LOCUS       NM_001378417            8651 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens histone deacetylase 4 (HDAC4), transcript variant 5,
            mRNA.
ACCESSION   NM_001378417
VERSION     NM_001378417.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8651)
  AUTHORS   Liu,W. and Luo,G.
  TITLE     NEDD9 is transcriptionally regulated by HDAC4 and promotes breast
            cancer metastasis and macrophage M2 polarization via the
            FAK/NF-kappaB signaling pathway
  JOURNAL   Neoplasia 57, 101059 (2024)
   PUBMED   39326322
  REMARK    GeneRIF: NEDD9 is transcriptionally regulated by HDAC4 and promotes
            breast cancer metastasis and macrophage M2 polarization via the
            FAK/NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 8651)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8651)
  AUTHORS   Di Giorgio,E., Dalla,E., Tolotto,V., D'Este,F., Paluvai,H.,
            Ranzino,L. and Brancolini,C.
  TITLE     HDAC4 influences the DNA damage response and counteracts senescence
            by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and
            homology-directed repair
  JOURNAL   Nucleic Acids Res 52 (14), 8218-8240 (2024)
   PUBMED   38874468
  REMARK    GeneRIF: HDAC4 influences the DNA damage response and counteracts
            senescence by assembling with HDAC1/HDAC2 to control H2BK120
            acetylation and homology-directed repair.
REFERENCE   4  (bases 1 to 8651)
  AUTHORS   Chen,Q. and Lao,J.
  TITLE     Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal
            Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced
            Alveolar Epithelial Cell Injury
  JOURNAL   J Physiol Investig 67 (4), 174-186 (2024)
   PUBMED   39133038
  REMARK    GeneRIF: Interference with Histone Deacetylase 4 Regulates c-Jun
            N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate
            Sepsis-induced Alveolar Epithelial Cell Injury.
REFERENCE   5  (bases 1 to 8651)
  AUTHORS   Dai,S., Guo,L., Dey,R., Guo,M., Zhang,X., Bates,D., Cayford,J.,
            Jiang,L., Wei,H., Chen,Z., Zhang,Y., Chen,L. and Chen,Y.
  TITLE     Structural insights into the HDAC4-MEF2A-DNA complex and its
            implication in long-range transcriptional regulation
  JOURNAL   Nucleic Acids Res 52 (5), 2711-2723 (2024)
   PUBMED   38281192
  REMARK    GeneRIF: Structural insights into the HDAC4-MEF2A-DNA complex and
            its implication in long-range transcriptional regulation.
REFERENCE   6  (bases 1 to 8651)
  AUTHORS   Pazin,M.J. and Kadonaga,J.T.
  TITLE     What's up and down with histone deacetylation and transcription?
  JOURNAL   Cell 89 (3), 325-328 (1997)
   PUBMED   9150131
  REMARK    Review article
REFERENCE   7  (bases 1 to 8651)
  AUTHORS   Wolffe,A.P.
  TITLE     Transcriptional control. Sinful repression
  JOURNAL   Nature 387 (6628), 16-17 (1997)
   PUBMED   9139815
REFERENCE   8  (bases 1 to 8651)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   9  (bases 1 to 8651)
  AUTHORS   Wilson,L.C., Leverton,K., Oude Luttikhuis,M.E., Oley,C.A.,
            Flint,J., Wolstenholme,J., Duckett,D.P., Barrow,M.A., Leonard,J.V.,
            Read,A.P. et al.
  TITLE     Brachydactyly and mental retardation: an Albright hereditary
            osteodystrophy-like syndrome localized to 2q37
  JOURNAL   Am J Hum Genet 56 (2), 400-407 (1995)
   PUBMED   7847374
REFERENCE   10 (bases 1 to 8651)
  AUTHORS   Doherty,E.S. and Lacbawan,F.L.
  TITLE     2q37 Microdeletion Syndrome - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301337
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC062017.6 and AC017028.11.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to class II of the histone deacetylase/acuc/apha
            family. It possesses histone deacetylase activity and represses
            transcription when tethered to a promoter. This protein does not
            bind DNA directly, but through transcription factors MEF2C and
            MEF2D. It seems to interact in a multiprotein complex with RbAp48
            and HDAC3. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.4159311.1,
                                           SRR14038197.2409688.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC062017.6         168432-168679       c
            249-489             AC062017.6         119709-119949       c
            490-561             AC062017.6         3625-3696           c
            562-806             AC017028.11        156837-157081       c
            807-957             AC017028.11        143417-143567       c
            958-1078            AC017028.11        130807-130927       c
            1079-1200           AC017028.11        123656-123777       c
            1201-1332           AC017028.11        111587-111718       c
            1333-1445           AC017028.11        106688-106800       c
            1446-1562           AC017028.11        101531-101647       c
            1563-1761           AC017028.11        101249-101447       c
            1762-1985           AC017028.11        93460-93683         c
            1986-2243           AC017028.11        82057-82314         c
            2244-2430           AC017028.11        78530-78716         c
            2431-2564           AC017028.11        75054-75187         c
            2565-2685           AC017028.11        69780-69900         c
            2686-2732           AC017028.11        62014-62060         c
            2733-2840           AC017028.11        57013-57120         c
            2841-2896           AC017028.11        54563-54618         c
            2897-2984           AC017028.11        51159-51246         c
            2985-3104           AC017028.11        49106-49225         c
            3105-3202           AC017028.11        48099-48196         c
            3203-3321           AC017028.11        35493-35611         c
            3322-3455           AC017028.11        33726-33859         c
            3456-3540           AC017028.11        21753-21837         c
            3541-3682           AC017028.11        20464-20605         c
            3683-8651           AC017028.11        15172-20140         c
FEATURES             Location/Qualifiers
     source          1..8651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..8651
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
     exon            1..248
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            249..489
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..3722
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /EC_number="3.5.1.98"
                     /note="isoform 2 is encoded by transcript variant 5;
                     histone deacetylase A"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform 2"
                     /protein_id="NP_001365346.1"
                     /db_xref="CCDS:CCDS2529.1"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     SAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSR
                     QHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEK
                     GKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQ
                     SGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPV
                     VTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLV
                     AREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTH
                     LTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVS
                     PSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKII
                     PKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESD
                     EEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGH
                     RPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRI
                     QSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLG
                     SLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR
                     PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPS
                     VLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTV
                     VMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLAL
                     EGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRC
                     LQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL"
     exon            490..561
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            562..806
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            807..957
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1078
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1200
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1332
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1445
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1562
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1761
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1985
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2243
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2430
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2564
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2685
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2732
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2840
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2896
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..2984
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3104
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3202
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3203..3321
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3455
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3456..3540
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3682
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..8651
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8106..8111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="hexamer: ATTAAA"
     polyA_site      8132
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="major polyA site"
     regulatory      8624..8629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="hexamer: AATAAA"
     polyA_site      8651
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="major polyA site"
ORIGIN      
        1 gccagtatcc aagatggacg ccgcggcgag gcctggccgg ctccccgcgt tagcctgcac
       61 cccattgtgt gccctctaag cgcgaattag gctcgcagac atgcggtgct gaccgctagg
      121 cagccatgcg ggctaccgag tgcgaccgga cacggccggg gcccgtgttt acggccacta
      181 ctggcccccg gtccctgcgc ctcctcaacc gcgaagcacc cagcggctgg cgcctggagc
      241 gtcttttggt tcatctgcag aagccagcgg acgcctctgt tcaacttgtg ggttacctgg
      301 ctcatgagac cttgccggcg aggctcggcg cttgaacgtc tgtgacccag ccctcaccgt
      361 cccggtactt gtatgtgttg gtgggagttt ggagctcgtt ggagctatcg tttccgtgga
      421 aattttgagc catttcgaat cacttaaagg agtggacatt gctagcaatg agctcccaaa
      481 gccatccaga tggactttct ggccgagacc agccagtgga gctgctgaat cctgcccgcg
      541 tgaaccacat gcccagcacg gtggatgtgg ccacggcgct gcctctgcaa gtggccccct
      601 cggcagtgcc catggacctg cgcctggacc accagttctc actgcctgtg gcagagccgg
      661 ccctgcggga gcagcagctg cagcaggagc tcctggcgct caagcagaag cagcagatcc
      721 agaggcagat cctcatcgct gagttccaga ggcagcacga gcagctctcc cggcagcacg
      781 aggcgcagct ccacgagcac atcaagcaac aacaggagat gctggccatg aagcaccagc
      841 aggagctgct ggaacaccag cggaagctgg agaggcaccg ccaggagcag gagctggaga
      901 agcagcaccg ggagcagaag ctgcagcagc tcaagaacaa ggagaagggc aaagagagtg
      961 ccgtggccag cacagaagtg aagatgaagt tacaagaatt tgtcctcaat aaaaagaagg
     1021 cgctggccca ccggaatctg aaccactgca tttccagcga ccctcgctac tggtacggga
     1081 aaacgcagca cagttccctt gaccagagtt ctccacccca gagcggagtg tcgacctcct
     1141 ataaccaccc ggtcctggga atgtacgacg ccaaagatga cttccctctt aggaaaacag
     1201 cttctgaacc gaatctgaaa ttacggtcca ggctaaagca gaaagtggcc gaaagacgga
     1261 gcagccccct gttacgcagg aaagacgggc cagtggtcac tgctctaaaa aagcgtccgt
     1321 tggatgtcac agactccgcg tgcagcagcg ccccaggctc cggacccagc tcacccaaca
     1381 acagctccgg gagcgtcagc gcggagaacg gtatcgcgcc cgccgtcccc agcatcccgg
     1441 cggagacgag tttggcgcac agacttgtgg cacgagaagg ctcggccgct ccacttcccc
     1501 tctacacatc gccatccttg cccaacatca cgctgggcct gcctgccacc ggcccctctg
     1561 cgggcacggc gggccagcag gacgccgaga gactcaccct tcccgccctc cagcagaggc
     1621 tctccctttt ccccggcacc cacctcactc cctacctgag cacctcgccc ttggagcggg
     1681 acggaggggc agcgcacagc cctcttctgc agcacatggt cttactggag cagccgccgg
     1741 cacaagcacc cctcgtcaca ggcctgggag cactgcccct ccacgcacag tccttggttg
     1801 gtgcagaccg ggtgtccccc tccatccaca agctgcggca gcaccgccca ctggggcgga
     1861 cccagtcggc cccgctgccc cagaacgccc aggctctgca gcacctggtc atccagcagc
     1921 agcatcagca gtttctggag aaacacaagc agcagttcca gcagcagcaa ctgcagatga
     1981 acaagatcat ccccaagcca agcgagccag cccggcagcc ggagagccac ccggaggaga
     2041 cggaggagga gctccgtgag caccaggctc tgctggacga gccctacctg gaccggctgc
     2101 cggggcagaa ggaggcgcac gcacaggccg gcgtgcaggt gaagcaggag cccattgaga
     2161 gcgatgagga agaggcagag cccccacggg aggtggagcc gggccagcgc cagcccagtg
     2221 agcaggagct gctcttcaga cagcaagccc tcctgctgga gcagcagcgg atccaccagc
     2281 tgaggaacta ccaggcgtcc atggaggccg ccggcatccc cgtgtccttc ggcggccaca
     2341 ggcctctgtc ccgggcgcag tcctcacccg cgtctgccac cttccccgtg tctgtgcagg
     2401 agccccccac caagccgagg ttcacgacag gcctcgtgta tgacacgctg atgctgaagc
     2461 accagtgcac ctgcgggagt agcagcagcc accccgagca cgccgggagg atccagagca
     2521 tctggtcccg cctgcaggag acgggcctcc ggggcaaatg cgagtgcatc cgcggacgca
     2581 aggccaccct ggaggagcta cagacggtgc actcggaagc ccacaccctc ctgtatggca
     2641 cgaaccccct caaccggcag aaactggaca gtaagaaact tctaggctcg ctcgcctccg
     2701 tgttcgtccg gctcccttgc ggtggtgttg gggtggacag tgacaccata tggaacgagg
     2761 tgcactcggc gggggcagcc cgcctggctg tgggctgcgt ggtagagctg gtcttcaagg
     2821 tggccacagg ggagctgaag aatggctttg ctgtggtccg cccccctgga caccatgcgg
     2881 aggagagcac gcccatgggc ttttgctact tcaactccgt ggccgtggca gccaagcttc
     2941 tgcagcagag gttgagcgtg agcaagatcc tcatcgtgga ctgggacgtg caccatggaa
     3001 acgggaccca gcaggctttc tacagcgacc ccagcgtcct gtacatgtcc ctccaccgct
     3061 acgacgatgg gaacttcttc ccaggcagcg gggctcctga tgaggtgggc acagggcccg
     3121 gcgtgggttt caacgtcaac atggctttca ccggcggcct ggaccccccc atgggagacg
     3181 ctgagtactt ggcggccttc agaacggtgg tcatgccgat cgccagcgag tttgccccgg
     3241 atgtggtgct ggtgtcatca ggcttcgatg ccgtggaggg ccaccccacc cctcttgggg
     3301 gctacaacct ctccgccaga tgcttcgggt acctgacgaa gcagctgatg ggcctggctg
     3361 gcggccggat tgtcctggcc ctcgagggag gccacgacct gaccgccatt tgcgacgcct
     3421 cggaagcatg tgtttctgcc ttgctgggaa acgagcttga tcctctccca gaaaaggttt
     3481 tacagcaaag acccaatgca aacgctgtcc gttccatgga gaaagtcatg gagatccaca
     3541 gcaagtactg gcgctgcctg cagcgcacaa cctccacagc ggggcgttct ctgatcgagg
     3601 ctcagacttg cgagaacgaa gaagccgaga cggtcaccgc catggcctcg ctgtccgtgg
     3661 gcgtgaagcc cgccgaaaag agaccagatg aggagcccat ggaagaggag ccgcccctgt
     3721 agcactccct cgaagctgct gttctcttgt ctgtctgtct ctgtcttgaa gctcagccaa
     3781 gaaactttcc cgtgtcacgc ctgcgtccca ccgtggggct ctcttggagc acccagggac
     3841 acccagcgtg caacagccac gggaagcctt tctgccgccc aggcccacag gtctcgagac
     3901 gcacatgcac gcctgggcgt ggcagcctca cagggaacac gggacagacg ccggcgacgc
     3961 gcagacacac ggacacgcgg aagccaagca cactctggcg ggtcccgcaa gggacgccgt
     4021 ggaagaaagg agcctgtggc aacaggcggc cgagctgccg aattcagttg acacgaggca
     4081 cagaaaacaa atatcaaaga tctaataata caaaacaaac ttgattaaaa ctggtgctta
     4141 aagtttatta cccacaactc cacagtctct gtgtaaacca ctcgactcat cttgtagctt
     4201 attttttttt aaagaggacg ttttctacgg ctgtggcccg cctctgtgaa ccatagcggt
     4261 gtgcggcggg gggtctgcac ccgggtgggg gacagaggga cctttaaaga aaacaaaact
     4321 ggacagaaac aggaatgtga gctgggggag ctggcttgag tttctcaaaa gccatcggaa
     4381 gatgcgagtt tgtgcctttt tttttattgc tctggtggat ttttgtggct gggttttctg
     4441 aagtctgagg aacaatgcct taagaaaaaa caaacagcag gaatcggtgg gacagtttcc
     4501 tgtggccagc cgagcctggc agtgctggca ccgcgagctg gcctgacgcc tcaagcacgg
     4561 gcaccagccg tcatctccgg ggccaggggc tgcagcccgg cggtccctgt tttgctttat
     4621 tgctgtttaa gaaaaatgga ggtagttcca aaaaagtggc aaatcccgtt ggaggttttg
     4681 aagtccaaca aattttaaac gaatccaaag tgttctcaca cgtcacatac gattgagcat
     4741 ctccatctgg tcgtgaagca tgtggtaggc acacttgcag tgttacgatc ggaatgcttt
     4801 ttattaaaag caagtagcat gaagtattgc ttaaatttta ggtataaata aatatatata
     4861 tgtataatat atattccaat gtattccaag ctaagaaact tacttgattc ttatgaaatc
     4921 ttgataaaat atttataatg catttataga aaaagtatat atatatatat aaaatgaatg
     4981 cagattgcga aggtccctgc aaatggatgg cttgtgaatt tgctctcaag gtgcttatgg
     5041 aaagggatcc tgattgattg aaattcatgt tttctcaagc tccagattgg ctagatttca
     5101 gatcgccaac acattcgcca ctgggcaact accctacaag tttgtacttt cattttaatt
     5161 attttctaac agaaccgctc ccgtctccaa gccttcatgc acatatgtac ctaatgagtt
     5221 tttatagcaa agaatataaa tttgctgttg atttttgtat gaattttttc acaaaaagat
     5281 cctgaataag cattgtttta tgaattttac atttttcctc accatttagc aattttctga
     5341 atggtaataa tgtctaaatc tttttccttt ctgaattctt gcttgtacat ttttttttac
     5401 ctttcaaagg tttttaatta tttttgtttt tatttttgta cgatgagttt tctgcagcgt
     5461 acagaattgt tgctgtcaga ttctattttc agaaagtgag aggagggacc gtaggtcttt
     5521 tcggagtgac accaacgatt gtgtctttcc tggtctgtcc taggagctgt ataaagaagc
     5581 ccaggggctc tttttaactt tcaacactag tagtattacg aggggtggtg tgtttttccc
     5641 ctccgtggca agggcaggga gggttgctta ggatgcccgg ccaccctggg aggcttgcca
     5701 gatgccgggg gcagtcagca ttaatgaaac tcatgtttaa acttctctga ccacatcgtc
     5761 aggatagaat tctaacttga gttttccaaa gaccttttga gcatgtcagc aatgcatggg
     5821 gcacacgtgg ggctctttac ccacttgggt ttttccactg cagccacgtg gccagccctg
     5881 gattttggag cctgtggctg caaggaaccc agggaccctt gttgcctggt gaacctgcag
     5941 ggagggtatg attgcctgac caggacagcc agtctttact ctttttctct tcaacagtaa
     6001 ctgacagtca cgttttactg gtaacttatt ttccagcaca tgaagccacc agtttcattc
     6061 caaagtgtat attgggttca gacttggggg cagaagttca gacacaccgt gctcaggagg
     6121 gacccagagc cgagtttcgg agtttggtaa agtttacagg gtagcttctg aaattaactc
     6181 aaacttttga ccaaatgagt gcagattctt ggattcactt ggtcactggg ctgctgatgg
     6241 tcagctctga gacagtggtt tgagagcagg cagaacggtc ttgggacttg tttgactttc
     6301 ccctccctgg tggccactct ttgctctgaa gcccagattg gcaagaggag ctggtccatt
     6361 ccccattcat ggcacagagc agtggcaggg cccagctagc aggctcttct ggcctccttg
     6421 gcctcattct ctgcatagcc ctctggggat cctgccacct gccctcttac cccgccgtgg
     6481 cttatgggga ggaatgcatc atctcacttt ttttttttaa gcagatgatg ggataacatg
     6541 gactgctcag tggccaggtt atcagtgggg ggacttaatt ctaatctcat tcaaatggag
     6601 acgccctctg caaaggcctg gcagggggag gcacgtttca tctgtcagct cactccagct
     6661 tcacaaatgt gctgagagca ttactgtgta gccttttctt tgaagacaca ctcggctctt
     6721 ctccacagca agcgtccagg gcagatggca gaggatctgc ctcggcgtct gcaggcggga
     6781 ccacgtcagg gagggttcct tcatgtgttc tccctgtggg tccttggacc tttagccttt
     6841 ttcttccttt gcaaaggcct tgggggcact ggctgggagt cagcaagcga gcactttata
     6901 tccctttgag ggaaaccctg atgacgccac tgggcctctt ggcgtctgcc ctgccctcgc
     6961 ggcttcccgc cgtgccgcag cgtgcccacg tgcccacgcc ccaccagcag gcggctgtcc
     7021 cggaggccgt ggcccgctgg gactggccgc ccctccccag cgtcccaggg ctctggttct
     7081 ggagggccac tttgtcaagg tgtttcagtt tttctttact tcttttgaaa atctgtttgc
     7141 aaggggaagg accatttcgt aatggtctga cacaaaagca agtttgattt ttgcagcact
     7201 agcaatggac tttgttgttt ttctttttga tcagaacatt ccttctttac tggtcacagc
     7261 cacgtgctca ttccattctt ctttttgtag actttgggcc cacgtgtttt atgggcattg
     7321 atacatatat aaatatatag atataaatat atatgaatat atttttttaa gtttcctaca
     7381 cctggaggtt gcatggactg tacgaccggc atgactttat attgtataca gattttgcac
     7441 gccaaactcg gcagctttgg ggaagaagaa aaatgccttt ctgttcccct ctcatgacat
     7501 ttgcagatac aaaagatgga aatttttctg taaaacaaaa ccttgaagga gaggagggcg
     7561 gggaagtttg cgtcttattg aacttattct taagaaattg tactttttat tgtaagaaaa
     7621 ataaaaagga ctacttaaac atttgtcata ttaagaaaaa aagtttatct agcacttgtg
     7681 acataccaat aatagagttt attgtattta tgtggaaaca gtgttttagg gaaactactc
     7741 agaattcaca gtgaactgcc tgtctctctc gagttgattt ggaggaattt tgttttgttt
     7801 tgttttgttt gtttcctttt atctccttcc acgggccagg cgagcgccgc ccgccctcac
     7861 tggccttgtg acggtttatt ctgattgaga actgggcgga ctcgaaagag tccccttttc
     7921 cgcacagctg tgttgacttt ttaattactt ttaggtgatg tatggctaag atttcacttt
     7981 aagcagtcgt gaactgtgcg agcactgtgg tttacaatta tactttgcat cgaaaggaaa
     8041 ccatttcttc attgtaacga agctgagcgt gttcttagct cggcctcact ttgtctctgg
     8101 cattgattaa aagtctgcta ttgaaagaaa aagaaagcga acagtttttg tttgtttttt
     8161 ttgccgtgtg tgctccatag tggaggcgct attttccaat tgatgagaat gacaaacata
     8221 tataatctat ctatctatct atctatctat ctatctatac agggggcttg aaccttactc
     8281 acccaagagc ttcttacgga atgtggtaga aaaccaagtt gtaacgacac tgtaacctac
     8341 ctgatgcctg ttcgcgcccg ccgtgagctg cgcactggcc gtggccacca ttcacctctg
     8401 taatttaatc cgtttctctt ggattgtctg gacgtgcccg atggttcttt cttttgctca
     8461 gtggagttgg aggttttgtg tttggttttc tcattcttgt cttgttttgt gtgggtggat
     8521 tttcaccgac caatgatatc ctcttctgac ggtcaccttc tttccacttc actggagtcc
     8581 agtattctgt accacatcac gcaacgtgtt atcttgtggt gtaaataaag actgcgttac
     8641 ttgccctccc a
//
