LOCUS       NM_032124               2185 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens haloacid dehalogenase like hydrolase domain containing
            2 (HDHD2), transcript variant 1, mRNA.
ACCESSION   NM_032124
VERSION     NM_032124.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Havugimana,P.C., Hart,G.T., Nepusz,T., Yang,H., Turinsky,A.L.,
            Li,Z., Wang,P.I., Boutz,D.R., Fong,V., Phanse,S., Babu,M.,
            Craig,S.A., Hu,P., Wan,C., Vlasblom,J., Dar,V.U., Bezginov,A.,
            Clark,G.W., Wu,G.C., Wodak,S.J., Tillier,E.R., Paccanaro,A.,
            Marcotte,E.M. and Emili,A.
  TITLE     A census of human soluble protein complexes
  JOURNAL   Cell 150 (5), 1068-1081 (2012)
   PUBMED   22939629
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC051635.7 and AC012254.12.
            
            On Nov 23, 2018 this sequence version replaced NM_032124.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038100.2, GQ900991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300605.11/ ENSP00000300605.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC051635.7         130219-130341
            124-234             AC012254.12        9748-9858
            235-443             AC012254.12        11493-11701
            444-528             AC012254.12        15869-15953
            529-745             AC012254.12        30849-31065
            746-809             AC012254.12        33157-33220
            810-2185            AC012254.12        37412-38787
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..2185
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /note="haloacid dehalogenase like hydrolase domain
                     containing 2"
                     /db_xref="GeneID:84064"
                     /db_xref="HGNC:HGNC:25364"
     exon            1..123
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     exon            124..234
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..913
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /note="isoform 1 is encoded by transcript variant 1;
                     haloacid dehalogenase-like hydrolase domain-containing
                     protein 2; epididymis secretory protein Li 301; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="haloacid dehalogenase-like hydrolase
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_115500.1"
                     /db_xref="CCDS:CCDS32829.1"
                     /db_xref="GeneID:84064"
                     /db_xref="HGNC:HGNC:25364"
                     /translation="MAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRF
                     VTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERKQVRPMLLVDDRALPDF
                     KGIQTSDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPG
                     PFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGM
                     LGILVKTGKYRASDEEKINPPPYLTCESFPHAVDHILQHLL"
     exon            235..443
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     exon            444..528
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     exon            529..745
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     exon            746..809
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     exon            810..2185
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /note="hexamer: AATAAA"
     polyA_site      2185
                     /gene="HDHD2"
                     /gene_synonym="3110052N05Rik; HEL-S-301"
                     /note="major polyA site"
ORIGIN      
        1 aacttccggc gtccgtcggg cagcagcggg gctgtctatc ccggctgagg acccgcggcc
       61 agtgcgggtg gctggctttg ccattagcgg gggcctttcc tgaggacggc gtacggagtg
      121 tggggaatga aggatggcag catgccgtgc attaaaagct gttttggtag atctcagtgg
      181 cacacttcac attgaagatg cagctgtgcc aggcgcacag gaagctctta aaaggttacg
      241 tggtgcttct gtaatcatta ggtttgtgac caatacaacc aaagagagca agcaagacct
      301 gttagaaagg ttgagaaaat tggaatttga tatctctgaa gatgaaatat tcacatctct
      361 gactgcagcc agaagtttac tagagcggaa acaagtcaga cccatgctgc tagttgatga
      421 tcgggcacta cctgatttca aaggaataca aacaagtgat cctaatgctg tggtcatggg
      481 attggcacca gaacattttc attatcaaat tctgaatcaa gcattccggt tactcctgga
      541 tggagcacct ctgatagcaa tccacaaagc caggtattac aagaggaaag atggcttagc
      601 cctggggcct ggaccatttg tgactgcttt agagtatgcc acagatacca aagccacagt
      661 cgtggggaaa ccagagaaga cgttcttttt ggaagcattg cggggcactg gctgtgaacc
      721 tgaggaggct gtcatgatag gagatgattg cagggatgat gttggtgggg ctcaagatgt
      781 cggcatgctg ggcatcttag taaagactgg gaaatatcga gcatcagatg aagaaaaaat
      841 taatccacct ccttacttaa cttgtgagag tttccctcat gctgtggacc acattctgca
      901 gcacctattg tgaagcagtg tgtgcatctg aagcaacttg aaatgcagct tcttattgtc
      961 tggaatgaat cccttaccaa ctcagtgcca gcatcggtag acaccagtca gtgctgatcg
     1021 ctttttaacc ctcttttgtt gtgcattaat tagaaagaaa ggtattgaat tgcggctagc
     1081 cagtaagcct tgctaatctc ttttattttg taactgaaga tgagacccaa agaaagggaa
     1141 agctgagatt ttgtgccatt ccttttaaaa tattcatcag gttaggtggg gctgtggggg
     1201 aaaagctact acagggaaga gtgttctctg ctgtctcttc actggaaaac agggaggggg
     1261 gatttcagac tgtgaagaaa gttgaatggt ggtttttaaa ttataaagta atgtattaaa
     1321 aggtgcatta ggctgtagtt ctaatattga gttcaactgt gaaatccatc agatgtgcca
     1381 aatggagaag acagaaagca acaaagtgaa ttgttcttta gcccaagtgg tacagtgaat
     1441 ttgctttaac agatgttgaa aactaaattt tctactgtat tcccagcacg ggtgacttct
     1501 ttttctcttc attagccaga gatgactaat ttaaatttag aaccagattt taatttaaat
     1561 taatatttcc attaataacc tattcattgc agatacctat tatactgtgt aacagttgtt
     1621 ttggaaattt tatgtaaaat taaaactatc agtattttac agatgtttta attagacatt
     1681 gttattaaca ggaacagtgc agaaactaga atcaagcctt ataatatctt atagaccatg
     1741 catttttgaa gttagtgtcc actagggtcc tattaactgt acatttgcaa gatttcatta
     1801 tttttgcctc tgacactatg ggaaaaattt tttagaagct attgggacag attcaagctt
     1861 ttatgcactt ggttactaca gctgtaaaat gaaatctcgt cttgtagcat ggattattct
     1921 tctcatgtta aacccaccaa aataaagggg actaaatagg taatgatttt cctagtgcat
     1981 ttgcatactg tgataatcct gggccttgca atagttctac agggctcttg ggcattgaat
     2041 tattaggatg taattgtaca tcattgtagt gttcacctta ttgaagctca ctctgatgtt
     2101 aatgagcttc gggttttgat gcttgtttag agatcagcag tcttggatgg gagggaacaa
     2161 agctaaataa atgttagttt ggtga
//
