LOCUS       NM_178425               9880 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 5,
            mRNA.
ACCESSION   NM_178425
VERSION     NM_178425.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9880)
  AUTHORS   Dang,Z., Li,H., Xue,S., Shao,B., Ning,Y., Su,G., Zhang,F., Yu,W.
            and Leng,S.
  TITLE     Histone deacetylase 9-mediated phenotypic transformation of
            vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection
  JOURNAL   Biomed Pharmacother 173, 116396 (2024)
   PUBMED   38460370
  REMARK    GeneRIF: Histone deacetylase 9-mediated phenotypic transformation
            of vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection.
REFERENCE   2  (bases 1 to 9880)
  AUTHORS   Liu,J., Meng,L., Liu,Z., Lu,M. and Wang,R.
  TITLE     Identification of HDAC9 and ARRDC4 as potential biomarkers and
            targets for treatment of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 7083 (2024)
   PUBMED   38528189
  REMARK    GeneRIF: Identification of HDAC9 and ARRDC4 as potential biomarkers
            and targets for treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9880)
  AUTHORS   Chen,Z., Lin,B., Yao,X., Weng,J., Liu,J., He,Q., Song,K., Zhou,C.,
            Zuo,Z., Huang,X., Liu,Z., Huang,Q., Xu,Q. and Guo,X.
  TITLE     Endothelial beta-catenin upregulation and Y142 phosphorylation
            drive diabetic angiogenesis via upregulating KDR/HDAC9
  JOURNAL   Cell Commun Signal 22 (1), 182 (2024)
   PUBMED   38491522
  REMARK    GeneRIF: Endothelial beta-catenin upregulation and Y142
            phosphorylation drive diabetic angiogenesis via upregulating
            KDR/HDAC9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9880)
  AUTHORS   Zheng,G., Li,C., Chen,X., Deng,Z., Xie,T., Huo,Z., Wei,X.,
            Huang,Y., Zeng,X., Luo,Y. and Bai,J.
  TITLE     HDAC9 inhibition reduces skeletal muscle atrophy and enhances
            regeneration in mice with cigarette smoke-induced COPD
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167023 (2024)
   PUBMED   38218381
  REMARK    GeneRIF: HDAC9 inhibition reduces skeletal muscle atrophy and
            enhances regeneration in mice with cigarette smoke-induced COPD.
REFERENCE   5  (bases 1 to 9880)
  AUTHORS   Zhang,H.L., Hu,S., Yang,P., Long,H.C., Ma,Q.H., Yin,D.M. and
            Xu,G.Y.
  TITLE     HDAC9-mediated calmodulin deacetylation induces memory impairment
            in Alzheimer's disease
  JOURNAL   CNS Neurosci Ther 30 (2), e14573 (2024)
   PUBMED   38421101
  REMARK    GeneRIF: HDAC9-mediated calmodulin deacetylation induces memory
            impairment in Alzheimer's disease.
REFERENCE   6  (bases 1 to 9880)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   7  (bases 1 to 9880)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
REFERENCE   8  (bases 1 to 9880)
  AUTHORS   Wang,A.H., Bertos,N.R., Vezmar,M., Pelletier,N., Crosato,M.,
            Heng,H.H., Th'ng,J., Han,J. and Yang,X.J.
  TITLE     HDAC4, a human histone deacetylase related to yeast HDA1, is a
            transcriptional corepressor
  JOURNAL   Mol Cell Biol 19 (11), 7816-7827 (1999)
   PUBMED   10523670
REFERENCE   9  (bases 1 to 9880)
  AUTHORS   Miska,E.A., Karlsson,C., Langley,E., Nielsen,S.J., Pines,J. and
            Kouzarides,T.
  TITLE     HDAC4 deacetylase associates with and represses the MEF2
            transcription factor
  JOURNAL   EMBO J 18 (18), 5099-5107 (1999)
   PUBMED   10487761
REFERENCE   10 (bases 1 to 9880)
  AUTHORS   Sparrow,D.B., Miska,E.A., Langley,E., Reynaud-Deonauth,S.,
            Kotecha,S., Towers,N., Spohr,G., Kouzarides,T. and Mohun,T.J.
  TITLE     MEF-2 function is modified by a novel co-repressor, MITR
  JOURNAL   EMBO J 18 (18), 5085-5098 (1999)
   PUBMED   10487760
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002433.2, AC002124.2,
            AC002088.2, AC002410.2, AC004994.1 and AC004744.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 8, 2021 this sequence version replaced NM_178425.3.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene has sequence homology to members of the histone
            deacetylase family. This gene is orthologous to the Xenopus and
            mouse MITR genes. The MITR protein lacks the histone deacetylase
            catalytic domain. It represses MEF2 activity through recruitment of
            multicomponent corepressor complexes that include CtBP and HDACs.
            This encoded protein may play a role in hematopoiesis. Multiple
            alternatively spliced transcripts have been described for this gene
            but the full-length nature of some of them has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5) has an alternate 3' sequence
            including the coding region and UTR, compared to variant 1. The
            resulting isoform 5 has a distinct C-terminus, compared to isoform
            1. This variant is incomplete at the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.788611.1,
                                           SRR11853559.29126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000686413.1/ ENSP00000509161.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC002433.2         95722-95996         c
            276-338             AC002433.2         95421-95483         c
            339-580             AC002433.2         6223-6464           c
            581-731             AC002433.2         1259-1409           c
            732-760             AC002433.2         201-229             c
            761-858             AC002124.2         100826-100923       c
            859-980             AC002124.2         98439-98560         c
            981-1112            AC002124.2         62987-63118         c
            1113-1228           AC002124.2         57726-57841         c
            1229-1351           AC002124.2         47675-47797         c
            1352-1565           AC002124.2         44470-44683         c
            1566-1783           AC002124.2         43785-44002         c
            1784-2047           AC002124.2         25992-26255         c
            2048-2225           AC002088.2         50338-50515         c
            2226-2359           AC002088.2         28957-29090         c
            2360-2480           AC002088.2         15818-15938         c
            2481-2530           AC002088.2         10940-10989         c
            2531-2638           AC002410.2         80660-80767         c
            2639-2694           AC002410.2         44896-44951         c
            2695-2782           AC002410.2         44564-44651         c
            2783-2902           AC002410.2         38526-38645         c
            2903-3000           AC002410.2         38115-38212         c
            3001-3119           AC004994.1         79647-79765         c
            3120-3253           AC004994.1         18301-18434         c
            3254-3338           AC004744.1         85392-85476         c
            3339-3486           AC004744.1         63669-63816         c
            3487-9880           AC004744.1         37206-43599         c
FEATURES             Location/Qualifiers
     source          1..9880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..9880
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="histone deacetylase 9"
                     /db_xref="GeneID:9734"
                     /db_xref="HGNC:HGNC:14065"
                     /db_xref="MIM:606543"
     exon            1..275
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            276..338
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..3526
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /EC_number="3.5.1.98"
                     /note="isoform 5 is encoded by transcript variant 5; MEF-2
                     interacting transcription repressor (MITR) protein;
                     histone deacetylase 7B; histone deacetylase 4/5-related
                     protein"
                     /codon_start=1
                     /product="histone deacetylase 9 isoform 5"
                     /protein_id="NP_848512.1"
                     /db_xref="CCDS:CCDS47553.1"
                     /db_xref="GeneID:9734"
                     /db_xref="HGNC:HGNC:14065"
                     /db_xref="MIM:606543"
                     /translation="MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREK
                     QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQEL
                     LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT
                     KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPL
                     RKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGS
                     GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNIT
                     LGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPN
                     SSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLN
                     RTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEA
                     EEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEM
                     ESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHP
                     AMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCER
                     IQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVD
                     SDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFF
                     NSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPG
                     SGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSA
                     GFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACV
                     NALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL
                     QEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL"
     exon            339..580
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            581..731
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            732..858
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            859..980
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1112
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1228
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1351
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1565
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1783
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..2047
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2225
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2359
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2480
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2530
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2638
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2694
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2782
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2902
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3000
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3119
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3253
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3338
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3486
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..9880
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9857..9862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="hexamer: AATAAA"
     polyA_site      9880
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="major polyA site"
ORIGIN      
        1 gaagagaggc acagacacag ataggagaag ggcaccggct ggagccactt gcaggactga
       61 gggtttttgc aacaaaaccc tagcagcctg aagaactcta agccaggttt aattggtttc
      121 tttttctcgt gggtagactt aataattttc tacgtattct gacaaagaaa taaccccgaa
      181 gcacgttcct atttcccacc tgcttgtagt ttccgggata acctaaactc cagagagcta
      241 tagcatccac tctgtccttt ctgctttgca cacagatggg gtggctggac gagagcagct
      301 cttggctcag caaagaatgc acagtatgat cagctcagtg gatgtgaagt cagaagttcc
      361 tgtgggcctg gagcccatct cacctttaga cctaaggaca gacctcagga tgatgatgcc
      421 cgtggtggac cctgttgtcc gtgagaagca attgcagcag gaattacttc ttatccagca
      481 gcagcaacaa atccagaagc agcttctgat agcagagttt cagaaacagc atgagaactt
      541 gacacggcag caccaggctc agcttcagga gcatatcaag ttgcaacagg aacttctagc
      601 cataaaacag caacaagaac tcctagaaaa ggagcagaaa ctggagcagc agaggcaaga
      661 acaggaagta gagaggcatc gcagagaaca gcagcttcct cctctcagag gcaaagatag
      721 aggacgagaa agggcagtgg caagtacaga agtaaagcag aagcttcaag agttcctact
      781 gagtaaatca gcaacgaaag acactccaac taatggaaaa aatcattccg tgagccgcca
      841 tcccaagctc tggtacacgg ctgcccacca cacatcattg gatcaaagct ctccacccct
      901 tagtggaaca tctccatcct acaagtacac attaccagga gcacaagatg caaaggatga
      961 tttccccctt cgaaaaactg cctctgagcc caacttgaag gtgcggtcca ggttaaaaca
     1021 gaaagtggca gagaggagaa gcagcccctt actcaggcgg aaggatggaa atgttgtcac
     1081 ttcattcaag aagcgaatgt ttgaggtgac agaatcctca gtcagtagca gttctccagg
     1141 ctctggtccc agttcaccaa acaatgggcc aactggaagt gttactgaaa atgagacttc
     1201 ggttttgccc cctacccctc atgccgagca aatggtttca cagcaacgca ttctaattca
     1261 tgaagattcc atgaacctgc taagtcttta tacctctcct tctttgccca acattacctt
     1321 ggggcttccc gcagtgccat cccagctcaa tgcttcgaat tcactcaaag aaaagcagaa
     1381 gtgtgagacg cagacgctta ggcaaggtgt tcctctgcct gggcagtatg gaggcagcat
     1441 cccggcatct tccagccacc ctcatgttac tttagaggga aagccaccca acagcagcca
     1501 ccaggctctc ctgcagcatt tattattgaa agaacaaatg cgacagcaaa agcttcttgt
     1561 agctggtgga gttcccttac atcctcagtc tcccttggca acaaaagaga gaatttcacc
     1621 tggcattaga ggtacccaca aattgccccg tcacagaccc ctgaaccgaa cccagtctgc
     1681 acctttgcct cagagcacgt tggctcagct ggtcattcaa cagcaacacc agcaattctt
     1741 ggagaagcag aagcaatacc agcagcagat ccacatgaac aaactgcttt cgaaatctat
     1801 tgaacaactg aagcaaccag gcagtcacct tgaggaagca gaggaagagc ttcaggggga
     1861 ccaggcgatg caggaagaca gagcgccctc tagtggcaac agcactagga gcgacagcag
     1921 tgcttgtgtg gatgacacac tgggacaagt tggggctgtg aaggtcaagg aggaaccagt
     1981 ggacagtgat gaagatgctc agatccagga aatggaatct ggggagcagg ctgcttttat
     2041 gcaacagcct ttcctggaac ccacgcacac acgtgcgctc tctgtgcgcc aagctccgct
     2101 ggctgcggtt ggcatggatg gattagagaa acaccgtctc gtctccagga ctcactcttc
     2161 ccctgctgcc tctgttttac ctcacccagc aatggaccgc cccctccagc ctggctctgc
     2221 aactggaatt gcctatgacc ccttgatgct gaaacaccag tgcgtttgtg gcaattccac
     2281 cacccaccct gagcatgctg gacgaataca gagtatctgg tcacgactgc aagaaactgg
     2341 gctgctaaat aaatgtgagc gaattcaagg tcgaaaagcc agcctggagg aaatacagct
     2401 tgttcattct gaacatcact cactgttgta tggcaccaac cccctggacg gacagaagct
     2461 ggaccccagg atactcctag gtgatgactc tcaaaagttt ttttcctcat taccttgtgg
     2521 tggacttggg gtggacagtg acaccatttg gaatgagcta cactcgtccg gtgctgcacg
     2581 catggctgtt ggctgtgtca tcgagctggc ttccaaagtg gcctcaggag agctgaagaa
     2641 tgggtttgct gttgtgaggc cccctggcca tcacgctgaa gaatccacag ccatggggtt
     2701 ctgctttttt aattcagttg caattaccgc caaatacttg agagaccaac taaatataag
     2761 caagatattg attgtagatc tggatgttca ccatggaaac ggtacccagc aggcctttta
     2821 tgctgacccc agcatcctgt acatttcact ccatcgctat gatgaaggga actttttccc
     2881 tggcagtgga gccccaaatg aggttggaac aggccttgga gaagggtaca atataaatat
     2941 tgcctggaca ggtggccttg atcctcccat gggagatgtt gagtaccttg aagcattcag
     3001 gaccatcgtg aagcctgtgg ccaaagagtt tgatccagac atggtcttag tatctgctgg
     3061 atttgatgca ttggaaggcc acacccctcc tctaggaggg tacaaagtga cggcaaaatg
     3121 ttttggtcat ttgacgaagc aattgatgac attggctgat ggacgtgtgg tgttggctct
     3181 agaaggagga catgatctca cagccatctg tgatgcatca gaagcctgtg taaatgccct
     3241 tctaggaaat gagctggagc cacttgcaga agatattctc caccaaagcc cgaatatgaa
     3301 tgctgttatt tctttacaga agatcattga aattcaaagc aagtattgga agtcagtaag
     3361 gatggtggct gtgccaaggg gctgtgctct ggctggtgct cagttgcaag aggagacaga
     3421 gaccgtttct gccctggcct ccctaacagt ggatgtggaa cagccctttg ctcaggaaga
     3481 cagcagaact gctggtgagc ctatggaaga ggagccagcc ttgtgaagtg ccaagtcccc
     3541 ctctgatatt tcctgtgtgt gacatcattg tgtatccccc caccccagta ccctcagaca
     3601 tgtcttgtct gctgcctggg tggcacagat tcaatggaac ataaacactg ggcacaaaat
     3661 tctgaacagc agcttcactt gttctttgga tggacttgaa agggcattaa agattcctta
     3721 aacgtaaccg ctgtgattct agagttacag taaaccacga ttggaagaaa ctgcttccag
     3781 catgctttta atatgctggg tgacccactc ctagacacca agtttgaact agaaacattc
     3841 agtacagcac tagatattgt taatttcaga agctatgaca gccagtgaaa ttttgggcaa
     3901 aacctgagac atagtcattc ctgacattct gatcagcttt ttttggggta atttgttttt
     3961 caaacagtct taacttgttt acaagatttg cttttagcta tgaacggatc gtaattccac
     4021 ccagaatgta atgtttcttg tttgtttgtt ttgttttgtt agggtttttt tctcaacttt
     4081 aacacacagt tcaactgttc ctagtaaaag ttcaagatgg aggaactagc atgaggcttt
     4141 tttcagtatc tcgaagtcca aatgccaaag gaacctcaca cactgtttgt aatggtgcaa
     4201 tattttatat cacttttttt taaacatccc caacatcttt gtgttctcac acacaggcaa
     4261 tttgcaatgt tgcaattgtg ttggagaatg aagtcccccc acctcccagc cacacacaca
     4321 tcctttgttc tcatgacagt aggtctgagc aaatgttcca ccaagcattt tcagtgtctt
     4381 tgaaaagcac gtaacttttc aaaggtggtc ttaatttgtt gcatatctat caaggactta
     4441 ttcactcacc tttccttttc tgccctctat caattgattt cttcttacct ttcatcattc
     4501 attccttcct ttagaaaaac tgaagattac ccataatctc ctcttattac ttgagggcct
     4561 tgactattta gtttattttg tttactttac aggttaacac agttgttttg tctgattgca
     4621 ttttattaac tgtgaagccg ttgaaatgaa tatcacttaa gcaacgttgc taaatttcta
     4681 tgtgtttgaa atgtgttaat gaaggcactg cttatttgta gtcaccttga actgacttaa
     4741 cctagaagct gtgccttctt gtgaaaaaaa aaaaaaacaa aaacaaaaaa cagcctttaa
     4801 acaagtttcc ttagtgtcaa aagttaaaaa taaaggacat ttatttctga gataaaaagt
     4861 aacttactaa atataagtag gttatcctcc tacctcctaa aattcgattt caacatataa
     4921 ctcaaacacc taaacatatt gaggtagaat atctcacagt atttaatatc tgacaatgct
     4981 tttgaaagag ttgatgtttc tttttatata tttttctaac tcaaaggata tattaaagcc
     5041 ataagtgaag attgtcatgc ttttattcag aaatctgaaa gaaaccttaa ttaaaacaag
     5101 gttttaggga aggccatgat atgaaagata tggaacaata tggttttagt tagagaggac
     5161 tctaacctgt aaatcaaaga tgaaagattt cactcaagta gaattatata actccctttg
     5221 ttatacagtc agaccatatt tttcatgcat ttggtttttt taggattacc attttaattt
     5281 taaagacttt tattacatat acaaaaatgg ctcaatactt ggtttaactt cttagaaatt
     5341 tgagacaccc tttgaaatag gaaatctgaa atggaatgta acttagtatt aggtaaaaat
     5401 tgctttcatt gcgtaagggc aaattcagtc tagattcata gtagtaatca attttttata
     5461 aattttattt tcatgagaaa ttcataccaa tcatatttgc tagcttatgt tattttgcag
     5521 tgattgcttg aggatattta cttaaaaaaa tagtagagcc aaaggcttaa caaaagactc
     5581 tcccccattt taaaaaggaa actcatgttt taattagaaa aataattgtg tagttttaaa
     5641 atcaacttca taattataaa tctctgtcat tactttttag tcctcccaga tattttttta
     5701 gttgttgaat aagaaaataa aacagtgtaa tgcaaacatg ctaatttact aaagtttcct
     5761 acaacagttt agccacatgt ttatgccaag ccattaatct gataaagcca aatcactagg
     5821 acatctccat ggttatttag atttaaaact tgacacatta atgagttaat cacacatact
     5881 cccatatgac accataccca attggttgca cttagagtct ttaaaatacc tggagaagca
     5941 aatgaactgt ggagaggatt atccacagca tgtagttgta agaacagaat gccattgctt
     6001 tttgattata ccattacaag atggagcata gccctgaggg acagaatgga ggctttccga
     6061 aaatatcaac acttcttttg aaatagacca gcactttttg aaagggtagt ttcacttggt
     6121 atagtttttc ttcacttacc cgtttaaatt ttattgctcg cagttgttct gaatgagagg
     6181 ctagaagagt attatcaatt ttgcatctcc ttgtgatact tactttgaag gaaaatcaca
     6241 tacgctctct catggtctca tggtatctca tacagggtga ataaaaatga tttttgataa
     6301 atctactagt aaataatact aggaatttaa taagctgtca aacgtaggta taaaaagaag
     6361 gcttaaaaat taattttccc aattgtataa tttggggctg tatattaaac taaaaaacac
     6421 agacagtttt attaaatagt aaccaaaatg gactcaaata aaaccagagg ctatgttacc
     6481 attgcttagt aaatggaaag aacattgtga gatgaactat ctttaaatat tgtaacaagt
     6541 ttataacatc aatagtggag acagaagtca gctttggaga aaatagagat atttatgaaa
     6601 aaactactac aaatcacatt tccattacca atcctgggga tggaaatatt gccttcagtt
     6661 tttactccag ccctatacga cactctcact aacctttcac tgacaacatc atggccttga
     6721 aagcagggat ctcctcccac aaaggcttca gaaattacag gactggtctc tcttaatagt
     6781 ttagtcctgc tttatttcca aagggcaatt ataaagcctc gtggatttac tgggtttctt
     6841 tacagactcc atatggaagt aaaatagaat gatcatttgg aaagtctcct gggaaaaaat
     6901 tcctcttcaa tcagcatttt aaaacttttt tatttttgag tcagagtttt gctcttggtg
     6961 cccaggctgg agtgcaatgg cgcaatctcg actcactgca acctccgcct cccgggttca
     7021 agcaattctc ctgacgagta gctgggcatg cgccaccacg tctggctaat ttttgtattt
     7081 ttagtagaga cggggtttct ccatgttggt caggctggtc tcaaactccc gacctcaggt
     7141 gatccgcccg cctcggcctc ccaaagtgct gaaattacag gtgtgagcca ctgcacccgg
     7201 ccaaacttat tgttttaatc ccagcattta tgtttagaag aattaattta aatatttctt
     7261 actatttctc tgtcgaatgt ttactctcat cttatctcaa tgaaagaagt attaaaagtc
     7321 ttatggcccc aaaagaaaca agccaaactg tactgtctta aaagtgattc attctgagct
     7381 tgaaacgact ctgtcagtgt ttgacattgt catttctagt ggcatgtatc ttaacattct
     7441 tttcctgctt caggaatgaa atcacttgtc ctgctgagaa aataagggga aaacaagata
     7501 gaagtaaaaa acaacacacc tgttgaacta ttttcataaa gatggcgttt tcactttcaa
     7561 aagaaatgaa aaccagatgg tctatgctaa gaagtgaagg cattttgttg tcttcagaac
     7621 tgatcaacat ggtcatgatc atcatcaaat ttcttgtttc caaaggccac tattgtagta
     7681 cagtctccag caggattttg taccatgtgc tgcctttgga ataaagtatt ataatgtatc
     7741 ttgtcacctt catcaacacc accattaaat atgtaagttc ctatatgtga ctttttctgg
     7801 gcatatttgc atcaaaaatc acagtccttg cctccttgct tgcttttact ccatgaaacg
     7861 cttcatgaag cagagcatga ttgtcaagtg accagaggat gacatttgta agtgaacgtg
     7921 gtatactcac acatgctata ctcatactac ataacttagt ttctccaaat caactgcagt
     7981 ccgttttatc tatgatattc ctggcttcgt ataatggttt tgtaaaatac attaaataca
     8041 attaagtccg ttattactat gctggaaata actaggtcag acaatgaaac cttagacttt
     8101 tgattggggc tgtttggact tgatccaatg ataaggtaat aaggttgttg caatttctca
     8161 aagcatctta attctcaaac tgaaacattt agcaaataca tggtgaatct ggtgtaaact
     8221 tacaatctaa caaataattt tctttcaact cttctctttt tctgcctaac aatctatacg
     8281 aaattgccaa tatctaagca atcaaaagtt tctgaaatct ctgtttcctt agtagaaatg
     8341 accttgacaa cttattttct gagataccac taggcctact gtctttcatg ccattttata
     8401 taaacatttt gatagatact ctgtcttttg ttttttatct cttctctttt caagagtcac
     8461 ttgacttttt caaatattct taaaagatag atttagttat tgtattttgg tctacaattt
     8521 tggacttggc agtttgtttt actaatgcag aattattctt tttgtttcaa acatagtttg
     8581 ccatcatctg gctactacct aatcatgttg tactagttat tgtggaaaga aaattgtaca
     8641 tacatttcct tgtcctttgg gagatgtctt tgagtcaaac ccacaagcat gaactctcac
     8701 ctgaaagaaa actggaaaag gagaaacttt aaatcagtat gttttgaaag gaagagattt
     8761 ccagactttt taaagcaaat tggaatcgtt ttattttttt gtttgggcct taggcacaat
     8821 agaagcaaat gttgcaatat taaatataat agggagagtt cactgtttcc tgggacattg
     8881 tggtcatgtc cttaatcctt cattgtgatg ccccttcttg gagttggcat tttgtgacaa
     8941 ttcatagaga tcttgcagca atatttggct attggtttta ttaacttaaa attcaacaga
     9001 aatggagtaa ttaaaaaaaa aaacaaaaaa cagagaagaa ttgcaaaatc tgaagtggaa
     9061 tggcacttcc ttgggtatgt aagggttgtt tttagataaa actcccgatt tgttcttcct
     9121 acactttaat agtctcaaat tctttctggg gaagcaacgt cagtgtctac ctccacagta
     9181 actatgatat aggaaattgt cctttcagtg gtttctaggt ataacaaaca agccgttaaa
     9241 aatgagtgac cattttgtag gttacagcct cagcaatctg tgtcatttga aagcaaatat
     9301 cctgatattt ttaaataagg tgagcagggc aggcaggaaa ccaatattta gtacttttgt
     9361 gattaaacat tctagaccag gcttgttgat atgtatgcca atagcctaga atttttggct
     9421 tagtgtaaaa taaaaatgtc ttttctattg tggtctgata tccgtttctg taataagatc
     9481 agtttgttgt cctctgtgca ccagtggttt tgcccttaat tttttttggc tagcatcacc
     9541 aagatctgtc atccagagct gctgagaaaa atacatgttg ccaaactttt cttaaaattg
     9601 tgctgccagt ggtattttcc cagatgtgaa aaataataat ctaataaagg attaatatct
     9661 aataacaata ccattgttga acatgctcat ggaatgtcca ccttcttctg attccttttt
     9721 tgtatttgaa aatgcaatgg tgtgttccaa attattgttg gtgttgttaa tgtcatgact
     9781 ctcctttgaa tagaataaaa taaccccttt tgttttgtgt tttctactga attagatttt
     9841 cctctagtcc tatgtgaata aaaagctatt tgaaataaaa
//
