LOCUS       NM_005474               5319 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 1,
            mRNA.
ACCESSION   NM_005474
VERSION     NM_005474.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5319)
  AUTHORS   Hui,S.E. and Westlund,K.N.
  TITLE     Role of HDAC5 Epigenetics in Chronic Craniofacial Neuropathic Pain
  JOURNAL   Int J Mol Sci 25 (13), 6889 (2024)
   PUBMED   38999998
  REMARK    GeneRIF: Role of HDAC5 Epigenetics in Chronic Craniofacial
            Neuropathic Pain.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5319)
  AUTHORS   Chang,M.M., Hong,Y.K., Hsu,C.K., Harn,H.I., Huang,B.M., Liu,Y.H.,
            Lu,F.I., Hsueh,Y.Y., Lin,S.P. and Wu,C.C.
  TITLE     Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation
            and Differentiation Signaling of Human Adipose-Derived Stem Cells
  JOURNAL   Stem Cells Transl Med 13 (3), 293-308 (2024)
   PUBMED   38173411
  REMARK    GeneRIF: Histone Trimethylations and HDAC5 Regulate Spheroid
            Subpopulation and Differentiation Signaling of Human
            Adipose-Derived Stem Cells.
REFERENCE   3  (bases 1 to 5319)
  AUTHORS   Zhang,Y., Huang,H., Liu,P. and Xie,Y.
  TITLE     NFYB increases chemosensitivity in glioblastoma by promoting
            HDAC5-mediated transcriptional inhibition of SHMT2
  JOURNAL   J Neuropathol Exp Neurol 82 (11), 911-920 (2023)
   PUBMED   37742129
  REMARK    GeneRIF: NFYB increases chemosensitivity in glioblastoma by
            promoting HDAC5-mediated transcriptional inhibition of SHMT2.
REFERENCE   4  (bases 1 to 5319)
  AUTHORS   Zhang,Y., Qiu,J.G., Jia,X.Y., Ke,Y., Zhang,M.K., Stieg,D.,
            Liu,W.J., Liu,L.Z., Wang,L. and Jiang,B.H.
  TITLE     METTL3-mediated N6-methyladenosine modification and HDAC5/YY1
            promote IFFO1 downregulation in tumor development and
            chemo-resistance
  JOURNAL   Cancer Lett 553, 215971 (2023)
   PUBMED   36257380
  REMARK    GeneRIF: METTL3-mediated N6-methyladenosine modification and
            HDAC5/YY1 promote IFFO1 downregulation in tumor development and
            chemo-resistance.
REFERENCE   5  (bases 1 to 5319)
  AUTHORS   Gao,Y., Liu,Y., Zheng,D., Ho,C., Wen,D., Sun,J., Huang,L., Liu,Y.,
            Li,Q. and Zhang,Y.
  TITLE     HDAC5-mediated Smad7 silencing through MEF2A is critical for
            fibroblast activation and hypertrophic scar formation
  JOURNAL   Int J Biol Sci 18 (15), 5724-5739 (2022)
   PUBMED   36263180
  REMARK    GeneRIF: HDAC5-mediated Smad7 silencing through MEF2A is critical
            for fibroblast activation and hypertrophic scar formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5319)
  AUTHORS   Huynh,K.D., Fischle,W., Verdin,E. and Bardwell,V.J.
  TITLE     BCoR, a novel corepressor involved in BCL-6 repression
  JOURNAL   Genes Dev 14 (14), 1810-1823 (2000)
   PUBMED   10898795
REFERENCE   7  (bases 1 to 5319)
  AUTHORS   Grozinger,C.M. and Schreiber,S.L.
  TITLE     Regulation of histone deacetylase 4 and 5 and transcriptional
            activity by 14-3-3-dependent cellular localization
  JOURNAL   Proc Natl Acad Sci U S A 97 (14), 7835-7840 (2000)
   PUBMED   10869435
REFERENCE   8  (bases 1 to 5319)
  AUTHORS   Lu,J., McKinsey,T.A., Nicol,R.L. and Olson,E.N.
  TITLE     Signal-dependent activation of the MEF2 transcription factor by
            dissociation from histone deacetylases
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4070-4075 (2000)
   PUBMED   10737771
REFERENCE   9  (bases 1 to 5319)
  AUTHORS   Grozinger,C.M., Hassig,C.A. and Schreiber,S.L.
  TITLE     Three proteins define a class of human histone deacetylases related
            to yeast Hda1p
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 4868-4873 (1999)
   PUBMED   10220385
REFERENCE   10 (bases 1 to 5319)
  AUTHORS   Scanlan,M.J., Chen,Y.T., Williamson,B., Gure,A.O., Stockert,E.,
            Gordan,J.D., Tureci,O., Sahin,U., Pfreundschuh,M. and Old,L.J.
  TITLE     Characterization of human colon cancer antigens recognized by
            autologous antibodies
  JOURNAL   Int J Cancer 76 (5), 652-658 (1998)
   PUBMED   9610721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM564861.1, AB011172.2,
            BC051824.1 and AC023855.15.
            
            On Jun 2, 2019 this sequence version replaced NM_005474.4.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to the class II histone deacetylase/acuc/apha
            family. It possesses histone deacetylase activity and represses
            transcription when tethered to a promoter. It coimmunoprecipitates
            only with HDAC3 family member and might form multicomplex proteins.
            It also interacts with myocyte enhancer factor-2 (MEF2) proteins,
            resulting in repression of MEF2-dependent genes. This gene is
            thought to be associated with colon cancer. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site compared to variant 3. The resulting isoform (1) has
            the same N- and C-termini but is 1 aa shorter compared to isoform
            3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.12276.1,
                                           SRR14372080.1876097.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682912.1/ ENSP00000507606.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               BM564861.1         3-478
            477-2377            AB011172.2         454-2354
            2378-3778           BC051824.1         2262-3662
            3779-5319           AC023855.15        57213-58753
FEATURES             Location/Qualifiers
     source          1..5319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..5319
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /note="histone deacetylase 5"
                     /db_xref="GeneID:10014"
                     /db_xref="HGNC:HGNC:14068"
                     /db_xref="MIM:605315"
     exon            1..138
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            139..349
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..3696
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 1;
                     antigen NY-CO-9"
                     /codon_start=1
                     /product="histone deacetylase 5 isoform 1"
                     /protein_id="NP_005465.2"
                     /db_xref="CCDS:CCDS45696.1"
                     /db_xref="GeneID:10014"
                     /db_xref="HGNC:HGNC:14068"
                     /db_xref="MIM:605315"
                     /translation="MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPS
                     SMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQH
                     DHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRL
                     EQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHH
                     ASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAER
                     RSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGF
                     TGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPK
                     LSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLL
                     LEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQAL
                     QQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGE
                     GALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGA
                     GYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFT
                     TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEI
                     QTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSS
                     SAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQ
                     QKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGP
                     GVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSP
                     LGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPL
                     DEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSA
                     MALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL"
     exon            350..421
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            422..681
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            682..853
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            854..968
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1099
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1246
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1359
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1491
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1714
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1926
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2211
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2377
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2511
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2632
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2682
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2790
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2846
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2934
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3054
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3152
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3271
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3405
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3490
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            3491..3656
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..5319
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3758..3763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /note="hexamer: AACAAA"
     polyA_site      3778
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /note="major polyA site"
     regulatory      5296..5301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
                     /note="hexamer: AATAAA"
     polyA_site      5319
                     /gene="HDAC5"
                     /gene_synonym="HD5; NY-CO-9"
ORIGIN      
        1 gttgttgttg gtggcggcgg cgagcggagc cggaggagcc gccgcaaaga tggaggagcc
       61 gtcgaggagg tgctgccgcc gctgccgccg ccgctgctgc cgccgccgcc cgcgaagccg
      121 gagctcgagc cgcagcgggg atgccgttct gagtgcctga ctgcctcgcc ccgaaggatg
      181 gcctcggatg ggcattagag gcacggcggc cccgggctcc cgtcccgtcc gtctgtctgt
      241 tatcgtctgt ctctcttgac atcaccgcag ctccaccccc tcccgtccca gcccccaacg
      301 ccagcttcct gcaggcccag agccggcatg aactctccca acgagtcgga tgggatgtca
      361 ggtcgggaac catccttgga aatcctgccg cggacttctc tgcacagcat ccctgtgaca
      421 gtggaggtga agccggtgct gccaagagcc atgcccagtt ccatgggggg tgggggtgga
      481 ggcagcccca gccctgtgga gctacggggg gctctggtgg gctctgtgga ccccacactg
      541 cgggagcagc aactgcagca ggagctcctg gcgctcaagc agcagcagca gctgcagaag
      601 cagctcctgt tcgctgagtt ccagaaacag catgaccacc tgacaaggca gcatgaggtc
      661 cagctgcaga agcacctcaa gcagcagcag gagatgctgg cagccaagca gcagcaggag
      721 atgctggcag ccaagcggca gcaggagctg gagcagcagc ggcagcggga gcagcagcgg
      781 caggaagagc tggagaagca gcggctggag cagcagctgc tcatcctgcg gaacaaggag
      841 aagagcaaag agagtgccat tgccagcact gaggtaaagc tgaggctcca ggaattcctc
      901 ttgtcgaagt caaaggagcc cacaccaggc ggcctcaacc attccctccc acagcacccc
      961 aaatgctggg gagcccacca tgcttctttg gaccagagtt cccctcccca gagcggcccc
     1021 cctgggacgc ctccctccta caaactgcct ttgcctgggc cctacgacag tcgagacgac
     1081 ttccccctcc gcaaaacagc ctctgaaccc aacttgaaag tgcgttcaag gctaaaacag
     1141 aaggtggctg agcggagaag cagtcccctc ctgcgtcgca aggatgggac tgttattagc
     1201 acctttaaga agagagctgt tgagatcaca ggtgccgggc ctggggcgtc gtccgtgtgt
     1261 aacagcgcac ccggctccgg ccccagctct cccaacagct cccacagcac catcgctgag
     1321 aatggcttta ctggctcagt ccccaacatc cccactgaga tgctccctca gcaccgagcc
     1381 ctccctctgg acagctcccc caaccagttc agcctctaca cgtctccttc tctgcccaac
     1441 atctccctag ggctgcaggc cacggtcact gtcaccaact cacacctcac tgcctccccg
     1501 aagctgtcga cacagcagga ggccgagagg caggccctcc agtccctgcg gcagggtggc
     1561 acgctgaccg gcaagttcat gagcacatcc tctattcctg gctgcctgct gggcgtggca
     1621 ctggagggcg acgggagccc ccacgggcat gcctccctgc tgcagcatgt gctgttgctg
     1681 gagcaggccc ggcagcagag caccctcatt gctgtgccac tccacgggca gtccccacta
     1741 gtgacgggtg aacgtgtggc caccagcatg cggacggtag gcaagctccc gcggcatcgg
     1801 cccctgagcc gcactcagtc ctcaccgctg ccgcagagtc cccaggccct gcagcagctg
     1861 gtcatgcaac aacagcacca gcagttcctg gagaagcaga agcagcagca gctacagctg
     1921 ggcaagatcc tcaccaagac aggggagctg cccaggcagc ccaccaccca ccctgaggag
     1981 acagaggagg agctgacgga gcagcaggag gtcttgctgg gggagggagc cctgaccatg
     2041 ccccgggagg gctccacaga gagtgagagc acacaggaag acctggagga ggaggacgag
     2101 gaagacgatg gggaggagga ggaggattgc atccaggtta aggacgagga gggcgagagt
     2161 ggtgctgagg aggggcccga cttggaggag cctggtgctg gatacaaaaa actgttctca
     2221 gatgcccagc cgctgcagcc tttgcaggtg taccaggcgc ccctcagcct ggccactgtg
     2281 ccccaccagg ccctgggccg tacccagtcc tcccctgctg cccctggggg catgaagagc
     2341 cccccagacc agcccgtcaa gcacctcttc accacaggtg tggtctacga cacgttcatg
     2401 ctaaagcacc agtgcatgtg cgggaacaca cacgtgcacc ctgagcatgc tggccggatc
     2461 cagagcatct ggtcccggct gcaggagaca ggcctgctta gcaagtgcga gcggatccga
     2521 ggtcgcaaag ccacgctaga tgagatccag acagtgcact ctgaatacca caccctgctc
     2581 tatgggacca gtcccctcaa ccggcagaag ctagacagca agaagttgct cggccccatc
     2641 agccagaaga tgtatgctgt gctgccttgt gggggcatcg gggtggacag tgacaccgtg
     2701 tggaatgaga tgcactcctc cagtgctgtg cgcatggcag tgggctgcct gctggagctg
     2761 gccttcaagg tggctgcagg agagctcaag aatggatttg ccatcatccg gcccccagga
     2821 caccacgccg aggaatccac agccatggga ttctgcttct tcaactctgt agccatcacc
     2881 gcaaaactcc tacagcagaa gttgaacgtg ggcaaggtcc tcatcgtgga ctgggacatt
     2941 caccatggca atggcaccca gcaggcgttc tacaatgacc cctctgtgct ctacatctct
     3001 ctgcatcgct atgacaacgg gaacttcttt ccaggctctg gggctcctga agaggttggt
     3061 ggaggaccag gcgtggggta caatgtgaac gtggcatgga caggaggtgt ggaccccccc
     3121 attggagacg tggagtacct tacagccttc aggacagtgg tgatgcccat tgcccacgag
     3181 ttctcacctg atgtggtcct agtctccgcc gggtttgatg ctgttgaagg acatctgtct
     3241 cctctgggtg gctactctgt caccgccaga tgttttggcc acttgaccag gcagctgatg
     3301 accctggcag ggggccgggt ggtgctggcc ctggagggag gccatgactt gaccgccatc
     3361 tgtgatgcct ctgaggcttg tgtctcggct ctgctcagtg tagagctgca gcccttggat
     3421 gaggcagtct tgcagcaaaa gcccaacatc aacgcagtgg ccacgctaga gaaagtcatc
     3481 gagatccaga gcaaacactg gagctgtgtg cagaagttcg ccgctggtct gggccggtcc
     3541 ctgcgagagg cccaagcagg tgagaccgag gaggccgaga ctgtgagcgc catggccttg
     3601 ctgtcggtgg gggccgagca ggcccaggct gcggcagccc gggaacacag ccccaggccg
     3661 gcagaggagc ccatggagca ggagcctgcc ctgtgacgcc ccggccccca tccctctggg
     3721 cttcaccatt gtgattttgt ttattttttc tattaaaaac aaaaagtcac acattcaaca
     3781 aggtgtgccg tgtgggtctc tcagccttgc ccctcctgct cctctacgct gcctcaggcc
     3841 cccagccctg tggcttccac ctcagctcta gaagcctgct ccctctgcag ggggtggtgg
     3901 tgtcttccca gccctgtccc atgtgtccct ccccccattt tcctgcattc tgtctgtcct
     3961 tttcctcctt ggagcctggg ccagctcaag gtgggcacgg gggcccagac agtactctcc
     4021 agttctgggg ccccccgagt gaggagggaa cgggaagtcg gtgccttggt ttcagctgat
     4081 ttggggggaa atgccttaat ttcactctcc tcccttctcc agcctcaggg gaggatctgg
     4141 aggatccact actgtcttta agatgcagag tggaggggag gtgggcaccc accctgcgat
     4201 tctccaccct ttccccttct ttcgtcctca ccatctctgc agacccctct cctcctcctt
     4261 cctcttggtc tcagcactga tgggaggctg gtgcccaagc tgtggcctgc agtctgtgag
     4321 gagggctgtc ttgcctcaca ctcctcacag cctacttccc cttccccggg gctgagaggg
     4381 tgaaagtgtg tggggaagga gaggactggt ttcctgggtt ctcaggggcc aggaggagta
     4441 acagaaccag gtctgctccc caccttactc ggatggcctc cctgcccctc tgctggcaca
     4501 gcctgggcaa ggggagaagg tggtccctgc agaggggctc caggctggtg agagcccccc
     4561 tgctgtcagg accagatttt cccagccatc cagcatgctg cggggagaag gggcagaggc
     4621 tcacctccct cctggggcct tttgttttgg atcctgggga tggtgagaat ggaggttcta
     4681 gaaggggtaa ggccagaacc cagggatcca ggagtcggct ctcagctgga gcttccatac
     4741 cttctgggct ccctttgctg accaccagcc caagggagct aagaccagga gggggctggg
     4801 cgctgtccct tctctttccc aggagccctg ccaggggctg tgggcctaca aggcttccag
     4861 gggatgccat ccagcctgta ggaaaccaaa gatgggaagt ggctcctagg gggctgactc
     4921 ttccttcctc ctcctcccca gtaccacata tactttctct ccttctatct ccagggcccc
     4981 accaatctgt ttacatattt attatcctat gggggcctga gcaggattga gggagccagg
     5041 ggaggggcag gagtcccagc accatcggtt catagtgtgc ttgtgtgttt gttttagatc
     5101 ctcctggggg atggggatgg ggccaggctc agtgtactag gcctctctgt gctgagcccc
     5161 aggctcccgg ccccttaccc actctctccc tgtggctggt ctggttctca tgtaaaccca
     5221 ctccttgctt tgtctccctg gatatggatt tcagttaagt attttgtaac ccgttacact
     5281 gtgtgtcctt gtgtaaataa acttgtttct ggcagtgcc
//
