LOCUS       NM_005336               6322 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens high density lipoprotein binding protein (HDLBP),
            transcript variant 1, mRNA.
ACCESSION   NM_005336
VERSION     NM_005336.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6322)
  AUTHORS   Mushtaq,A., Mir,U.S. and Altaf,M.
  TITLE     Multifaceted functions of RNA-binding protein vigilin in gene
            silencing, genome stability, and autism-related disorders
  JOURNAL   J Biol Chem 299 (3), 102988 (2023)
   PUBMED   36758804
  REMARK    GeneRIF: Multifaceted functions of RNA-binding protein vigilin in
            gene silencing, genome stability, and autism-related disorders.
            Review article
REFERENCE   2  (bases 1 to 6322)
  AUTHORS   Yuan,J., Lv,T., Yang,J., Wu,Z., Yan,L., Yang,J., Shi,Y. and
            Jiang,L.
  TITLE     HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib
            Resistance by Suppressing Trim71-dependent RAF1 Degradation
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (2), 307-325 (2023)
   PUBMED   36244648
  REMARK    GeneRIF: HDLBP Promotes Hepatocellular Carcinoma Proliferation and
            Sorafenib Resistance by Suppressing Trim71-dependent RAF1
            Degradation.
REFERENCE   3  (bases 1 to 6322)
  AUTHORS   Yuan,J., Lv,T., Yang,J., Wu,Z., Yan,L., Yang,J. and Shi,Y.
  TITLE     HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability by
            diminishing Trim69-dependent FSP1 degradation in hepatocellular
            carcinoma
  JOURNAL   Redox Biol 58, 102546 (2022)
   PUBMED   36423520
  REMARK    GeneRIF: HDLBP-stabilized lncFAL inhibits ferroptosis vulnerability
            by diminishing Trim69-dependent FSP1 degradation in hepatocellular
            carcinoma.
REFERENCE   4  (bases 1 to 6322)
  AUTHORS   Yuan,J., Lv,T., Yang,J., Wu,Z., Yan,L., Yang,J., Shi,Y. and
            Jiang,L.
  TITLE     The lipid transporter HDLBP promotes hepatocellular carcinoma
            metastasis through BRAF-dependent epithelial-mesenchymal transition
  JOURNAL   Cancer Lett 549, 215921 (2022)
   PUBMED   36122630
  REMARK    GeneRIF: The lipid transporter HDLBP promotes hepatocellular
            carcinoma metastasis through BRAF-dependent epithelial-mesenchymal
            transition.
REFERENCE   5  (bases 1 to 6322)
  AUTHORS   Rohwedel,J., Kugler,S., Engebrecht,T., Purschke,W., Muller,P.K. and
            Kruse,C.
  TITLE     Evidence for posttranscriptional regulation of the multi K homology
            domain protein vigilin by a small peptide encoded in the 5' leader
            sequence
  JOURNAL   Cell Mol Life Sci 60 (8), 1705-1715 (2003)
   PUBMED   14504658
REFERENCE   6  (bases 1 to 6322)
  AUTHORS   Kugler,S., Plenz,G. and Muller,P.K.
  TITLE     Two additional 5' exons in the human Vigilin gene distinguish it
            from the chicken gene and provide the structural basis for
            differential routes of gene expression
  JOURNAL   Eur J Biochem 238 (2), 410-417 (1996)
   PUBMED   8681952
REFERENCE   7  (bases 1 to 6322)
  AUTHORS   Plenz,G., Kugler,S., Schnittger,S., Rieder,H., Fonatsch,C. and
            Muller,P.K.
  TITLE     The human vigilin gene: identification, chromosomal localization
            and expression pattern
  JOURNAL   Hum Genet 93 (5), 575-582 (1994)
   PUBMED   8168838
REFERENCE   8  (bases 1 to 6322)
  AUTHORS   Xia,Y.R., Klisak,I., Sparkes,R.S., Oram,J. and Lusis,A.J.
  TITLE     Localization of the gene for high-density lipoprotein binding
            protein (HDLBP) to human chromosome 2q37
  JOURNAL   Genomics 16 (2), 524-525 (1993)
   PUBMED   8390966
REFERENCE   9  (bases 1 to 6322)
  AUTHORS   McKnight,G.L., Reasoner,J., Gilbert,T., Sundquist,K.O., Hokland,B.,
            McKernan,P.A., Champagne,J., Johnson,C.J., Bailey,M.C., Holly,R. et
            al.
  TITLE     Cloning and expression of a cellular high density
            lipoprotein-binding protein that is up-regulated by cholesterol
            loading of cells
  JOURNAL   J Biol Chem 267 (17), 12131-12141 (1992)
   PUBMED   1318310
REFERENCE   10 (bases 1 to 6322)
  AUTHORS   Graham,D.L. and Oram,J.F.
  TITLE     Identification and characterization of a high density
            lipoprotein-binding protein in cell membranes by ligand blotting
  JOURNAL   J Biol Chem 262 (16), 7439-7442 (1987)
   PUBMED   3034894
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104841.6 and KF456779.1.
            
            On Oct 7, 2020 this sequence version replaced NM_005336.5.
            
            Summary: The protein encoded by this gene binds high density
            lipoprotein (HDL) and may function to regulate excess cholesterol
            levels in cells. The encoded protein also binds RNA and can induce
            heterochromatin formation. [provided by RefSeq, Mar 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312335.1, SRR11853563.20023.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310931.10/ ENSP00000312042.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 14504658
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC104841.6         33957-34059
            104-168             AC104841.6         81088-81152
            169-281             AC104841.6         82723-82835
            282-439             KF456779.1         124-281             c
            440-655             AC104841.6         86703-86918
            656-862             AC104841.6         92823-93029
            863-1078            AC104841.6         93230-93445
            1079-1285           AC104841.6         94049-94255
            1286-1393           AC104841.6         94471-94578
            1394-1498           AC104841.6         96132-96236
            1499-1577           AC104841.6         96594-96672
            1578-1717           AC104841.6         99649-99788
            1718-1822           AC104841.6         101281-101385
            1823-1936           AC104841.6         101513-101626
            1937-2023           AC104841.6         102487-102573
            2024-2155           AC104841.6         102746-102877
            2156-2374           AC104841.6         106951-107169
            2375-2596           AC104841.6         109507-109728
            2597-2815           AC104841.6         109809-110027
            2816-2954           AC104841.6         110842-110980
            2955-3109           AC104841.6         112860-113014
            3110-3214           AC104841.6         114035-114139
            3215-3349           AC104841.6         114374-114508
            3350-3493           AC104841.6         115666-115809
            3494-3679           AC104841.6         118685-118870
            3680-3796           AC104841.6         119360-119476
            3797-3925           AC104841.6         119668-119796
            3926-6322           AC104841.6         119942-122338
FEATURES             Location/Qualifiers
     source          1..6322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..6322
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /note="high density lipoprotein binding protein"
                     /db_xref="GeneID:3069"
                     /db_xref="HGNC:HGNC:4857"
                     /db_xref="MIM:142695"
     exon            1..103
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      28..69
                     /regulatory_class="uORF"
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:14504658]"
                     /note="this uORF is predicted to encode a 13 aa peptide
                     (PMID:14504658)"
     exon            104..168
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            169..281
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..4012
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /note="isoform a is encoded by transcript variant 1;
                     vigilin; HDL-binding protein"
                     /codon_start=1
                     /product="vigilin isoform a"
                     /protein_id="NP_005327.1"
                     /db_xref="CCDS:CCDS2547.1"
                     /db_xref="GeneID:3069"
                     /db_xref="HGNC:HGNC:4857"
                     /db_xref="MIM:142695"
                     /translation="MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAF
                     PPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAK
                     ICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKE
                     HHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAE
                     QDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQ
                     LAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPS
                     DSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQ
                     QMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHL
                     IGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENER
                     TKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKC
                     TKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNS
                     ETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEE
                     CGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHK
                     FLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLD
                     NVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCV
                     EAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREE
                     NAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKCEAAKEALEALVP
                     VTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRA
                     KAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQF
                     PDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHARIIGAR
                     GKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDS
                     EALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPKTL
                     PWGPKR"
     exon            282..439
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            440..655
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            656..862
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1078
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1285
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1393
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1498
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1577
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1717
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1822
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1936
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2023
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2155
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2374
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2596
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2815
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2954
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3109
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3214
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3349
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3493
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..3679
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3796
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3925
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     exon            3926..6322
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4371..4376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /note="hexamer: AATAAA"
     polyA_site      4401
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /note="major polyA site"
     regulatory      6304..6309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
                     /note="hexamer: AATAAA"
     polyA_site      6322
                     /gene="HDLBP"
                     /gene_synonym="HBP; PRO2900; VGL"
ORIGIN      
        1 aagcgtagcc tcttctcctt taccaagatg gcggcttgtc cctgtttcgc cacagttcct
       61 accttatgag ctcggttttc ttatgcttat aagagtggaa cagcaaaagc tggcaggctg
      121 acagaggcgg cctcaggacg gaccttctgg ctactgaccg ttttgctgtg gttttcccgg
      181 attgtgtgta ggtgtgagat caaccatgag ttccgttgca gttttgaccc aagagagttt
      241 tgctgaacac cgaagtgggc tggttccgca acaaatcaaa gttgccactc taaattcaga
      301 agaggagagc gaccctccaa cctacaagga tgccttccct ccacttcctg agaaagctgc
      361 ttgcctggaa agtgcccagg aacccgctgg agcctggggg aacaagatcc gacccatcaa
      421 ggcttctgtc atcactcagg tgttccatgt acccctggag gagagaaaat acaaggatat
      481 gaaccagttt ggagaaggtg aacaagcaaa aatctgcctt gagatcatgc agagaactgg
      541 tgctcacttg gagctgtctt tggccaaaga ccaaggcctc tccatcatgg tgtcaggaaa
      601 gctggatgct gtcatgaaag ctcggaagga cattgttgct agactgcaga ctcaggcctc
      661 agcaactgtt gccattccca aagaacacca tcgctttgtt attggcaaaa atggagagaa
      721 actgcaagac ttggagctaa aaactgcaac caaaatccag atcccacgcc cagatgaccc
      781 cagcaatcag atcaagatca ctggcaccaa agagggcatc gagaaagctc gccatgaagt
      841 cttactcatc tctgccgagc aggacaaacg tgctgtggag aggctagaag tagaaaaggc
      901 attccacccc ttcatcgctg ggccgtataa tagactggtt ggcgagatca tgcaggagac
      961 aggcacgcgc atcaacatcc ccccacccag cgtgaaccgg acagagattg tcttcactgg
     1021 agagaaggaa cagttggctc aggctgtggc tcgcatcaag aagatttatg aggagaagaa
     1081 aaagaagact acaaccattg cagtggaagt gaagaaatcc caacacaagt atgtcattgg
     1141 gcccaagggc aattcattgc aggagatcct tgagagaact ggagtttccg ttgagatccc
     1201 accctcagac agcatctctg agactgtaat acttcgaggc gaacctgaaa agttaggtca
     1261 ggcgttgact gaagtctatg ccaaggccaa tagcttcacc gtctcctctg tcgccgcccc
     1321 ttcctggctt caccgtttca tcattggcaa gaaagggcag aacctggcca aaatcactca
     1381 gcagatgcca aaggttcaca tcgagttcac agagggcgaa gacaagatca ccctggaggg
     1441 ccctacagag gatgtcaatg tggcccagga acagatagaa ggcatggtca aagatttgat
     1501 taaccggatg gactatgtgg agatcaacat cgaccacaag ttccacaggc acctcattgg
     1561 gaagagcggt gccaacataa acagaatcaa agaccagtac aaggtgtccg tgcgcatccc
     1621 tcctgacagt gagaagagca atttgatccg catcgagggg gacccacagg gcgtgcagca
     1681 ggccaagcga gagctgctgg agcttgcatc tcgcatggaa aatgagcgta ccaaggatct
     1741 aatcattgag caaagatttc atcgcacaat cattgggcag aagggtgaac ggatccgtga
     1801 aattcgtgac aaattcccag aggtcatcat taactttcca gacccagcac aaaaaagtga
     1861 cattgtccag ctcagaggac ctaagaatga ggtggaaaaa tgcacaaaat acatgcagaa
     1921 gatggtggca gatctggtgg aaaatagcta ttcaatttct gttccgatct tcaaacagtt
     1981 tcacaagaat atcattggga aaggaggcgc aaacattaaa aagattcgtg aagaaagcaa
     2041 caccaaaatc gaccttccag cagagaatag caattcagag accattatca tcacaggcaa
     2101 gcgagccaac tgcgaagctg cccggagcag gattctgtct attcagaaag acctggccaa
     2161 catagccgag gtagaggtct ccatccctgc caagctgcac aactccctca ttggcaccaa
     2221 gggccgtctg atccgctcca tcatggagga gtgcggcggg gtccacattc actttcccgt
     2281 ggaaggttca ggaagcgaca ccgttgttat caggggccct tcctcggatg tggagaaggc
     2341 caagaagcag ctcctgcatc tggcggagga gaagcaaacc aagagtttca ctgttgacat
     2401 ccgcgccaag ccagaatacc acaaattcct catcggcaag gggggcggca aaattcgcaa
     2461 ggtgcgcgac agcactggag cacgtgtcat cttccctgcg gctgaggaca aggaccagga
     2521 cctgatcacc atcattggaa aggaggacgc cgtccgagag gcacagaagg agctggaggc
     2581 cttgatccaa aacctggata atgtggtgga agactccatg ctggtggacc ccaagcacca
     2641 ccgccacttc gtcatccgca gaggccaggt cttgcgggag attgctgaag agtatggcgg
     2701 ggtgatggtc agcttcccac gctctggcac acagagcgac aaagtcaccc tcaagggcgc
     2761 caaggactgt gtggaggcag ccaagaaacg cattcaggag atcattgagg acctggaagc
     2821 tcaggtgaca ttagaatgtg ctatacccca gaaattccat cgatctgtca tgggccccaa
     2881 aggttccaga atccagcaga ttactcggga tttcagtgtt caaattaaat tcccagacag
     2941 agaggagaac gcagttcaca gtacagagcc agttgtccag gagaatgggg acgaagctgg
     3001 ggaggggaga gaggctaaag attgtgaccc cggctctcca aggaggtgtg acatcatcat
     3061 catctctggc cggaaagaaa agtgtgaggc tgccaaggaa gctctggagg cattggttcc
     3121 tgtcaccatt gaagtagagg tgccctttga ccttcaccgt tacgttattg ggcagaaagg
     3181 aagtgggatc cgcaagatga tggatgagtt tgaggtgaac atacatgtcc cggcacctga
     3241 gctgcagtct gacatcatcg ccatcacggg cctcgctgca aatttggacc gggccaaggc
     3301 tggactgctg gagcgtgtga aggagctaca ggccgagcag gaggaccggg ctttaaggag
     3361 ttttaagctg agtgtcactg tagaccccaa ataccatccc aagattatcg ggagaaaggg
     3421 ggcagtaatt acccaaatcc ggttggagca tgacgtgaac atccagtttc ctgataagga
     3481 cgatgggaac cagccccagg accaaattac catcacaggg tacgaaaaga acacagaagc
     3541 tgccagggat gctatactga gaattgtggg tgaacttgag cagatggttt ctgaggacgt
     3601 cccgctggac caccgcgttc acgcccgcat cattggtgcc cgcggcaaag ccattcgcaa
     3661 aatcatggac gaattcaagg tggacattcg cttcccacag agcggagccc cagaccccaa
     3721 ctgcgtcact gtgacggggc tcccagagaa tgtggaggaa gccatcgacc acatcctcaa
     3781 tctggaggag gaatacctag ctgacgtggt ggacagtgag gcgctgcagg tatacatgaa
     3841 acccccagca cacgaagagg ccaaggcacc ttccagaggc tttgtggtgc gggacgcacc
     3901 ctggaccgcc agcagcagtg agaaggctcc tgacatgagc agctctgagg aatttcccag
     3961 ctttggggct caggtggctc ccaagaccct cccttggggc cccaaacgat aatgatcaaa
     4021 aagaacagaa ccctctccag cctgctgacc caaacccaac cacacaatgg tttgtctcaa
     4081 tctgacccag cggctggacc ctccgtaaat tgttgacgct cttccccctt cccgaggtcc
     4141 cgcagggagc ctagcgcctg gctgtgtgtg cggccgctcc tccaggcctg gccgtgcccg
     4201 ctcaggacct gctccactgt ttaacactaa accaaggtca tgagcattcg tgctaagata
     4261 acagactcca gctcctggtc cacccggcat gtcagtcagc actctggcct tcatcacgag
     4321 agctccgcag ccgtggctag gattccactt cctgtgtcat gacctcagga aataaacgtc
     4381 cttgacttta taaaagccaa acgtttgccc tcttcctttc ccacctccct cctgccagtt
     4441 tcccttggtc cagacagtcc tgtttgtgga gtgcaatcag cctcctccag ctgccagagc
     4501 gcctcagcac aggtgtcagg gtgcaaggaa gacctggcaa tggacagcag gaggcaggtt
     4561 cctggagctg gggggtgacc tgagaggcag agggtgacgg gttctcaggc agtcctgatt
     4621 ttacctgccg tggggtctga aagcaccaag ggtccctgcc cctacctcca ctgccagacc
     4681 ctcagcctga ggtctggtga gtggagcctg gaggcaaggt ggtaggcacc atctgggtcc
     4741 cctgtggccg tcacagtgtc tgctgtgatt gagatgcgca caggttgggg gaggtagggc
     4801 cttacgcttg tcctcagtgg gggcagtttg ccttagatga cagctgggct cttcttcaca
     4861 ccacctgcag cccctccctg cccctgccct agctgctgtg tgttcagttg ccttctttct
     4921 acctcagccg gcgtggagtg gtctctgtgc agttagtgcc accccacaca cccgtctctt
     4981 gattgagatg tttctggtgg ttatgggttt cccgtggagc tgggggtggg cgccgtgtac
     5041 ctaagctgga ggctggcgct ctccctcagc acaggtgggt cagtggccag caggcccatc
     5101 tggagtggga gtgggcactt ccaccccgcc cacaggccat ccggctgtgc aggccagccc
     5161 ctaggagcag gtcccgggtg actggcagtt ttcacggtct agggccgaga cgatggcatg
     5221 gggcctagag catgaggtag agcagaatgc agaccacgcc gctggatgcc gagagaccct
     5281 gctctccgag ggaggcatct gtgtcatgct gtgagggctg aggacggggc cctagtctct
     5341 ggttttctgg tcttaacatc cttatctgtg tccgccacgg aggtgactga gctgctagcg
     5401 agttgtcctg tcccaggtac ttgagttttg gaaaagctga ctcacgccca tccatctcac
     5461 agcccttccc tggggacagt cgcttccgcc ttgacacctc actctcagtt gaataactca
     5521 agcttggtca tcttcagact cgaattcttg agtagaccca gacggcttag cccaagtcta
     5581 gttgcagctg cctcggcaag tccccatttg ctcaggcagc cctgaatggg cctgtttaca
     5641 ggaatggtaa attgggattg gaaggaatat agcttccagc ttcataggct agggtgacca
     5701 cggcttagga aacagggaaa gaaagcaagg cccttttcct gcctttcccg ggatctgtct
     5761 actccacctc cacgggggag gccagtgggg aagggctgtc acctcttccc catctgcatg
     5821 agttctggaa ctctgtcctg ttggctgctt gcttccagct ccccccaatc tccatcgcag
     5881 cgggttcctc ctgtcttttc tacagtgtca taaaacatcc tgcccctacc ctctcccaaa
     5941 ggtcaatttt aattctcacc aagttttgca catctctgta tgtcgcttga tgtcttagac
     6001 gcgagccctt tcctaaactg ttcagcgctc tcttttcctt tgggtggttg ttgcaagggt
     6061 gatgacatga ctgtccccag gcctgtctcc ctgaagcgtc tgtgctgtca ggacagccct
     6121 gggcagagat gaggcagggg tgaggcgtgc gtgtgctttt cctccttgtt ggatgtcttc
     6181 catatcatct gtttccatag ctacaatcca tcccttggcc ttaactttgg aatttggaga
     6241 ttatatgcaa acatgtgtaa aggctcatga atatggatga cactggaatt ttataaattc
     6301 taaaataaaa cccgaaacca ga
//
