LOCUS       NM_016063               1446 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens HD domain containing 2 (HDDC2), mRNA.
ACCESSION   NM_016063
VERSION     NM_016063.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB447428.1, BE743302.1, BP257644.1 and AL121938.10.
            
            On May 17, 2019 this sequence version replaced NM_016063.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.266223.1,
                                           SRR1660803.249042.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398153.7/ ENSP00000381220.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               DB447428.1         175-441
            268-610             BE743302.1         350-692
            611-984             BP257644.1         167-540
            985-1446            AL121938.10        97048-97509         c
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..1446
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="HD domain containing 2"
                     /db_xref="GeneID:51020"
                     /db_xref="HGNC:HGNC:21078"
     exon            1..119
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..650
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /EC_number="3.1.3.89"
                     /note="HD domain-containing protein 2; HCV
                     NS5A-transactivated protein 2; hepatitis C virus
                     NS5A-transactivated protein 2; testicular tissue protein
                     Li 83"
                     /codon_start=1
                     /product="5'-deoxynucleotidase HDDC2"
                     /protein_id="NP_057147.2"
                     /db_xref="CCDS:CCDS43503.1"
                     /db_xref="GeneID:51020"
                     /db_xref="HGNC:HGNC:21078"
                     /translation="MASVSSATFSGHGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPE
                     SVSDHMYRMAVMAMVIKDDRLNKDRCVRLALVHDMAECIVGDIAPADNIPKEEKHRRE
                     EEAMKQITQLLPEDLRKELYELWEEYETQSSAEAKFVKQLDQCEMILQASEYEDLEHK
                     PGRLQDFYDSTAGKFNHPEIVQLVSELEAERSTNIAAAASEPHS"
     exon            120..241
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..344
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..413
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..552
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1446
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      893..898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="hexamer: AATAAA"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="hexamer: ATTAAA"
     polyA_site      914
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="major polyA site"
     polyA_site      924
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="hexamer: TATAAA"
     regulatory      1257..1262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="hexamer: TATAAA"
     polyA_site      1269
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
     polyA_site      1285
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="hexamer: TATAAA"
     polyA_site      1332
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
     regulatory      1355..1360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
                     /note="hexamer: TATAAA"
     polyA_site      1398
                     /gene="HDDC2"
                     /gene_synonym="C6orf74; CGI-130; dJ167O5.2; NS5ATP2"
ORIGIN      
        1 gcggcctgct ccgcccagcc ggggtcggtg gccgcatggc ttcggtctcc tctgcgacct
       61 tctcgggcca cggggctcgg tccctactgc agttcctgcg gctggtaggg cagctcaaga
      121 gagtcccacg aactggctgg gtatacagaa atgtccagag gccggagagc gtttcagatc
      181 acatgtaccg gatggcagtt atggctatgg tgatcaaaga tgaccgtctt aacaaagacc
      241 gatgtgtacg cctagccctg gttcatgata tggcagaatg catcgttggg gacatagcac
      301 cagcagataa catccccaaa gaagaaaaac ataggcgaga agaggaagct atgaagcaga
      361 taacccagct cctaccagag gacctcagaa aggagctcta tgaactttgg gaagagtacg
      421 agacccaatc tagtgcagaa gccaaatttg tgaagcagct agaccaatgt gaaatgattc
      481 ttcaagcatc tgaatatgaa gaccttgaac acaaacctgg gagactgcaa gacttctatg
      541 attccacagc aggaaaattc aatcaccctg agatagtcca gcttgtttct gaacttgagg
      601 cagaaagaag cactaacata gctgcagctg ccagtgagcc acactcctga gacactctct
      661 aaattgctgc actcctgtaa caaacattat ttttccattt cattgtattg tgttttgcca
      721 ttgttggtct gttgatttcc ctagatgtga gtctgtttgt tttcaattgt ctgaacttca
      781 gcaagaaatg tgatacaact tgggcactaa aagaagccac agaacaggaa gcggtcatga
      841 aagtgccatg gatgaacact ggaggtggca gtgcctgttt atgaactaaa taaataaata
      901 ttaaacacct aaaatattag aatatttatt ggagatttaa aatcatctta ttctgactta
      961 attaccgata tccccgaagg ctaggttcat tgaataatag aaaatttcat tatgattgct
     1021 tttaagaaca gattcttcag ctgatttagt gataagaatc cagaaaagaa aatgtactag
     1081 tgatgtattc tctccccaga tgaaattgct gccttattca gatttactct cttgagccag
     1141 attttgaatt tcactgcaga ctgcttcaga cttctaatca taggcttgta aacctactaa
     1201 taggctctgc ccctcttccc aatacttttt gtcatttaga gatataaacc ggggcatata
     1261 aaaatgcaac ttgtattcct ttgtatattt ttccctgtct gacttataaa tcttgagacc
     1321 tttattgtaa aagcatgtat catcaggtga gaaatataaa taggaactgg ggtcattgag
     1381 cctcaggtag ggaatatatc aacccgattt cttcctctct tttccctttt ataggataaa
     1441 taatcc
//
