LOCUS       NM_006044               4118 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens histone deacetylase 6 (HDAC6), transcript variant 5,
            mRNA.
ACCESSION   NM_006044
VERSION     NM_006044.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4118)
  AUTHORS   Leslie,K.A., Lekka,C., Richardson,S.J., Russell,M.A. and
            Morgan,N.G.
  TITLE     Regulation of STAT1 Signaling in Human Pancreatic beta-Cells by the
            Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1
            Diabetes?
  JOURNAL   Diabetes 73 (9), 1473-1485 (2024)
   PUBMED   38869827
  REMARK    GeneRIF: Regulation of STAT1 Signaling in Human Pancreatic
            beta-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic
            Opportunity in Type 1 Diabetes?
REFERENCE   2  (bases 1 to 4118)
  AUTHORS   Rana,P.S., Ignatz-Hoover,J.J., Kim,B.G., Malek,E., Federov,Y.,
            Adams,D., Chan,T. and Driscoll,J.J.
  TITLE     HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the
            Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
  JOURNAL   Cancer Res Commun 4 (6), 1517-1532 (2024)
   PUBMED   38747592
  REMARK    GeneRIF: HDAC6 Inhibition Releases HR23B to Activate Proteasomes,
            Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma
            Activity.
REFERENCE   3  (bases 1 to 4118)
  AUTHORS   Luo,C., Wen,B., Liu,J. and Yang,W.
  TITLE     HDAC6-mediated deacetylation of FLOT2 maintains stability and
            tumorigenic function of FLOT2 in nasopharyngeal carcinoma
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 49 (5), 687-697 (2024)
   PUBMED   39174882
  REMARK    GeneRIF: HDAC6-mediated deacetylation of FLOT2 maintains stability
            and tumorigenic function of FLOT2 in nasopharyngeal carcinoma.
REFERENCE   4  (bases 1 to 4118)
  AUTHORS   Zhang,T., Tong,Y., Zhu,R., Liang,Y., Zhang,J., Hu,C., He,M., Hu,Z.,
            Shen,Z., Niu,J., Zhang,J., Yu,Y., Jin,B., Lei,S., Zeng,Z., Wu,Y.,
            Cheng,Z., Xiao,Z., Guo,B., Zhao,S., Xu,G., Pan,W. and Chen,T.
  TITLE     HDAC6-dependent deacetylation of NGF dictates its ubiquitination
            and maintains primordial follicle dormancy
  JOURNAL   Theranostics 14 (6), 2345-2366 (2024)
   PUBMED   38646645
  REMARK    GeneRIF: HDAC6-dependent deacetylation of NGF dictates its
            ubiquitination and maintains primordial follicle dormancy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4118)
  AUTHORS   Zhao,W., Wu,Y., Wang,S., Zhao,F., Liu,W., Xue,Z., Zhang,L.,
            Wang,J., Han,M., Li,X. and Huang,B.
  TITLE     HTRA1 promotes EMT through the HDAC6/Ac-alpha-tubulin pathway in
            human GBM cells
  JOURNAL   CNS Neurosci Ther 30 (2), e14605 (2024)
   PUBMED   38334007
  REMARK    GeneRIF: HTRA1 promotes EMT through the HDAC6/Ac-alpha-tubulin
            pathway in human GBM cells.
REFERENCE   6  (bases 1 to 4118)
  AUTHORS   Mahlknecht,U., Schnittger,S., Landgraf,F., Schoch,C., Ottmann,O.G.,
            Hiddemann,W. and Hoelzer,D.
  TITLE     Assignment of the human histone deacetylase 6 gene (HDAC6) to X
            chromosome p11.23 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 135-136 (2001)
   PUBMED   11474198
REFERENCE   7  (bases 1 to 4118)
  AUTHORS   Huynh,K.D., Fischle,W., Verdin,E. and Bardwell,V.J.
  TITLE     BCoR, a novel corepressor involved in BCL-6 repression
  JOURNAL   Genes Dev 14 (14), 1810-1823 (2000)
   PUBMED   10898795
REFERENCE   8  (bases 1 to 4118)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
REFERENCE   9  (bases 1 to 4118)
  AUTHORS   Pazin,M.J. and Kadonaga,J.T.
  TITLE     What's up and down with histone deacetylation and transcription?
  JOURNAL   Cell 89 (3), 325-328 (1997)
   PUBMED   9150131
  REMARK    Review article
REFERENCE   10 (bases 1 to 4118)
  AUTHORS   Wolffe,A.P.
  TITLE     Transcriptional control. Sinful repression
  JOURNAL   Nature 387 (6628), 16-17 (1997)
   PUBMED   9139815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC377684.1, AJ011972.1,
            AC231533.2 and AL137696.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_006044.3.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to class II of the histone deacetylase/acuc/apha
            family. It contains an internal duplication of two catalytic
            domains which appear to function independently of each other. This
            protein possesses histone deacetylase activity and represses
            transcription. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.144770.1,
                                           SRR1660803.117327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334136.11/ ENSP00000334061.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC377684.1         52-64
            14-3086             AJ011972.1         1-3073
            3087-3087           AC231533.2         17786-17786         c
            3088-4112           AJ011972.1         3075-4099
            4113-4118           AL137696.1         4824-4829
FEATURES             Location/Qualifiers
     source          1..4118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..4118
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /note="histone deacetylase 6"
                     /db_xref="GeneID:10013"
                     /db_xref="HGNC:HGNC:14064"
                     /db_xref="MIM:300272"
     exon            1..76
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            77..199
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..3754
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /EC_number="3.5.1.98"
                     /note="isoform b is encoded by transcript variant 5;
                     protein phosphatase 1, regulatory subunit 90;
                     tubulin-lysine deacetylase HDAC6; alpha-tubulin
                     deacetylase HDAC6; protein deacetylase HDAC6"
                     /codon_start=1
                     /product="histone deacetylase 6 isoform b"
                     /protein_id="NP_006035.2"
                     /db_xref="CCDS:CCDS14306.1"
                     /db_xref="GeneID:10013"
                     /db_xref="HGNC:HGNC:14064"
                     /db_xref="MIM:300272"
                     /translation="MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSI
                     PNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWD
                     DSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMN
                     EGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQ
                     HSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIH
                     RYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEF
                     QPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALA
                     EGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNM
                     EEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRIL
                     RIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNF
                     DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFN
                     SVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPM
                     GDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAG
                     FDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSL
                     LGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAP
                     QPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAA
                     TGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVG
                     GATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQ
                     TPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMAD
                     SMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCL
                     SCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQ
                     NKFGEDMPHPH"
     exon            200..328
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            329..417
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            418..502
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            503..543
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            544..640
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            641..738
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            739..843
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            844..912
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1039
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1105
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1165
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1255
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1362
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1430
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1599
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1728
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1897
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2031
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2100
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2293
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2443
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2618
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..3295
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3409
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3556
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3685
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     exon            3686..4118
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4095..4100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /note="hexamer: AATAAA"
     polyA_site      4118
                     /gene="HDAC6"
                     /gene_synonym="CPBHM; HD6; JM21; KDAC6; PPP1R90"
                     /note="major polyA site"
ORIGIN      
        1 ggttgaagga acggggcagt cccctgagga gcggggctgg ttgaaacgct aggggcggga
       61 tctggcggag tggaagaacc gcggcagggg ccaagcctcc tcaactatga cctcaaccgg
      121 ccaggattcc accacaacca ggcagcgaag aagtaggcag aacccccagt cgccccctca
      181 ggactccagt gtcacttcga agcgaaatat taaaaaggga gccgttcccc gctctatccc
      241 caatctagcg gaggtaaaga agaaaggcaa aatgaagaag ctcggccaag caatggaaga
      301 agacctaatc gtgggactgc aagggatgga tctgaacctt gaggctgaag cactggctgg
      361 cactggcttg gtgttggatg agcagttaaa tgaattccat tgcctctggg atgacagctt
      421 cccggaaggc cctgagcggc tccatgccat caaggagcaa ctgatccagg agggcctcct
      481 agatcgctgc gtgtcctttc aggcccggtt tgctgaaaag gaagagctga tgttggttca
      541 cagcctagaa tatattgatc tgatggaaac aacccagtac atgaatgagg gagaactccg
      601 tgtcctagca gacacctacg actcagttta tctgcatccg aactcatact cctgtgcctg
      661 cctggcctca ggctctgtcc tcaggctggt ggatgcggtc ctgggggctg agatccggaa
      721 tggcatggcc atcattaggc ctcctggaca tcacgcccag cacagtctta tggatggcta
      781 ttgcatgttc aaccacgtgg ctgtggcagc ccgctatgct caacagaaac accgcatccg
      841 gagggtcctt atcgtagatt gggatgtgca ccacggtcaa ggaacacagt tcaccttcga
      901 ccaggacccc agtgtcctct atttctccat ccaccgctac gagcagggta ggttctggcc
      961 ccacctgaag gcctctaact ggtccaccac aggtttcggc caaggccaag gatataccat
     1021 caatgtgcct tggaaccagg tggggatgcg ggatgctgac tacattgctg ctttcctgca
     1081 cgtcctgctg ccagtcgccc tcgagttcca gcctcagctg gtcctggtgg ctgctggatt
     1141 tgatgccctg caaggggacc ccaagggtga gatggccgcc actccggcag ggttcgccca
     1201 gctaacccac ctgctcatgg gtctggcagg aggcaagctg atcctgtctc tggagggtgg
     1261 ctacaacctc cgcgccctgg ctgaaggcgt cagtgcttcg ctccacaccc ttctgggaga
     1321 cccttgcccc atgctggagt cacctggtgc cccctgccgg agtgcccagg cttcagtttc
     1381 ctgtgctctg gaagcccttg agcccttctg ggaggttctt gtgagatcaa ctgagaccgt
     1441 ggagagggac aacatggagg aggacaatgt agaggagagc gaggaggaag gaccctggga
     1501 gccccctgtg ctcccaatcc tgacatggcc agtgctacag tctcgcacag ggctggtcta
     1561 tgaccaaaat atgatgaatc actgcaactt gtgggacagc caccaccctg aggtacccca
     1621 gcgcatcttg cggatcatgt gccgtctgga ggagctgggc cttgccgggc gctgcctcac
     1681 cctgacaccg cgccctgcca cagaggctga gctgctcacc tgtcacagtg ctgagtacgt
     1741 gggtcatctc cgggccacag agaaaatgaa aacccgggag ctgcaccgtg agagttccaa
     1801 ctttgactcc atctatatct gccccagtac cttcgcctgt gcacagcttg ccactggcgc
     1861 tgcctgccgc ctggtggagg ctgtgctctc aggagaggtt ctgaatggtg ctgctgtggt
     1921 gcgtccccca ggacaccacg cagagcagga tgcagcttgc ggtttttgct ttttcaactc
     1981 tgtggctgtg gctgctcgcc atgcccagac tatcagtggg catgccctac ggatcctgat
     2041 tgtggattgg gatgtccacc acggtaatgg aactcagcac atgtttgagg atgaccccag
     2101 tgtgctatat gtgtccctgc accgctatga tcatggcacc ttcttcccca tgggggatga
     2161 gggtgccagc agccagatcg gccgggctgc gggcacaggc ttcaccgtca acgtggcatg
     2221 gaacgggccc cgcatgggtg atgctgacta cctagctgcc tggcatcgcc tggtgcttcc
     2281 cattgcctac gagtttaacc cagaactggt gctggtctca gctggctttg atgctgcacg
     2341 gggggatccg ctggggggct gccaggtgtc acctgagggt tatgcccacc tcacccacct
     2401 gctgatgggc cttgccagtg gccgcattat ccttatccta gagggtggct ataacctgac
     2461 atccatctca gagtccatgg ctgcctgcac tcgctccctc cttggagacc caccacccct
     2521 gctgaccctg ccacggcccc cactatcagg ggccctggcc tcaatcactg agaccatcca
     2581 agtccatcgc agatactggc gcagcttacg ggtcatgaag gtagaagaca gagaaggacc
     2641 ctccagttct aagttggtca ccaagaaggc accccaacca gccaaaccta ggttagctga
     2701 gcggatgacc acacgagaaa agaaggttct ggaagcaggc atggggaaag tcacctcggc
     2761 atcatttggg gaagagtcca ctccaggcca gactaactca gagacagctg tggtggccct
     2821 cactcaggac cagccctcag aggcagccac agggggagcc actctggccc agaccatttc
     2881 tgaggcagcc attgggggag ccatgctggg ccagaccacc tcagaggagg ctgtcggggg
     2941 agccactccg gaccagacca cctcagagga gactgtggga ggagccattc tggaccagac
     3001 cacctcagag gatgctgttg ggggagccac gctgggccag actacctcag aggaggctgt
     3061 aggaggagct acactggccc agaccacctc ggaggcagcc atggagggag ccacactgga
     3121 ccagactacg tcagaggagg ctccaggggg caccgagctg atccaaactc ctctagcctc
     3181 gagcacagac caccagaccc ccccaacctc acctgtgcag ggaactacac cccagatatc
     3241 tcccagtaca ctgattggga gtctcaggac cttggagcta ggcagcgaat ctcagggggc
     3301 ctcagaatct caggccccag gagaggagaa cctactagga gaggcagctg gaggtcagga
     3361 catggctgat tcgatgctga tgcagggatc taggggcctc actgatcagg ccatatttta
     3421 tgctgtgaca ccactgccct ggtgtcccca tttggtggca gtatgcccca tacctgcagc
     3481 aggcctagac gtgacccaac cttgtgggga ctgtggaaca atccaagaga attgggtgtg
     3541 tctctcttgc tatcaggtct actgtggtcg ttacatcaat ggccacatgc tccaacacca
     3601 tggaaattct ggacacccgc tggtcctcag ctacatcgac ctgtcagcct ggtgttacta
     3661 ctgtcaggcc tatgtccacc accaggctct cctagatgtg aagaacatcg cccaccagaa
     3721 caagtttggg gaggatatgc cccacccaca ctaagcccca gaatacggtc cctcttcacc
     3781 ttctgaggcc cacgatagac cagctgtagc tcattccagc ctgtaccttg gatgaggggt
     3841 agcctcccac tgcatcccat cctgaatatc ctttgcaact ccccaagagt gcttatttaa
     3901 gtgttaatac ttttaagaga actgcgacga ttaattgtgg atctccccct gcccattgcc
     3961 tgcttgaggg gcaccactac tccagcccag aaggaaaggg gggcagctca gtggccccaa
     4021 gagggagctg atatcatgag gataacattg gcgggagggg agttaactgg caggcatggc
     4081 aaggttgcat atgtaataaa gtacaagctg ttaaaaaa
//
