LOCUS       NM_002112               2405 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens histidine decarboxylase (HDC), transcript variant 1,
            mRNA.
ACCESSION   NM_002112
VERSION     NM_002112.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Li,Y., Gao,J., Zhao,D., Guan,X., Morris,S.C., Finkelman,F.D. and
            Huang,H.
  TITLE     The Hdc GC box is critical for Hdc gene transcription and
            histamine-mediated anaphylaxis
  JOURNAL   J Allergy Clin Immunol 152 (1), 195-204 (2023)
   PUBMED   36804390
  REMARK    GeneRIF: The Hdc GC box is critical for Hdc gene transcription and
            histamine-mediated anaphylaxis.
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   Inami,Y., Fukushima,M. and Murota,H.
  TITLE     Correlation between histidine decarboxylase expression of
            keratinocytes and visual analogue scale in patients with atopic
            dermatitis
  JOURNAL   J Dermatol Sci 103 (2), 120-123 (2021)
   PUBMED   34140200
  REMARK    GeneRIF: Correlation between histidine decarboxylase expression of
            keratinocytes and visual analogue scale in patients with atopic
            dermatitis.
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Inami,Y., Fukushima,M. and Murota,H.
  TITLE     Expression of histidine decarboxylase in melanocytes of the human
            skin
  JOURNAL   Biochem Biophys Res Commun 535, 19-24 (2021)
   PUBMED   33340761
  REMARK    GeneRIF: Expression of histidine decarboxylase in melanocytes of
            the human skin.
REFERENCE   4  (bases 1 to 2405)
  AUTHORS   Nicoud,M.B., Sterle,H.A., Massari,N.A., Taquez Delgado,M.A.,
            Formoso,K., Herrero Ducloux,M.V., Martinel Lamas,D., Cremaschi,G.A.
            and Medina,V.A.
  TITLE     Study of the antitumour effects and the modulation of immune
            response by histamine in breast cancer
  JOURNAL   Br J Cancer 122 (3), 348-360 (2020)
   PUBMED   31748740
  REMARK    GeneRIF: Study of the antitumour effects and the modulation of
            immune response by histamine in breast cancer.
REFERENCE   5  (bases 1 to 2405)
  AUTHORS   Sanchez-Jimenez,F., Pino-Angeles,A., Rodriguez-Lopez,R., Morales,M.
            and Urdiales,J.L.
  TITLE     Structural and functional analogies and differences between
            histidine decarboxylase and aromatic l-amino acid decarboxylase
            molecular networks: Biomedical implications
  JOURNAL   Pharmacol Res 114, 90-102 (2016)
   PUBMED   27769832
  REMARK    GeneRIF: Human histidine decarboxylase (HDC) and dopa decarboxilase
            (DDC) are highly homologous enzymes responsible for the synthesis
            of biogenic amines (BA) like histamine, and serotonin and dopamine,
            respectively. This review summarizes the analogies and differences
            in their origin as well as their common pathophysiological
            scenarios. [review]
            Review article
REFERENCE   6  (bases 1 to 2405)
  AUTHORS   Richard,I., Broux,O., Chiannilkulchai,N., Fougerousse,F.,
            Allamand,V., Bourg,N., Brenguier,L., Devaud,C., Pasturaud,P.,
            Roudaut,C. et al.
  TITLE     Regional localization of human chromosome 15 loci
  JOURNAL   Genomics 23 (3), 619-627 (1994)
   PUBMED   7851890
REFERENCE   7  (bases 1 to 2405)
  AUTHORS   Bruneau,G., Nguyen,V.C., Gros,F., Bernheim,A. and Thibault,J.
  TITLE     Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe
            by PCR and assignment of the human HDC gene to chromosome 15
  JOURNAL   Hum Genet 90 (3), 235-238 (1992)
   PUBMED   1487235
REFERENCE   8  (bases 1 to 2405)
  AUTHORS   Mamune-Sato,R., Yamauchi,K., Tanno,Y., Ohkawara,Y., Ohtsu,H.,
            Katayose,D., Maeyama,K., Watanabe,T., Shibahara,S. and Takishima,T.
  TITLE     Functional analysis of alternatively spliced transcripts of the
            human histidine decarboxylase gene and its expression in human
            tissues and basophilic leukemia cells
  JOURNAL   Eur J Biochem 209 (2), 533-539 (1992)
   PUBMED   1425659
REFERENCE   9  (bases 1 to 2405)
  AUTHORS   Zahnow,C.A., Yi,H.F., McBride,O.W. and Joseph,D.R.
  TITLE     Cloning of the cDNA encoding human histidine decarboxylase from an
            erythroleukemia cell line and mapping of the gene locus to
            chromosome 15
  JOURNAL   DNA Seq 1 (6), 395-400 (1991)
   PUBMED   1768863
REFERENCE   10 (bases 1 to 2405)
  AUTHORS   Yamauchi,K., Sato,R., Tanno,Y., Ohkawara,Y., Maeyama,K.,
            Watanabe,T., Satoh,K., Yoshizawa,M., Shibahara,S. and Takishima,T.
  TITLE     Nucleotide sequence of the cDNA encoding L-histidine decarboxylase
            derived from human basophilic leukemia cell line, KU-812-F
  JOURNAL   Nucleic Acids Res 18 (19), 5891 (1990)
   PUBMED   2216786
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL041199.1 and M60445.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002112.3.
            
            Summary: This gene encodes a member of the group II decarboxylase
            family and forms a homodimer that converts L-histidine to histamine
            in a pyridoxal phosphate dependent manner. Histamine regulates
            several physiologic processes, including neurotransmission, gastric
            acid secretion,inflamation, and smooth muscle tone.[provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M60445.1, SRR1660803.257783.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267845.8/ ENSP00000267845.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AL041199.1         302-353
            53-2405             M60445.1           1-2353
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..2405
                     /gene="HDC"
                     /note="histidine decarboxylase"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
     exon            1..134
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2092
                     /gene="HDC"
                     /EC_number="4.1.1.22"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="histidine decarboxylase isoform 1"
                     /protein_id="NP_002103.2"
                     /db_xref="CCDS:CCDS10134.1"
                     /db_xref="GeneID:3067"
                     /db_xref="HGNC:HGNC:4855"
                     /db_xref="MIM:142704"
                     /translation="MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLP
                     ESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCL
                     GFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLA
                     ARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFS
                     LRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAY
                     AGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIY
                     LRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLV
                     RNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTV
                     TSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQS
                     VSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLS
                     SFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMM
                     LKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV"
     exon            135..307
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            308..421
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            422..544
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            545..679
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            680..823
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            824..890
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1053
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1144
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1243
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1345
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..2405
                     /gene="HDC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2377..2382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDC"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="HDC"
                     /note="major polyA site"
ORIGIN      
        1 gagtgcgcag gactggcaag agggaagccg ggctgctcca cgcctttcac gccttccacc
       61 tcctgcgtgt ccatctgtga gaaggagcca gagcccaagg gagatgatgg agcctgagga
      121 gtacagagag agagggagag agatggtgga ttacatctgc cagtacctga gcactgtgcg
      181 ggagagacgt gtgacgccag acgtgcagcc tggctacctg cgagcccagc tgcctgagag
      241 tgctcctgag gaccccgaca gctgggacag catctttggg gacattgaac gaatcatcat
      301 gcctggggtg gtacattggc agagccccca tatgcacgcc tactacccag ccctcacctc
      361 ttggccctcc ctgctaggag acatgctggc tgatgccatc aactgcttgg gattcacctg
      421 ggcatccagc cctgcgtgta cagagctgga gatgaacgtc atggactggt tggcaaaaat
      481 gctgggactt ccagagcact tcttgcacca ccaccccagc agccagggcg gaggcgtcct
      541 gcagagcacg gtcagtgaat ccactttgat tgccctgctg gcagcaagga agaacaaaat
      601 cctggaaatg aaaacgtctg agcccgatgc tgatgagtcc tgcctaaatg cccgactcgt
      661 ggcctatgcc tctgaccagg ctcactcctc tgtggaaaag gctggtttga tttcccttgt
      721 gaagatgaaa tttctgcctg tggatgacaa cttctcactc cgaggggaag ctcttcagaa
      781 ggccatcgag gaagacaagc agcggggctt ggtgcccgtc tttgtctgtg caacactagg
      841 gaccactggg gtctgtgcat ttgactgcct gtcagagctg ggccccatct gtgcccgtga
      901 ggggctgtgg ctccacatcg atgctgctta tgcaggcact gccttcctgt gccccgagtt
      961 ccgggggttt ctgaagggga ttgagtatgc cgactccttc acctttaatc cttccaagtg
     1021 gatgatggtg cattttgact gtactgggtt ctgggtcaag gacaagtaca agctgcagca
     1081 gaccttcagt gtgaatccca tctacctcag gcatgccaac tcaggcgtgg ccaccgactt
     1141 catgcactgg cagatccccc tgagccgacg gtttcgctct gttaaactct ggttcgtgat
     1201 tcggtccttc ggggtgaaga atcttcaagc acatgtcaga catggtactg aaatggctaa
     1261 atattttgaa tctctggtca gaaacgaccc ttcctttgaa attcctgcca agaggcacct
     1321 tggcctggtg gtttttcgtc taaagggtcc taattgtctc acagaaaatg tgttaaagga
     1381 aatagctaaa gctggccgtc tcttcctcat cccggccact atccaggaca agttaatcat
     1441 ccgtttcact gtgacatccc agtttaccac tagggatgac atcctgagag actggaatct
     1501 cattcgagat gctgccactc tcatcctgag tcagcactgt acttcccaac ccagccctcg
     1561 ggttgggaac ctcatctccc aaatcagggg tgccagagcc tgggcctgtg gaacgtccct
     1621 tcagtctgtc agtggggcag gagatgatcc agtccaggcc aggaagatca tcaagcagcc
     1681 tcagcgtgtg ggagccggtc ccatgaaaag ggaaaatggc ctccatcttg aaaccctgct
     1741 ggacccagtt gatgactgct tttcagaaga ggccccagat gccaccaagc acaagctgtc
     1801 ctccttcctg ttcagttact tgtctgtgca gactaagaag aagacggtgc gctccctcag
     1861 ttgcaacagt gtgccagtga gtgctcagaa gccactgccc acagaggcct ctgtgaagaa
     1921 tgggggctcc tccagggtca gaatcttttc caggtttcca gaagacatga tgatgctgaa
     1981 gaaaagtgcc ttcaaaaaac tcatcaaatt ctacagcgtc cccagctttc ctgaatgcag
     2041 ctctcaatgt ggactccagc tgccctgttg ccctctgcag gccatggttt agacacaggg
     2101 ccttcagcca gagtctgagg atatacttca gggactctgt gaacccctca caattgtatg
     2161 ccaactttgt gtgcttatgt gtacatgcat ttttcttggg gcgagttcat aattttaatc
     2221 aaattctcat aggggttcat gacccacaat aggatacaaa cgaagagttt aagccagcat
     2281 gatccagatg ggttcagcag tctggtcagt gagaaagggc cgagggtaga caggcagctt
     2341 ctgtggttca gcttgtgaca tgatatataa cacagaaata aattatgctt gtccctgaaa
     2401 caaaa
//
