LOCUS       NM_001286451            1856 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens HD domain containing 3 (HDDC3), transcript variant 1,
            mRNA.
ACCESSION   NM_001286451 XM_005254909
VERSION     NM_001286451.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Ding,C.C., Rose,J., Sun,T., Wu,J., Chen,P.H., Lin,C.C., Yang,W.H.,
            Chen,K.Y., Lee,H., Xu,E., Tian,S., Akinwuntan,J., Zhao,J., Guan,Z.,
            Zhou,P. and Chi,J.T.
  TITLE     MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
  JOURNAL   Nat Metab 2 (3), 270-277 (2020)
   PUBMED   32462112
  REMARK    GeneRIF: MESH1 is a cytosolic NADPH phosphatase that regulates
            ferroptosis.
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Sun,D., Lee,G., Lee,J.H., Kim,H.Y., Rhee,H.W., Park,S.Y., Kim,K.J.,
            Kim,Y., Kim,B.Y., Hong,J.I., Park,C., Choy,H.E., Kim,J.H.,
            Jeon,Y.H. and Chung,J.
  TITLE     A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in
            starvation responses
  JOURNAL   Nat Struct Mol Biol 17 (10), 1188-1194 (2010)
   PUBMED   20818390
  REMARK    GeneRIF: Mesh1, encoded by HDDC3 in humans, contains an active site
            for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+)
            binding. It catalyzes hydrolysis of ppGpp both in vitro and in
            vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068831.17.
            
            On Aug 7, 2019 this sequence version replaced NM_001286451.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2017959.1,
                                           SRR3476690.1176030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394272.8/ ENSP00000377814.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC068831.17        21268-21388         c
            122-177             AC068831.17        20894-20949         c
            178-418             AC068831.17        20543-20783         c
            419-1856            AC068831.17        18807-20244         c
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..1856
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /note="HD domain containing 3"
                     /db_xref="GeneID:374659"
                     /db_xref="HGNC:HGNC:30522"
     exon            1..121
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..549
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /EC_number="3.1.7.2"
                     /note="isoform 1 is encoded by transcript variant 1; HD
                     domain-containing protein 3;
                     guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
                     MESH1; penta-phosphate guanosine-3'-pyrophosphohydrolase;
                     metazoan SpoT homolog 1; myeloid leukemia noncoding
                     regulatory locus on chromosome 15"
                     /codon_start=1
                     /product="guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase MESH1 isoform 1"
                     /protein_id="NP_001273380.1"
                     /db_xref="CCDS:CCDS66866.1"
                     /db_xref="GeneID:374659"
                     /db_xref="HGNC:HGNC:30522"
                     /translation="MGSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILT
                     HEAGITDIVVLQAALLHDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERKR
                     LQVEQAPHSSPGAKLVKLADKLYNLRDLNRCTPEGWSEHRVQEYFEWAAQVVKGLQGT
                     NRQLEEALKHLFKQRGLTI"
     exon            122..177
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /inference="alignment:Splign:2.1.0"
     exon            178..418
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /inference="alignment:Splign:2.1.0"
     exon            419..1856
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      878..883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /note="hexamer: AATAAA"
     polyA_site      906
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /note="major polyA site"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
                     /note="hexamer: ATTAAA"
     polyA_site      1856
                     /gene="HDDC3"
                     /gene_synonym="(ppGpp)ase; MESH1; MYNRL15"
ORIGIN      
        1 atccgcgcga tgggctctga ggcggcgcag ctgctggagg ctgccgactt cgcggctcgc
       61 aagcaccggc agcagcggcg gaaggacccc gaggggaccc cctacatcaa ccaccccatc
      121 ggtgtggcac ggatcctgac ccacgaggcg ggaatcactg acattgtggt gttacaggcg
      181 gccctgctcc atgacacggt ggaggacaca gacaccaccc tggatgaggt ggagctacac
      241 tttggggcac aagtgcggcg cctggtggag gaggtaacag atgacaagac tctgcccaag
      301 ctggagagaa agaggctgca ggtggagcaa gcgccccaca gtagccccgg ggccaaactg
      361 gtgaagctgg cagacaagct gtacaatctg agggacctga atcgctgcac cccagaggga
      421 tggtcagaac atcgagtcca ggaatacttc gagtgggcag cgcaggtggt gaaggggctt
      481 cagggaacaa accggcaact ggaagaggct ctaaagcatc tgttcaagca gcgggggctg
      541 acaatctgat cagtgcttga agctatccag aggcacaact ccagcctcgt tcaggccgga
      601 caggattcat acgccatctt ttctgtgtct cctgagctcc ctccatcctt cccagatatt
      661 agaggccaaa aaaagacttg cattttttct cagtctgaag gtctcctgct aactaagctg
      721 agccccgcgt ggtgggaatc agatgtaccc atccatttct gatgcactca ccgcctctcc
      781 ccaagtcttg ggtctgtttg ctattttgca tggtgggatc tctggcccct cagggacttg
      841 agattattta agtactagtt cctaacacgt tctggaaaat aaaaataact ctgggttaag
      901 gtttaagctg ctgctgctcc ttctccagcc tccgactggt gggctgcata tctttccttc
      961 agcaaagcag gactaattgt gtgtcccgga gtcacctccc tcaggttgcg ggcctcaacc
     1021 cctccgaacc tggcttcctt gtcagtgaca tgggttgtgt aattatcagg ttagactgtg
     1081 acgtgcctga tggagcctga cacataggtg ctcaagaaat ggtagcagcc tttcccgtta
     1141 agaaagttgg aagggggcca ggcgcggtgt ctctcgcctg taatcccagc actctgggag
     1201 accgaggcgg gcggatcact tgaggtcagg agttcaagac cagcctggcc agcatggcga
     1261 ggccccgtct ctactaaaaa tacaaaaaaa aattagccgg gcgcagtggc tcgcgcctgt
     1321 aatcccagct actcaggagg ctgaggcagg agactcgctt gaacccggga ggcggagttt
     1381 gtactgagcc gagatcgcgc cactgcactc cagcttgggt gacacagcga gactccgtct
     1441 caaaaatgaa aaaagaaaag acgtatcgga agggagtgcc gcccgcttac tgacaaccac
     1501 tgctgggcac cggagagacc ccagcagcaa catgattggg ccggtggggg attccggttc
     1561 cccagtacct caagccgcgc gggaaactcg gtgactcgca atcccctcgc ccttccgcat
     1621 tgcgggttac ttcggttgtt aagtgacagg gacttccggg aaggcccgga agtggcccgg
     1681 ggctgtccga ccccgggagc ccggcggtcg gcgtagggga ggcggtggaa ctttgctcgg
     1741 tggccatggg gagggattgc ccggtggtgg tttttcagtc gttgctgagc agctgaggtt
     1801 tatttttatg tattttattc tgcatccagt catccattaa agccaaagtt tattaa
//
