LOCUS       NM_001321877            9748 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 20,
            mRNA.
ACCESSION   NM_001321877
VERSION     NM_001321877.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9748)
  AUTHORS   Dang,Z., Li,H., Xue,S., Shao,B., Ning,Y., Su,G., Zhang,F., Yu,W.
            and Leng,S.
  TITLE     Histone deacetylase 9-mediated phenotypic transformation of
            vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection
  JOURNAL   Biomed Pharmacother 173, 116396 (2024)
   PUBMED   38460370
  REMARK    GeneRIF: Histone deacetylase 9-mediated phenotypic transformation
            of vascular smooth muscle cells is a potential target for treating
            aortic aneurysm/dissection.
REFERENCE   2  (bases 1 to 9748)
  AUTHORS   Liu,J., Meng,L., Liu,Z., Lu,M. and Wang,R.
  TITLE     Identification of HDAC9 and ARRDC4 as potential biomarkers and
            targets for treatment of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 7083 (2024)
   PUBMED   38528189
  REMARK    GeneRIF: Identification of HDAC9 and ARRDC4 as potential biomarkers
            and targets for treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9748)
  AUTHORS   Chen,Z., Lin,B., Yao,X., Weng,J., Liu,J., He,Q., Song,K., Zhou,C.,
            Zuo,Z., Huang,X., Liu,Z., Huang,Q., Xu,Q. and Guo,X.
  TITLE     Endothelial beta-catenin upregulation and Y142 phosphorylation
            drive diabetic angiogenesis via upregulating KDR/HDAC9
  JOURNAL   Cell Commun Signal 22 (1), 182 (2024)
   PUBMED   38491522
  REMARK    GeneRIF: Endothelial beta-catenin upregulation and Y142
            phosphorylation drive diabetic angiogenesis via upregulating
            KDR/HDAC9.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9748)
  AUTHORS   Zheng,G., Li,C., Chen,X., Deng,Z., Xie,T., Huo,Z., Wei,X.,
            Huang,Y., Zeng,X., Luo,Y. and Bai,J.
  TITLE     HDAC9 inhibition reduces skeletal muscle atrophy and enhances
            regeneration in mice with cigarette smoke-induced COPD
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167023 (2024)
   PUBMED   38218381
  REMARK    GeneRIF: HDAC9 inhibition reduces skeletal muscle atrophy and
            enhances regeneration in mice with cigarette smoke-induced COPD.
REFERENCE   5  (bases 1 to 9748)
  AUTHORS   Zhang,H.L., Hu,S., Yang,P., Long,H.C., Ma,Q.H., Yin,D.M. and
            Xu,G.Y.
  TITLE     HDAC9-mediated calmodulin deacetylation induces memory impairment
            in Alzheimer's disease
  JOURNAL   CNS Neurosci Ther 30 (2), e14573 (2024)
   PUBMED   38421101
  REMARK    GeneRIF: HDAC9-mediated calmodulin deacetylation induces memory
            impairment in Alzheimer's disease.
REFERENCE   6  (bases 1 to 9748)
  AUTHORS   Lemercier,C., Verdel,A., Galloo,B., Curtet,S., Brocard,M.P. and
            Khochbin,S.
  TITLE     mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A
            transcriptional activity
  JOURNAL   J Biol Chem 275 (20), 15594-15599 (2000)
   PUBMED   10748098
REFERENCE   7  (bases 1 to 9748)
  AUTHORS   Zhou,X., Richon,V.M., Rifkind,R.A. and Marks,P.A.
  TITLE     Identification of a transcriptional repressor related to the
            noncatalytic domain of histone deacetylases 4 and 5
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1056-1061 (2000)
   PUBMED   10655483
REFERENCE   8  (bases 1 to 9748)
  AUTHORS   Wang,A.H., Bertos,N.R., Vezmar,M., Pelletier,N., Crosato,M.,
            Heng,H.H., Th'ng,J., Han,J. and Yang,X.J.
  TITLE     HDAC4, a human histone deacetylase related to yeast HDA1, is a
            transcriptional corepressor
  JOURNAL   Mol Cell Biol 19 (11), 7816-7827 (1999)
   PUBMED   10523670
REFERENCE   9  (bases 1 to 9748)
  AUTHORS   Miska,E.A., Karlsson,C., Langley,E., Nielsen,S.J., Pines,J. and
            Kouzarides,T.
  TITLE     HDAC4 deacetylase associates with and represses the MEF2
            transcription factor
  JOURNAL   EMBO J 18 (18), 5099-5107 (1999)
   PUBMED   10487761
REFERENCE   10 (bases 1 to 9748)
  AUTHORS   Sparrow,D.B., Miska,E.A., Langley,E., Reynaud-Deonauth,S.,
            Kotecha,S., Towers,N., Spohr,G., Kouzarides,T. and Mohun,T.J.
  TITLE     MEF-2 function is modified by a novel co-repressor, MITR
  JOURNAL   EMBO J 18 (18), 5085-5098 (1999)
   PUBMED   10487760
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC333611.1, AC002433.2,
            AC002124.2, AC002088.2, AC002410.2, AC004994.1, AC004744.1 and
            BQ575888.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001321877.1.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene has sequence homology to members of the histone
            deacetylase family. This gene is orthologous to the Xenopus and
            mouse MITR genes. The MITR protein lacks the histone deacetylase
            catalytic domain. It represses MEF2 activity through recruitment of
            multicomponent corepressor complexes that include CtBP and HDACs.
            This encoded protein may play a role in hematopoiesis. Multiple
            alternatively spliced transcripts have been described for this gene
            but the full-length nature of some of them has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.946526.1,
                                           SRR18074967.3139489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               DC333611.1         40-377
            339-580             AC002433.2         6223-6464           c
            581-731             AC002433.2         1259-1409           c
            732-760             AC002433.2         201-229             c
            761-858             AC002124.2         100826-100923       c
            859-980             AC002124.2         98439-98560         c
            981-1096            AC002124.2         57726-57841         c
            1097-1219           AC002124.2         47675-47797         c
            1220-1433           AC002124.2         44470-44683         c
            1434-1651           AC002124.2         43785-44002         c
            1652-1915           AC002124.2         25992-26255         c
            1916-2093           AC002088.2         50338-50515         c
            2094-2227           AC002088.2         28957-29090         c
            2228-2348           AC002088.2         15818-15938         c
            2349-2398           AC002088.2         10940-10989         c
            2399-2506           AC002410.2         80660-80767         c
            2507-2562           AC002410.2         44896-44951         c
            2563-2650           AC002410.2         44564-44651         c
            2651-2770           AC002410.2         38526-38645         c
            2771-2868           AC002410.2         38115-38212         c
            2869-2987           AC004994.1         79647-79765         c
            2988-3121           AC004994.1         18301-18434         c
            3122-3206           AC004744.1         85392-85476         c
            3207-3354           AC004744.1         63669-63816         c
            3355-9155           AC004744.1         37799-43599         c
            9156-9748           BQ575888.1         15-607              c
FEATURES             Location/Qualifiers
     source          1..9748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..9748
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="histone deacetylase 9"
                     /db_xref="GeneID:9734"
                     /db_xref="HGNC:HGNC:14065"
                     /db_xref="MIM:606543"
     exon            1..275
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            276..338
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..3394
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /EC_number="3.5.1.98"
                     /note="isoform 20 is encoded by transcript variant 20;
                     MEF-2 interacting transcription repressor (MITR) protein;
                     histone deacetylase 7B; histone deacetylase 4/5-related
                     protein"
                     /codon_start=1
                     /product="histone deacetylase 9 isoform 20"
                     /protein_id="NP_001308806.1"
                     /db_xref="CCDS:CCDS83163.1"
                     /db_xref="GeneID:9734"
                     /db_xref="HGNC:HGNC:14065"
                     /db_xref="MIM:606543"
                     /translation="MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREK
                     QLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQEL
                     LEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSAT
                     KDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPL
                     RKTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMN
                     LLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPAS
                     SSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPG
                     IRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKS
                     IEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKE
                     EPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVS
                     RTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIW
                     SRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQ
                     KFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPG
                     HHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILY
                     ISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKP
                     VAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGG
                     HDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRM
                     VAVPRGCALAGAQLQEETETVSALASLTVDVEQPFAQEDSRTAGEPMEEEPAL"
     exon            339..580
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            581..731
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            732..858
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            859..980
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1096
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1219
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1433
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1651
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1915
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2093
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2227
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2348
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2398
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2506
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2562
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2650
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2770
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2868
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2987
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3121
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3206
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3354
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..9748
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9725..9730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="hexamer: AATAAA"
     polyA_site      9748
                     /gene="HDAC9"
                     /gene_synonym="ARCND4; HD7; HD7b; HD9; HDAC; HDAC7;
                     HDAC7B; HDAC9B; HDAC9FL; HDRP; MITR"
                     /note="major polyA site"
ORIGIN      
        1 gaagagaggc acagacacag ataggagaag ggcaccggct ggagccactt gcaggactga
       61 gggtttttgc aacaaaaccc tagcagcctg aagaactcta agccaggttt aattggtttc
      121 tttttctcgt gggtagactt aataattttc tacgtattct gacaaagaaa taaccccgaa
      181 gcacgttcct atttcccacc tgcttgtagt ttccgggata acctaaactc cagagagcta
      241 tagcatccac tctgtccttt ctgctttgca cacagatggg gtggctggac gagagcagct
      301 cttggctcag caaagaatgc acagtatgat cagctcagtg gatgtgaagt cagaagttcc
      361 tgtgggcctg gagcccatct cacctttaga cctaaggaca gacctcagga tgatgatgcc
      421 cgtggtggac cctgttgtcc gtgagaagca attgcagcag gaattacttc ttatccagca
      481 gcagcaacaa atccagaagc agcttctgat agcagagttt cagaaacagc atgagaactt
      541 gacacggcag caccaggctc agcttcagga gcatatcaag ttgcaacagg aacttctagc
      601 cataaaacag caacaagaac tcctagaaaa ggagcagaaa ctggagcagc agaggcaaga
      661 acaggaagta gagaggcatc gcagagaaca gcagcttcct cctctcagag gcaaagatag
      721 aggacgagaa agggcagtgg caagtacaga agtaaagcag aagcttcaag agttcctact
      781 gagtaaatca gcaacgaaag acactccaac taatggaaaa aatcattccg tgagccgcca
      841 tcccaagctc tggtacacgg ctgcccacca cacatcattg gatcaaagct ctccacccct
      901 tagtggaaca tctccatcct acaagtacac attaccagga gcacaagatg caaaggatga
      961 tttccccctt cgaaaaactg aatcctcagt cagtagcagt tctccaggct ctggtcccag
     1021 ttcaccaaac aatgggccaa ctggaagtgt tactgaaaat gagacttcgg ttttgccccc
     1081 tacccctcat gccgagcaaa tggtttcaca gcaacgcatt ctaattcatg aagattccat
     1141 gaacctgcta agtctttata cctctccttc tttgcccaac attaccttgg ggcttcccgc
     1201 agtgccatcc cagctcaatg cttcgaattc actcaaagaa aagcagaagt gtgagacgca
     1261 gacgcttagg caaggtgttc ctctgcctgg gcagtatgga ggcagcatcc cggcatcttc
     1321 cagccaccct catgttactt tagagggaaa gccacccaac agcagccacc aggctctcct
     1381 gcagcattta ttattgaaag aacaaatgcg acagcaaaag cttcttgtag ctggtggagt
     1441 tcccttacat cctcagtctc ccttggcaac aaaagagaga atttcacctg gcattagagg
     1501 tacccacaaa ttgccccgtc acagacccct gaaccgaacc cagtctgcac ctttgcctca
     1561 gagcacgttg gctcagctgg tcattcaaca gcaacaccag caattcttgg agaagcagaa
     1621 gcaataccag cagcagatcc acatgaacaa actgctttcg aaatctattg aacaactgaa
     1681 gcaaccaggc agtcaccttg aggaagcaga ggaagagctt cagggggacc aggcgatgca
     1741 ggaagacaga gcgccctcta gtggcaacag cactaggagc gacagcagtg cttgtgtgga
     1801 tgacacactg ggacaagttg gggctgtgaa ggtcaaggag gaaccagtgg acagtgatga
     1861 agatgctcag atccaggaaa tggaatctgg ggagcaggct gcttttatgc aacagccttt
     1921 cctggaaccc acgcacacac gtgcgctctc tgtgcgccaa gctccgctgg ctgcggttgg
     1981 catggatgga ttagagaaac accgtctcgt ctccaggact cactcttccc ctgctgcctc
     2041 tgttttacct cacccagcaa tggaccgccc cctccagcct ggctctgcaa ctggaattgc
     2101 ctatgacccc ttgatgctga aacaccagtg cgtttgtggc aattccacca cccaccctga
     2161 gcatgctgga cgaatacaga gtatctggtc acgactgcaa gaaactgggc tgctaaataa
     2221 atgtgagcga attcaaggtc gaaaagccag cctggaggaa atacagcttg ttcattctga
     2281 acatcactca ctgttgtatg gcaccaaccc cctggacgga cagaagctgg accccaggat
     2341 actcctaggt gatgactctc aaaagttttt ttcctcatta ccttgtggtg gacttggggt
     2401 ggacagtgac accatttgga atgagctaca ctcgtccggt gctgcacgca tggctgttgg
     2461 ctgtgtcatc gagctggctt ccaaagtggc ctcaggagag ctgaagaatg ggtttgctgt
     2521 tgtgaggccc cctggccatc acgctgaaga atccacagcc atggggttct gcttttttaa
     2581 ttcagttgca attaccgcca aatacttgag agaccaacta aatataagca agatattgat
     2641 tgtagatctg gatgttcacc atggaaacgg tacccagcag gccttttatg ctgaccccag
     2701 catcctgtac atttcactcc atcgctatga tgaagggaac tttttccctg gcagtggagc
     2761 cccaaatgag gttggaacag gccttggaga agggtacaat ataaatattg cctggacagg
     2821 tggccttgat cctcccatgg gagatgttga gtaccttgaa gcattcagga ccatcgtgaa
     2881 gcctgtggcc aaagagtttg atccagacat ggtcttagta tctgctggat ttgatgcatt
     2941 ggaaggccac acccctcctc taggagggta caaagtgacg gcaaaatgtt ttggtcattt
     3001 gacgaagcaa ttgatgacat tggctgatgg acgtgtggtg ttggctctag aaggaggaca
     3061 tgatctcaca gccatctgtg atgcatcaga agcctgtgta aatgcccttc taggaaatga
     3121 gctggagcca cttgcagaag atattctcca ccaaagcccg aatatgaatg ctgttatttc
     3181 tttacagaag atcattgaaa ttcaaagcaa gtattggaag tcagtaagga tggtggctgt
     3241 gccaaggggc tgtgctctgg ctggtgctca gttgcaagag gagacagaga ccgtttctgc
     3301 cctggcctcc ctaacagtgg atgtggaaca gccctttgct caggaagaca gcagaactgc
     3361 tggtgagcct atggaagagg agccagcctt gtgaagtgcc aagtccccct ctgatatttc
     3421 ctgtgtgtga catcattgtg tatcccccca ccccagtacc ctcagacatg tcttgtctgc
     3481 tgcctgggtg gcacagattc aatggaacat aaacactggg cacaaaattc tgaacagcag
     3541 cttcacttgt tctttggatg gacttgaaag ggcattaaag attccttaaa cgtaaccgct
     3601 gtgattctag agttacagta aaccacgatt ggaagaaact gcttccagca tgcttttaat
     3661 atgctgggtg acccactcct agacaccaag tttgaactag aaacattcag tacagcacta
     3721 gatattgtta atttcagaag ctatgacagc cagtgaaatt ttgggcaaaa cctgagacat
     3781 agtcattcct gacattctga tcagcttttt ttggggtaat ttgtttttca aacagtctta
     3841 acttgtttac aagatttgct tttagctatg aacggatcgt aattccaccc agaatgtaat
     3901 gtttcttgtt tgtttgtttt gttttgttag ggtttttttc tcaactttaa cacacagttc
     3961 aactgttcct agtaaaagtt caagatggag gaactagcat gaggcttttt tcagtatctc
     4021 gaagtccaaa tgccaaagga acctcacaca ctgtttgtaa tggtgcaata ttttatatca
     4081 ctttttttta aacatcccca acatctttgt gttctcacac acaggcaatt tgcaatgttg
     4141 caattgtgtt ggagaatgaa gtccccccac ctcccagcca cacacacatc ctttgttctc
     4201 atgacagtag gtctgagcaa atgttccacc aagcattttc agtgtctttg aaaagcacgt
     4261 aacttttcaa aggtggtctt aatttgttgc atatctatca aggacttatt cactcacctt
     4321 tccttttctg ccctctatca attgatttct tcttaccttt catcattcat tccttccttt
     4381 agaaaaactg aagattaccc ataatctcct cttattactt gagggccttg actatttagt
     4441 ttattttgtt tactttacag gttaacacag ttgttttgtc tgattgcatt ttattaactg
     4501 tgaagccgtt gaaatgaata tcacttaagc aacgttgcta aatttctatg tgtttgaaat
     4561 gtgttaatga aggcactgct tatttgtagt caccttgaac tgacttaacc tagaagctgt
     4621 gccttcttgt gaaaaaaaaa aaaaacaaaa acaaaaaaca gcctttaaac aagtttcctt
     4681 agtgtcaaaa gttaaaaata aaggacattt atttctgaga taaaaagtaa cttactaaat
     4741 ataagtaggt tatcctccta cctcctaaaa ttcgatttca acatataact caaacaccta
     4801 aacatattga ggtagaatat ctcacagtat ttaatatctg acaatgcttt tgaaagagtt
     4861 gatgtttctt tttatatatt tttctaactc aaaggatata ttaaagccat aagtgaagat
     4921 tgtcatgctt ttattcagaa atctgaaaga aaccttaatt aaaacaaggt tttagggaag
     4981 gccatgatat gaaagatatg gaacaatatg gttttagtta gagaggactc taacctgtaa
     5041 atcaaagatg aaagatttca ctcaagtaga attatataac tccctttgtt atacagtcag
     5101 accatatttt tcatgcattt ggttttttta ggattaccat tttaatttta aagactttta
     5161 ttacatatac aaaaatggct caatacttgg tttaacttct tagaaatttg agacaccctt
     5221 tgaaatagga aatctgaaat ggaatgtaac ttagtattag gtaaaaattg ctttcattgc
     5281 gtaagggcaa attcagtcta gattcatagt agtaatcaat tttttataaa ttttattttc
     5341 atgagaaatt cataccaatc atatttgcta gcttatgtta ttttgcagtg attgcttgag
     5401 gatatttact taaaaaaata gtagagccaa aggcttaaca aaagactctc ccccatttta
     5461 aaaaggaaac tcatgtttta attagaaaaa taattgtgta gttttaaaat caacttcata
     5521 attataaatc tctgtcatta ctttttagtc ctcccagata tttttttagt tgttgaataa
     5581 gaaaataaaa cagtgtaatg caaacatgct aatttactaa agtttcctac aacagtttag
     5641 ccacatgttt atgccaagcc attaatctga taaagccaaa tcactaggac atctccatgg
     5701 ttatttagat ttaaaacttg acacattaat gagttaatca cacatactcc catatgacac
     5761 catacccaat tggttgcact tagagtcttt aaaatacctg gagaagcaaa tgaactgtgg
     5821 agaggattat ccacagcatg tagttgtaag aacagaatgc cattgctttt tgattatacc
     5881 attacaagat ggagcatagc cctgagggac agaatggagg ctttccgaaa atatcaacac
     5941 ttcttttgaa atagaccagc actttttgaa agggtagttt cacttggtat agtttttctt
     6001 cacttacccg tttaaatttt attgctcgca gttgttctga atgagaggct agaagagtat
     6061 tatcaatttt gcatctcctt gtgatactta ctttgaagga aaatcacata cgctctctca
     6121 tggtctcatg gtatctcata cagggtgaat aaaaatgatt tttgataaat ctactagtaa
     6181 ataatactag gaatttaata agctgtcaaa cgtaggtata aaaagaaggc ttaaaaatta
     6241 attttcccaa ttgtataatt tggggctgta tattaaacta aaaaacacag acagttttat
     6301 taaatagtaa ccaaaatgga ctcaaataaa accagaggct atgttaccat tgcttagtaa
     6361 atggaaagaa cattgtgaga tgaactatct ttaaatattg taacaagttt ataacatcaa
     6421 tagtggagac agaagtcagc tttggagaaa atagagatat ttatgaaaaa actactacaa
     6481 atcacatttc cattaccaat cctggggatg gaaatattgc cttcagtttt tactccagcc
     6541 ctatacgaca ctctcactaa cctttcactg acaacatcat ggccttgaaa gcagggatct
     6601 cctcccacaa aggcttcaga aattacagga ctggtctctc ttaatagttt agtcctgctt
     6661 tatttccaaa gggcaattat aaagcctcgt ggatttactg ggtttcttta cagactccat
     6721 atggaagtaa aatagaatga tcatttggaa agtctcctgg gaaaaaattc ctcttcaatc
     6781 agcattttaa aactttttta tttttgagtc agagttttgc tcttggtgcc caggctggag
     6841 tgcaatggcg caatctcgac tcactgcaac ctccgcctcc cgggttcaag caattctcct
     6901 gacgagtagc tgggcatgcg ccaccacgtc tggctaattt ttgtattttt agtagagacg
     6961 gggtttctcc atgttggtca ggctggtctc aaactcccga cctcaggtga tccgcccgcc
     7021 tcggcctccc aaagtgctga aattacaggt gtgagccact gcacccggcc aaacttattg
     7081 ttttaatccc agcatttatg tttagaagaa ttaatttaaa tatttcttac tatttctctg
     7141 tcgaatgttt actctcatct tatctcaatg aaagaagtat taaaagtctt atggccccaa
     7201 aagaaacaag ccaaactgta ctgtcttaaa agtgattcat tctgagcttg aaacgactct
     7261 gtcagtgttt gacattgtca tttctagtgg catgtatctt aacattcttt tcctgcttca
     7321 ggaatgaaat cacttgtcct gctgagaaaa taaggggaaa acaagataga agtaaaaaac
     7381 aacacacctg ttgaactatt ttcataaaga tggcgttttc actttcaaaa gaaatgaaaa
     7441 ccagatggtc tatgctaaga agtgaaggca ttttgttgtc ttcagaactg atcaacatgg
     7501 tcatgatcat catcaaattt cttgtttcca aaggccacta ttgtagtaca gtctccagca
     7561 ggattttgta ccatgtgctg cctttggaat aaagtattat aatgtatctt gtcaccttca
     7621 tcaacaccac cattaaatat gtaagttcct atatgtgact ttttctgggc atatttgcat
     7681 caaaaatcac agtccttgcc tccttgcttg cttttactcc atgaaacgct tcatgaagca
     7741 gagcatgatt gtcaagtgac cagaggatga catttgtaag tgaacgtggt atactcacac
     7801 atgctatact catactacat aacttagttt ctccaaatca actgcagtcc gttttatcta
     7861 tgatattcct ggcttcgtat aatggttttg taaaatacat taaatacaat taagtccgtt
     7921 attactatgc tggaaataac taggtcagac aatgaaacct tagacttttg attggggctg
     7981 tttggacttg atccaatgat aaggtaataa ggttgttgca atttctcaaa gcatcttaat
     8041 tctcaaactg aaacatttag caaatacatg gtgaatctgg tgtaaactta caatctaaca
     8101 aataattttc tttcaactct tctctttttc tgcctaacaa tctatacgaa attgccaata
     8161 tctaagcaat caaaagtttc tgaaatctct gtttccttag tagaaatgac cttgacaact
     8221 tattttctga gataccacta ggcctactgt ctttcatgcc attttatata aacattttga
     8281 tagatactct gtcttttgtt ttttatctct tctcttttca agagtcactt gactttttca
     8341 aatattctta aaagatagat ttagttattg tattttggtc tacaattttg gacttggcag
     8401 tttgttttac taatgcagaa ttattctttt tgtttcaaac atagtttgcc atcatctggc
     8461 tactacctaa tcatgttgta ctagttattg tggaaagaaa attgtacata catttccttg
     8521 tcctttggga gatgtctttg agtcaaaccc acaagcatga actctcacct gaaagaaaac
     8581 tggaaaagga gaaactttaa atcagtatgt tttgaaagga agagatttcc agacttttta
     8641 aagcaaattg gaatcgtttt atttttttgt ttgggcctta ggcacaatag aagcaaatgt
     8701 tgcaatatta aatataatag ggagagttca ctgtttcctg ggacattgtg gtcatgtcct
     8761 taatccttca ttgtgatgcc ccttcttgga gttggcattt tgtgacaatt catagagatc
     8821 ttgcagcaat atttggctat tggttttatt aacttaaaat tcaacagaaa tggagtaatt
     8881 aaaaaaaaaa acaaaaaaca gagaagaatt gcaaaatctg aagtggaatg gcacttcctt
     8941 gggtatgtaa gggttgtttt tagataaaac tcccgatttg ttcttcctac actttaatag
     9001 tctcaaattc tttctgggga agcaacgtca gtgtctacct ccacagtaac tatgatatag
     9061 gaaattgtcc tttcagtggt ttctaggtat aacaaacaag ccgttaaaaa tgagtgacca
     9121 ttttgtaggt tacagcctca gcaatctgtg tcatttgaaa gcaaatatcc tgatattttt
     9181 aaataaggtg agcagggcag gcaggaaacc aatatttagt acttttgtga ttaaacattc
     9241 tagaccaggc ttgttgatat gtatgccaat agcctagaat ttttggctta gtgtaaaata
     9301 aaaatgtctt ttctattgtg gtctgatatc cgtttctgta ataagatcag tttgttgtcc
     9361 tctgtgcacc agtggttttg cccttaattt tttttggcta gcatcaccaa gatctgtcat
     9421 ccagagctgc tgagaaaaat acatgttgcc aaacttttct taaaattgtg ctgccagtgg
     9481 tattttccca gatgtgaaaa ataataatct aataaaggat taatatctaa taacaatacc
     9541 attgttgaac atgctcatgg aatgtccacc ttcttctgat tccttttttg tatttgaaaa
     9601 tgcaatggtg tgttccaaat tattgttggt gttgttaatg tcatgactct cctttgaata
     9661 gaataaaata accccttttg ttttgtgttt tctactgaat tagattttcc tctagtccta
     9721 tgtgaataaa aagctatttg aaataaaa
//
