LOCUS       NP_060956                377 aa            linear   PRI 27-APR-2025
DEFINITION  histone deacetylase 8 isoform 1 [Homo sapiens].
ACCESSION   NP_060956
VERSION     NP_060956.1
DBSOURCE    REFSEQ: accession NM_018486.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 377)
  AUTHORS   Sang,C., Li,X., Liu,J., Chen,Z., Xia,M., Yu,M. and Yu,W.
  TITLE     Reversible acetylation of HDAC8 regulates cell cycle
  JOURNAL   EMBO Rep 25 (9), 3925-3943 (2024)
   PUBMED   39043961
  REMARK    GeneRIF: Reversible acetylation of HDAC8 regulates cell cycle.
REFERENCE   2  (residues 1 to 377)
  AUTHORS   Wang,L., Bai,X., Zhang,X., Wang,X., Chen,S., Wu,S. and Lin,L.
  TITLE     Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma
            Cells via TP53 and STAT3/ERK Signaling Pathways
  JOURNAL   Ann Clin Lab Sci 53 (6), 920-930 (2023)
   PUBMED   38182151
  REMARK    GeneRIF: Activation of HDAC8 Can Suppress the Proliferation of
            Osteosarcoma Cells via TP53 and STAT3/ERK Signaling Pathways.
REFERENCE   3  (residues 1 to 377)
  AUTHORS   Vannini,A., Volpari,C., Filocamo,G., Casavola,E.C., Brunetti,M.,
            Renzoni,D., Chakravarty,P., Paolini,C., De Francesco,R.,
            Gallinari,P., Steinkuhler,C. and Di Marco,S.
  TITLE     Crystal structure of a eukaryotic zinc-dependent histone
            deacetylase, human HDAC8, complexed with a hydroxamic acid
            inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 101 (42), 15064-15069 (2004)
   PUBMED   15477595
  REMARK    GeneRIF: crystal structure
REFERENCE   4  (residues 1 to 377)
  AUTHORS   Buggy,J.J., Sideris,M.L., Mak,P., Lorimer,D.D., McIntosh,B. and
            Clark,J.M.
  TITLE     Cloning and characterization of a novel human histone deacetylase,
            HDAC8
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 199-205 (2000)
   PUBMED   10926844
REFERENCE   5  (residues 1 to 377)
  AUTHORS   Van den Wyngaert,I., de Vries,W., Kremer,A., Neefs,J.,
            Verhasselt,P., Luyten,W.H. and Kass,S.U.
  TITLE     Cloning and characterization of human histone deacetylase 8
  JOURNAL   FEBS Lett 478 (1-2), 77-83 (2000)
   PUBMED   10922473
REFERENCE   6  (residues 1 to 377)
  AUTHORS   Hu,E., Chen,Z., Fredrickson,T., Zhu,Y., Kirkpatrick,R., Zhang,G.F.,
            Johanson,K., Sung,C.M., Liu,R. and Winkler,J.
  TITLE     Cloning and characterization of a novel human class I histone
            deacetylase that functions as a transcription repressor
  JOURNAL   J Biol Chem 275 (20), 15254-15264 (2000)
   PUBMED   10748112
REFERENCE   7  (residues 1 to 377)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   8  (residues 1 to 377)
  AUTHORS   Deardorff,M.A., Noon,S.E. and Krantz,I.D.
  TITLE     Cornelia de Lange Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301283
REFERENCE   9  (residues 1 to 377)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
REFERENCE   10 (residues 1 to 377)
  AUTHORS   Wilson,M., Mulley,J., Gedeon,A., Robinson,H. and Turner,G.
  TITLE     New X-linked syndrome of mental retardation, gynecomastia, and
            obesity is linked to DXS255
  JOURNAL   Am J Med Genet 40 (4), 406-413 (1991)
   PUBMED   1746601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP229332.1, AJ277724.1 and
            BC050433.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to class I of the histone deacetylase family. It
            catalyzes the deacetylation of lysine residues in the histone
            N-terminal tails and represses transcription in large multiprotein
            complexes with transcriptional co-repressors. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: A downstream translational start codon is selected
            for this RefSeq based on a strong Kozak signal and transcript
            support. An upstream in-frame start codon is also present but has a
            weaker Kozak signal and sparse transcript support. Use of the
            upstream start codon would result in a protein that is 38 aa longer
            at the N-terminus. Leaky scanning by ribosomes may allow
            translation initiation at the downstream start codon, which is
            supported by 5'RACE experiments described in PubMed: 10922473 and
            encodes a protein with an N-terminus similar to other family
            members.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ277724.1, BC050433.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373573.9/ ENSP00000362674.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     Protein         1..377
                     /product="histone deacetylase 8 isoform 1"
                     /EC_number="3.5.1.98"
                     /note="histone deacetylase-like 1; protein deacetylase
                     HDAC8; protein decrotonylase HDAC8"
                     /calculated_mol_wt=41627
     Region          14..324
                     /region_name="Histone deacetylase"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BY41.2)"
     Region          16..377
                     /region_name="HDAC8"
                     /note="Histone deacetylase 8 (HDAC8); cd10000"
                     /db_xref="CDD:212524"
     Site            39
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:15242608; propagated from
                     UniProtKB/Swiss-Prot (Q9BY41.2)"
     Site            order(100..101,141..143,151..152,178,180,208,267,274,304,
                     306)
                     /site_type="active"
                     /db_xref="CDD:212524"
     CDS             1..377
                     /gene="HDAC8"
                     /gene_synonym="CDA07; CDLS5; HD8; HDACL1; KDAC8; MRXS6;
                     RPD3; WTS"
                     /coded_by="NM_018486.3:83..1216"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS14420.1"
                     /db_xref="GeneID:55869"
                     /db_xref="HGNC:HGNC:13315"
                     /db_xref="MIM:300269"
ORIGIN      
        1 meepeepads gqslvpvyiy speyvsmcds lakipkrasm vhslieayal hkqmrivkpk
       61 vasmeematf htdaylqhlq kvsqegdddh pdsieyglgy dcpategifd yaaaiggati
      121 taaqclidgm ckvainwsgg whhakkdeas gfcylndavl gilrlrrkfe rilyvdldlh
      181 hgdgvedafs ftskvmtvsl hkfspgffpg tgdvsdvglg kgryysvnvp iqdgiqdeky
      241 yqicesvlke vyqafnpkav vlqlgadtia gdpmcsfnmt pvgigkclky ilqwqlatli
      301 lggggynlan tarcwtyltg vilgktlsse ipdhefftay gpdyvleitp scrpdrneph
      361 riqqilnyik gnlkhvv
//
