LOCUS       XM_011512226            8389 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens histone deacetylase 4 (HDAC4), transcript
            variant X21, mRNA.
ACCESSION   XM_011512226
VERSION     XM_011512226.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011512226.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..8389
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="histone deacetylase 4; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 19 ESTs, 400 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
     CDS             263..3460
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform X17"
                     /protein_id="XP_011510528.1"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
                     /translation="MSSQSHPVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALRE
                     QQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQE
                     LLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKK
                     ALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLR
                     KTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
                     SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGL
                     PATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQH
                     MVLLEQPPAQAPLVTDWYLSGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAP
                     LPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEE
                     ELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSE
                     QELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSV
                     QEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECI
                     RGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSD
                     TIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNS
                     VAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSG
                     APDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGF
                     DAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSA
                     LLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCE
                     NEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL"
ORIGIN      
        1 gcctggctcg acgctggagt ggggagaagc atcatggttc aacgttcatc tgcagaagcc
       61 agcggacgcc tctgttcaac ttgtgggtta cctggctcat gagaccttgc cggcgaggct
      121 cggcgcttga acgtctgtga cccagccctc accgtcccgg tacttgtatg tgttggtggg
      181 agtttggagc tcgttggagc tatcgtttcc gtggaaattt tgagccattt cgaatcactt
      241 aaaggagtgg acattgctag caatgagctc ccaaagccat ccagtggatg tggccacggc
      301 gctgcctctg caagtggccc cctcggcagt gcccatggac ctgcgcctgg accaccagtt
      361 ctcactgcct gtggcagagc cggccctgcg ggagcagcag ctgcagcagg agctcctggc
      421 gctcaagcag aagcagcaga tccagaggca gatcctcatc gctgagttcc agaggcagca
      481 cgagcagctc tcccggcagc acgaggcgca gctccacgag cacatcaagc aacaacagga
      541 gatgctggcc atgaagcacc agcaggagct gctggaacac cagcggaagc tggagaggca
      601 ccgccaggag caggagctgg agaagcagca ccgggagcag aagctgcagc agctcaagaa
      661 caaggagaag ggcaaagaga gtgccgtggc cagcacagaa gtgaagatga agttacaaga
      721 atttgtcctc aataaaaaga aggcgctggc ccaccggaat ctgaaccact gcatttccag
      781 cgaccctcgc tactggtacg ggaaaacgca gcacagttcc cttgaccaga gttctccacc
      841 ccagagcgga gtgtcgacct cctataacca cccggtcctg ggaatgtacg acgccaaaga
      901 tgacttccct cttaggaaaa cagcttctga accgaatctg aaattacggt ccaggctaaa
      961 gcagaaagtg gccgaaagac ggagcagccc cctgttacgc aggaaagacg ggccagtggt
     1021 cactgctcta aaaaagcgtc cgttggatgt cacagactcc gcgtgcagca gcgccccagg
     1081 ctccggaccc agctcaccca acaacagctc cgggagcgtc agcgcggaga acggtatcgc
     1141 gcccgccgtc cccagcatcc cggcggagac gagtttggcg cacagacttg tggcacgaga
     1201 aggctcggcc gctccacttc ccctctacac atcgccatcc ttgcccaaca tcacgctggg
     1261 cctgcctgcc accggcccct ctgcgggcac ggcgggccag caggacgccg agagactcac
     1321 ccttcccgcc ctccagcaga ggctctccct tttccccggc acccacctca ctccctacct
     1381 gagcacctcg cccttggagc gggacggagg ggcagcgcac agccctcttc tgcagcacat
     1441 ggtcttactg gagcagccgc cggcacaagc acccctcgtc acagactggt atctttcagg
     1501 cctgggagca ctgcccctcc acgcacagtc cttggttggt gcagaccggg tgtccccctc
     1561 catccacaag ctgcggcagc accgcccact ggggcggacc cagtcggccc cgctgcccca
     1621 gaacgcccag gctctgcagc acctggtcat ccagcagcag catcagcagt ttctggagaa
     1681 acacaagcag cagttccagc agcagcaact gcagatgaac aagatcatcc ccaagccaag
     1741 cgagccagcc cggcagccgg agagccaccc ggaggagacg gaggaggagc tccgtgagca
     1801 ccaggctctg ctggacgagc cctacctgga ccggctgccg gggcagaagg aggcgcacgc
     1861 acaggccggc gtgcaggtga agcaggagcc cattgagagc gatgaggaag aggcagagcc
     1921 cccacgggag gtggagccgg gccagcgcca gcccagtgag caggagctgc tcttcagaca
     1981 gcaagccctc ctgctggagc agcagcggat ccaccagctg aggaactacc aggcgtccat
     2041 ggaggccgcc ggcatccccg tgtccttcgg cggccacagg cctctgtccc gggcgcagtc
     2101 ctcacccgcg tctgccacct tccccgtgtc tgtgcaggag ccccccacca agccgaggtt
     2161 cacgacaggc ctcgtgtatg acacgctgat gctgaagcac cagtgcacct gcgggagtag
     2221 cagcagccac cccgagcacg ccgggaggat ccagagcatc tggtcccgcc tgcaggagac
     2281 gggcctccgg ggcaaatgcg agtgcatccg cggacgcaag gccaccctgg aggagctaca
     2341 gacggtgcac tcggaagccc acaccctcct gtatggcacg aaccccctca accggcagaa
     2401 actggacagt aagaaacttc taggctcgct cgcctccgtg ttcgtccggc tcccttgcgg
     2461 tggtgttggg gtggacagtg acaccatatg gaacgaggtg cactcggcgg gggcagcccg
     2521 cctggctgtg ggctgcgtgg tagagctggt cttcaaggtg gccacagggg agctgaagaa
     2581 tggctttgct gtggtccgcc cccctggaca ccatgcggag gagagcacgc ccatgggctt
     2641 ttgctacttc aactccgtgg ccgtggcagc caagcttctg cagcagaggt tgagcgtgag
     2701 caagatcctc atcgtggact gggacgtgca ccatggaaac gggacccagc aggctttcta
     2761 cagcgacccc agcgtcctgt acatgtccct ccaccgctac gacgatggga acttcttccc
     2821 aggcagcggg gctcctgatg aggtgggcac agggcccggc gtgggtttca acgtcaacat
     2881 ggctttcacc ggcggcctgg acccccccat gggagacgct gagtacttgg cggccttcag
     2941 aacggtggtc atgccgatcg ccagcgagtt tgccccggat gtggtgctgg tgtcatcagg
     3001 cttcgatgcc gtggagggcc accccacccc tcttgggggc tacaacctct ccgccagatg
     3061 cttcgggtac ctgacgaagc agctgatggg cctggctggc ggccggattg tcctggccct
     3121 cgagggaggc cacgacctga ccgccatttg cgacgcctcg gaagcatgtg tttctgcctt
     3181 gctgggaaac gagcttgatc ctctcccaga aaaggtttta cagcaaagac ccaatgcaaa
     3241 cgctgtccgt tccatggaga aagtcatgga gatccacagc aagtactggc gctgcctgca
     3301 gcgcacaacc tccacagcgg ggcgttctct gatcgaggct cagacttgcg agaacgaaga
     3361 agccgagacg gtcaccgcca tggcctcgct gtccgtgggc gtgaagcccg ccgaaaagag
     3421 accagatgag gagcccatgg aagaggagcc gcccctgtag cactccctcg aagctgctgt
     3481 tctcttgtct gtctgtctct gtcttgaagc tcagccaaga aactttcccg tgtcacgcct
     3541 gcgtcccacc gtggggctct cttggagcac ccagggacac ccagcgtgca acagccacgg
     3601 gaagcctttc tgccgcccag gcccacaggt ctcgagacgc acatgcacgc ctgggcgtgg
     3661 cagcctcaca gggaacacgg gacagacgcc ggcgacgcgc agacacacgg acacgcggaa
     3721 gccaagcaca ctctggcggg tcccgcaagg gacgccgtgg aagaaaggag cctgtggcaa
     3781 caggcggccg agctgccgaa ttcagttgac acgaggcaca gaaaacaaat atcaaagatc
     3841 taataataca aaacaaactt gattaaaact ggtgcttaaa gtttattacc cacaactcca
     3901 cagtctctgt gtaaaccact cgactcatct tgtagcttat ttttttttaa agaggacgtt
     3961 ttctacggct gtggcccgcc tctgtgaacc atagcggtgt gcggcggggg gtctgcaccc
     4021 gggtggggga cagagggacc tttaaagaaa acaaaactgg acagaaacag gaatgtgagc
     4081 tgggggagct ggcttgagtt tctcaaaagc catcggaaga tgcgagtttg tgcctttttt
     4141 tttattgctc tggtggattt ttgtggctgg gttttctgaa gtctgaggaa caatgcctta
     4201 agaaaaaaca aacagcagga atcggtggga cagtttcctg tggccagccg agcctggcag
     4261 tgctggcacc gcgagctggc ctgacgcctc aagcacgggc accagccgtc atctccgggg
     4321 ccaggggctg cagcccggcg gtccctgttt tgctttattg ctgtttaaga aaaatggagg
     4381 tagttccaaa aaagtggcaa atcccgttgg aggttttgaa gtccaacaaa ttttaaacga
     4441 atccaaagtg ttctcacacg tcacatacga ttgagcatct ccatctggtc gtgaagcatg
     4501 tggtaggcac acttgcagtg ttacgatcgg aatgcttttt attaaaagca agtagcatga
     4561 agtattgctt aaattttagg tataaataaa tatatatatg tataatatat attccaatgt
     4621 attccaagct aagaaactta cttgattctt atgaaatctt gataaaatat ttataatgca
     4681 tttatagaaa aagtatatat atatatataa aatgaatgca gattgcgaag gtccctgcaa
     4741 atggatggct tgtgaatttg ctctcaaggt gcttatggaa agggatcctg attgattgaa
     4801 attcatgttt tctcaagctc cagattggct agatttcaga tcgccaacac attcgccact
     4861 gggcaactac cctacaagtt tgtactttca ttttaattat tttctaacag aaccgctccc
     4921 gtctccaagc cttcatgcac atatgtacct aatgagtttt tatagcaaag aatataaatt
     4981 tgctgttgat ttttgtatga attttttcac aaaaagatcc tgaataagca ttgttttatg
     5041 aattttacat ttttcctcac catttagcaa ttttctgaat ggtaataatg tctaaatctt
     5101 tttcctttct gaattcttgc ttgtacattt ttttttacct ttcaaaggtt tttaattatt
     5161 tttgttttta tttttgtacg atgagttttc tgcagcgtac agaattgttg ctgtcagatt
     5221 ctattttcag aaagtgagag gagggaccgt aggtcttttc ggagtgacac caacgattgt
     5281 gtctttcctg gtctgtccta ggagctgtat aaagaagccc aggggctctt tttaactttc
     5341 aacactagta gtattacgag gggtggtgtg tttttcccct ccgtggcaag ggcagggagg
     5401 gttgcttagg atgcccggcc accctgggag gcttgccaga tgccgggggc agtcagcatt
     5461 aatgaaactc atgtttaaac ttctctgacc acatcgtcag gatagaattc taacttgagt
     5521 tttccaaaga ccttttgagc atgtcagcaa tgcatggggc acacgtgggg ctctttaccc
     5581 acttgggttt ttccactgca gccacgtggc cagccctgga ttttggagcc tgtggctgca
     5641 aggaacccag ggacccttgt tgcctggtga acctgcaggg agggtatgat tgcctgacca
     5701 ggacagccag tctttactct ttttctcttc aacagtaact gacagtcacg ttttactggt
     5761 aacttatttt ccagcacatg aagccaccag tttcattcca aagtgtatat tgggttcaga
     5821 cttgggggca gaagttcaga cacaccgtgc tcaggaggga cccagagccg agtttcggag
     5881 tttggtaaag tttacagggt agcttctgaa attaactcaa acttttgacc aaatgagtgc
     5941 agattcttgg attcacttgg tcactgggct gctgatggtc agctctgaga cagtggtttg
     6001 agagcaggca gaacggtctt gggacttgtt tgactttccc ctccctggtg gccactcttt
     6061 gctctgaagc ccagattggc aagaggagct ggtccattcc ccattcatgg cacagagcag
     6121 tggcagggcc cagctagcag gctcttctgg cctccttggc ctcattctct gcatagccct
     6181 ctggggatcc tgccacctgc cctcttaccc cgccgtggct tatggggagg aatgcatcat
     6241 ctcacttttt ttttttaagc agatgatggg ataacatgga ctgctcagtg gccaggttat
     6301 cagtgggggg acttaattct aatctcattc aaatggagac gccctctgca aaggcctggc
     6361 agggggaggc acgtttcatc tgtcagctca ctccagcttc acaaatgtgc tgagagcatt
     6421 actgtgtagc cttttctttg aagacacact cggctcttct ccacagcaag cgtccagggc
     6481 agatggcaga ggatctgcct cggcgtctgc aggcgggacc acgtcaggga gggttccttc
     6541 atgtgttctc cctgtgggtc cttggacctt tagccttttt cttcctttgc aaaggccttg
     6601 ggggcactgg ctgggagtca gcaagcgagc actttatatc cctttgaggg aaaccctgat
     6661 gacgccactg ggcctcttgg cgtctgccct gccctcgcgg cttcccgccg tgccgcagcg
     6721 tgcccacgtg cccacgcccc accagcaggc ggctgtcccg gaggccgtgg cccgctggga
     6781 ctggccgccc ctccccagcg tcccagggct ctggttctgg agggccactt tgtcaaggtg
     6841 tttcagtttt tctttacttc ttttgaaaat ctgtttgcaa ggggaaggac catttcgtaa
     6901 tggtctgaca caaaagcaag tttgattttt gcagcactag caatggactt tgttgttttt
     6961 ctttttgatc agaacattcc ttctttactg gtcacagcca cgtgctcatt ccattcttct
     7021 ttttgtagac tttgggccca cgtgttttat gggcattgat acatatataa atatatagat
     7081 ataaatatat atgaatatat ttttttaagt ttcctacacc tggaggttgc atggactgta
     7141 cgaccggcat gactttatat tgtatacaga ttttgcacgc caaactcggc agctttgggg
     7201 aagaagaaaa atgcctttct gttcccctct catgacattt gcagatacaa aagatggaaa
     7261 tttttctgta aaacaaaacc ttgaaggaga ggagggcggg gaagtttgcg tcttattgaa
     7321 cttattctta agaaattgta ctttttattg taagaaaaat aaaaaggact acttaaacat
     7381 ttgtcatatt aagaaaaaaa gtttatctag cacttgtgac ataccaataa tagagtttat
     7441 tgtatttatg tggaaacagt gttttaggga aactactcag aattcacagt gaactgcctg
     7501 tctctctcga gttgatttgg aggaattttg ttttgttttg ttttgtttgt ttccttttat
     7561 ctccttccac gggccaggcg agcgccgccc gccctcactg gccttgtgac ggtttattct
     7621 gattgagaac tgggcggact cgaaagagtc cccttttccg cacagctgtg ttgacttttt
     7681 aattactttt aggtgatgta tggctaagat ttcactttaa gcagtcgtga actgtgcgag
     7741 cactgtggtt tacaattata ctttgcatcg aaaggaaacc atttcttcat tgtaacgaag
     7801 ctgagcgtgt tcttagctcg gcctcacttt gtctctggca ttgattaaaa gtctgctatt
     7861 gaaagaaaaa gaaagcgaac agtttttgtt tgtttttttt gccgtgtgtg ctccatagtg
     7921 gaggcgctat tttccaattg atgagaatga caaacatata taatctatct atctatctat
     7981 ctatctatct atctatacag ggggcttgaa ccttactcac ccaagagctt cttacggaat
     8041 gtggtagaaa accaagttgt aacgacactg taacctacct gatgcctgtt cgcgcccgcc
     8101 gtgagctgcg cactggccgt ggccaccatt cacctctgta atttaatccg tttctcttgg
     8161 attgtctgga cgtgcccgat ggttctttct tttgctcagt ggagttggag gttttgtgtt
     8221 tggttttctc attcttgtct tgttttgtgt gggtggattt tcaccgacca atgatatcct
     8281 cttctgacgg tcaccttctt tccacttcac tggagtccag tattctgtac cacatcacgc
     8341 aacgtgttat cttgtggtgt aaataaagac tgcgttactt gccctccca
//
