LOCUS       NM_001378415            8666 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens histone deacetylase 4 (HDAC4), transcript variant 3,
            mRNA.
ACCESSION   NM_001378415 XM_011512221
VERSION     NM_001378415.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8666)
  AUTHORS   Liu,W. and Luo,G.
  TITLE     NEDD9 is transcriptionally regulated by HDAC4 and promotes breast
            cancer metastasis and macrophage M2 polarization via the
            FAK/NF-kappaB signaling pathway
  JOURNAL   Neoplasia 57, 101059 (2024)
   PUBMED   39326322
  REMARK    GeneRIF: NEDD9 is transcriptionally regulated by HDAC4 and promotes
            breast cancer metastasis and macrophage M2 polarization via the
            FAK/NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 8666)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8666)
  AUTHORS   Di Giorgio,E., Dalla,E., Tolotto,V., D'Este,F., Paluvai,H.,
            Ranzino,L. and Brancolini,C.
  TITLE     HDAC4 influences the DNA damage response and counteracts senescence
            by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and
            homology-directed repair
  JOURNAL   Nucleic Acids Res 52 (14), 8218-8240 (2024)
   PUBMED   38874468
  REMARK    GeneRIF: HDAC4 influences the DNA damage response and counteracts
            senescence by assembling with HDAC1/HDAC2 to control H2BK120
            acetylation and homology-directed repair.
REFERENCE   4  (bases 1 to 8666)
  AUTHORS   Chen,Q. and Lao,J.
  TITLE     Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal
            Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced
            Alveolar Epithelial Cell Injury
  JOURNAL   J Physiol Investig 67 (4), 174-186 (2024)
   PUBMED   39133038
  REMARK    GeneRIF: Interference with Histone Deacetylase 4 Regulates c-Jun
            N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate
            Sepsis-induced Alveolar Epithelial Cell Injury.
REFERENCE   5  (bases 1 to 8666)
  AUTHORS   Dai,S., Guo,L., Dey,R., Guo,M., Zhang,X., Bates,D., Cayford,J.,
            Jiang,L., Wei,H., Chen,Z., Zhang,Y., Chen,L. and Chen,Y.
  TITLE     Structural insights into the HDAC4-MEF2A-DNA complex and its
            implication in long-range transcriptional regulation
  JOURNAL   Nucleic Acids Res 52 (5), 2711-2723 (2024)
   PUBMED   38281192
  REMARK    GeneRIF: Structural insights into the HDAC4-MEF2A-DNA complex and
            its implication in long-range transcriptional regulation.
REFERENCE   6  (bases 1 to 8666)
  AUTHORS   Pazin,M.J. and Kadonaga,J.T.
  TITLE     What's up and down with histone deacetylation and transcription?
  JOURNAL   Cell 89 (3), 325-328 (1997)
   PUBMED   9150131
  REMARK    Review article
REFERENCE   7  (bases 1 to 8666)
  AUTHORS   Wolffe,A.P.
  TITLE     Transcriptional control. Sinful repression
  JOURNAL   Nature 387 (6628), 16-17 (1997)
   PUBMED   9139815
REFERENCE   8  (bases 1 to 8666)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   9  (bases 1 to 8666)
  AUTHORS   Wilson,L.C., Leverton,K., Oude Luttikhuis,M.E., Oley,C.A.,
            Flint,J., Wolstenholme,J., Duckett,D.P., Barrow,M.A., Leonard,J.V.,
            Read,A.P. et al.
  TITLE     Brachydactyly and mental retardation: an Albright hereditary
            osteodystrophy-like syndrome localized to 2q37
  JOURNAL   Am J Hum Genet 56 (2), 400-407 (1995)
   PUBMED   7847374
REFERENCE   10 (bases 1 to 8666)
  AUTHORS   Doherty,E.S. and Lacbawan,F.L.
  TITLE     2q37 Microdeletion Syndrome - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301337
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC062017.6 and AC017028.11.
            
            On Feb 12, 2020 this sequence version replaced XM_011512221.1.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to class II of the histone deacetylase/acuc/apha
            family. It possesses histone deacetylase activity and represses
            transcription when tethered to a promoter. This protein does not
            bind DNA directly, but through transcription factors MEF2C and
            MEF2D. It seems to interact in a multiprotein complex with RbAp48
            and HDAC3. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2237633.1,
                                           SRR14038191.494124.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC062017.6         168432-168679       c
            249-489             AC062017.6         119709-119949       c
            490-561             AC062017.6         3625-3696           c
            562-806             AC017028.11        156837-157081       c
            807-957             AC017028.11        143417-143567       c
            958-1078            AC017028.11        130807-130927       c
            1079-1200           AC017028.11        123656-123777       c
            1201-1332           AC017028.11        111587-111718       c
            1333-1445           AC017028.11        106688-106800       c
            1446-1562           AC017028.11        101531-101647       c
            1563-1761           AC017028.11        101249-101447       c
            1762-2000           AC017028.11        93460-93698         c
            2001-2258           AC017028.11        82057-82314         c
            2259-2445           AC017028.11        78530-78716         c
            2446-2579           AC017028.11        75054-75187         c
            2580-2700           AC017028.11        69780-69900         c
            2701-2747           AC017028.11        62014-62060         c
            2748-2855           AC017028.11        57013-57120         c
            2856-2911           AC017028.11        54563-54618         c
            2912-2999           AC017028.11        51159-51246         c
            3000-3119           AC017028.11        49106-49225         c
            3120-3217           AC017028.11        48099-48196         c
            3218-3336           AC017028.11        35493-35611         c
            3337-3470           AC017028.11        33726-33859         c
            3471-3555           AC017028.11        21753-21837         c
            3556-3697           AC017028.11        20464-20605         c
            3698-8666           AC017028.11        15172-20140         c
FEATURES             Location/Qualifiers
     source          1..8666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..8666
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
     exon            1..248
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            249..489
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..3737
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 3;
                     histone deacetylase A"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform 1"
                     /protein_id="NP_001365344.1"
                     /db_xref="CCDS:CCDS92981.1"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     SAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSR
                     QHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEK
                     GKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQ
                     SGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPV
                     VTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLV
                     AREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTH
                     LTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTDWYLSGLGALPLHAQSLVG
                     ADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQ
                     MNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQE
                     PIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPV
                     SFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPE
                     HAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDS
                     KKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNG
                     FAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAF
                     YSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLA
                     AFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR
                     IVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHS
                     KYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPP
                     L"
     exon            490..561
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            562..806
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            807..957
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1078
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1200
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1332
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1445
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1562
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1761
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2000
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2258
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2445
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2579
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2700
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2747
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2855
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2911
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..2999
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3119
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3217
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3336
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3470
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3471..3555
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3697
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..8666
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8121..8126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="hexamer: ATTAAA"
     polyA_site      8147
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="major polyA site"
     regulatory      8639..8644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="hexamer: AATAAA"
     polyA_site      8666
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="major polyA site"
ORIGIN      
        1 gccagtatcc aagatggacg ccgcggcgag gcctggccgg ctccccgcgt tagcctgcac
       61 cccattgtgt gccctctaag cgcgaattag gctcgcagac atgcggtgct gaccgctagg
      121 cagccatgcg ggctaccgag tgcgaccgga cacggccggg gcccgtgttt acggccacta
      181 ctggcccccg gtccctgcgc ctcctcaacc gcgaagcacc cagcggctgg cgcctggagc
      241 gtcttttggt tcatctgcag aagccagcgg acgcctctgt tcaacttgtg ggttacctgg
      301 ctcatgagac cttgccggcg aggctcggcg cttgaacgtc tgtgacccag ccctcaccgt
      361 cccggtactt gtatgtgttg gtgggagttt ggagctcgtt ggagctatcg tttccgtgga
      421 aattttgagc catttcgaat cacttaaagg agtggacatt gctagcaatg agctcccaaa
      481 gccatccaga tggactttct ggccgagacc agccagtgga gctgctgaat cctgcccgcg
      541 tgaaccacat gcccagcacg gtggatgtgg ccacggcgct gcctctgcaa gtggccccct
      601 cggcagtgcc catggacctg cgcctggacc accagttctc actgcctgtg gcagagccgg
      661 ccctgcggga gcagcagctg cagcaggagc tcctggcgct caagcagaag cagcagatcc
      721 agaggcagat cctcatcgct gagttccaga ggcagcacga gcagctctcc cggcagcacg
      781 aggcgcagct ccacgagcac atcaagcaac aacaggagat gctggccatg aagcaccagc
      841 aggagctgct ggaacaccag cggaagctgg agaggcaccg ccaggagcag gagctggaga
      901 agcagcaccg ggagcagaag ctgcagcagc tcaagaacaa ggagaagggc aaagagagtg
      961 ccgtggccag cacagaagtg aagatgaagt tacaagaatt tgtcctcaat aaaaagaagg
     1021 cgctggccca ccggaatctg aaccactgca tttccagcga ccctcgctac tggtacggga
     1081 aaacgcagca cagttccctt gaccagagtt ctccacccca gagcggagtg tcgacctcct
     1141 ataaccaccc ggtcctggga atgtacgacg ccaaagatga cttccctctt aggaaaacag
     1201 cttctgaacc gaatctgaaa ttacggtcca ggctaaagca gaaagtggcc gaaagacgga
     1261 gcagccccct gttacgcagg aaagacgggc cagtggtcac tgctctaaaa aagcgtccgt
     1321 tggatgtcac agactccgcg tgcagcagcg ccccaggctc cggacccagc tcacccaaca
     1381 acagctccgg gagcgtcagc gcggagaacg gtatcgcgcc cgccgtcccc agcatcccgg
     1441 cggagacgag tttggcgcac agacttgtgg cacgagaagg ctcggccgct ccacttcccc
     1501 tctacacatc gccatccttg cccaacatca cgctgggcct gcctgccacc ggcccctctg
     1561 cgggcacggc gggccagcag gacgccgaga gactcaccct tcccgccctc cagcagaggc
     1621 tctccctttt ccccggcacc cacctcactc cctacctgag cacctcgccc ttggagcggg
     1681 acggaggggc agcgcacagc cctcttctgc agcacatggt cttactggag cagccgccgg
     1741 cacaagcacc cctcgtcaca gactggtatc tttcaggcct gggagcactg cccctccacg
     1801 cacagtcctt ggttggtgca gaccgggtgt ccccctccat ccacaagctg cggcagcacc
     1861 gcccactggg gcggacccag tcggccccgc tgccccagaa cgcccaggct ctgcagcacc
     1921 tggtcatcca gcagcagcat cagcagtttc tggagaaaca caagcagcag ttccagcagc
     1981 agcaactgca gatgaacaag atcatcccca agccaagcga gccagcccgg cagccggaga
     2041 gccacccgga ggagacggag gaggagctcc gtgagcacca ggctctgctg gacgagccct
     2101 acctggaccg gctgccgggg cagaaggagg cgcacgcaca ggccggcgtg caggtgaagc
     2161 aggagcccat tgagagcgat gaggaagagg cagagccccc acgggaggtg gagccgggcc
     2221 agcgccagcc cagtgagcag gagctgctct tcagacagca agccctcctg ctggagcagc
     2281 agcggatcca ccagctgagg aactaccagg cgtccatgga ggccgccggc atccccgtgt
     2341 ccttcggcgg ccacaggcct ctgtcccggg cgcagtcctc acccgcgtct gccaccttcc
     2401 ccgtgtctgt gcaggagccc cccaccaagc cgaggttcac gacaggcctc gtgtatgaca
     2461 cgctgatgct gaagcaccag tgcacctgcg ggagtagcag cagccacccc gagcacgccg
     2521 ggaggatcca gagcatctgg tcccgcctgc aggagacggg cctccggggc aaatgcgagt
     2581 gcatccgcgg acgcaaggcc accctggagg agctacagac ggtgcactcg gaagcccaca
     2641 ccctcctgta tggcacgaac cccctcaacc ggcagaaact ggacagtaag aaacttctag
     2701 gctcgctcgc ctccgtgttc gtccggctcc cttgcggtgg tgttggggtg gacagtgaca
     2761 ccatatggaa cgaggtgcac tcggcggggg cagcccgcct ggctgtgggc tgcgtggtag
     2821 agctggtctt caaggtggcc acaggggagc tgaagaatgg ctttgctgtg gtccgccccc
     2881 ctggacacca tgcggaggag agcacgccca tgggcttttg ctacttcaac tccgtggccg
     2941 tggcagccaa gcttctgcag cagaggttga gcgtgagcaa gatcctcatc gtggactggg
     3001 acgtgcacca tggaaacggg acccagcagg ctttctacag cgaccccagc gtcctgtaca
     3061 tgtccctcca ccgctacgac gatgggaact tcttcccagg cagcggggct cctgatgagg
     3121 tgggcacagg gcccggcgtg ggtttcaacg tcaacatggc tttcaccggc ggcctggacc
     3181 cccccatggg agacgctgag tacttggcgg ccttcagaac ggtggtcatg ccgatcgcca
     3241 gcgagtttgc cccggatgtg gtgctggtgt catcaggctt cgatgccgtg gagggccacc
     3301 ccacccctct tgggggctac aacctctccg ccagatgctt cgggtacctg acgaagcagc
     3361 tgatgggcct ggctggcggc cggattgtcc tggccctcga gggaggccac gacctgaccg
     3421 ccatttgcga cgcctcggaa gcatgtgttt ctgccttgct gggaaacgag cttgatcctc
     3481 tcccagaaaa ggttttacag caaagaccca atgcaaacgc tgtccgttcc atggagaaag
     3541 tcatggagat ccacagcaag tactggcgct gcctgcagcg cacaacctcc acagcggggc
     3601 gttctctgat cgaggctcag acttgcgaga acgaagaagc cgagacggtc accgccatgg
     3661 cctcgctgtc cgtgggcgtg aagcccgccg aaaagagacc agatgaggag cccatggaag
     3721 aggagccgcc cctgtagcac tccctcgaag ctgctgttct cttgtctgtc tgtctctgtc
     3781 ttgaagctca gccaagaaac tttcccgtgt cacgcctgcg tcccaccgtg gggctctctt
     3841 ggagcaccca gggacaccca gcgtgcaaca gccacgggaa gcctttctgc cgcccaggcc
     3901 cacaggtctc gagacgcaca tgcacgcctg ggcgtggcag cctcacaggg aacacgggac
     3961 agacgccggc gacgcgcaga cacacggaca cgcggaagcc aagcacactc tggcgggtcc
     4021 cgcaagggac gccgtggaag aaaggagcct gtggcaacag gcggccgagc tgccgaattc
     4081 agttgacacg aggcacagaa aacaaatatc aaagatctaa taatacaaaa caaacttgat
     4141 taaaactggt gcttaaagtt tattacccac aactccacag tctctgtgta aaccactcga
     4201 ctcatcttgt agcttatttt tttttaaaga ggacgttttc tacggctgtg gcccgcctct
     4261 gtgaaccata gcggtgtgcg gcggggggtc tgcacccggg tgggggacag agggaccttt
     4321 aaagaaaaca aaactggaca gaaacaggaa tgtgagctgg gggagctggc ttgagtttct
     4381 caaaagccat cggaagatgc gagtttgtgc cttttttttt attgctctgg tggatttttg
     4441 tggctgggtt ttctgaagtc tgaggaacaa tgccttaaga aaaaacaaac agcaggaatc
     4501 ggtgggacag tttcctgtgg ccagccgagc ctggcagtgc tggcaccgcg agctggcctg
     4561 acgcctcaag cacgggcacc agccgtcatc tccggggcca ggggctgcag cccggcggtc
     4621 cctgttttgc tttattgctg tttaagaaaa atggaggtag ttccaaaaaa gtggcaaatc
     4681 ccgttggagg ttttgaagtc caacaaattt taaacgaatc caaagtgttc tcacacgtca
     4741 catacgattg agcatctcca tctggtcgtg aagcatgtgg taggcacact tgcagtgtta
     4801 cgatcggaat gctttttatt aaaagcaagt agcatgaagt attgcttaaa ttttaggtat
     4861 aaataaatat atatatgtat aatatatatt ccaatgtatt ccaagctaag aaacttactt
     4921 gattcttatg aaatcttgat aaaatattta taatgcattt atagaaaaag tatatatata
     4981 tatataaaat gaatgcagat tgcgaaggtc cctgcaaatg gatggcttgt gaatttgctc
     5041 tcaaggtgct tatggaaagg gatcctgatt gattgaaatt catgttttct caagctccag
     5101 attggctaga tttcagatcg ccaacacatt cgccactggg caactaccct acaagtttgt
     5161 actttcattt taattatttt ctaacagaac cgctcccgtc tccaagcctt catgcacata
     5221 tgtacctaat gagtttttat agcaaagaat ataaatttgc tgttgatttt tgtatgaatt
     5281 ttttcacaaa aagatcctga ataagcattg ttttatgaat tttacatttt tcctcaccat
     5341 ttagcaattt tctgaatggt aataatgtct aaatcttttt cctttctgaa ttcttgcttg
     5401 tacatttttt tttacctttc aaaggttttt aattattttt gtttttattt ttgtacgatg
     5461 agttttctgc agcgtacaga attgttgctg tcagattcta ttttcagaaa gtgagaggag
     5521 ggaccgtagg tcttttcgga gtgacaccaa cgattgtgtc tttcctggtc tgtcctagga
     5581 gctgtataaa gaagcccagg ggctcttttt aactttcaac actagtagta ttacgagggg
     5641 tggtgtgttt ttcccctccg tggcaagggc agggagggtt gcttaggatg cccggccacc
     5701 ctgggaggct tgccagatgc cgggggcagt cagcattaat gaaactcatg tttaaacttc
     5761 tctgaccaca tcgtcaggat agaattctaa cttgagtttt ccaaagacct tttgagcatg
     5821 tcagcaatgc atggggcaca cgtggggctc tttacccact tgggtttttc cactgcagcc
     5881 acgtggccag ccctggattt tggagcctgt ggctgcaagg aacccaggga cccttgttgc
     5941 ctggtgaacc tgcagggagg gtatgattgc ctgaccagga cagccagtct ttactctttt
     6001 tctcttcaac agtaactgac agtcacgttt tactggtaac ttattttcca gcacatgaag
     6061 ccaccagttt cattccaaag tgtatattgg gttcagactt gggggcagaa gttcagacac
     6121 accgtgctca ggagggaccc agagccgagt ttcggagttt ggtaaagttt acagggtagc
     6181 ttctgaaatt aactcaaact tttgaccaaa tgagtgcaga ttcttggatt cacttggtca
     6241 ctgggctgct gatggtcagc tctgagacag tggtttgaga gcaggcagaa cggtcttggg
     6301 acttgtttga ctttcccctc cctggtggcc actctttgct ctgaagccca gattggcaag
     6361 aggagctggt ccattcccca ttcatggcac agagcagtgg cagggcccag ctagcaggct
     6421 cttctggcct ccttggcctc attctctgca tagccctctg gggatcctgc cacctgccct
     6481 cttaccccgc cgtggcttat ggggaggaat gcatcatctc actttttttt tttaagcaga
     6541 tgatgggata acatggactg ctcagtggcc aggttatcag tggggggact taattctaat
     6601 ctcattcaaa tggagacgcc ctctgcaaag gcctggcagg gggaggcacg tttcatctgt
     6661 cagctcactc cagcttcaca aatgtgctga gagcattact gtgtagcctt ttctttgaag
     6721 acacactcgg ctcttctcca cagcaagcgt ccagggcaga tggcagagga tctgcctcgg
     6781 cgtctgcagg cgggaccacg tcagggaggg ttccttcatg tgttctccct gtgggtcctt
     6841 ggacctttag cctttttctt cctttgcaaa ggccttgggg gcactggctg ggagtcagca
     6901 agcgagcact ttatatccct ttgagggaaa ccctgatgac gccactgggc ctcttggcgt
     6961 ctgccctgcc ctcgcggctt cccgccgtgc cgcagcgtgc ccacgtgccc acgccccacc
     7021 agcaggcggc tgtcccggag gccgtggccc gctgggactg gccgcccctc cccagcgtcc
     7081 cagggctctg gttctggagg gccactttgt caaggtgttt cagtttttct ttacttcttt
     7141 tgaaaatctg tttgcaaggg gaaggaccat ttcgtaatgg tctgacacaa aagcaagttt
     7201 gatttttgca gcactagcaa tggactttgt tgtttttctt tttgatcaga acattccttc
     7261 tttactggtc acagccacgt gctcattcca ttcttctttt tgtagacttt gggcccacgt
     7321 gttttatggg cattgataca tatataaata tatagatata aatatatatg aatatatttt
     7381 tttaagtttc ctacacctgg aggttgcatg gactgtacga ccggcatgac tttatattgt
     7441 atacagattt tgcacgccaa actcggcagc tttggggaag aagaaaaatg cctttctgtt
     7501 cccctctcat gacatttgca gatacaaaag atggaaattt ttctgtaaaa caaaaccttg
     7561 aaggagagga gggcggggaa gtttgcgtct tattgaactt attcttaaga aattgtactt
     7621 tttattgtaa gaaaaataaa aaggactact taaacatttg tcatattaag aaaaaaagtt
     7681 tatctagcac ttgtgacata ccaataatag agtttattgt atttatgtgg aaacagtgtt
     7741 ttagggaaac tactcagaat tcacagtgaa ctgcctgtct ctctcgagtt gatttggagg
     7801 aattttgttt tgttttgttt tgtttgtttc cttttatctc cttccacggg ccaggcgagc
     7861 gccgcccgcc ctcactggcc ttgtgacggt ttattctgat tgagaactgg gcggactcga
     7921 aagagtcccc ttttccgcac agctgtgttg actttttaat tacttttagg tgatgtatgg
     7981 ctaagatttc actttaagca gtcgtgaact gtgcgagcac tgtggtttac aattatactt
     8041 tgcatcgaaa ggaaaccatt tcttcattgt aacgaagctg agcgtgttct tagctcggcc
     8101 tcactttgtc tctggcattg attaaaagtc tgctattgaa agaaaaagaa agcgaacagt
     8161 ttttgtttgt tttttttgcc gtgtgtgctc catagtggag gcgctatttt ccaattgatg
     8221 agaatgacaa acatatataa tctatctatc tatctatcta tctatctatc tatacagggg
     8281 gcttgaacct tactcaccca agagcttctt acggaatgtg gtagaaaacc aagttgtaac
     8341 gacactgtaa cctacctgat gcctgttcgc gcccgccgtg agctgcgcac tggccgtggc
     8401 caccattcac ctctgtaatt taatccgttt ctcttggatt gtctggacgt gcccgatggt
     8461 tctttctttt gctcagtgga gttggaggtt ttgtgtttgg ttttctcatt cttgtcttgt
     8521 tttgtgtggg tggattttca ccgaccaatg atatcctctt ctgacggtca ccttctttcc
     8581 acttcactgg agtccagtat tctgtaccac atcacgcaac gtgttatctt gtggtgtaaa
     8641 taaagactgc gttacttgcc ctccca
//
