LOCUS       NM_001321895            4113 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 33,
            mRNA.
ACCESSION   NM_001321895
VERSION     NM_001321895.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4113)
  AUTHORS   Dang,Z., Li,H., Xue,S., Shao,B., Ning,Y., Su,G., Zhang,F., Yu,W.
            and Leng,S.
  TITLE     Histone deacetylase 9-mediated phenotypic transformation of
            vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection
  JOURNAL   Biomed Pharmacother 173, 116396 (2024)
   PUBMED   38460370
  REMARK    GeneRIF: Histone deacetylase 9-mediated phenotypic transformation
            of vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection.
REFERENCE   2  (bases 1 to 4113)
  AUTHORS   Liu,J., Meng,L., Liu,Z., Lu,M. and Wang,R.
  TITLE     Identification of HDAC9 and ARRDC4 as potential biomarkers and
            targets for treatment of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 7083 (2024)
   PUBMED   38528189
  REMARK    GeneRIF: Identification of HDAC9 and ARRDC4 as potential biomarkers
            and targets for treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4113)
  AUTHORS   Chen,Z., Lin,B., Yao,X., Weng,J., Liu,J., He,Q., Song,K., Zhou,C.,
            Zuo,Z., Huang,X., Liu,Z., Huang,Q., Xu,Q. and Guo,X.
  TITLE     Endothelial beta-catenin upregulation and Y142 phosphorylation
            drive diabetic angiogenesis via upregulating KDR/HDAC9
  JOURNAL   Cell Commun Signal 22 (1), 182 (2024)
   PUBMED   38491522
  REMARK    GeneRIF: Endothelial beta-catenin upregulation and Y142
            phosphorylation drive diabetic angiogenesis via upregulating
            KDR/HDAC9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4113)
  AUTHORS   Zheng,G., Li,C., Chen,X., Deng,Z., Xie,T., Huo,Z., Wei,X.,
            Huang,Y., Zeng,X., Luo,Y. and Bai,J.
  TITLE     HDAC9 inhibition reduces skeletal muscle atrophy and enhances
            regeneration in mice with cigarette smoke-induced COPD
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167023 (2024)
   PUBMED   38218381
  REMARK    GeneRIF: HDAC9 inhibition reduces skeletal muscle atrophy and
            enhances regeneration in mice with cigarette smoke-induced COPD.
REFERENCE   5  (bases 1 to 4113)
  AUTHORS   Zhang,H.L., Hu,S., Yang,P., Long,H.C., Ma,Q.H., Yin,D.M. and
            Xu,G.Y.
  TITLE     HDAC9-mediated calmodulin deacetylation induces memory impairment
            in Alzheimer's disease
  JOURNAL   CNS Neurosci Ther 30 (2), e14573 (2024)
   PUBMED   38421101
  REMARK    GeneRIF: HDAC9-mediated calmodulin deacetylation induces memory
            impairment in Alzheimer's disease.
REFERENCE   6  (bases 1 to 4113)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   7  (bases 1 to 4113)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
REFERENCE   8  (bases 1 to 4113)
  AUTHORS   Wang,A.H., Bertos,N.R., Vezmar,M., Pelletier,N., Crosato,M.,
            Heng,H.H., Th'ng,J., Han,J. and Yang,X.J.
  TITLE     HDAC4, a human histone deacetylase related to yeast HDA1, is a
            transcriptional corepressor
  JOURNAL   Mol Cell Biol 19 (11), 7816-7827 (1999)
   PUBMED   10523670
REFERENCE   9  (bases 1 to 4113)
  AUTHORS   Miska,E.A., Karlsson,C., Langley,E., Nielsen,S.J., Pines,J. and
            Kouzarides,T.
  TITLE     HDAC4 deacetylase associates with and represses the MEF2
            transcription factor
  JOURNAL   EMBO J 18 (18), 5099-5107 (1999)
   PUBMED   10487761
REFERENCE   10 (bases 1 to 4113)
  AUTHORS   Sparrow,D.B., Miska,E.A., Langley,E., Reynaud-Deonauth,S.,
            Kotecha,S., Towers,N., Spohr,G., Kouzarides,T. and Mohun,T.J.
  TITLE     MEF-2 function is modified by a novel co-repressor, MITR
  JOURNAL   EMBO J 18 (18), 5085-5098 (1999)
   PUBMED   10487760
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC333611.1, AC002433.2,
            AC002124.2 and BC150328.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001321895.1.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene has sequence homology to members of the histone
            deacetylase family. This gene is orthologous to the Xenopus and
            mouse MITR genes. The MITR protein lacks the histone deacetylase
            catalytic domain. It represses MEF2 activity through recruitment of
            multicomponent corepressor complexes that include CtBP and HDACs.
            This encoded protein may play a role in hematopoiesis. Multiple
            alternatively spliced transcripts have been described for this gene
            but the full-length nature of some of them has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.69023.1,
                                           SRR1660809.190885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DC333611.1         40-51
            13-106              AC002433.2         95891-95984         c
            107-169             AC002433.2         95421-95483         c
            170-411             AC002433.2         6223-6464           c
            412-562             AC002433.2         1259-1409           c
            563-591             AC002433.2         201-229             c
            592-689             AC002124.2         100826-100923       c
            690-811             AC002124.2         98439-98560         c
            812-927             AC002124.2         57726-57841         c
            928-1050            AC002124.2         47675-47797         c
            1051-1264           AC002124.2         44470-44683         c
            1265-1482           AC002124.2         43785-44002         c
            1483-4079           AC002124.2         23659-26255         c
            4080-4113           BC150328.1         4217-4250
FEATURES             Location/Qualifiers
     source          1..4113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..4113
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="histone deacetylase 9"
                     /db_xref="GeneID:9734"
                     /db_xref="HGNC:HGNC:14065"
                     /db_xref="MIM:606543"
     exon            1..106
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            107..169
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1797
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /EC_number="3.5.1.98"
                     /note="isoform 8 is encoded by transcript variant 33;
                     MEF-2 interacting transcription repressor (MITR) protein;
                     histone deacetylase 7B; histone deacetylase 4/5-related
                     protein"
                     /codon_start=1
                     /product="histone deacetylase 9 isoform 8"
                     /protein_id="NP_001308824.1"
                     /db_xref="CCDS:CCDS75565.1"
                     /db_xref="GeneID:9734"
                     /db_xref="HGNC:HGNC:14065"
                     /db_xref="MIM:606543"
                     /translation="MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREK
                     QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQEL
                     LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT
                     KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPL
                     RKTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMN
                     LLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPAS
                     SSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPG
                     IRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKS
                     IEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE
                     EPVDSDEDAQIQEMESGEQAAFMQQVIGKDLAPGFVIKVII"
     exon            170..411
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            412..562
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            563..689
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            690..811
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            812..927
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1050
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1264
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1482
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..4113
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4093..4098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="hexamer: AATAAA"
     polyA_site      4113
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="major polyA site"
ORIGIN      
        1 gaagagaggc acagacacag ataggagaag ggcaccggct ggagccactt gcaggactga
       61 gggtttttgc aacaaaaccc tagcagcctg aagaactcta agccagatgg ggtggctgga
      121 cgagagcagc tcttggctca gcaaagaatg cacagtatga tcagctcagt ggatgtgaag
      181 tcagaagttc ctgtgggcct ggagcccatc tcacctttag acctaaggac agacctcagg
      241 atgatgatgc ccgtggtgga ccctgttgtc cgtgagaagc aattgcagca ggaattactt
      301 cttatccagc agcagcaaca aatccagaag cagcttctga tagcagagtt tcagaaacag
      361 catgagaact tgacacggca gcaccaggct cagcttcagg agcatatcaa gttgcaacag
      421 gaacttctag ccataaaaca gcaacaagaa ctcctagaaa aggagcagaa actggagcag
      481 cagaggcaag aacaggaagt agagaggcat cgcagagaac agcagcttcc tcctctcaga
      541 ggcaaagata gaggacgaga aagggcagtg gcaagtacag aagtaaagca gaagcttcaa
      601 gagttcctac tgagtaaatc agcaacgaaa gacactccaa ctaatggaaa aaatcattcc
      661 gtgagccgcc atcccaagct ctggtacacg gctgcccacc acacatcatt ggatcaaagc
      721 tctccacccc ttagtggaac atctccatcc tacaagtaca cattaccagg agcacaagat
      781 gcaaaggatg atttccccct tcgaaaaact gaatcctcag tcagtagcag ttctccaggc
      841 tctggtccca gttcaccaaa caatgggcca actggaagtg ttactgaaaa tgagacttcg
      901 gttttgcccc ctacccctca tgccgagcaa atggtttcac agcaacgcat tctaattcat
      961 gaagattcca tgaacctgct aagtctttat acctctcctt ctttgcccaa cattaccttg
     1021 gggcttcccg cagtgccatc ccagctcaat gcttcgaatt cactcaaaga aaagcagaag
     1081 tgtgagacgc agacgcttag gcaaggtgtt cctctgcctg ggcagtatgg aggcagcatc
     1141 ccggcatctt ccagccaccc tcatgttact ttagagggaa agccacccaa cagcagccac
     1201 caggctctcc tgcagcattt attattgaaa gaacaaatgc gacagcaaaa gcttcttgta
     1261 gctggtggag ttcccttaca tcctcagtct cccttggcaa caaaagagag aatttcacct
     1321 ggcattagag gtacccacaa attgccccgt cacagacccc tgaaccgaac ccagtctgca
     1381 cctttgcctc agagcacgtt ggctcagctg gtcattcaac agcaacacca gcaattcttg
     1441 gagaagcaga agcaatacca gcagcagatc cacatgaaca aactgctttc gaaatctatt
     1501 gaacaactga agcaaccagg cagtcacctt gaggaagcag aggaagagct tcagggggac
     1561 caggcgatgc aggaagacag agcgccctct agtggcaaca gcactaggag cgacagcagt
     1621 gcttgtgtgg atgacacact gggacaagtt ggggctgtga aggtcaagga ggaaccagtg
     1681 gacagtgatg aagatgctca gatccaggaa atggaatctg gggagcaggc tgcttttatg
     1741 caacaggtaa taggcaaaga tttagctcca ggatttgtaa ttaaagtcat tatctgaaca
     1801 tgaaatgcat tgcaggtttg gtaaatggat atgatttcct atcagtttat atttctctat
     1861 gatttgagtt cagtgtttaa ggattctacc taatgcagat atatgtatat atctatatag
     1921 aggtctttct atatactgat ctctatatag atatcaatgt ttcattgaaa atccactggt
     1981 aaggaaatac ctgttatact aaaattatga tacataatat ctgagcagtt aataggcttt
     2041 aaatttatcc caaagcctgc tacaccaatt acttctaaag aaaacaaatt cactgttatt
     2101 ttgagtttat gtgttgagat cagtgactgc tggatagtct cccagtctga tcaatgaagc
     2161 attcgattag tttttgattt tttgcaacat ctagaattta attttcacat cactgtacat
     2221 aatgtatcat actatagtct tgaacactgt taaaggtagt ctgccccttc cttcctctct
     2281 ctttttttag ttaagtagaa atgttctggt caccatgcca gtagtcctag gttattgtgt
     2341 aggttgcaat tgaacatatt aggaatacag gtggttttaa atatatagat gcaaattgca
     2401 gcactacttt aaatattaga ttatgtctca catagcactg ctcattttac ttttattttg
     2461 tgtaatttga tgacactgtc tatcaaaaaa gagcaaatga agcagatgca aatgttagtg
     2521 agaagtaatg tgcagcatta tggtccaatc agatacaata ttgtgtctac aattgcaaaa
     2581 aacacagtaa caggatgaat attatctgat atcaagtcaa aatcagtttg aaaagaaggt
     2641 gtatcatatt ttatattgtc actagaatct cttaagtata attccataat gacatgggca
     2701 tataccgtaa cattctggca aataacaatt agaaaagata ggtttaacaa aaaaatttac
     2761 ttgtatataa tgcaccttca ggaggactat gtcctttgat gctataaaat acaaacaact
     2821 ttgaaggcaa cagaagacac tgtttattca agtcagttct ttgtcaggtt cctgctgttc
     2881 tcctacagaa aagtgattct gtgagggtga acaggaaatg ccttgtggaa acaggaagtc
     2941 caagtgattc atgtactgag gaatgtagga aaaaaaatct gaggatagtg ctttactctt
     3001 tctgttttta aagggcactc tatgaattga tttattgtct aagaaaataa caccacaagt
     3061 agggaaattg ttacggaagc ttttcactgg aacatttcct tcatattccc ttttgatatg
     3121 tttaccttgt tttataggtt tacttttgtt aagctagtta aaggttcgtt gtattaagac
     3181 ccctttaata tggataatcc aaattgacct agaatctttg tgaggttttt tctattaaaa
     3241 tatttatatt tctaaatccg aggtatttca aggtgtagta tcctatttca aaggagatat
     3301 agcagttttg ccaaatgtag acattgttca actgtatgtt attggcacgt gttgtttaca
     3361 ttttgctgtg acatttaaaa atatttcttt aaaaatgtta ctgctaaaga tacattatcc
     3421 ttttttaaaa agtctccatt caaattaaat taacataact agaagttaga aagtttaaaa
     3481 gttttccaca taatgaaagt ccttctgata atttgacaaa tagctataat aggaacactc
     3541 cctatcacca acatattttg gttagtatat tccttcatat taaaatgact ttttgtcagt
     3601 tgttttgcat taaaaatatg gcatgcctaa gataaaattg tatatttttt ccatctcata
     3661 aatattcatt ttcttcaaag tcttttttca atctcataaa aaagggatag tgcatctttt
     3721 aaaatacatt ttatttgggg aggaacatgt ggctgagcag acttttgtat aatattactt
     3781 caaagatatg taatcacaaa caaaaaaaac tattttttat aatgtcattt gagagagttt
     3841 catcagtaca gttggtggac gttaattgtt tgaatttgat agtctttgaa tttaatcaag
     3901 aaactacctg gaaccagtga aaaggaaagc tggacttaaa taatcttaga attaattgat
     3961 aaatgtctct tttaaaatct actgtattta ttataattta cacccttgaa ggtgatctct
     4021 tgttttgtgt tgtaaatata ttgtttgtat gtttcccttc ttgccttctg ttataagtct
     4081 cttcctttct caaataaagt tttttttaaa aga
//
