LOCUS       NM_004494               2309 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens heparin binding growth factor (HDGF), transcript
            variant 1, mRNA.
ACCESSION   NM_004494
VERSION     NM_004494.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Wu,J.K., Lee,Y.Y., Hung,H., Chang,Y.P., Tai,M.H. and Fan,H.F.
  TITLE     Binding Behavior of Human Hepatoma-Derived Growth Factor on SMYD1
  JOURNAL   J Phys Chem B 128 (32), 7722-7735 (2024)
   PUBMED   39091133
  REMARK    GeneRIF: Binding Behavior of Human Hepatoma-Derived Growth Factor
            on SMYD1.
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Jia,Y., Liu,S., Zhang,M., Wu,X., Chen,X., Xing,M., Hou,X. and
            Jiang,W.
  TITLE     The m6A reader IGF2BP2 promotes ESCC progression by stabilizing
            HDGF mRNA
  JOURNAL   J Cancer Res Ther 20 (4), 1173-1185 (2024)
   PUBMED   39206979
  REMARK    GeneRIF: The m6A reader IGF2BP2 promotes ESCC progression by
            stabilizing HDGF mRNA.
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   Zhou,J., Huang,C.L., Liu,H.W., Zeng,Z.Y. and Tan,J.
  TITLE     [miR-29a-3p Targets Hepatoma-Derived Growth Factor to Inhibit the
            Proliferation and Promote the Apoptosis of E6-1 Cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (6), 1650-1654 (2022)
   PUBMED   36476884
  REMARK    GeneRIF: [miR-29a-3p Targets Hepatoma-Derived Growth Factor to
            Inhibit the Proliferation and Promote the Apoptosis of E6-1 Cells].
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Hoelzinger,D.B., Quinton,S.J., Walters,D.K., Vardam-Kaur,T.,
            Tschumper,R.C., Borges da Silva,H. and Jelinek,D.F.
  TITLE     Extracellular vesicle proteomic analysis leads to the discovery of
            HDGF as a new factor in multiple myeloma biology
  JOURNAL   Blood Adv 6 (11), 3458-3471 (2022)
   PUBMED   35395072
  REMARK    GeneRIF: Extracellular vesicle proteomic analysis leads to the
            discovery of HDGF as a new factor in multiple myeloma biology.
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Fang,Y. and Yang,Q.
  TITLE     Specificity protein 1-induced serine peptidase inhibitor, Kunitz
            Type 1 antisense RNA1 regulates colorectal cancer cell
            proliferation, migration, invasion and apoptosis through targeting
            heparin binding growth factor via sponging microRNA-214
  JOURNAL   Bioengineered 13 (2), 3309-3322 (2022)
   PUBMED   35068341
  REMARK    GeneRIF: Specificity protein 1-induced serine peptidase inhibitor,
            Kunitz Type 1 antisense RNA1 regulates colorectal cancer cell
            proliferation, migration, invasion and apoptosis through targeting
            heparin binding growth factor via sponging microRNA-214.
REFERENCE   6  (bases 1 to 2309)
  AUTHORS   Mori,M., Morishita,H., Nakamura,H., Matsuoka,H., Yoshida,K.,
            Kishima,Y., Zhou,Z., Kida,H., Funakoshi,T., Goya,S., Yoshida,M.,
            Kumagai,T., Tachibana,I., Yamamoto,Y., Kawase,I. and Hayashi,S.
  TITLE     Hepatoma-derived growth factor is involved in lung remodeling by
            stimulating epithelial growth
  JOURNAL   Am J Respir Cell Mol Biol 30 (4), 459-469 (2004)
   PUBMED   12972397
  REMARK    GeneRIF: may be involved in lung remodeling after injury
REFERENCE   7  (bases 1 to 2309)
  AUTHORS   Yoshida,K., Nakamura,H., Okuda,Y., Enomoto,H., Kishima,Y.,
            Uyama,H., Ito,H., Hirasawa,T., Inagaki,S. and Kawase,I.
  TITLE     Expression of hepatoma-derived growth factor in
            hepatocarcinogenesis
  JOURNAL   J Gastroenterol Hepatol 18 (11), 1293-1301 (2003)
   PUBMED   14535987
REFERENCE   8  (bases 1 to 2309)
  AUTHORS   Kishima,Y., Yamamoto,H., Izumoto,Y., Yoshida,K., Enomoto,H.,
            Yamamoto,M., Kuroda,T., Ito,H., Yoshizaki,K. and Nakamura,H.
  TITLE     Hepatoma-derived growth factor stimulates cell growth after
            translocation to the nucleus by nuclear localization signals
  JOURNAL   J Biol Chem 277 (12), 10315-10322 (2002)
   PUBMED   11751870
  REMARK    GeneRIF: Hepatoma-derived growth factor stimulates cell growth
            after translocation to the nucleus
REFERENCE   9  (bases 1 to 2309)
  AUTHORS   Wanschura,S., Schoenmakers,E.F., Huysmans,C., Bartnitzke,S., Van de
            Ven,W.J. and Bullerdiek,J.
  TITLE     Mapping of the gene encoding the human hepatoma-derived growth
            factor (HDGF) with homology to the high-mobility group (HMG)-1
            protein to Xq25
  JOURNAL   Genomics 32 (2), 298-300 (1996)
   PUBMED   8833162
REFERENCE   10 (bases 1 to 2309)
  AUTHORS   Nakamura,H., Izumoto,Y., Kambe,H., Kuroda,T., Mori,T., Kawamura,K.,
            Yamamoto,H. and Kishimoto,T.
  TITLE     Molecular cloning of complementary DNA for a novel human
            hepatoma-derived growth factor. Its homology with high mobility
            group-1 protein
  JOURNAL   J Biol Chem 269 (40), 25143-25149 (1994)
   PUBMED   7929202
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590666.8.
            
            On Nov 23, 2018 this sequence version replaced NM_004494.2.
            
            Summary: This gene encodes a member of the hepatoma-derived growth
            factor family. The encoded protein has mitogenic and DNA-binding
            activity and may play a role in cellular proliferation and
            differentiation. High levels of expression of this gene enhance the
            growth of many tumors. This gene was thought initially to be
            located on chromosome X; however, that location has been determined
            to correspond to a related pseudogene. Alternatively spliced
            transcript variants encoding distinct isoforms have been described.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence and uses an alternate in-frame splice junction
            compared to variant 4. The resulting isoform (a) has a shorter and
            distinct N-terminus and lacks an alternate internal segment
            compared to isoform d.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279872.2695.1, D16431.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357325.10/ ENSP00000349878.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               AL590666.8         99968-100300        c
            334-410             AL590666.8         93922-93998         c
            411-549             AL590666.8         93633-93771         c
            550-735             AL590666.8         92788-92973         c
            736-962             AL590666.8         92277-92503         c
            963-2309            AL590666.8         90734-92080         c
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..2309
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /note="heparin binding growth factor"
                     /db_xref="GeneID:3068"
                     /db_xref="HGNC:HGNC:4856"
                     /db_xref="MIM:600339"
     exon            1..333
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..969
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /note="isoform a is encoded by transcript variant 1; high
                     mobility group protein 1-like 2; hepatoma derived growth
                     factor; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="hepatoma-derived growth factor isoform a"
                     /protein_id="NP_004485.1"
                     /db_xref="CCDS:CCDS1156.1"
                     /db_xref="GeneID:3068"
                     /db_xref="HGNC:HGNC:4856"
                     /db_xref="MIM:600339"
                     /translation="MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANK
                     YQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQS
                     SQKKSCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGD
                     LLEDSPKRPKEAENPEGEEKEAATLEVERPLPMEVEKNSTPSEPGSGRGPPQEEEEEE
                     DEEEEATKEDAEAPGIRDHESL"
     exon            334..410
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..549
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..735
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..962
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..2309
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /note="hexamer: AATAAA"
     polyA_site      2309
                     /gene="HDGF"
                     /gene_synonym="HMG1L2"
                     /note="major polyA site"
ORIGIN      
        1 caaacacaaa caactgcacg agcgcgcacc caccgcgccg gagccttgcc ccgatccgcg
       61 cccgccccgt ccgtgcggcg cgcgggcgga gacgccgtgg ccgcgccgga gctcgggccg
      121 ggggccacca tcgaggcggg ggccgcgcga gggccggagc ggagcggcgc cgccaccgcc
      181 gcacgcgcaa acttgggctc gcgcttcccg gcccggcgcg gagcccgggg cgcccggagc
      241 cccgccatgt cgcgatccaa ccggcagaag gagtacaaat gcggggacct ggtgttcgcc
      301 aagatgaagg gctacccaca ctggccggcc cggattgacg agatgcctga ggctgccgtg
      361 aaatcaacag ccaacaaata ccaagtcttt tttttcggga cccacgagac ggcattcctg
      421 ggccccaaag acctcttccc ttacgaggaa tccaaggaga agtttggcaa gcccaacaag
      481 aggaaagggt tcagcgaggg gctgtgggag atcgagaaca accctactgt caaggcttcc
      541 ggctatcagt cctcccagaa aaagagctgt gtggaagagc ctgaaccaga gcccgaagct
      601 gcagagggtg acggtgataa gaaggggaat gcagagggca gcagcgacga ggaagggaag
      661 ctggtcattg atgagccagc caaggagaag aacgagaaag gagcgttgaa gaggagagca
      721 ggggacttgc tggaggactc tcctaaacgt cccaaggagg cagaaaaccc tgaaggagag
      781 gagaaggagg cagccacctt ggaggttgag aggccccttc ctatggaggt ggaaaagaat
      841 agcaccccct ctgagcccgg ctctggccgg gggcctcccc aagaggaaga agaggaggag
      901 gatgaagagg aagaggctac caaggaagat gctgaggccc caggcatcag agatcatgag
      961 agcctgtagc caccaatgtt tcaagaggag cccccaccct gttcctgctg ctgtctgggt
     1021 gctactgggg aaactggcca tggcctgcaa actgggaacc cctttcccac cccaacctgc
     1081 tctcctcttc tactcacttt tcccactcca agcccagccc atggagattg acctggatgg
     1141 ggcaggccac ctggctctca cctctaggtc cccatactcc tatgatctga gtcagagcca
     1201 tgtcttctcc ctggaatgag ttgaggccac tgtgttcctt ccgcttggag ctattttcca
     1261 ggcttctgct ggggcctggg acaactgctc ccacctcctg acacccttct cccactctcc
     1321 taggcattct ggacctctgg gttgggatca ggggtaggaa tggaaaggat ggagcatcaa
     1381 cagcagggtg ggcttgtggg gcctgggagg ggcaatcctc aaatgcgggg tgggggcagc
     1441 acaggagggc ggcctccttc tgagctcctg tcccctgcta cacctattat cccagctgcc
     1501 tagattcagg gaaagtggga cagcttgtag gggaggggct cctttccata aatccttgat
     1561 gattgacaac acccattttt ccttttgccg accccaagag ttttgggagt tgtagttaat
     1621 catcaagaga atttggggct tccaagttgt tcgggccaag gacctgagac ctgaagggtt
     1681 gactttaccc atttgggtgg gagtgttgag catctgtccc cctttagatc tctgaagcca
     1741 caaataggat gcttgggaag actcctagct gtcctttttc ctctccacac agtgctcaag
     1801 gccagcttat agtcatatat atcacccaga cataaaggaa aagacacatt ttttaggaaa
     1861 tgtttttaat aaaagaaaat tacaaaaaaa aattttaaag acccctaacc ctttgtgtgc
     1921 tctccattct gctccttccc catcgttgcc cccatttctg aggtgcactg ggaggctccc
     1981 cttctatttg gggcttgatg actttctttt tgtagctggg gctttgatgt tccttccagt
     2041 gtcatttctc atccacatac cctgacctgg ccccctcagt gttgtcacca gatctgattt
     2101 gtaacccact gagaggacag agagaaataa gtgccctctc ccaccctctt cctactggtc
     2161 tctctatgcc tctctacagt ctcgtctctt ttaccctggc ccctctccct tgggctctga
     2221 tgaaaaattg ctgactgtag ctttggaagt ttagctctga gaaccgtaga tgatttcagt
     2281 tctaggaaaa taaaacccgt tgattacta
//
