LOCUS       NM_016073              12538 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens HDGF like 3 (HDGFL3), mRNA.
ACCESSION   NM_016073
VERSION     NM_016073.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12538)
  AUTHORS   Xiao,C. and Liang,W.
  TITLE     Bulk RNA-Seq Combined with Single-Cell Transcriptome Sequencing
            Reveals the Possible Mechanisms by Which HDGFL3 Involves in
            Prostate Cancer Growth and Metastasis
  JOURNAL   Arch Esp Urol 76 (6), 425-438 (2023)
   PUBMED   37681334
  REMARK    GeneRIF: Bulk RNA-Seq Combined with Single-Cell Transcriptome
            Sequencing Reveals the Possible Mechanisms by Which HDGFL3 Involves
            in Prostate Cancer Growth and Metastasis.
REFERENCE   2  (bases 1 to 12538)
  AUTHORS   Zhang,Z., Samsa,W.E., De,Y., Zhang,F., Reizes,O., Almasan,A. and
            Gong,Z.
  TITLE     HDGFRP3 interaction with 53BP1 promotes DNA double-strand break
            repair
  JOURNAL   Nucleic Acids Res 51 (5), 2238-2256 (2023)
   PUBMED   36794849
  REMARK    GeneRIF: HDGFRP3 interaction with 53BP1 promotes DNA double-strand
            break repair.
            Erratum:[Nucleic Acids Res. 2024 Mar 21;52(5):2759-2760. doi:
            10.1093/nar/gkae146.. PMID: 38407480]
REFERENCE   3  (bases 1 to 12538)
  AUTHORS   Yun,H.S., Lee,J., Kim,J.Y., Sim,Y.J., Lee,C.W., Park,J.K.,
            Kim,J.S., Ahn,J., Song,J.Y., Baek,J.H. and Hwang,S.G.
  TITLE     A novel function of HRP-3 in regulating cell cycle progression via
            the HDAC-E2F1-Cyclin E pathway in lung cancer
  JOURNAL   Cancer Sci 113 (1), 145-155 (2022)
   PUBMED   34714604
  REMARK    GeneRIF: A novel function of HRP-3 in regulating cell cycle
            progression via the HDAC-E2F1-Cyclin E pathway in lung cancer.
REFERENCE   4  (bases 1 to 12538)
  AUTHORS   Milanesi,E., Voinsky,I., Hadar,A., Srouji,A., Maj,C., Shekhtman,T.,
            Gershovits,M., Gilad,S., Chillotti,C., Squassina,A., Potash,J.B.,
            Schulze,T.G., Goes,F.S., Zandi,P., Kelsoe,J.R. and Gurwitz,D.
  TITLE     RNA sequencing of bipolar disorder lymphoblastoid cell lines
            implicates the neurotrophic factor HRP-3 in lithium's clinical
            efficacy
  JOURNAL   World J Biol Psychiatry 20 (6), 449-461 (2019)
   PUBMED   28854847
  REMARK    GeneRIF: The study observed higher expression levels of HDGFRP3 and
            ID2 in bipolar disorder (BD) patients who favourably respond to
            lithium. Both of these genes are involved in neurogenesis, and
            HDGFRP3 has been suggested to be a neurotrophic factor.
REFERENCE   5  (bases 1 to 12538)
  AUTHORS   Tian,W., Yan,P., Xu,N., Chakravorty,A., Liefke,R., Xi,Q. and
            Wang,Z.
  TITLE     The HRP3 PWWP domain recognizes the minor groove of double-stranded
            DNA and recruits HRP3 to chromatin
  JOURNAL   Nucleic Acids Res 47 (10), 5436-5448 (2019)
   PUBMED   31162607
  REMARK    GeneRIF: HRP3 PWWP is a new family of minor groove-specific
            DNA-binding proteins
REFERENCE   6  (bases 1 to 12538)
  AUTHORS   Yun,H.S., Hong,E.H., Lee,S.J., Baek,J.H., Lee,C.W., Yim,J.H.,
            Um,H.D. and Hwang,S.G.
  TITLE     Depletion of hepatoma-derived growth factor-related protein-3
            induces apoptotic sensitization of radioresistant A549 cells via
            reactive oxygen species-dependent p53 activation
  JOURNAL   Biochem Biophys Res Commun 439 (3), 333-339 (2013)
   PUBMED   24012673
  REMARK    GeneRIF: Depletion of HRP-3 induces apoptosis of radio- and
            chemoresistant A549 cells. HRP-3 is essential for regulating
            reactive oxygen species-dependent, p53-induced cell death.
REFERENCE   7  (bases 1 to 12538)
  AUTHORS   El-Tahir,H.M., Abouzied,M.M., Gallitzendoerfer,R., Gieselmann,V.
            and Franken,S.
  TITLE     Hepatoma-derived growth factor-related protein-3 interacts with
            microtubules and promotes neurite outgrowth in mouse cortical
            neurons
  JOURNAL   J Biol Chem 284 (17), 11637-11651 (2009)
   PUBMED   19237540
  REMARK    GeneRIF: Hepatoma-derived growth factor-related protein-3 interacts
            with microtubules and promotes neurite outgrowth in mouse cortical
            neurons
REFERENCE   8  (bases 1 to 12538)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 12538)
  AUTHORS   Cherepanov,P., Devroe,E., Silver,P.A. and Engelman,A.
  TITLE     Identification of an evolutionarily conserved domain in human lens
            epithelium-derived growth factor/transcriptional co-activator p75
            (LEDGF/p75) that binds HIV-1 integrase
  JOURNAL   J Biol Chem 279 (47), 48883-48892 (2004)
   PUBMED   15371438
  REMARK    GeneRIF: LEDGF/p75 and HRP2 IBDs avidly bind HIV-1 Integrase, share
            a similar domain organization and have an evident evolutionary and
            likely functional relationship
REFERENCE   10 (bases 1 to 12538)
  AUTHORS   Ikegame,K., Yamamoto,M., Kishima,Y., Enomoto,H., Yoshida,K.,
            Suemura,M., Kishimoto,T. and Nakamura,H.
  TITLE     A new member of a hepatoma-derived growth factor gene family can
            translocate to the nucleus
  JOURNAL   Biochem Biophys Res Commun 266 (1), 81-87 (1999)
   PUBMED   10581169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040554.1, AC103876.2, BC015483.1, AA725615.1 and AC024270.6.
            
            On Nov 22, 2018 this sequence version replaced NM_016073.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.167388.1,
                                           SRR1803611.222116.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299633.7/ ENSP00000299633.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BC040554.1         196-243
            49-311              AC103876.2         17854-18116         c
            312-2113            BC015483.1         1-1802
            2114-2239           AA725615.1         13-138              c
            2240-12538          AC024270.6         110136-120434       c
FEATURES             Location/Qualifiers
     source          1..12538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..12538
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="HDGF like 3"
                     /db_xref="GeneID:50810"
                     /db_xref="HGNC:HGNC:24937"
                     /db_xref="MIM:616643"
     exon            1..493
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..1021
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="hepatoma-derived growth factor 2; hepatoma-derived
                     growth factor, related protein 3"
                     /codon_start=1
                     /product="hepatoma-derived growth factor-related protein
                     3"
                     /protein_id="NP_057157.1"
                     /db_xref="CCDS:CCDS32314.1"
                     /db_xref="GeneID:50810"
                     /db_xref="HGNC:HGNC:24937"
                     /db_xref="MIM:616643"
                     /translation="MARPRPREYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKY
                     PIFFFGTHETAFLGPKDLFPYKEYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAI
                     QQQSSSETEGEGGNTADASSEEEGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSR
                     KSPGDEDDKDCKEEENKSSSEGGDAGNDTRNTTSDLQKTSEGT"
     exon            494..570
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            571..709
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..868
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1015
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..12538
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="hexamer: AATAAA"
     polyA_site      1852
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="major polyA site"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="hexamer: AATAAA"
     polyA_site      2113
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="major polyA site"
     regulatory      6155..6160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="hexamer: AATAAA"
     polyA_site      6173
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="major polyA site"
     regulatory      6192..6197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="hexamer: AATACA"
     polyA_site      6215
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
     regulatory      12519..12524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
                     /note="hexamer: AATAAA"
     polyA_site      12538
                     /gene="HDGFL3"
                     /gene_synonym="CGI-142; HDGF-2; HDGF2; HDGFRP3; HRP-3"
ORIGIN      
        1 gagaaggaat tcggagcaga cgcgaggccc ggcgctcgcg ccgcgcccgg gagcccggga
       61 gggagaccgg cagcggcggc atgaggcagg cgacgcggcg ctggtgagca gcgcgcgcgg
      121 cggcggcggc ggcggcggcg gggaccttgg cgcggccgga cgcgggcgag cgccgaacgg
      181 ccgggggctc ccctcccccg ctgccgggcc gtgatttgcc gggcctgctg cgccccccgc
      241 ccaccccttg cctcagccgc cgcctcgccg cttcccctcg tcggagcggc cgctcgtccg
      301 cccggcttga ggcccgcggg gagcgcggcg caattcgtcg gcccgcgggg gggcggcctc
      361 ccggcatctt cgcggcgacc aaggactacc aggaagggga gcggctggga tggcgcgtcc
      421 gcggccccgc gagtacaaag cgggcgacct ggtcttcgcc aagatgaagg gctacccgca
      481 ctggccggcc cggattgatg aactcccaga gggcgctgtg aagcctccag caaacaagta
      541 tcctatcttc ttttttggca cccatgaaac tgcatttcta ggtcccaaag acctttttcc
      601 atataaggag tacaaagaca agtttggaaa gtcaaacaaa cggaaaggat ttaacgaagg
      661 attgtgggaa atagaaaata acccaggagt aaagtttact ggctaccagg caattcagca
      721 acagagctct tcagaaactg agggagaagg tggaaatact gcagatgcaa gcagtgagga
      781 agaaggtgat agagtagaag aagatggaaa aggcaaaaga aagaatgaaa aagcaggctc
      841 aaaacggaaa aagtcatata cttcaaagaa atcctctaaa cagtcccgga aatctccagg
      901 agatgaagat gacaaagact gcaaagaaga ggaaaacaaa agcagctctg agggtggaga
      961 tgcgggcaac gacacaagaa acacaacttc agacttgcag aaaaccagtg aagggaccta
     1021 actaccataa tgaatgctgc atattaagag aaaccacaag aaggttatat gtttggttgt
     1081 ctaatattct tggatttgat atgaaccaac acatagtcct tgttgtcatt gacagaaccc
     1141 cagtttgtat gtacattatt catattcctc tctgttgtgt ttcgggggga aaagacattt
     1201 tagccttttt taaaagttac tgatttaatt tcatgttatt tggttgcatg aagttgccct
     1261 taaccactaa ggattatcaa gatttttgcg cagacttata catgtctagg atccttttat
     1321 caaggcagtt atgatcatcg ttttcctgcc ttgaccccac catcatcaaa cactcagtta
     1381 aatataaatt aacatttttt agatgaccac tcaacataat gcttaagaat ggaatttcct
     1441 ctctgtgaca gaacccagga attaattcct aaatacataa cgttggtata ttgaagacga
     1501 aattaaaatt gtccttcagt tttgaggcca tgtgtaaagt ttaaccatat tgtaaaatat
     1561 ctattccgta ttagaaatag ctagttgaca gcttatactt ctcaaaattc atattgttat
     1621 gtacacaaac taagtttcta tatgtgaagt tagtgagtct ttttgtgtta ctccaaaata
     1681 aaggcaatga tttatttttt tcccagtgcc aatacaattt tgagctaagc actcaaggtg
     1741 gatactttac attttaaagc tggaatcagc aacagcccta tgggaaacca gacaaagcat
     1801 tgacttttaa atgtagactt ttaaaataaa ctgttttctt ttggaactac aattagaata
     1861 gttaatattc atccttaaac cattattatg tgtacattat tgttgctatt gtgataatag
     1921 agaattttat ttatttttat gccagcttat attgtgagaa cacatttagt cagtttgggt
     1981 tttatcaatc ctgttaatgc ttgtccttgg aacatctttc gcgtattcac ggtttgtagt
     2041 tgaaaagttt actgtaaaaa aatcaaaaac aaaaaaatgt attgttttta cagaataaat
     2101 ttattggaat gtgtactggg agtaagattt gaggttgtaa gcaaactaag ttagtgtaat
     2161 ttggcttcat atatgtaacg tgaggtatta atgtaattca tatattaaag caaaaattgt
     2221 tcacagcaag ctgacaatag aatcaagtgc aggtgagggt ttttcttttt ctttcttttt
     2281 ttttttttaa acactctctg ggttttagat tatttgaaaa cactgtaggg gatgatgggg
     2341 agatgactac atgatttgct tacacttaca tatttaccag cccagtggac cctagatttt
     2401 gtaatttgat attatccatg cattgatttg tatcccattt tcttttggtt ttcttgatga
     2461 gagctaataa aaacatgaga aaatgtgagc agacctaaaa gcctagggcc gttaataatg
     2521 atgatggtga tgatggcagc taagggtatg aaagcaccag tccatttatc attccagggc
     2581 acagtgagga ggtggctgtt tgtatttttg gtgtgtttct ttcatttagt gaatactgat
     2641 tttctctagt atactcaaca tacaatccca aacatgaaaa gttcataaaa agatagtagg
     2701 gatgtcgatc taatacttct tccttaaaag gtccttttta attttgaata tttgaatgta
     2761 ttttttaatt aatgaaattt aattcatcaa aagacctctt cattgctcac actgaaacat
     2821 aaggggaatg tagatggcat tttgaattgg aatatacaac tcacaaattt tctttaaaag
     2881 cgttttatgt gtatatatga aatgtttcaa atttaataag atttgtcttt ataagaggcc
     2941 aaaaataatt ttattaaaaa tatacacaga aatacaatag aaatatttcc agccaccaat
     3001 aaaacaaatg ttcattaagg atagagataa agttactgat ccctatttag ctgtttaaat
     3061 tcacacaaaa aaatttagta aaagtaattt tcttgaaaca gcagcaaata ataaactttc
     3121 cttgggaaaa catttttcaa acaacattta aaaatattct gatgatttgc cttttatatt
     3181 gagtttaata atgaagcata ttcatcttat ttgcaaaagt tactcctcca gtctgcattc
     3241 actgttttga attttttaat atgcacaggc catattctct tttgaatagt ttcatttcat
     3301 gctcactact gttggcacta aattgtaatt ttttacactt ataattattt tatatgtcaa
     3361 acaatattga gatggatgat caagtttatt cacaaatgat tttgaatata tttctttaaa
     3421 caaactgttt ctcaagaatt tccattttcc ttcaaaaaaa atttacacaa taccatatag
     3481 ctcacacata cagtgcagag caagaatgta catattctta agtactcacg tatgagaaga
     3541 gagtgaaatg ggacaaaata tcagtaccag tataacaaaa gttagtaatt tagaaaggag
     3601 gaacatgaag taatattttt attccacttt ttcttctgcc tttgttttta tgaagaactc
     3661 tggtttgtag atacaacgat aggccaagag ctgaggaaga actccatatg ctatgtttaa
     3721 tgctaaaaaa aggatttttg cttcttcagg gactctgtag acataagcag ttctagcatg
     3781 aagagatgca ccaatgtgag aaaactgagc ctgttgcatt taaaaaaaaa aaattgagta
     3841 agcatgaaac gtgttcagtt ggatgcatga tgagttctga atggttcatt caggctacgt
     3901 ttctgtgccc tcaaaaccag tctcacctgc aggcaaaata ccttcaaaca atccagagtc
     3961 tttaatgtca gagtctttca ttaaatttag tccttgatta aatttagggc cattcttgat
     4021 atgactgttc aaataaagta gatattattt agtgtagttt tatcatgcca gttgtgtttt
     4081 ttaaccatca agtgcccctt accgaacatt agtggctcaa tctaatagaa aaatctgaat
     4141 aaaatctcaa atttttttct gatttgcgtt ctggagatcc tgcatacaga ctcagttgtg
     4201 gttcacaaat tgcgttccaa taaaaatgaa gaaagcgcag agttttaaaa aacaaatatt
     4261 tttagcataa actattgaaa gggaagcact ggggggacct cagcttcatt tatcagtctt
     4321 tcatctactc cttgcagcaa gagctcatac cctttcccta tgtgtttttt gtttattcat
     4381 ttattcatgt atttgttttt tctgcagctt ttaaaatatt aagggttgtt tgtaagataa
     4441 ggttgttacc aacttgggtg gaggtaggag tacggttgct ctttgtaaaa tggcaaatgt
     4501 acatgcaggc aaccttttta aatcaaatta taatttattt agaagtacga catgtcagca
     4561 ttatccgcat ttgcaaaatg gcctccctct ctacttatat acttattcag aaaacacatt
     4621 cagaatgtgc caattggtct tttttgatat ttttcgcaag cacagaggaa aaccgtattg
     4681 gaaagggtaa aacagaccac agcaggatta aaagctcctg tcagaaaatt tcctcagaag
     4741 gcttgtatca ttacaaaatg tacccctgga gtctgcattt tcatatcttg ctgaaattca
     4801 agatacacat gaataaagga ttgggaatct aaatgtaata agtagtaaat tatcagttca
     4861 tcaggatcaa agagacaaaa gactgcacta tagagaaggc atagaagtaa caagaatgaa
     4921 gaactagata atttgcttta aatacatata agttatttta catttcttcc atatgaaacc
     4981 aatttattct gctgagtgat ttcacagata aaggtgttac ttacttgact tcaccatgac
     5041 aagaaaagga caagtttttt taagcagcat ctttatgaat tttttatcag tggcagatat
     5101 tttaatgggc tgcattttta caaattcctg atatattctg gagacctgtg gtacattttt
     5161 gctactctgg agatataaat taaattagca tgatgtattg ccaaggacca gcacgtggat
     5221 tgtctacatt gtgatccatg aggcactgag aggactcggc cctcagatac aactcccctg
     5281 ggtagatgcc caggcagaac ccagcaaatg tatatgcatc tctgggctct gaggacaaaa
     5341 tgccttgaga gtaaagggca ctttcagggc tgccctgagg aggtgctttc tggacattct
     5401 aggaactctg agcaggagca tggctcccat actgtttttc cttagggcct gttttgaata
     5461 atagtgtttt tctgaatata taaccaagca ttttctctgg actggaagcc acatttgatc
     5521 cctggttctc agaaatctgg gtttggtggt tctgtcttta tagatacttg tacacatcac
     5581 aaaatcacca aatttgggga aatgccaacc atactttgag agaataaata tgagcagttg
     5641 tgcctacttg cataggggag cctgtgtaaa aagtcagtga ttccgtaggc tcttttcctg
     5701 cactaaccag tgcagttaat acctcacttt catgaacagc aaactcatgg caacattaag
     5761 tgaatcatgg ccgggcgcag tggctcacgc ctgtaatccc agtactttgg gaggccaagg
     5821 cgggtggatc acctgaggtc aggagttcaa gacgagcctg gccaacatag tgaaacccca
     5881 tctctactaa aaaatacaaa aaattagccg ggcgtggtgg cagacgcctg taatctcagc
     5941 tgctcgggag gctgaggcag gagaattgct tgaacccggg gagtggaggt tgcagtgagc
     6001 caagattgtg ccactgcact ccagcctggg tgacagagtg agactctgtc tttaaaaaaa
     6061 aaaaaagatt catgtcctta gattagattg taagcccact gggcaggtac tgtgtctaat
     6121 gttttgtgtg gcacctgtca cattgttaga gctcaataaa cgttcaacaa caatggactt
     6181 gtgactgtca aaatacaaaa agggtctaca aagcatttct ctagttttgt atgtatttta
     6241 gtaggcctct ttattcagaa ttattaaaca aggcacaaaa attttaacat tcataatcaa
     6301 aagaggcatt tgtatgtgag agaagaactc taaggccagt ggtgtgcagc tcccagtact
     6361 gctcatagtc ctaatggatg tacttatggt ggccacactt ccagctgagt gagcacctga
     6421 ccatagcttt ctcctaaggc ataggatgtt aagtgttcag ggttctgaag ttcagaaaaa
     6481 cagtctcacc tgaggaggtt tctcttccca agcacatagc taataaaggg ctgcaggttt
     6541 tctcctgggt gatgttccca gcagcacaag gcctctcatg gcaggacctg aagagctcag
     6601 cctgagcctg tgctggggtc aggtggctca gtgaactcaa tgctgctgaa ttaacaggag
     6661 gcccaggatt acagatatga gttgttgatc ctagaaattt ctccagaatt tagcaatgtg
     6721 aggttgagtc cctaataatt tttcttccac ttcattctaa atcattttca ccttacagaa
     6781 ataattaaga gatatactct gatttttttt taagaatgga tgattggaat ggcaaatgag
     6841 acaataaggt gaacaaaggt taaattttaa gagctgtttt cttacatgta tagagacaat
     6901 ctgtaaagga taactaaaaa agttaatcgt ggttccacaa ggaggaactg aaagagtgtt
     6961 atatgtccat gtgaatgtta taggcagaaa acttaggtga ccattgggat gatagccagg
     7021 gtcttttgct aatacagtat aaatagctaa tctagaactg tgttatcttt tcttagagtt
     7081 ttctgagcaa catagttcat tggttcagaa cactgacttt ggaactagac atccagagtc
     7141 aaatcacagc tccaccacaa accagccgta tggcctcggg tgaggtgtgg aacccacctc
     7201 ataggttgtt atgagggttc agtgaggtga tgtttgtgac atgcttagac agtgtcaagc
     7261 acttggggct attctgtaga cacaagtaca aaactgaaat acccattcat gatctggtgc
     7321 tcgactgtag aaaatctggg ccctttgttt ttagattctc ttgacctttt gaccttttta
     7381 ctgtgagtgt ctccatgaaa ggataagtac ataaaagatg ttaaatcagt ataatttaat
     7441 actaaataaa gatgtttagc aatgaatcac accagaagca aatgaagaaa acaagatttg
     7501 cattagtatc ccaactatcc gtgttcttcc taaactgtta ctttcagatt tttcttaacg
     7561 tctccatgag ggaaaaaccg tatgaaattt acttccaggc tgagcgtggt ggctcatacc
     7621 tataatccca gcactttggg atgccaaggc gggagggtca cttgagtcca ggagtttgag
     7681 accagcctgg gcaacatagc aagaccctgt ctcaagttaa aaaaaaaatg ataaatttac
     7741 ttcagtaaac tcttcacaac caaattattc acacgtaagt ttccatatct ctttgtgaga
     7801 aaaagacatg acatagcacc tacatagcca gggagttaga gagtctgagg gcagcacctg
     7861 actgaagtaa ctgaacctcc ttcgctggct gtgggatggc aggctcctta ccaagcccat
     7921 ggtgagtctg tcccaaagct ttcacccagt ttctttgttt tcttggtaat tatatacaat
     7981 acacttaatt taattagttt gtcttcaggt taatcttcgg aacaacataa ggcatatctc
     8041 caaattctta ctgggaatct tctaccagta atagtagcaa caaagggtta catagctgtt
     8101 atgtgccaga cactgtttta agccctttac atgtattacc tcatccaacc ctaacagcaa
     8161 ttccatgaga aagctactgt tattatcctc actttacaga agaggaaact gaggatcaga
     8221 gaggtaaagt agccaaggtc attgtgctca tcagcaacag gctagaatct gaaccagttc
     8281 acctccagag cttatgttcc taactatatg aactctactg gctttggctt tttttcattt
     8341 tcattgatat tttagcagag aaaatgcttc aattgatagg aaatgctaat aagtggatct
     8401 aagcagccta taatgccttt cagattacac ttgcagcttt aatcctatgg ttagcatttt
     8461 atatgaaaag atacctgggt tatgagtaag tccccagtgg aactctttgg tctaaaatgt
     8521 gtcctggttt cattttattc aatcttcttt tactctttcc ttgatctttt gatttctgaa
     8581 ggcagcagat ttggcagact cctacatggt ctgaaatcaa ggccccaata actactcact
     8641 cttttttctt tctttttttt gagacagtct tgctctgtca cccaggctgc agtgtagtgg
     8701 gcgtgatctt ggcacactgc agcctctgcc tcccaggttc aagcgattct cctgcctcag
     8761 cctcccaagt agctgggatt atagatgccc accaccacac ccagctaatt ttttgtattt
     8821 ttagtagaga cggggtttcg tcatgttggc caggctggtc tcaaactcct gacctcaggt
     8881 gatccacctg cctggtcctc ccaaagtgct agggttacat gtgtgagcca ctgcgcctgg
     8941 ccactactca atatttcttc cattggccta tactgatcta gaacttttca aaggtggttt
     9001 ttttttccct tactaagttg catagattct tgagagttta ctagatgttt cagtaaaagt
     9061 aagttttagt aaagttagtg ggatcatgaa tgcataaggt ttctaaataa gaatggcaat
     9121 tttagcaagc aaagatgctg attaaagtta cagaaaaatg cctatttttg ttttgttttg
     9181 tttttttgtg gtggtgggag agacagggtc tctctctgtc acctgggctg gagagtgcag
     9241 tgacacagtc tcggctcact gcaacctctg cctcctggtt caagtgatcc tcccacctca
     9301 gccttcctag tagctgggac tgcaggcata tgccatcacg ccagcctaat ttttgtattt
     9361 tttgtagaga tggggtttta ccatgttgcc caggctggtt tcaaactcct gacttcaagc
     9421 agtccaccca cctcgggctc ccaaagtgct gggattacag gtgtgagcca ccgtgccttg
     9481 ctggagagtg ctttctgtga tgaatgtgtc agatactccc ataagatgag actccatttc
     9541 ataagcgagt atttgctaag tacaaaacaa ataacgtaat tcagtattct ggtcatatct
     9601 attgttttgt tgcggcatgg cttctaactt ttccttagcc tacacactat aagtgggtag
     9661 atattaaagc tcagccaaga gctgtgggaa tcagacccat aattctttac tcagtctgtc
     9721 ttcacctgct gggctgggag aaacatcctt ctgacattta caggatctgg tccttagcct
     9781 taggctctgg atctgggcat tcaccatcaa gagaggggct tcaggctgcc ttatcaactg
     9841 ggcagtgatg gataagcccc aggatgcctg acgtctgaca tgaatgaggt aatgcccctg
     9901 cggctgccag ctgctctgta gtccacactg cccttctcag aaccacttgg ctggagtaat
     9961 aagtgcccac ctgcaagctt agcttcacca acagattagg gtttgtctta ttgctacagg
    10021 cttaccacac ccattttcct ctaagctatg accttcctaa gcttcctgac tgttgaccct
    10081 ggccatgtga ctaggctttt gcctaggttt tcctgctgtt tccatttgtc tcctgagact
    10141 tgaccaggtc caacatctgg tctctttaac cagcctgctg gctgatgaca cttagcattc
    10201 ctgcatcagg gactggtacc aggccgacca ggcacatggc aggcagagga ggcctgattg
    10261 tgcaggcaaa gcacaattga cacaggtaat aggtgtcaaa ctgaacagct gtcaaactga
    10321 acagtctaat cctctaaaga aagggctggc aagagtgaag tgggtatgcg gccatctgtt
    10381 ctgaaggata caggagaata aggcagagga accaggccaa aaaaaaaggc aaggcttact
    10441 ctgccctcag acctgctgca tatgcccaca cctcagtgtt tccctgggtt attccctgga
    10501 gaggctcagc ctaataaagc cccacttggc cctcagagtc caactcggaa tgtcactgcc
    10561 ttccacccac aaggttctcc agcacctcgt actacataca gtcttttgtg ctgtaggact
    10621 ctgtgccata gttcattgtt tgcatggggt gggtgagata acacaatgga gaagaatatg
    10681 agctttggag tcagacagga tttcataaac ctattctgcc atttaataac tgtaatctta
    10741 ggcaaataat ttcaggtgga ctgagcctca gcctcctcat ctttaaattg gggttttttt
    10801 cccagagcta ttacaaaaga tattattatg tgtccattgt gctgtttatt ctgaggcagg
    10861 caggaagacc acagtcacca gcctcccctc agttgacctg gtgccaggcc tggaccttga
    10921 aaatatccca catgatcttt gcataaaaaa gaattaaaat tttaattgtg ttaagctact
    10981 ctgagtattt gttacagcag cagagcacat agcctatcct tagacaaata ggtaagtaaa
    11041 acttttaacg tggtttgcct ggcatgaagt aaggtaatga gagctcagac tagtgtaggg
    11101 gcagcggagc tggaaaaaaa aaatgggttg gagaatcact ggagtaaaac taactggacc
    11161 tggttgggtg tggtggctca cacctgtaat cctaccactt tgggaggctg aggcaggagg
    11221 attacttgaa gcaggcattt gagaataagc tgggcaacaa aataagatcc catctcttta
    11281 aaaaatttaa aaattagctg tgtgcggtgg tgtatgtctg tagtcccagc tactctggag
    11341 acagaggcag gaggattgct tgagcctagg agtccgaggc tgcggtgagc tatgactgtg
    11401 ccatcacact ccagcctggg agatggagca agaccctgtc tctttaaaag aaaaaaaaaa
    11461 ggacttagtg gtggtctaga tgtagaggat gaggagtgta aataattact ccaagtttct
    11521 ggcttgagtt gctggatgca attggactat ttaaacagat aatgaaaaaa tggaagagag
    11581 gttgtgggga ggatcaggtc ctattttata tattaaatct gaggtgctag tgaggcatgc
    11641 aagtaaaaag actgagtttg gaatgaaata caggagtctg ggaacggtgt gggccgaagg
    11701 tagaaaactg gaagttatca gcttatagtt ggtattgaaa gatacaaaga taaagaccta
    11761 aaatacagaa ataaacccca aggactgagg aatcaggtat ttagaggtct gcaaaggaaa
    11821 aacaaccagc aaagagcaat aaatgttagt tctcttcctt cttaagcccc tcaaggaaag
    11881 gacaggaacc attacttctg gatgctacat caactttttc gatactacta tgctaatttt
    11941 ataattaaga attacctcaa actgaaagga tttaatgcat tgacccctta aatactatat
    12001 ttttcaaccg tgtgaattct agtatgtctt acgatcatga ttattatacc atgcatataa
    12061 ttgactgtac aagcctacag tttctagatg aacctcattc ttataactgc ttgaaaagaa
    12121 caagatgaag ctaatgtttt taaatgataa gttcatttgt tttatttcta gtaagaaaaa
    12181 ttaattttct tccttgttca gaagattgat ttgttttgct aattatcttg taaaaatgtg
    12241 ctttatgtta tgtgtgaagt tctccataga taatttcatt ttcagttaaa cgcagtaagc
    12301 attcactgaa cacctactct aggccaaata tttggcaagg tgccagcgga aaaggaatga
    12361 aatgacaggc ccagaacatt ttttaaacca gtttccctgg ttctgtatag catagcgtag
    12421 tggaattctg aagtcttaaa tttggatgga cattttgaag gtgacagctc tcaatccttt
    12481 tttagtagcc atggtattca gagattgtga aacagtccaa taaaacaaca atgccaca
//
