LOCUS       NM_015401               4213 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 1,
            mRNA.
ACCESSION   NM_015401 NM_001098415
VERSION     NM_015401.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4213)
  AUTHORS   Maciejewski,K., Giers,M., Oleksiewicz,U. and Czerwinska,P.
  TITLE     The Epigenetic Modifiers HDAC2 and HDAC7 Inversely Associate with
            Cancer Stemness and Immunity in Solid Tumors
  JOURNAL   Int J Mol Sci 25 (14), 7841 (2024)
   PUBMED   39063083
  REMARK    GeneRIF: The Epigenetic Modifiers HDAC2 and HDAC7 Inversely
            Associate with Cancer Stemness and Immunity in Solid Tumors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4213)
  AUTHORS   Lu,W., Zhuang,G., Guan,Y., Li,Y., Liu,L. and Xiao,M.
  TITLE     Comprehensive analysis of HDAC7 expression and its prognostic value
            in diffuse large B cell lymphoma: A review
  JOURNAL   Medicine (Baltimore) 102 (45), e34577 (2023)
   PUBMED   37960766
  REMARK    GeneRIF: Comprehensive analysis of HDAC7 expression and its
            prognostic value in diffuse large B cell lymphoma: A review.
            Review article
REFERENCE   3  (bases 1 to 4213)
  AUTHORS   Ling,S., Chen,T., Wang,S., Zhang,W., Zhou,R., Xia,X., Yao,Z.,
            Fan,Y., Ning,S., Liu,J., Qin,L., Tucker,H.O., Wang,N. and Guo,X.
  TITLE     Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of
            mesenchymal stem cells
  JOURNAL   Stem Cell Res Ther 14 (1), 188 (2023)
   PUBMED   37507770
  REMARK    GeneRIF: Deacetylation of FOXP1 by HDAC7 potentiates self-renewal
            of mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4213)
  AUTHORS   Zhang,X.L., Chen,X.H., Xu,B., Chen,M., Zhu,S., Meng,N., Wang,J.Z.,
            Zhu,H., Chen,D., Liu,J.B. and Yan,G.R.
  TITLE     K235 acetylation couples with PSPC1 to regulate the m6A
            demethylation activity of ALKBH5 and tumorigenesis
  JOURNAL   Nat Commun 14 (1), 3815 (2023)
   PUBMED   37369679
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4213)
  AUTHORS   Ma,Z.Q., Feng,Y.T., Guo,K., Liu,D., Shao,C.J., Pan,M.H.,
            Zhang,Y.M., Zhang,Y.X., Lu,D., Huang,D., Zhang,F., Wang,J.L.,
            Yang,B., Han,J., Yan,X.L. and Hu,Y.
  TITLE     Melatonin inhibits ESCC tumor growth by mitigating the
            HDAC7/beta-catenin/c-Myc positive feedback loop and suppressing the
            USP10-maintained HDAC7 protein stability
  JOURNAL   Mil Med Res 9 (1), 54 (2022)
   PUBMED   36163081
  REMARK    GeneRIF: Melatonin inhibits ESCC tumor growth by mitigating the
            HDAC7/beta-catenin/c-Myc positive feedback loop and suppressing the
            USP10-maintained HDAC7 protein stability.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4213)
  AUTHORS   Lemercier,C., Brocard,M.P., Puvion-Dutilleul,F., Kao,H.Y.,
            Albagli,O. and Khochbin,S.
  TITLE     Class II histone deacetylases are directly recruited by BCL6
            transcriptional repressor
  JOURNAL   J Biol Chem 277 (24), 22045-22052 (2002)
   PUBMED   11929873
  REMARK    GeneRIF: Class II histone deacetylases are directly recruited by
            BCL6 transcriptional repressor
REFERENCE   7  (bases 1 to 4213)
  AUTHORS   Fischle,W., Dequiedt,F., Fillion,M., Hendzel,M.J., Voelter,W. and
            Verdin,E.
  TITLE     Human HDAC7 histone deacetylase activity is associated with HDAC3
            in vivo
  JOURNAL   J Biol Chem 276 (38), 35826-35835 (2001)
   PUBMED   11466315
REFERENCE   8  (bases 1 to 4213)
  AUTHORS   Lee,H.J., Chun,M. and Kandror,K.V.
  TITLE     Tip60 and HDAC7 interact with the endothelin receptor a and may be
            involved in downstream signaling
  JOURNAL   J Biol Chem 276 (20), 16597-16600 (2001)
   PUBMED   11262386
REFERENCE   9  (bases 1 to 4213)
  AUTHORS   Marks,P.A., Richon,V.M. and Rifkind,R.A.
  TITLE     Histone deacetylase inhibitors: inducers of differentiation or
            apoptosis of transformed cells
  JOURNAL   J Natl Cancer Inst 92 (15), 1210-1216 (2000)
   PUBMED   10922406
  REMARK    Review article
REFERENCE   10 (bases 1 to 4213)
  AUTHORS   Kao,H.Y., Downes,M., Ordentlich,P. and Evans,R.M.
  TITLE     Isolation of a novel histone deacetylase reveals that class I and
            class II deacetylases promote SMRT-mediated repression
  JOURNAL   Genes Dev 14 (1), 55-66 (2000)
   PUBMED   10640276
  REMARK    GeneRIF: Characterization of the mouse HDAC7 ortholog.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC376749.1, AY302468.1 and
            BC020505.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015401.4.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene has sequence homology to members of the histone
            deacetylase family. This gene is orthologous to mouse HDAC7 gene
            whose protein promotes repression mediated via the transcriptional
            corepressor SMRT. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, also known as variant 3)
            encodes isoform a (also known as isoform c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299292.1, AY302468.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000080059.12/ ENSP00000080059.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               DC376749.1         78-516
            440-3094            AY302468.1         322-2976
            3095-4213           BC020505.2         2139-3257
FEATURES             Location/Qualifiers
     source          1..4213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..4213
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /note="histone deacetylase 7"
                     /db_xref="GeneID:51564"
                     /db_xref="HGNC:HGNC:14067"
                     /db_xref="MIM:606542"
     exon            1..137
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..3094
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /EC_number="3.5.1.98"
                     /note="isoform a is encoded by transcript variant 1;
                     histone deacetylase 7A; protein deacetylase HDAC7"
                     /codon_start=1
                     /product="histone deacetylase 7 isoform a"
                     /protein_id="NP_056216.2"
                     /db_xref="CCDS:CCDS8756.2"
                     /db_xref="GeneID:51564"
                     /db_xref="HGNC:HGNC:14067"
                     /db_xref="MIM:606542"
                     /translation="MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPMDLRV
                     GQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQE
                     QELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLE
                     TEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRK
                     ESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQE
                     TSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLE
                     PEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPL
                     SRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET
                     DGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTV
                     LLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSV
                     MLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERH
                     VLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAG
                     SVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKI
                     LIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNV
                     AWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA
                     KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQK
                     PNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGI
                     LAEDRPSEQLVEEEEPMNL"
     exon            138..188
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            189..376
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            377..467
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            468..579
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            580..695
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            696..821
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            822..913
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1024
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1205
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1402
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1576
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1796
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1930
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2051
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2101
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2209
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2265
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2353
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2473
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2571
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2690
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2824
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2909
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..3048
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..4213
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /note="hexamer: AATAAA"
     polyA_site      4213
                     /gene="HDAC7"
                     /gene_synonym="HD7; HD7A; HDAC7A"
                     /note="major polyA site"
ORIGIN      
        1 cttcctctcg ccgtctcaca gtcgctctgc agcctccggc gactgggggg atgtgaggcc
       61 ggcgccccag ccccccgccc cgccatgagc cccccgctct gagggccccg gcccctggat
      121 gcacagcccc ggcgctgatg ggacccaggt gagcccgggt gcccactact gcagccccac
      181 tggcgcaggc tgccccaggc cctgtgcaga cacaccaggc cctcagccgc agcccatgga
      241 cctgcgggtg ggccagcggc ccccagtgga gcccccacca gagcccacat tgctggccct
      301 gcagcgtccc cagcgcctgc accaccacct cttcctagca ggcctgcagc agcagcgctc
      361 ggtggagccc atgaggctct ccatggacac gccgatgccc gagttgcagg tgggacccca
      421 ggaacaagag ctgcggcagc ttctccacaa ggacaagagc aagcgaagtg ctgtagccag
      481 cagcgtggtc aagcagaagc tagcggaggt gattctgaaa aaacagcagg cggccctaga
      541 aagaacagtc catcccaaca gccccggcat tccctacaga accctggagc ccctggagac
      601 ggaaggagcc acccgctcca tgctcagcag ctttttgcct cctgttccca gcctgcccag
      661 tgacccccca gagcacttcc ctctgcgcaa gacagtctct gagcccaacc tgaagctgcg
      721 ctataagccc aagaagtccc tggagcggag gaagaatcca ctgctccgaa aggagagtgc
      781 gccccccagc ctccggcggc ggcccgcaga gaccctcgga gactcctccc caagtagtag
      841 cagcacgccc gcatcagggt gcagctcccc caatgacagc gagcacggcc ccaatcccat
      901 cctgggctcg gaggcgctct tgggccagcg gctgcggctg caggagactt ctgtggcccc
      961 gttcgccttg ccgacagtgt ccttgctgcc cgcaatcact ctggggctgc ccgcccctgc
     1021 cagggctgac agtgaccgca ggacccatcc gactctgggc cctcgggggc caatcctggg
     1081 gagcccccac actcccctct tcctgcccca tggcttggag cccgaggctg ggggcacctt
     1141 gccctctcgc ctgcagccca ttctcctcct ggacccctca ggctctcatg ccccgctgct
     1201 gactgtgccc gggcttgggc ccttgccctt ccactttgcc cagtccttaa tgaccaccga
     1261 gcggctctct gggtcaggcc tccactggcc actgagccgg actcgctcag agcccctgcc
     1321 ccccagtgcc accgctcccc caccgccggg ccccatgcag ccccgcctgg agcagctcaa
     1381 aactcacgtc caggtgatca agaggtcagc caagccgagt gagaagcccc ggctgcggca
     1441 gataccctcg gctgaagacc tggagacaga tggcggggga ccgggccagg tggtggacga
     1501 tggcctggag cacagggagc tgggccatgg gcagcctgag gccagaggcc ccgctcctct
     1561 ccagcagcac cctcaggtgt tgctctggga acagcagcga ctggctgggc ggctcccccg
     1621 gggcagcacc ggggacactg tgctgcttcc tctggcccag ggtgggcacc ggcctctgtc
     1681 ccgggctcag tcttccccag ccgcacctgc ctcactgtca gccccagagc ctgccagcca
     1741 ggcccgagtc ctctccagct cagagacccc tgccaggacc ctgcccttca ccacagggct
     1801 gatctatgac tcggtcatgc tgaagcacca gtgctcctgc ggtgacaaca gcaggcaccc
     1861 ggagcacgcc ggccgcatcc agagcatctg gtcccggctg caggagcggg ggctccggag
     1921 ccagtgtgag tgtctccgag gccggaaggc ctccctggaa gagctgcagt cggtccactc
     1981 tgagcggcac gtgctcctct acggcaccaa cccgctcagc cgcctcaaac tggacaacgg
     2041 gaagctggca gggctcctgg cacagcggat gtttgtgatg ctgccctgtg gtggggttgg
     2101 ggtggacact gacaccatct ggaatgagct tcattcctcc aatgcagccc gctgggccgc
     2161 tggcagtgtc actgacctcg ccttcaaagt ggcttctcgt gagctaaaga atggtttcgc
     2221 tgtggtgcgg cccccaggac accatgcaga tcattcaaca gccatgggct tctgcttctt
     2281 caactcagtg gccatcgcct gccggcagct gcaacagcag agcaaggcca gcaagatcct
     2341 cattgtagac tgggacgtgc accatggcaa cggcacccag caaaccttct accaagaccc
     2401 cagtgtgctc tacatctccc tgcatcgcca tgacgacggc aacttcttcc cggggagtgg
     2461 ggctgtggat gaggtagggg ctggcagcgg tgagggcttc aatgtcaatg tggcctgggc
     2521 tggaggtctg gaccccccca tgggggatcc tgagtacctg gctgctttca ggatagtcgt
     2581 gatgcccatc gcccgagagt tctctccaga cctagtcctg gtgtctgctg gatttgatgc
     2641 tgctgagggt cacccggccc cactgggtgg ctaccatgtt tctgccaaat gttttggata
     2701 catgacgcag caactgatga acctggcagg aggcgcagtg gtgctggcct tggagggtgg
     2761 ccatgacctc acagccatct gtgacgcctc tgaggcctgt gtggctgctc ttctgggtaa
     2821 cagggtggat cccctttcag aagaaggctg gaaacagaaa cccaacctca atgccatccg
     2881 ctctctggag gccgtgatcc gggtgcacag taaatactgg ggctgcatgc agcgcctggc
     2941 ctcctgtcca gactcctggg tgcctagagt gccaggggct gacaaagaag aagtggaggc
     3001 agtgaccgca ctggcgtccc tctctgtggg catcctggct gaagataggc cctcggagca
     3061 gctggtggag gaggaagaac ctatgaatct ctaaggctct ggaaccatct gcccgcccac
     3121 catgcccttg ggacctggtt ctcttctaac ccctggcaat agcccccatt cctgggtctt
     3181 tagagatcct gtgggcaagt agttggaacc agagaacagc ctgcctgctt tgacagttat
     3241 cccagggagc gtgagaaaat ccctgggtct agaatgggaa ctggagagga ccctgagagg
     3301 agacgggctg ggcggcgacc cccacagggc tctcgagaac agattctccc ctccagtatg
     3361 ggccctggct gtggccccca ttcctcagga ctgcacagag gaggactggc tccggctccg
     3421 tcgggctcac ccttaaccac tattcctggc tctgcaaacc ccagactttg cacacagcct
     3481 caggctccac acagaaatgt gaacttggcc tcagacaggc tggcccttcc taggctctag
     3541 gggctagggg ggagtgggga gccaagaggt cccatattcc tgagtgcagg ggtagtccct
     3601 ctcacctgct tcctcagacg actctggaag cttccctcta ccactgggca ctgagacgaa
     3661 gctccctgac agccgagact ggcagccctc catctggtcc gtaccctcgc cagaggcccc
     3721 cctacatcaa cctcctggcg atgccctggt ggagcagatg ggtgctctgg gagtcctgtg
     3781 cttcctgatc caatggtgcc aaacccttca tctccccaag aagcgcagca tacccctggg
     3841 acccctcggc cactgcccac tcggggagcc ttctctgttt ctggggcctc ccccaccata
     3901 gctctgattc ccaccccaca taggagtagc ctgactgagg gggaaggggt gggagagaag
     3961 atacagacat ggaggagggg aggctgctct ggcaaagtct tcaaggcttt tgggggtcca
     4021 ggcctggggt caagaaggaa aatgtgtgtg agcatgtgtg tgagtgaggc gtgtgtgtga
     4081 gcgtgtgtgt gagtgaggcg tgtgtgtgtg tctttcctag gacccaccat accctgtgta
     4141 tgtatgcatg tttttgtaaa aaggaagaaa atggaaaaaa atctgaacaa taaatgtttt
     4201 atttgcttta aaa
//
