LOCUS       NM_001001520            2267 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens HDGF like 2 (HDGFL2), transcript variant 1, mRNA.
ACCESSION   NM_001001520
VERSION     NM_001001520.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2267)
  AUTHORS   Wang,J., Zhu,X., Dang,L., Jiang,H., Xie,Y., Li,X., Guo,J., Wang,Y.,
            Peng,Z., Wang,M., Wang,J., Wang,S., Li,Q., Wang,Y., Wang,Q., Ye,L.,
            Zhang,L. and Liu,Z.
  TITLE     Epigenomic reprogramming via HRP2-MINA dictates response to
            proteasome inhibitors in multiple myeloma with t(4;14)
            translocation
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   35166240
  REMARK    GeneRIF: Epigenomic reprogramming via HRP2-MINA dictates response
            to proteasome inhibitors in multiple myeloma with t(4;14)
            translocation.
REFERENCE   2  (bases 1 to 2267)
  AUTHORS   Van Belle,S., El Ashkar,S., Cermakova,K., Matthijssens,F.,
            Goossens,S., Canella,A., Hodges,C.H., Christ,F., De Rijck,J., Van
            Vlierberghe,P., Veverka,V. and Debyser,Z.
  TITLE     Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R
            Leukemogenesis but Important for Leukemic Cell Survival
  JOURNAL   Cells 10 (1), 192 (2021)
   PUBMED   33477970
  REMARK    GeneRIF: Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for
            MLL-R Leukemogenesis but Important for Leukemic Cell Survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2267)
  AUTHORS   Zhu,X., Lan,B., Yi,X., He,C., Dang,L., Zhou,X., Lu,Y., Sun,Y.,
            Liu,Z., Bai,X., Zhang,K., Li,B., Li,M.J., Chen,Y. and Zhang,L.
  TITLE     HRP2-DPF3a-BAF complex coordinates histone modification and
            chromatin remodeling to regulate myogenic gene transcription
  JOURNAL   Nucleic Acids Res 48 (12), 6563-6582 (2020)
   PUBMED   32459350
REFERENCE   4  (bases 1 to 2267)
  AUTHORS   LeRoy,G., Oksuz,O., Descostes,N., Aoi,Y., Ganai,R.A., Kara,H.O.,
            Yu,J.R., Lee,C.H., Stafford,J., Shilatifard,A. and Reinberg,D.
  TITLE     LEDGF and HDGF2 relieve the nucleosome-induced barrier to
            transcription in differentiated cells
  JOURNAL   Sci Adv 5 (10), eaay3068 (2019)
   PUBMED   31616795
  REMARK    GeneRIF: LEDGF and HDGF2 colocalize with Histone H3 lysine 36
            methylation 2/3 at genomic regions containing active genes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2267)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
  REMARK    GeneRIF: HDGFRP2 promotes DNA repair by homologous recombination.
REFERENCE   6  (bases 1 to 2267)
  AUTHORS   Schrijvers,R., Vets,S., De Rijck,J., Malani,N., Bushman,F.D.,
            Debyser,Z. and Gijsbers,R.
  TITLE     HRP-2 determines HIV-1 integration site selection in LEDGF/p75
            depleted cells
  JOURNAL   Retrovirology 9, 84 (2012)
   PUBMED   23046603
  REMARK    GeneRIF: Authors show that HRP-2 functions as a co-factor of HIV-1
            IN in LEDGF/p75-depleted cells.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2267)
  AUTHORS   Xiao,K., McClatchy,D.B., Shukla,A.K., Zhao,Y., Chen,M.,
            Shenoy,S.K., Yates,J.R. 3rd and Lefkowitz,R.J.
  TITLE     Functional specialization of beta-arrestin interactions revealed by
            proteomic analysis
  JOURNAL   Proc Natl Acad Sci U S A 104 (29), 12011-12016 (2007)
   PUBMED   17620599
REFERENCE   8  (bases 1 to 2267)
  AUTHORS   Vandegraaff,N., Devroe,E., Turlure,F., Silver,P.A. and Engelman,A.
  TITLE     Biochemical and genetic analyses of integrase-interacting proteins
            lens epithelium-derived growth factor (LEDGF)/p75 and
            hepatoma-derived growth factor related protein 2 (HRP2) in
            preintegration complex function and HIV-1 replication
  JOURNAL   Virology 346 (2), 415-426 (2006)
   PUBMED   16337983
  REMARK    GeneRIF: Here, we show that recombinant HDGF2 host cell factor
            efficiently reconstitutes the in vitro activity of HIV-1
            preintegration complexes.
REFERENCE   9  (bases 1 to 2267)
  AUTHORS   Cherepanov,P., Devroe,E., Silver,P.A. and Engelman,A.
  TITLE     Identification of an evolutionarily conserved domain in human lens
            epithelium-derived growth factor/transcriptional co-activator p75
            (LEDGF/p75) that binds HIV-1 integrase
  JOURNAL   J Biol Chem 279 (47), 48883-48892 (2004)
   PUBMED   15371438
REFERENCE   10 (bases 1 to 2267)
  AUTHORS   Izumoto,Y., Kuroda,T., Harada,H., Kishimoto,T. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor belongs to a gene family in mice
            showing significant homology in the amino terminus
  JOURNAL   Biochem Biophys Res Commun 238 (1), 26-32 (1997)
   PUBMED   9299445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF294267.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001001520.2.
            
            Summary: This gene encodes a member of the hepatoma-derived growth
            factor (HDGF) family. The protein includes an N-terminal PWWP
            domain that binds to methyl-lysine-containing histones, with
            specific binding of this protein to tri-methylated lysines 36 and
            79 of histone H3, and di- and tri-methylated lysine 20 of histone
            H4. The protein functions in LEDGF/p75-independent HIV-1
            replication by determining HIV-1 integration site selection.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.159326.1, AF294267.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616600.5/ ENSP00000483345.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2267              AF294267.1         9-2275
FEATURES             Location/Qualifiers
     source          1..2267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2267
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /note="HDGF like 2"
                     /db_xref="GeneID:84717"
                     /db_xref="HGNC:HGNC:14680"
                     /db_xref="MIM:617884"
     exon            1..126
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2070
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatoma-derived growth factor-related protein 2;
                     HDGF-related protein 2"
                     /codon_start=1
                     /product="hepatoma-derived growth factor-related protein 2
                     isoform 1"
                     /protein_id="NP_001001520.1"
                     /db_xref="CCDS:CCDS42472.1"
                     /db_xref="GeneID:84717"
                     /db_xref="HGNC:HGNC:14680"
                     /db_xref="MIM:617884"
                     /translation="MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFF
                     FGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSD
                     SEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTP
                     ALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRG
                     PLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRG
                     RKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRRE
                     QEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRG
                     PPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERT
                     RKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQV
                     TSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGM
                     EKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRD
                     SEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDSEALDEES"
     exon            127..203
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..342
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..543
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..660
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            661..732
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            733..892
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..968
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1278
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1382
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1456
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1527
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1629
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1843
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1970
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2267
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2243..2248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /note="hexamer: TATAAA"
     polyA_site      2267
                     /gene="HDGFL2"
                     /gene_synonym="HDGF-2; HDGF2; HDGFRP2; HRP-2; HRP2"
                     /note="major polyA site"
ORIGIN      
        1 agccgctacc gccgctgcag ccgctttccg cggcctgggc ctctcgccgt cagcatgcca
       61 cacgccttca agcccgggga cttggtgttc gctaagatga agggctaccc tcactggcct
      121 gccaggatcg acgacatcgc ggatggcgcc gtgaagcccc cacccaacaa gtaccccatc
      181 tttttctttg gcacacacga aacagccttc ctgggaccca aggacctgtt cccctacgac
      241 aaatgtaaag acaagtacgg gaagcccaac aagaggaaag gcttcaatga agggctgtgg
      301 gagatccaga acaaccccca cgccagctac agcgcccctc cgccagtgag ctcctccgac
      361 agcgaggccc ccgaggccaa ccccgccgac ggcagtgacg ctgacgagga cgatgaggac
      421 cggggggtca tggccgtcac agcggtaacc gccacagctg ccagcgacag gatggagagc
      481 gactcagact cagacaagag tagcgacaac agtggcctga agaggaagac gcctgcgcta
      541 aagatgtcgg tctcgaaacg agcccgaaag gcctccagcg acctggatca ggccagcgtg
      601 tccccatccg aagaggagaa ctcggaaagc tcatctgagt cggagaagac cagcgaccag
      661 gacttcacac ctgagaagaa agcagcggtc cgggcgccac ggaggggccc tctgggggga
      721 cggaaaaaaa agaaggcgcc atcagcctcc gactccgact ccaaggccga ttcggacggg
      781 gccaagcctg agccggtggc catggcgcgg tcggcgtcct cctcctcctc ttcctcctcc
      841 tcctccgact ccgatgtgtc tgtgaagaag cctccgaggg gcaggaagcc agcggagaag
      901 cctctcccga agccgcgagg gcggaaaccg aagcctgaac ggcctccgtc cagctccagc
      961 agtgacagtg acagcgacga ggtggaccgc atcagtgagt ggaagcggcg ggacgaggcg
     1021 cggaggcgcg agctggaggc ccggcggcgg cgagagcagg aggaggagct gcggcgcctg
     1081 cgggagcagg agaaggagga gaaggagcgg aggcgcgagc gggccgaccg cggggaggct
     1141 gagcggggca gcggcggcag cagcggggac gagctcaggg aggacgatga gcccgtcaag
     1201 aagcggggac gcaagggccg gggccggggt cccccgtcct cctctgactc cgagcccgag
     1261 gccgagctgg agagagaggc caagaaatca gcgaagaagc cgcagtcctc aagcacagag
     1321 cccgccagga aacctggcca gaaggagaag agagtgcggc ccgaggagaa gcaacaagcc
     1381 aagcccgtga aggtggagcg gacccggaag cggtccgagg gcttctcgat ggacaggaag
     1441 gtagagaaga agaaagagcc ctccgtggag gagaagctgc agaagctgca cagtgagatc
     1501 aagtttgccc taaaggtcga cagcccggac gtgaagaggt gcctgaatgc cctagaggag
     1561 ctgggaaccc tgcaggtgac ctctcagatc ctccagaaga acacagacgt ggtggccacc
     1621 ttgaagaaga ttcgccgtta caaagcgaac aaggacgtaa tggagaaggc agcagaagtc
     1681 tatacccggc tcaagtcgcg ggtcctcggc ccaaagatcg aggcggtgca gaaagtgaac
     1741 aaggctggga tggagaagga gaaggccgag gagaagctgg ccggggagga gctggccggg
     1801 gaggaggccc cccaggagaa ggcggaggac aagcccagca ccgatctctc agccccagtg
     1861 aatggcgagg ccacatcaca gaagggggag agcgcagagg acaaggagca cgaggagggt
     1921 cgggactcgg aggaggggcc aaggtgtggc tcctctgaag acctgcacga cagcgtacgg
     1981 gagggtcccg acctggacag gcctgggagc gaccggcagg agcgcgagag ggcacggggg
     2041 gactcggagg ccctggacga ggagagctga gccgcgggca gccaggccca gcccccgccc
     2101 gagctcaggc tgcccctctc cttccccggc tcgcaggaga gcagagcaga gaactgtggg
     2161 gaacgctgtg ctgtttgtat ttgttccctt gggttttttt ttcctgccta atttctgtga
     2221 tttccaacca acatgaaatg actataaatg gttttttaat gaaaaaa
//
