacattg tcctgagcta ctaactgaag atgtgattcg aaaattgatg
     2041 acccctattg aatgtgccat gactatgatg tcacacattc catctgtaat gaaagcccat
     2101 ggagctcatc tgaaagctag tgctgcaatg gtccgtttaa gactttatga tatcttggct
     2161 ttgttacctc caaaaactta tgaaggatct tttaatgcac ttcttagaga actggtagcg
     2221 gaattcactt tgactgacaa ctcagccaac acaactactt ccctcctcag atccctctgc
     2281 cattatgatg atagtgttct tcttggttct tggcttcagg aaactgatca taaatcaatt
     2341 gaagaccagc tccagccaaa cagtgcctct ggaagtgggg ctctggagca tgatccttcc
     2401 tctatttatt tacgcatacc tgctggagaa gcagtacctg gtcccctccc tctcggagtc
     2461 tcagtcattg atgcttctgt ggcccttttt ggtgtagtgt ttcctcatgt ttcttataaa
     2521 caccgattac aaatgttgga tcactttgct gaatgtgtta aacaagctaa aggtgtccgc
     2581 cagcaggctg tgcagcttaa catatttact gctgttctta gtgcactaaa gggcttagct
     2641 gaaaacaaaa gtactttagg acctgaggaa gttcgtaaat ctgccctgac actggttatg
     2701 ggtcctctgg acaacccaaa ccccatctta cgttgtgcag cgggggaagc tcttggaaga
     2761 atggctcagg tggttggaga agcaactttt attgctagaa tggcccaata tagctttgac
     2821 aagttgaaat cggctcgaga tgttgtatct aggactggtc attcattggc tcttggttgt
     2881 ttgcatcgtt atgttggtgg aataggctca ggacaacatc tgaagaccag tgtcagcatt
     2941 ttattggctc tagcacaaga tgggacatcc cctgaagtcc agacttggtc tcttcattca
     3001 cttgctttga tagtggattc tagtggtccg atgtatcgtg gctatgtgga accaacatta
     3061 tctctagttc ttaccttgct gttgacagtt ccgccttcac atacagaagt tcatcagtgt
     3121 ttgggtcgat gcttgggtgc tataataact actgttggcc ctgaactaca agggaatgga
     3181 gcaacaactt ctacaattcg ttcctcttgt ttggtgggtt gtgcaataac acaagaccat
     3241 tcagattctc ttgttcaggc agctgccata tcttgccttc agcagcttca catgtttgca
     3301 ccacgacatg tcaatctatc tagccttgtt cctagccttt gtgttcactt atgtagttcc
     3361 catttgttac ttcgacgagc agctgtggca tgtcttcggc aacttgcaca aagagaagca
     3421 gcggaagtat gtgaatatgc catgagcctg gcaaaaaata caggggacaa agagagcagt
     3481 agtgccaatg tcagtccttt tgcccctggg gttagttctc gaactgatat ccattgccgg
     3541 caccaaggtg ttaatataac agaaactggt cttgagggac ttctttttgg aatgctagac
     3601 cgggagacag atcgaaaatt atgttctgat attcatgaca ctttgggaca tatgctttct
     3661 tcgctggcag tagaaaaact ttctcattgg ctaatgcttt gtaaagatgt cctggcagct
     3721 tctagtgata tgagtactgc aactctctta agtagtggaa aagatgaaga agctgaaaag
     3781 aaagatgaga tggatgatga taccatgttt accacgttag gtgaagaaga taaatcaaag
     3841 ccctttgtgg cccctcgctg ggccactcga gtatttgctg ccgattgcct gtgtcgaatc
     3901 atcaatttgt gtgagaatgc agaccaggct cactttgatc ttgccttggc acgttctgct
     3961 aaacttcgaa accctacaaa tgacctcttg gtacttcatc tctctgacct cattcgcatg
     4021 gcattcatgg ctgcaactga tcatagcaac cagctgcgaa tggctgggct ccaggcgctt
     4081 gaagacatta tcaagaagtt tgcgtctgtg cctgagccag aatttccagg tcatgtgata
     4141 ctggagcagt atcaggctaa tgtgggagct gctctaagac cagccttttc acaagataca
     4201 ccatcagata taatagcgaa agcttgccag gtatgtagta catggatagg aagtggagtt
     4261 gtcagtgatc tcaatgatct ccgtcgagta cacaatcttc ttgtttcttc tctggacaaa
     4321 gttcaggctg gaaaaggatc ttccagccag ctgtaccgag agagtgccac gaccatggaa
     4381 aaactggctg ttctcaaagc ttgggcagag gtatatgtgg tcgctatgaa tattaaaaag
     4441 gaagcagagt caaaaccaaa aagagcaatt aaaaatactg acgatgatga tgacgactgt
     4501 ggtaccatcg atgaactgcc accagatagt ttaataacac tggtacaacc tgaactacca
     4561 acactcagtc gcctgtggtt agcagcatta aaagattatg cactcttgac tttaccagcc
     4621 gaattttcta gtcagcttcc tccagatggt ggagcatttt atacccctga aactattgat
     4681 acagctagac ttcactatcg gaattcctgg gccccaattc tccatgcggt ggcactttgg
     4741 ttaaatagca caggatttac gtgctcagag tctacagaag cagcagcaat atctggttta
     4801 caaaaacgtt ctacatctgt caatttaaac caggcatcag gagcagtggg tagtgctaaa
     4861 tctttgccag aaattaacaa agacagaatg catctgattt taggtgtgag tatacagttt
     4921 ctttgttccc ctagacctga ggagcccatt gaacatgtta cagcatgcct gcaggcctta
     4981 cataccttgc tagactcccc ttatgctcga gtccatattg cagaagatca gctgataggt
     5041 gttgagttgc tgagtgtttt gcaccgcctt ctattgacct ggaatccatc atctgtccag
     5101 ctgttggtta ctggagttgt acaacagata gtaagagctg ctcaggatta tttgcaagag
     5161 aaaagaaaca ctctaaatga agatgatatg gaaaaagagg cctgtaccgt attgggagaa
     5221 ggaggtgaca gcggtggtct cattcctgga aaatctcttg tgtttgcaac tatggagctg
     5281 ctgatgttca ttttagtacg gcatatgcca catctcagta ccaaggtgtc agactctcca
     5341 agtcacatag ccactaaaac tcgactatca gaagaaagtg ctcgtttggt ggcagccaca
     5401 gttaccatac tctctgattt accatccctt tgttcacccg ctggatgtat gacaatcctg
     5461 cccacaattc tgttcttaat tgcaagaata ttgaaagaca cagcaataaa gtctgcagat
     5521 aatcaggttc ctccaccagt cagtgcagct cttcaaggga ttaaaagtat tgtgacactt
     5581 tcaatggcca aaactgaggc tggcgttcaa aaacagtgga cagctctgat tcgtagcacg
     5641 cttgcttgca tcctggaata ttctcaacca gaagactctg tacctacacc tgatgaagta
     5701 agcatgctaa cagcaattgc actcttcctg tggtctgcta gtaatgaaat aataggagtc
     5761 cagtcattac agaatggctg catgaacaga tttaaaaatg cattaaattc atgcgaccca
     5821 tgggttcaag ccaaatgtta ccagcttctc ctctcagtct tccagcattc caatcgtgcc
     5881 ctttcaactc cttatattca ttcattagct ccaatagtgg ttgaaaagct aaaagctgtt
     5941 gaaagaaaca gaccagccag taacatagag cttttagcgg ttcaagaagg aataaaagtt
     6001 cttgaaacac tggttgctct tggtgaagaa caaaacagag tccagctact tgctctttta
     6061 gttcccactt tgatatctta cctgctggat gaaaattctt ttgcctcagc aagttcagct
     6121 tccaaagatc ttcatgagtt tgcactccag aatttaatgc atattggacc tctgtatcca
     6181 catgctttca agacagtaat gggggctgct cctgagttga aagtgcgtct agaaactgcc
     6241 gttcgagcaa gccaagcgag caaagctaaa gcggctgcca gacaaccagc ccccgccata
     6301 cattctgcac caacaattaa gctaaaaaca agtttttttt aatttgtaat ttcatttatt
     6361 tgtatttatg ttgtcaacta gcccctaatt agtgatggcc actgtatcat tccaggctac
     6421 ctatgggttc tgttttattt gtatattggt attatagtgc ttccaagtag gttaagtgaa
     6481 ataatgctca caccacttat tgatttttaa ggagtgattt tttttatcat gtggtgaata
     6541 tgttttcatt ttcctcctaa taatgtttct cttttgttaa cttatttatt tttcaaacac
     6601 tgagccatag tcttaaattt aaatgctaaa aacaattgta tcatgtagtc gggcagccta
     6661 ttgatactgt caggggaaaa aaatgggtca gaactcagca tctgtcatga aaaaaatcaa
     6721 ttgaaaaaca agcagatttt aaattttgaa gtaatcaaaa taatggaaag tgtctgtttt
     6781 gtggtgtata tactatgaat aaaatcacag cattttctaa gcatttccca aaatgtcctt
     6841 atctttctga tggatctttt agctttcata tcaaattact aaattatgct atgtatattt
     6901 tagttggtaa caattaaaat tctcatttaa aggttca
//
