LOCUS       NM_001220484            3551 bp    mRNA    linear   PRI 31-MAY-2024
DEFINITION  Homo sapiens HEAT repeat containing 4 (HEATR4), transcript variant
            1, mRNA.
ACCESSION   NM_001220484
VERSION     NM_001220484.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3551)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   2  (bases 1 to 3551)
  AUTHORS   Li,J., Liu,F., Wang,H., Liu,X., Liu,J., Li,N., Wan,F., Wang,W.,
            Zhang,C., Jin,S., Liu,J., Zhu,P. and Liu,Y.
  TITLE     Systematic mapping and functional analysis of a family of human
            epididymal secretory sperm-located proteins
  JOURNAL   Mol Cell Proteomics 9 (11), 2517-2528 (2010)
   PUBMED   20736409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005225.2, AK302564.1 and AC005280.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript and conservation data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302564.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553558.6/ ENSP00000450444.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC005225.2         101420-101445
            27-345              AK302564.1         1-319
            346-816             AC005225.2         137212-137682
            817-2441            AK302564.1         791-2415
            2442-2442           AC005225.2         157461-157461
            2443-2894           AK302564.1         2417-2868
            2895-2895           AC005280.5         3080-3080
            2896-3549           AK302564.1         2870-3523
            3550-3551           AC005280.5         21274-21275
FEATURES             Location/Qualifiers
     source          1..3551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..3551
                     /gene="HEATR4"
                     /note="HEAT repeat containing 4"
                     /db_xref="GeneID:399671"
                     /db_xref="HGNC:HGNC:16761"
     exon            1..197
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            198..276
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            277..1229
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..3429
                     /gene="HEATR4"
                     /codon_start=1
                     /product="HEAT repeat-containing protein 4"
                     /protein_id="NP_001207413.1"
                     /db_xref="CCDS:CCDS9815.2"
                     /db_xref="GeneID:399671"
                     /db_xref="HGNC:HGNC:16761"
                     /translation="MTRTQKGKTFLPHCFYQSLPPRLGWGMILNYSKLKGKEECASVS
                     SVPMVFFSSQYRLHRKSQYLKMAAANLTFSQEVVWQRGLPSIPYSQYSFDHLYNTNDI
                     IHTPQIRKARPQKPVSFKFLGSSSPLTGDTSLAVKTESSANPEKKLKKSKPASTVREA
                     PRPLIHHPCMHPDMLGRPPSLDVNLEEREAWLLPPEKEARAWEATVLEKLNERTARWI
                     QSKRPRRPGASPNKWQSFLRQQYDWSHIRDELTSASDLELLKQLEAEETAEFEDQSVI
                     LPPQEKKKPELLLPVYYRLPSYFQQAETVEIMPGNKSTEDIHEKTSLSQPQTQSYFRQ
                     VTPRAGKFAYSTDNTFEQEIYFDEVQIIHQIGAKRDQIVLENLNRYNKQLSKVFPETP
                     EKWSAQAIPEASYRPVQGALRWTALPTPAKDMLLQVGEKDVPIKTRRLKKQAKSLQED
                     VTWELVVLRRMLKEWKTAWALIIEWHHETVENLLQSLGDLHDDVRIKAITTCATAALE
                     RPRIATSQRDSDKTIQDLPEVLLPALEAALCDKNAHVRMAAAICQYAIQSHNPLARNI
                     MQTALLKGNSVDSWAAAQCLALEGTATYPVIKRILHQLFTKKNEDTEEQSYILLSYLS
                     EKTTLIHTMLAVELNSCQWKNRIVACQAFSRISGNVCLDMKHKLIQLMWNDWNKEVRR
                     AAAQALGQMSLGKEVHDIIRVKLGQGNSQERVEALYLIGELKLMTAKLLPSFLHCFSD
                     DFTAVRRAACLAAGALQIRDKMVLECLLNLMQRDPYWKIKAFAIRALGQIGQVSPELT
                     DLLLWAIHYEESPGVRLEACRSILALKLQGDRVRDTFLDVLLLENHDAVLKEMYQTMK
                     ILNLGNEGNQEMLQEIKNRIKTLSQKDLLTHKILKLEMVMGKVREEAKRVYLKPKGEQ
                     GPLTLQTLLQETFQDEMVLPRRPSEVCDTEAVIKPVKPRAPNPWLQSSVPGLTTRSKV
                     RSSLVKDLRTSPEKRIAVGPFRSDYPALYLGKFSERTFFSPIMSSPSGKKGAHL"
     exon            1230..1417
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1558
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1762
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1906
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2068
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2229
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2334
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2453
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2634
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2704
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2894
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..2973
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3133
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3192
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3551
                     /gene="HEATR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3527..3532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR4"
                     /note="hexamer: TATAAA"
     polyA_site      3551
                     /gene="HEATR4"
                     /note="major polyA site"
ORIGIN      
        1 ggaacctaag aaaccaagga aggcttaaga tgcagaacct tgcttctctc tgaggactgc
       61 cttttaggag gccatttgga aagtaatttt gaaacactgc tcctttgcca gtatctgaaa
      121 ggtgctggat ggtgtcagct ggaagatgag gggcaacctg aggtagctga aaaaactttg
      181 gattaggtgt caaaagggcg cagtcccagc atttctggag gccaaggcag gaagatcgct
      241 tgattccagg agtttgaaac cagcctggac aacatagtgc caggtctcat ctccaggcct
      301 ttcctctagg ccaggcagtg tggaaggaag catttgctgg gacgcggtat gaccaggacc
      361 cagaagggaa agacctttct cccccattgc ttctatcagt cactgccccc acgactggga
      421 tggggcatga ttttaaacta ctcaaaattg aaaggcaagg aggagtgtgc ctctgtctcc
      481 agtgtgccta tggtcttctt cagctcacag taccgtctac accgcaagag ccaatatttg
      541 aaaatggctg ctgcaaacct taccttctct caggaggtgg tgtggcagcg aggcctgccc
      601 agcattcctt atagccagta cagctttgac cacctctaca ataccaatga catcatccat
      661 actccccaga tcaggaaggc ccggcctcag aaacctgtta gcttcaagtt cctgggttcc
      721 tcaagtccct taacaggaga cacctccctg gctgtgaaga cagaaagctc tgccaatccc
      781 gaaaagaagc tgaagaaatc aaagccagcc agcaccgtcc gggaagcacc ccgccctctc
      841 atccatcatc cctgcatgca tccagatatg ctgggtcggc caccttctct agatgtgaac
      901 ctggaggaaa gagaagcctg gcttctgcct cctgagaagg aggccagagc gtgggaggcc
      961 actgtgctgg aaaagctgaa cgagcgcaca gcccgatgga tccagagcaa gcgtcctcga
     1021 aggcctgggg catcccccaa caagtggcag agcttcctgc gccagcagta cgactggagt
     1081 cacattcggg atgagcttac ctctgccagt gacctggagc tcctgaaaca gctggaggca
     1141 gaagagacag cagagtttga ggatcaaagt gtcatcctgc ccccacagga aaagaagaag
     1201 ccagaactgc tgcttcccgt ttactacaga ttgcccagtt acttccaaca agcagagaca
     1261 gttgagatca tgcctggcaa caagagcact gaggatatcc atgaaaagac gagcctctcc
     1321 cagccccaaa cccagagcta ctttcgccag gtgactcccc gagctggaaa gtttgcctac
     1381 tccacagaca acacctttga acaggagatt tactttgatg aagtccagat catccaccag
     1441 attggtgcaa agagagacca gattgtcctg gaaaacctaa atcggtacaa caagcagcta
     1501 tctaaggtct tccctgaaac tccagaaaag tggagtgccc aggcaattcc tgaagcatct
     1561 tacagacctg tgcaaggagc cctgcgctgg actgctttgc ccacccccgc caaggatatg
     1621 ctgctgcagg tgggtgagaa ggatgtgcct attaagacca ggagattgaa gaagcaggca
     1681 aaatcactgc aggaggatgt gacctgggaa ctggtggtcc tgcggaggat gctgaaggaa
     1741 tggaagactg cctgggctct gatcatagag tggcaccatg agacagtaga gaacctgctt
     1801 cagagcttgg gagacctgca tgatgacgtt cggatcaaag ctatcaccac atgtgccaca
     1861 gctgctttgg aacggccccg gattgccacc agccagagag actcagacaa gaccatccag
     1921 gacttgccgg aggttctact gcctgcccta gaggctgctc tttgtgacaa gaatgcccat
     1981 gtgcggatgg cagcagcaat atgccaatat gccatacagt cacataatcc ccttgcccgg
     2041 aacatcatgc agactgccct tctgaagggt aacagtgtgg atagctgggc tgcagctcag
     2101 tgcttggctc tggaaggtac tgctacttac cctgtgatta agaggatcct ccaccagctg
     2161 tttacaaaga agaatgagga cactgaggaa cagtcttata tcctcctgag ctatctgagt
     2221 gagaagacaa ccctgataca caccatgctt gctgtggagc tgaacagctg tcaatggaag
     2281 aaccggattg tggcctgcca ggctttctcc cggatcagtg gaaatgtctg cttggatatg
     2341 aaacataagt tgatccagct gatgtggaat gactggaata aggaagtgag gagagcagct
     2401 gcacaggcgc ttgggcaaat gagcctcggg aaagaggtgc acgacataat cagggtcaag
     2461 ctaggtcaag gaaattccca ggagcgtgtg gaagctctct acctgatagg tgagctcaag
     2521 cttatgaccg ccaagcttct cccaagcttc ctgcactgct tctctgatga cttcacagca
     2581 gttcggcggg cagcctgttt ggcagctggt gccctgcaga tccgcgacaa gatggtgctt
     2641 gaatgcctcc tgaacctgat gcagagagat ccttactgga aaatcaaggc ctttgccatt
     2701 cgagctttgg gacagattgg gcaagtaagt cccgagctga cggatcttct gctctgggct
     2761 atccactatg aagagtcacc aggtgtacgg ctggaagctt gccgtagcat cctagccctg
     2821 aaacttcaag gggaccgggt cagggacacc ttcctagacg tgctgctcct ggagaaccac
     2881 gatgctgttc taaaagaaat gtaccagaca atgaagatac tcaacttagg aaatgaagga
     2941 aaccaagaaa tgcttcagga gatcaagaac aggattaaaa cactaagcca aaaggacttg
     3001 ctgacacaca aaatactcaa gctggagatg gtcatgggaa aagtgaggga ggaagcaaaa
     3061 cgtgtttact tgaaacccaa aggagaacaa ggaccactaa cactccagac tttactccaa
     3121 gaaacttttc aggatgagat ggttcttcct agaagacctt ccgaggtttg tgacactgaa
     3181 gcagtgataa agcctgtgaa gccccgcgca ccaaatccct ggttacaaag ttcagtccca
     3241 ggcctaacca cacgaagcaa agttcgttca tcacttgtca aagatctacg cacctccccc
     3301 gagaaaagga ttgctgtggg accatttaga tccgactacc cagctcttta tctgggtaaa
     3361 ttctcagaga gaacattttt ttctcccatc atgtcttctc cctctggaaa gaaaggtgct
     3421 catctctaag ctgaacactt gtcttacttc aagatgcagg aagcagtgga cctggtcaca
     3481 ttgggtcttt ttaattgata ctgtacaatc ttgttgtcac tatgtttata aagagaaatt
     3541 atttaacagt a
//
