LOCUS       NM_001177479            6305 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens highly divergent homeobox (HDX), transcript variant 1,
            mRNA.
ACCESSION   NM_001177479
VERSION     NM_001177479.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6305)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6305)
  AUTHORS   Hamidian,A., Vaapil,M., von Stedingk,K., Fujita,T., Persson,C.U.,
            Eriksson,P., Veerla,S., De Preter,K., Speleman,F., Fujii,H.,
            Pahlman,S. and Mohlin,S.
  TITLE     Promoter-associated proteins of EPAS1 identified by enChIP-MS - A
            putative role of HDX as a negative regulator
  JOURNAL   Biochem Biophys Res Commun 499 (2), 291-298 (2018)
   PUBMED   29577908
  REMARK    GeneRIF: HDX negatively regulates EPAS1 expression through a
            release-of-inhibition mechanism.
REFERENCE   3  (bases 1 to 6305)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   4  (bases 1 to 6305)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA719263.1, BC143522.1, AL022160.1 and AL035552.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001177479.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.199079.1, BC143522.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373177.3/ ENSP00000362272.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DA719263.1         29-90
            63-1410             BC143522.1         1-1348
            1411-1411           AL022160.1         98259-98259
            1412-2339           BC143522.1         1350-2277
            2340-6305           AL035552.9         85283-89248         c
FEATURES             Location/Qualifiers
     source          1..6305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..6305
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /note="highly divergent homeobox"
                     /db_xref="GeneID:139324"
                     /db_xref="HGNC:HGNC:26411"
                     /db_xref="MIM:300994"
     exon            1..112
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            113..221
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2294
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="highly divergent homeobox isoform 1"
                     /protein_id="NP_001170950.1"
                     /db_xref="CCDS:CCDS35342.1"
                     /db_xref="GeneID:139324"
                     /db_xref="HGNC:HGNC:26411"
                     /db_xref="MIM:300994"
                     /translation="MNLRSVFTVEQQRILQRYYENGMTNQSKNCFQLILQCAQETKLD
                     FSVVRTWVGNKRRKMSSKNSESGTATTGTSLSAPDITVRNVVNIARPSSQQSSWTSAN
                     NDVIVTGIYSPASSSSRQGTNKHTDTQITEAHKIPIQKTATKNDTEFQLHIPVQRQVA
                     HCKNASLLLGEKTIILSRQTSVLNAGNSVFNHAKKNYGNSSVQASEMTVPQKPSVCHR
                     PCKIEPVGIQRSYKPEHTGPALHNLCGQKPTIRDPYCRTQNLEIREVFSLAVSDYPQR
                     ILGGNAPQKPSSAEGNCLSIAMETGDAEDEYAREEELASMRAQIPSYSRFYESGSSLR
                     AENQSTTLPGPGRNMPNSQMVNIRDMSDNVLYQNRNYHLTPRTSLHTASSTMYSNTNP
                     LRSNFSPHFASSNQLRLSQNQNNYQISGNLTVPWITGCSRKRALQDRTQFSDRDLATL
                     KKYWDNGMTSLGSVCREKIEAVATELNVDCEIVRTWIGNRRRKYRLMGIEVPPPRGGP
                     ADFSEQPESGSLSALTPGEEAGPEVGEDNDRNDEVSICLSEGSSQEEPNEVVPNDARA
                     HKEEDHHAVTTDNVKIEIIDDEESDMISNSEVEQVNSFLDYKNEEVKFIENELEIQKQ
                     KYFKLQTFVRSLILAMKADDKEQQQALLSDLPPELEEMDFNHASLEPDDTSFSVSSLS
                     EKNVSESL"
     exon            222..368
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..1472
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1526
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1673
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1881
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1961
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2045
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2168
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..6305
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2986
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /note="major polyA site"
     regulatory      6286..6291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6305
                     /gene="HDX"
                     /gene_synonym="CXorf43; D030011N01Rik"
ORIGIN      
        1 attgtctgaa gcggcactgg agacccagga aaaatctcgc tgaatccgcc tgccccagca
       61 gcggcctgat ctgggttccg ctgattcctt tcgtaaccgc accacacccg agctacaatc
      121 tctggacaaa attttaagag aaactccctc agaactccta aaggtaaaca aaagcaggca
      181 gattgaggat ggcagtcaga atatgaagtg accatatatg gatgaatcta cgttctgtat
      241 ttactgtaga acaacaaagg attttacagc gttattatga aaatggaatg acaaatcaaa
      301 gtaaaaattg ctttcagctc atattacagt gtgcacagga gactaagctg gacttcagtg
      361 tagtcaggac gtgggttggc aataagagaa gaaagatgag tagtaagaac tctgaatctg
      421 gaacagcaac aacaggaacc tctttgtcag ctccagacat cacagtcaga aatgtggtta
      481 atattgctcg accctcaagc cagcagtctt cttggacatc tgccaataat gatgtcattg
      541 taactggtat atacagtcca gccagttcat caagtaggca aggaacaaac aaacatacag
      601 acacacaaat tacagaagca cataaaatcc ctattcagaa aacagccact aaaaatgata
      661 ctgagtttca gttacacatt cctgtccaaa gacaagtagc acactgtaaa aatgcttccc
      721 tactcctagg tgaaaaaaca attattttgt caagacagac aagtgtgcta aatgctggaa
      781 actcagtatt caatcacgca aagaaaaact atggaaactc ttcagtacaa gcttctgaaa
      841 tgacagtacc tcaaaagcct tctgtgtgcc accgaccttg taaaattgaa ccagttggga
      901 ttcaaaggtc atataagcct gaacacacag gcccagcatt acataactta tgtgggcaaa
      961 agccaactat tagagaccct tactgtagaa cacaaaactt ggaaatccgt gaagtgtttt
     1021 cattggcagt tagcgattac ccccagagaa ttctgggagg aaatgcccca cagaagccta
     1081 gctcagcaga aggaaattgt ttgtccattg caatggagac tggagatgct gaggatgaat
     1141 atgccagaga ggaagagctg gcatcgatga gagcacagat accaagctat tcgagatttt
     1201 atgaaagtgg cagttccctt cgagctgaga accaaagtac aaccttgccc ggaccaggaa
     1261 gaaatatgcc aaattcacaa atggtgaata ttagagatat gtcagacaat gtactgtatc
     1321 aaaacagaaa ctaccatttg acaccacgga cctcattaca tacagcatct agtacaatgt
     1381 acagtaatac caatccatta cggagtaatt tttctcctca ttttgcatca tcaaaccaat
     1441 tgagattatc acaaaaccaa aacaattacc agatttcagg aaaccttact gtgccttgga
     1501 ttacagggtg ttctagaaaa agagcactac aggaccgcac tcagttcagt gaccgagact
     1561 tagccaccct taagaagtat tgggacaatg gcatgaccag cctgggctct gtttgtagag
     1621 agaaaattga agctgtggca actgaattaa atgttgactg tgaaatagtt cggacttgga
     1681 ttgggaatcg aagaaggaaa tatcgtttaa tggggattga agttccacct ccaagaggag
     1741 gccctgctga tttctctgag cagcctgagt ctggttcttt atctgcactc acaccaggag
     1801 aggaagctgg gcctgaagta ggagaggata atgacagaaa tgatgaagta tccatctgtt
     1861 tgtctgaagg aagctctcaa gaagagccca atgaagttgt tccgaatgat gcaagggctc
     1921 ataaggaaga ggaccaccat gcagtaacca cagataatgt gaaaatagaa attattgatg
     1981 atgaagaaag tgacatgata agtaattctg aagtagaaca agtaaactct ttcttggatt
     2041 ataagaatga agaagtcaaa ttcattgaaa atgagctcga gattcaaaag caaaaatact
     2101 ttaaacttca gacttttgtt agaagcttga tattagcaat gaaagctgat gataaggaac
     2161 aacagcaggc actgctgtca gatttacctc ctgaattaga ggaaatggat ttcaatcatg
     2221 cctcactgga gcctgatgat acctcattca gtgtatcttc tttgtcagag aaaaatgtct
     2281 cagaaagttt gtgatttcag ttggagggaa tatatgatac agtcttttgg cttcgtaaca
     2341 ggtgtgcatt tcaagataac tgcattctgt tgccctggta ttctttagtt gggaaaacac
     2401 attgttgaaa cggacgtatt ctgtgaagaa tgtacaagat ataatggcta cagtgcaaca
     2461 aaaatgtagg tgaaatttaa aagcattgtt tgagagagta tttttttaac tgatggaact
     2521 ctggaaaaaa attatattta agtttcagca gtttaaccct gaaattcatt atgtctaatt
     2581 tctaaccaga gacaaaataa ctaaagacat ttcagcattg cttatcaagt tgctacagct
     2641 tgattagtct tgtttttgta gccattacat cttctttctt cttctctcct tttcctatca
     2701 tccacttaca ctttttctca ggaaagtgga ctgaacattt aaaacaaaac tttaaaaaat
     2761 tatttaactc attatttaat gagttctctg atttagtttt taacccctat gaaaatttga
     2821 cttaaactaa tgactgaaaa ttaaatgatt acaggtatgt aattgtaaat tgctggtgtt
     2881 cttctattat ctaacccaaa tatttgtgtg ggggtgggga agcacaatgg aaaggtaatt
     2941 taaccaacat aacgtcaaat aaattacgaa gtgtacagaa acaaaatgtt gtcaaaatta
     3001 gtcttgatgg ggattcttca ttactacaaa tgacaagtat tgatacgatt gacattccag
     3061 tagtaaattt gtatacctgg gttagatgaa gtgttacaca aatattttaa atttatcacc
     3121 atctttataa ttctttttta gttcttacat gttatgaaac aggaagtcaa ggtaagctgc
     3181 tgagattttt taaaaattta gtcattcagc tttgccacaa aatttacctc atttccatat
     3241 gaggcctgta cagagccatc agccaaggat agtattcaaa aagagttata ctactttggt
     3301 tgtaaatcac agtcttctga attccatgaa tactattcta tgagtacaca cctaaaatgg
     3361 gcaagctacc cagttttcta ttattagtag gtaccagatg gcaacacact gtagactgtt
     3421 ctttgtagtt cttcctttct ggagtaccag atggtattac caagacccat agaagaaaaa
     3481 atgtcagttt ctccctaagc ccacagtgtc atatatttgt gacttggcag tgtgcaattg
     3541 tgttgcatgg ttaaattact atctatacct aaaagattaa tgaagtagct ggatggctgt
     3601 ttcagccatc aagtttctgt ttccaatttg tttttaattt ttgttggtac ctagtaggta
     3661 ttcagatatt tttaaaaatt tgtaattaga gccaaatttg atcttgaaat ttactagtac
     3721 taacttatga acacagaaag gcagtcataa atgtctttac ccttgaagtg tcccatcctc
     3781 ccacacacac aaataggtaa gctcccactg atagtctttc attttgtcac ttatttgttt
     3841 atattgctgc catactactg atatggtccc tttgttagta ggaatatttc agtgttcaga
     3901 tatgcttcct tgagccatat ggagttttgc aaacaatagt tagtttttct tgctgacaag
     3961 tcaaattcca ttcagagaaa gcagcagaga gtaacagagc ctcagatatt acgattaaat
     4021 gtaccagtca caccaactcc tccatgagat gaagagtcgc ccccatatac aacgaagtta
     4081 gaaaccactt attaagtagc atgaacaaat tccaggcctt caagtctctc ctagggtctg
     4141 cttcatagtc attgagttta tctttcaaat ataattactt ctgcttcaat ttaagcccct
     4201 tcttatttgg ttctcattgc aaattaacta taggtatatt ctctcctaca gcttttaaca
     4261 ctatagattt tatttgtcac gcatcagcca ttagtcacta aatcgaaaaa tacttgttga
     4321 gctcctgcta tagagaagac actgtgctgg acattggatt tctcagcaag ctgtaaacat
     4381 cacaaataat tatttctttt taacatcttc tatgatatta ataaaccata tttaagtaga
     4441 atttttaata gatttaaggt tctgctaggt gtgattctta gaaggattcc tagtccacaa
     4501 ttttgagaga aagcatagat gatctttttg tctctgttta acatttcatc aaaatagaaa
     4561 ctatataaat cataacaata catttagaac tccttttgtc ttgaaatttg tgtttcagca
     4621 ccagaatatt tttcttcacc atcattggaa ttaaaacact tctaaaatga aatgtggcta
     4681 ttctgtagca ggaactgaag gaaatacctc tatctataga aaaagaatca taattgccag
     4741 attgaaatta ttcatggtag actttgaaaa agatgtcaag gtcaagcttt gaaaagttgt
     4801 tatgaagaaa gtatattttt tacatatgta gataggagtt ggttttgaga tatgttagag
     4861 caggaaaaat tatcagctta taattactct tgtggacatc ttcatggctg gggataaaaa
     4921 ttaactaact agtgtttctt tctttagggc tttgagatta ttaaaacaga ccttactatc
     4981 tgaaggctct ctcagggaga cagaagccaa tgtggaaaaa aacaaaaaac aaaaaacaac
     5041 aacaagaaaa aacttctttt tttctttcaa ctacatttct atgtctgctt taagcttaga
     5101 acagccaagc agtttttaag ccagaaatgt gtatgtaaga gcacttacct tccaaaatgt
     5161 gtacatatga aaaaaaaagg aaggtatttt cttcttttca gccaagctaa acttattcac
     5221 aagaaaatga gaattgcaat tgctctggag aataggaaaa ttagcacatg caaagaaaac
     5281 cttaaaagaa aattggcctc ttcatggaaa ctggggatgt tttgtcctaa ggtcagttat
     5341 caacagcagg atttttgtat tgccattgca agcatgtgat agaaatgttt gttattgttg
     5401 gagaagaaaa ggctgagacc caattatacc ctgtactctt tattcgacca agacctcaaa
     5461 agatgtcaaa gaagccattt ctccaaagac agcaacatct attgtgaggc actttcatat
     5521 tcagcagtct gtaagtttgt aggagaaaac ataagtggtt aatttaaaat aattttgggc
     5581 tctaaaatgg actttgttgc cttttttggt gggggtggtg ggaatcggat tcagcccatt
     5641 tccaagggat agtttcttca tctcagacaa ctattttgtg atccttttta aaagacattc
     5701 tgaaaacttt aactcctgcc cttcttccgt attacagttg tgttattcca gaaatattgt
     5761 ctactttttt aatatattag attttcattc agatcttaaa catgcaaaca tgtgataggt
     5821 tagcttttta agggagttat cagtaccact gtatctaaat gttaggtaaa tgggtagatt
     5881 tctctttgaa gttggtattt tccttggcag acagcactgt atcatgctct tcaccaagct
     5941 atgctctgta atgctataat caaggaggct actaacttgt gaacctacag tcaacacacc
     6001 attgctgaaa acaaactttg attaagaaca gatttgctag ggggaaaaaa gagtaaagtg
     6061 atattttcaa gcaaatataa ttaaaattgt ttcattaaaa tatatactga gtgtatattg
     6121 ctccacactg aaattttatt ttgcattaac ttgttaagta attcatttta gcaatcctgc
     6181 atcccatttt actagtacta cctctgaaat atactgtcac cttaaaacca catcagactg
     6241 taatgtgaat ttttgtagag tttttattta aacttttata gaggcaataa atgatttcca
     6301 actaa
//
