LOCUS       NM_018072               8459 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens HEAT repeat containing 1 (HEATR1), mRNA.
ACCESSION   NM_018072 NM_001007545 XM_496445
VERSION     NM_018072.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8459)
  AUTHORS   Diaz,L.R., Gil-Ranedo,J., Jaworek,K.J., Nsek,N., Marques,J.P.,
            Costa,E., Hilton,D.A., Bieluczyk,H., Warrington,O., Hanemann,C.O.,
            Futschik,M.E., Bossing,T. and Barros,C.S.
  TITLE     Ribogenesis boosts controlled by HEATR1-MYC interplay promote
            transition into brain tumour growth
  JOURNAL   EMBO Rep 25 (1), 168-197 (2024)
   PUBMED   38225354
  REMARK    GeneRIF: Ribogenesis boosts controlled by HEATR1-MYC interplay
            promote transition into brain tumour growth.
REFERENCE   2  (bases 1 to 8459)
  AUTHORS   Yang,X.M., Wang,X.Q., Hu,L.P., Feng,M.X., Zhou,Y.Q., Li,D.X.,
            Li,J., Miao,X.C., Zhang,Y.L., Yao,L.L., Nie,H.Z., Huang,S., Xia,Q.,
            Zhang,X.L., Jiang,S.H. and Zhang,Z.G.
  TITLE     Nucleolar HEAT Repeat Containing 1 Up-regulated by the Mechanistic
            Target of Rapamycin Complex 1 Signaling Promotes Hepatocellular
            Carcinoma Growth by Dominating Ribosome Biogenesis and Proteome
            Homeostasis
  JOURNAL   Gastroenterology 165 (3), 629-646 (2023)
   PUBMED   37247644
  REMARK    GeneRIF: Nucleolar HEAT Repeat Containing 1 Up-regulated by the
            Mechanistic Target of Rapamycin Complex 1 Signaling Promotes
            Hepatocellular Carcinoma Growth by Dominating Ribosome Biogenesis
            and Proteome Homeostasis.
REFERENCE   3  (bases 1 to 8459)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 8459)
  AUTHORS   Nakamura,A., Kakihara,Y., Funayama,A., Haga,K., Mikami,T.,
            Kobayashi,D., Yoshida,Y., Izumi,K., Kobayashi,T. and Saeki,M.
  TITLE     HEATR1, a novel interactor of Pontin/Reptin, stabilizes
            Pontin/Reptin and promotes cell proliferation of oral squamous cell
            carcinoma
  JOURNAL   Biochem Biophys Res Commun 557, 294-301 (2021)
   PUBMED   33894417
  REMARK    GeneRIF: HEATR1, a novel interactor of Pontin/Reptin, stabilizes
            Pontin/Reptin and promotes cell proliferation of oral squamous cell
            carcinoma.
REFERENCE   5  (bases 1 to 8459)
  AUTHORS   Zhao,J., Zhu,Y., Fu,Q., Zhu,Y. and Zhao,G.
  TITLE     HEATR1 promotes proliferation in gastric cancer in vitro and in
            vivo
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 52 (9), 1030-1039 (2020)
   PUBMED   32634230
  REMARK    GeneRIF: HEATR1 promotes proliferation in gastric cancer in vitro
            and in vivo.
REFERENCE   6  (bases 1 to 8459)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8459)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 8459)
  AUTHORS   Prieto,J.L. and McStay,B.
  TITLE     Recruitment of factors linking transcription and processing of
            pre-rRNA to NOR chromatin is UBF-dependent and occurs independent
            of transcription in human cells
  JOURNAL   Genes Dev 21 (16), 2041-2054 (2007)
   PUBMED   17699751
REFERENCE   9  (bases 1 to 8459)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 8459)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB067322.1, BC150614.1, AL359921.13, AK095692.1, BC130000.1,
            BC035302.1 and BC065205.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018072.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.263557.1,
                                           SRR1803615.40838.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366582.8/ ENSP00000355541.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               DB067322.1         26-539
            515-1169            BC150614.1         410-1064
            1170-1217           AL359921.13        72640-72687         c
            1218-1320           AL359921.13        71112-71214         c
            1321-1431           AL359921.13        69623-69733         c
            1432-1498           AL359921.13        69144-69210         c
            1499-1968           BC150614.1         1394-1863
            1969-2187           AK095692.1         1957-2175
            2188-4424           BC130000.1         137-2373
            4425-5745           BC035302.1         25-1345
            5746-6751           BC130000.1         3695-4700
            6752-7907           AL359921.13        26657-27812         c
            7908-8459           BC065205.1         4669-5220
FEATURES             Location/Qualifiers
     source          1..8459
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..8459
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /note="HEAT repeat containing 1"
                     /db_xref="GeneID:55127"
                     /db_xref="HGNC:HGNC:25517"
                     /db_xref="MIM:620390"
     exon            1..95
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            96..269
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..6562
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /note="protein BAP28; UTP10, small subunit (SSU)
                     processome component, homolog; U3 small nucleolar
                     RNA-associated protein 10 homolog"
                     /codon_start=1
                     /product="HEAT repeat-containing protein 1"
                     /protein_id="NP_060542.4"
                     /db_xref="CCDS:CCDS31066.1"
                     /db_xref="GeneID:55127"
                     /db_xref="HGNC:HGNC:25517"
                     /db_xref="MIM:620390"
                     /translation="MTSLAQQLQRLALPQSDASLLSRDEVASLLFDPKEAATIDRDTA
                     FAIGCTGLEELLGIDPSFEQFEAPLFSQLAKTLERSVQTKAVNKQLDENISLFLIHLS
                     PYFLLKPAQKCLEWLIHRFHIHLYNQDSLIACVLPYHETRIFVRVIQLLKINNSKHRW
                     FWLLPVKQSGVPLAKGTLITHCYKDLGFMDFICSLVTKSVKVFAEYPGSSAQLRVLLA
                     FYASTIVSALVAAEDVSDNIIAKLFPYIQKGLKSSLPDYRAATYMIICQISVKVTMEN
                     TFVNSLASQIIKTLTKIPSLIKDGLSCLIVLLQRQKPESLGKKPFPHLCNVPDLITIL
                     HGISETYDVSPLLHYMLPHLVVSIIHHVTGEETEGMDGQIYKRHLEAILTKISLKNNL
                     DHLLASLLFEEYISYSSQEEMDSNKVSLLNEQFLPLIRLLESKYPRTLDVVLEEHLKE
                     IADLKKQELFHQFVSLSTSGGKYQFLADSDTSLMLSLNHPLAPVRILAMNHLKKIMKT
                     SKEGVDESFIKEAVLARLGDDNIDVVLSAISAFEIFKEHFSSEVTISNLLNLFQRAEL
                     SKNGEWYEVLKIAADILIKEEILSENDQLSNQVVVCLLPFMVINNDDTESAEMKIAIY
                     LSKSGICSLHPLLRGWEEALENVIKSTKPGKLIGVANQKMIELLADNINLGDPSSMLK
                     MVEDLISVGEEESFNLKQKVTFHVILSVLVSCCSSLKETHFPFAIRVFSLLQKKIKKL
                     ESVITAVEIPSEWHIELMLDRGIPVELWAHYVEELNSTQRVAVEDSVFLVFSLKKFIY
                     ALKAPKSFPKGDIWWNPEQLKEDSRDYLHLLIGLFEMMLNGADAVHFRVLMKLFIKVH
                     LEDVFQLFKFCSVLWTYGSSLSNPLNCSVKTVLQTQALYVGCAMLSSQKTQCKHQLAS
                     ISSPVVTSLLINLGSPVKEVRRAAIQCLQALSGVASPFYLIIDHLISKAEEITSDAAY
                     VIQDLATLFEELQREKKLKSHQKLSETLKNLLSCVYSCPSYIAKDLMKVLQGVNGEMV
                     LSQLLPMAEQLLEKIQKEPTAVLKDEAMVLHLTLGKYNEFSVSLLNEDPKSLDIFIKA
                     VHTTKELYAGMPTIQITALEKITKPFFAAISDEKVQQKLLRMLFDLLVNCKNSHCAQT
                     VSSVFKGISVNAEQVRIELEPPDKAKPLGTVQQKRRQKMQQKKSQDLESVQEVGGSYW
                     QRVTLILELLQHKKKLRSPQILVPTLFNLLSRCLEPLPQEQGNMEYTKQLILSCLLNI
                     CQKLSPDGGKIPKDILDEEKFNVELIVQCIRLSEMPQTHHHALLLLGTVAGIFPDKVL
                     HNIMSIFTFMGANVMRLDDTYSFQVINKTVKMVIPALIQSDSGDSIEVSRNVEEIVVK
                     IISVFVDALPHVPEHRRLPILVQLVDTLGAEKFLWILLILLFEQYVTKTVLAAAYGEK
                     DAILEADTEFWFSVCCEFSVQHQIQSLMNILQYLLKLPEEKEETIPKAVSFNKSESQE
                     EMLQVFNVETHTSKQLRHFKFLSVSFMSQLLSSNNFLKKVVESGGPEILKGLEERLLE
                     TVLGYISAVAQSMERNADKLTVKFWRALLSKAYDLLDKVNALLPTETFIPVIRGLVGN
                     PLPSVRRKALDLLNNKLQQNISWKKTIVTRFLKLVPDLLAIVQRKKKEGEEEQAINRQ
                     TALYTLKLLCKNFGAENPDPFVPVLNTAVKLIAPERKEEKNVLGSALLCIAEVTSTLE
                     ALAIPQLPSLMPSLLTTMKNTSELVSSEVYLLSALAALQKVVETLPHFISPYLEGILS
                     QVIHLEKITSEMGSASQANIRLTSLKKTLATTLAPRVLLPAIKKTYKQIEKNWKNHMG
                     PFMSILQEHIGVMKKEELTSHQSQLTAFFLEALDFRAQHSENDLEEVGKTENCIIDCL
                     VAMVVKLSEVTFRPLFFKLFDWAKTEDAPKDRLLTFYNLADCIAEKLKGLFTLFAGHL
                     VKPFADTLNQVNISKTDEAFFDSENDPEKCCLLLQFILNCLYKIFLFDTQHFISKERA
                     EALMMPLVDQLENRLGGEEKFQERVTKHLIPCIAQFSVAMADDSLWKPLNYQILLKTR
                     DSSPKVRFAALITVLALAEKLKENYIVLLPESIPFLAELMEDECEEVEHQCQKTIQQL
                     ETVLGEPLQSYF"
     exon            270..486
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            487..628
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            629..730
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            731..871
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1083
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1217
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1320
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1431
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1549
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1657
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1753
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1842
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2054
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2176
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2368
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2552
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2689
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2882
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3052
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3211
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3454
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3586
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3690
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..3834
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3953
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            3954..4075
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4204
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4205..4435
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4436..4562
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4563..4726
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..4773
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4774..4897
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            4898..5038
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5331
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            5332..5482
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5641
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            5642..5776
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            5777..5881
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            5882..6050
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            6051..6205
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            6206..6364
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            6365..6473
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     exon            6474..8459
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6771..6776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /note="hexamer: AGTAAA"
     polyA_site      6800
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /note="major polyA site"
     regulatory      8438..8443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /note="hexamer: CATAAA"
     polyA_site      8459
                     /gene="HEATR1"
                     /gene_synonym="BAP28; UTP10"
                     /note="major polyA site"
ORIGIN      
        1 aggtttccgg gtgagggttg ggctccttgg taccatgtgg gaagcgctgt gaagagttgt
       61 tgccttccaa gatataccca aattcccagt tccagcccgt gtcattaaaa ctccgctggc
      121 gtgaaagatg acgtccttag cccagcagct gcaacgactc gccctccctc aaagtgatgc
      181 cagcctctta tctagagatg aagttgcttc tttgttattt gaccctaagg aagcggccac
      241 aatcgacagg gacaccgcct tcgccattgg atgtactggc ctggaagagt tgcttggaat
      301 tgatccttcc tttgagcagt ttgaagcacc gttgttcagt cagctagcaa aaaccttgga
      361 gcgaagtgtt cagaccaaag cagtaaacaa acagttggat gaaaacattt cattattcct
      421 tattcacttg tcgccttact tcctgcttaa gccagcacag aagtgtctgg agtggttgat
      481 tcacaggttc catatacatc tctataatca agatagcctc attgcttgtg ttctgccata
      541 ccacgagaca agaatatttg tgcgagtcat acagcttcta aaaattaata attcaaagca
      601 cagatggttc tggttgttgc cagttaagca atctggagtg ccgttagcta aaggaacttt
      661 gattacccac tgctacaaag atcttggatt catggatttc atttgcagtt tggtgacaaa
      721 atctgtgaag gtttttgctg agtacccggg cagctcagct cagttgaggg tgctcttggc
      781 tttctatgct tctaccatag tgtcggcgct ggtagctgca gaggacgtat cagacaatat
      841 catcgccaaa ctatttccct atatccaaaa gggattgaaa tcatctttac cagattacag
      901 agctgcaaca tacatgataa tatgtcagat ttctgtgaaa gtgaccatgg aaaatacctt
      961 tgtgaattca ttggcatcac agatcatcaa aacattgacc aagattccct ctttgatcaa
     1021 ggatgggtta agttgcttga tagtgctcct gcagagacag aagccagaga gccttgggaa
     1081 aaagccattc cctcacttat gtaatgttcc tgatcttatt acaatacttc atgggatttc
     1141 tgaaacttac gatgtcagtc ctcttctgca ttacatgctt ccccatctgg tcgtctccat
     1201 cattcatcat gttacaggag aagaaactga aggaatggat ggtcaaatct acaagagaca
     1261 cttagaagct atacttacaa aaatatcact gaagaacaac ttagaccatt tgttggctag
     1321 ccttctattt gaagagtata tttcatatag ttcacaggaa gaaatggatt ctaataaagt
     1381 gtctttgctt aatgaacaat ttcttccact cattaggctt ttagaaagca aataccccag
     1441 aacattagat gttgtattag aggaacactt aaaggaaatt gcagatctga aaaaacaaga
     1501 gcttttccat cagtttgttt ctctttctac aagtggagga aagtatcagt ttttagcaga
     1561 ttctgatact tctttgatgc tcagcctgaa tcatccactt gctcctgtga gaattctggc
     1621 catgaatcat ttgaaaaaga tcatgaaaac atcaaaggag ggtgttgatg aatctttcat
     1681 aaaagaagct gttttagccc gattaggtga tgataatata gatgttgttt tgtcggctat
     1741 aagtgctttt gagattttca aagaacactt cagttcagaa gtgacgattt caaatcttct
     1801 gaatctcttt caaagagcag aactttcaaa gaatggagaa tggtacgagg tacttaagat
     1861 agccgctgac atattaatta aagaagagat actgagtgaa aatgatcagt tgtcaaatca
     1921 ggtggttgta tgtttgctgc catttatggt tatcaataat gatgatacgg aatctgctga
     1981 gatgaaaatt gctatatatt tatcaaaatc aggaatctgc tccctgcacc ctctattaag
     2041 aggctgggaa gaagctcttg aaaatgtaat taaaagcaca aagccaggaa aactaatcgg
     2101 tgtagcaaat cagaagatga ttgagttgtt ggctgataat ataaatttag gagatccttc
     2161 ttcaatgtta aagatggtgg aggatttaat aagcgtgggt gaggaggagt cctttaacct
     2221 gaagcagaaa gtaacgtttc atgtgatcct gtctgtgctc gtctcttgtt gttcatcttt
     2281 aaaagaaacc cactttccat ttgcgataag agtcttcagt ttgttgcaga aaaaaataaa
     2341 gaagcttgaa agtgtcatta ctgcagtgga aatcccctca gaatggcaca ttgaactgat
     2401 gttagacaga gggatcccag tggagctgtg ggcacattat gtagaagagc tcaacagcac
     2461 tcagagggtg gccgtggagg actcggtttt tcttgtattt tccttgaaaa aatttattta
     2521 tgcactgaaa gctcctaaat cttttcctaa aggtgatata tggtggaatc ctgaacaact
     2581 gaaagaagac agcagggact atctgcactt gctcattggg ctgtttgaga tgatgctcaa
     2641 tggtgccgat gctgttcatt tcagagttct gatgaaactt ttcataaagg tgcatctaga
     2701 agatgttttt cagttattca agttctgttc tgttttatgg acctatggtt ctagcctttc
     2761 aaatccacta aactgcagtg tgaaaacagt gctgcagact caagctcttt atgtgggctg
     2821 tgcaatgctt tcttctcaga agacacagtg taaacaccaa ctggcatcca tatcttctcc
     2881 agtggtgaca tctttactca ttaacctggg aagccccgta aaagaagttc gtagggctgc
     2941 cattcagtgt ctccaggccc tcagtggagt ggcatccccg ttttatctga taatagatca
     3001 tttgatttct aaagcagagg agatcacttc agatgctgcc tatgttattc aggatttggc
     3061 tactttattt gaggaactac agagagaaaa gaaactgaaa tctcatcaga agttgtctga
     3121 aactttgaaa aacttactta gttgtgtgta tagttgccca tcttatatag caaaagattt
     3181 gatgaaagta cttcagggag tcaacggtga gatggtgctt tctcagctat tgcctatggc
     3241 tgaacaactg ctagaaaaga tccagaagga gcccacagct gtgctgaaag atgaggccat
     3301 ggttctgcat ctcactctgg gaaagtataa tgaattttca gtttcccttt taaatgagga
     3361 tccgaagagt ctagatatat ttataaaagc tgtgcacaca acaaaggaac tttacgcggg
     3421 aatgccaacc attcagatca cagcccttga aaagattaca aaaccatttt ttgcagccat
     3481 atcagatgaa aaagttcagc agaagctttt aagaatgttg tttgatttat tggtgaactg
     3541 taaaaactca cattgtgctc agactgtcag cagtgttttt aaagggattt ccgttaatgc
     3601 tgaacaagtc cgaatagaac tggagccacc agataaagct aaacccttgg gcacagttca
     3661 gcaaaaaaga aggcaaaaaa tgcagcagaa aaaatcacaa gatctagaat ctgttcagga
     3721 agttggaggt tcttactggc aaagagtaac tctcatcctg gaattactgc agcacaaaaa
     3781 gaagctcaga agtcctcaga tattggtgcc aactcttttt aacttgctat caagatgttt
     3841 agaacccttg ccacaagagc agggaaatat ggaatacacc aaacaattaa ttcttagttg
     3901 tctgctcaac atctgccaaa aactatctcc agatggtggc aaaataccca aagatatttt
     3961 agatgaggag aagttcaacg tggagttgat agttcagtgc atccgccttt cggagatgcc
     4021 gcagacccat caccatgccc ttttactttt gggcactgtt gctggaatat ttccggataa
     4081 agttttacac aatatcatgt ctatttttac atttatggga gccaatgtca tgcgcctaga
     4141 tgatacttac agttttcaag ttattaacaa gacagtgaaa atggttattc ccgcacttat
     4201 tcagtctgat agtggagatt ctatagaagt ttcaagaaac gttgaagaga ttgtggtaaa
     4261 aatcattagt gtatttgtgg atgcgctgcc acacgtcccg gagcacaggc gcctgcccat
     4321 ccttgttcaa cttgttgata cactgggtgc agagaaattc ctctggattc tcctcatctt
     4381 gctttttgaa cagtatgtca caaaaacagt gctggcggct gcctatggcg aaaaggatgc
     4441 tattttagaa gcagacactg aattttggtt ttcagtctgt tgtgagttta gtgtccagca
     4501 tcagatacaa agcttgatga atatcctcca gtacttacta aagctgccag aggaaaaaga
     4561 agaaaccatt cccaaagcag tgtcatttaa taagagtgaa tcacaagaag aaatgctaca
     4621 ggtttttaat gtagagactc acactagcaa gcaactgcgg cattttaaat ttttgtcagt
     4681 gtccttcatg tctcagctcc tgtcttccaa taattttctg aaaaaggtag ttgagagtgg
     4741 tggtcctgag attttaaaag gccttgaaga gaggttgctg gagaccgttc tcggctatat
     4801 cagtgcagtt gcacagtcca tggaaaggaa cgcagacaaa ctcaccgtga agttctggcg
     4861 cgcgctcctt agtaaagctt acgacctgtt agataaggtc aatgccttgc tgcccacaga
     4921 gacattcatt cctgtgatca gagggctggt gggcaatccc ctgccatctg ttcgccgcaa
     4981 agcgctggac cttttgaata acaagctgca gcaaaatata tcctggaaga agacaatagt
     5041 tacccgtttc ctaaaactgg ttccagacct tttggccatt gtgcagcgta agaaaaagga
     5101 aggggaagaa gaacaagcaa tcaacagaca gacagcgttg tataccttaa agcttttatg
     5161 caagaatttt ggtgcagaaa atccagatcc ttttgtccca gtgctgaaca ctgctgtgaa
     5221 actgattgct ccagagagaa aggaggagaa gaatgtcctg ggaagcgcgc tgctgtgcat
     5281 agcagaggtg acctccaccc tggaggcgct ggccatcccc cagcttccca gcctgatgcc
     5341 atcgttgctg acaacaatga agaacaccag cgagctggtc tccagcgagg tctacctgct
     5401 cagtgccttg gctgctctgc agaaggttgt ggagactctc ccgcacttca tcagccccta
     5461 tctggaaggc attctctccc aggtgattca tctggagaaa atcactagtg aaatgggttc
     5521 tgcgtcacag gctaatatcc gtctcacatc tcttaaaaag acactggcta ccacacttgc
     5581 accccgagtc ctgttgcccg ccatcaaaaa aacttacaag cagattgaga agaactggaa
     5641 gaatcacatg ggtccgttta tgagcatctt gcaagagcat attggggtga tgaagaagga
     5701 agagctcacc tcccatcagt ctcagctaac cgcctttttc ctggaagccc tggacttccg
     5761 agcccagcac tctgagaacg atctggagga agttggaaaa acggaaaatt gtatcattga
     5821 ctgtctagta gccatggttg tcaaactttc cgaggtcaca ttcaggcccc tgttcttcaa
     5881 gctgtttgat tgggctaaaa cagaagatgc cccaaaggac aggttgttga cattttacaa
     5941 cttggcagat tgcattgctg aaaagctgaa agggcttttt actctgtttg ccggccactt
     6001 agtgaagcct tttgctgaca ccttgaacca ggtgaacatc tccaaaacag atgaagcatt
     6061 ttttgactct gaaaatgacc ctgaaaagtg ctgcttgctg ttgcagttta ttttgaactg
     6121 tttatacaaa atcttccttt ttgataccca gcattttata agtaaagaga gagcagaagc
     6181 cttgatgatg cctctggtgg atcagctgga aaacaggctt gggggagaag agaaattcca
     6241 ggaacgggtg acaaagcacc tgataccatg catcgcacag ttttcggtgg ccatggcgga
     6301 tgactctctt tggaaaccac tgaactacca gattctgcta aagacgagag actcctcgcc
     6361 taaggttcga tttgctgctt tgattactgt gttagcactg gctgaaaaac taaaggagaa
     6421 ttatattgtc ttgctaccag aatccattcc tttcttagca gagttgatgg aagatgaatg
     6481 tgaagaagta gaacatcagt gccaaaagac tattcagcaa ctggaaactg tcctgggaga
     6541 gccactccag agctatttct aagactttct gtggtgtttc atactctact cagagttcac
     6601 actcatattt catattttta tttttgggtg ttgggtgcca tgttactttt ggtgccttaa
     6661 tacacctact tggattactt acaaatgttt tatcacttct ttacaaaatc cccacctggc
     6721 ttgtgctgcc acataagcct ctcctgccta tcgtatagag ctgcagaaag agtaaatgat
     6781 acacggtatt tttatacaga ctgctgtgtt tgtttaaaca tttattattc tcttcctgat
     6841 tgatggtaat aatattagac ttgttaattt tagcacccaa agctgacgcc tcatttgcac
     6901 tgtaagcctt aactcttctg tacagcagta tcttacatac atggtatcca tgttgcagat
     6961 ttcactcaaa gttgctctat ttcaagaaaa tgaagttatt tagcaatcaa cagaagtact
     7021 tttgactgta aagcctactt ttcattttgg gtaggcgaac ttcagccttc gtttctttgt
     7081 tgtgcccata aagagaagtg gttctggaat gcttttttta acccaggagt gtgactgtca
     7141 cctttatcct ttgttctttt gggaaacggg agagatgaag gcaacacgct gcttctaaaa
     7201 cagctcacac ctggctgctc acacagaggg cccagaaaca ctgggtggca cgaggaagct
     7261 cctccaggat tcagaatgaa cccagttcca ttggtggtta actaagaact acttgtctaa
     7321 gaaagtaagt atcagtagat ttttttcaat gctttgaagt gccctaatct ctagtactgg
     7381 gtcatggtga agttggaaag tgagggttca aataaaatta gatctgcccc ctttttaaag
     7441 gcatctaaga acatcccgta gaatgttcgc attgagttta aaagcctttg aagctaatat
     7501 agaagtttaa tgcagaaatg tggcaagcaa aaggccaact tgcattttag agacagagct
     7561 tgctagtata gaagtgcata tttctaagaa atgtctcagt aaaattcatt aataaatact
     7621 aatagctttt taaatttttt tcctccacgt aaaatgaaaa tgaacttaag acttacaagg
     7681 aatgatgtga gtgggctatt tttttcctaa atgcctcaca gtctccaaca gctcagttaa
     7741 gcactctgat ggtctttatg gagaaaaata actctggggg attctcgagt cttcttgcct
     7801 tctacagctt tccctgtggc accctccacc cccaaccagt gtctttgagc ttggtgagac
     7861 tctgcataca ttaatatgaa aagctggaaa agaattaagg gctagcgatt tctacactga
     7921 gtacttttaa aaaaataaga ttgacaatgg tattcttttc aatatatgga tagaaataat
     7981 atctaaaatc tgttctgaaa atattcctaa atcctggcag agttctgccc cagtctaatg
     8041 tgataaaatg atcctcactg actgagcttt tttccctccc cactcccaaa cctttgaaat
     8101 ttcctgtaac aagatctgac ctgtaaagat cccatataca tggaacttct gccaactccc
     8161 ctcaaataat agaaaaatca cagaaatgga accatttaac ttgctgatac aggtttgatt
     8221 ttaatcacgt aaagtggaag agtgctttga tctcagttgc taatgatgat ggactaatct
     8281 ttagaagaac ggaggccttg attggtgatt tcatgggaac aaaacagatt tctgcattac
     8341 ctctgcctgc tttgtgggtc ccttagttgg cgtacacttt ctgatagtgc ctgccttatg
     8401 aatgcctgaa gtctaatcct gaccttactt tgttgcccat aaatatcttt caaattgaa
//
