LOCUS       NM_001378414            8461 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens histone deacetylase 4 (HDAC4), transcript variant 1,
            mRNA.
ACCESSION   NM_001378414 XM_006712878
VERSION     NM_001378414.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8461)
  AUTHORS   Liu,W. and Luo,G.
  TITLE     NEDD9 is transcriptionally regulated by HDAC4 and promotes breast
            cancer metastasis and macrophage M2 polarization via the
            FAK/NF-kappaB signaling pathway
  JOURNAL   Neoplasia 57, 101059 (2024)
   PUBMED   39326322
  REMARK    GeneRIF: NEDD9 is transcriptionally regulated by HDAC4 and promotes
            breast cancer metastasis and macrophage M2 polarization via the
            FAK/NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 8461)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8461)
  AUTHORS   Di Giorgio,E., Dalla,E., Tolotto,V., D'Este,F., Paluvai,H.,
            Ranzino,L. and Brancolini,C.
  TITLE     HDAC4 influences the DNA damage response and counteracts senescence
            by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and
            homology-directed repair
  JOURNAL   Nucleic Acids Res 52 (14), 8218-8240 (2024)
   PUBMED   38874468
  REMARK    GeneRIF: HDAC4 influences the DNA damage response and counteracts
            senescence by assembling with HDAC1/HDAC2 to control H2BK120
            acetylation and homology-directed repair.
REFERENCE   4  (bases 1 to 8461)
  AUTHORS   Chen,Q. and Lao,J.
  TITLE     Interference with Histone Deacetylase 4 Regulates c-Jun N-terminal
            Kinase/Activating Protein-1 Signaling to Ameliorate Sepsis-induced
            Alveolar Epithelial Cell Injury
  JOURNAL   J Physiol Investig 67 (4), 174-186 (2024)
   PUBMED   39133038
  REMARK    GeneRIF: Interference with Histone Deacetylase 4 Regulates c-Jun
            N-terminal Kinase/Activating Protein-1 Signaling to Ameliorate
            Sepsis-induced Alveolar Epithelial Cell Injury.
REFERENCE   5  (bases 1 to 8461)
  AUTHORS   Dai,S., Guo,L., Dey,R., Guo,M., Zhang,X., Bates,D., Cayford,J.,
            Jiang,L., Wei,H., Chen,Z., Zhang,Y., Chen,L. and Chen,Y.
  TITLE     Structural insights into the HDAC4-MEF2A-DNA complex and its
            implication in long-range transcriptional regulation
  JOURNAL   Nucleic Acids Res 52 (5), 2711-2723 (2024)
   PUBMED   38281192
  REMARK    GeneRIF: Structural insights into the HDAC4-MEF2A-DNA complex and
            its implication in long-range transcriptional regulation.
REFERENCE   6  (bases 1 to 8461)
  AUTHORS   Pazin,M.J. and Kadonaga,J.T.
  TITLE     What's up and down with histone deacetylation and transcription?
  JOURNAL   Cell 89 (3), 325-328 (1997)
   PUBMED   9150131
  REMARK    Review article
REFERENCE   7  (bases 1 to 8461)
  AUTHORS   Wolffe,A.P.
  TITLE     Transcriptional control. Sinful repression
  JOURNAL   Nature 387 (6628), 16-17 (1997)
   PUBMED   9139815
REFERENCE   8  (bases 1 to 8461)
  AUTHORS   Ohara,O., Nagase,T., Ishikawa,K., Nakajima,D., Ohira,M., Seki,N.
            and Nomura,N.
  TITLE     Construction and characterization of human brain cDNA libraries
            suitable for analysis of cDNA clones encoding relatively large
            proteins
  JOURNAL   DNA Res 4 (1), 53-59 (1997)
   PUBMED   9179496
REFERENCE   9  (bases 1 to 8461)
  AUTHORS   Wilson,L.C., Leverton,K., Oude Luttikhuis,M.E., Oley,C.A.,
            Flint,J., Wolstenholme,J., Duckett,D.P., Barrow,M.A., Leonard,J.V.,
            Read,A.P. et al.
  TITLE     Brachydactyly and mental retardation: an Albright hereditary
            osteodystrophy-like syndrome localized to 2q37
  JOURNAL   Am J Hum Genet 56 (2), 400-407 (1995)
   PUBMED   7847374
REFERENCE   10 (bases 1 to 8461)
  AUTHORS   Doherty,E.S. and Lacbawan,F.L.
  TITLE     2q37 Microdeletion Syndrome - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301337
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC062017.6 and AC017028.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 12, 2020 this sequence version replaced XM_006712878.3.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to class II of the histone deacetylase/acuc/apha
            family. It possesses histone deacetylase activity and represses
            transcription when tethered to a promoter. This protein does not
            bind DNA directly, but through transcription factors MEF2C and
            MEF2D. It seems to interact in a multiprotein complex with RbAp48
            and HDAC3. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.16775.1,
                                           SRR14038194.3429702.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543185.6/ ENSP00000440481.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC062017.6         168008-168050       c
            44-284              AC062017.6         119709-119949       c
            285-356             AC062017.6         3625-3696           c
            357-601             AC017028.11        156837-157081       c
            602-752             AC017028.11        143417-143567       c
            753-873             AC017028.11        130807-130927       c
            874-995             AC017028.11        123656-123777       c
            996-1127            AC017028.11        111587-111718       c
            1128-1240           AC017028.11        106688-106800       c
            1241-1357           AC017028.11        101531-101647       c
            1358-1556           AC017028.11        101249-101447       c
            1557-1795           AC017028.11        93460-93698         c
            1796-2053           AC017028.11        82057-82314         c
            2054-2240           AC017028.11        78530-78716         c
            2241-2374           AC017028.11        75054-75187         c
            2375-2495           AC017028.11        69780-69900         c
            2496-2542           AC017028.11        62014-62060         c
            2543-2650           AC017028.11        57013-57120         c
            2651-2706           AC017028.11        54563-54618         c
            2707-2794           AC017028.11        51159-51246         c
            2795-2914           AC017028.11        49106-49225         c
            2915-3012           AC017028.11        48099-48196         c
            3013-3131           AC017028.11        35493-35611         c
            3132-3265           AC017028.11        33726-33859         c
            3266-3350           AC017028.11        21753-21837         c
            3351-3492           AC017028.11        20464-20605         c
            3493-8461           AC017028.11        15172-20140         c
FEATURES             Location/Qualifiers
     source          1..8461
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..8461
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="histone deacetylase 4"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
     exon            1..43
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            44..284
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3532
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone deacetylase A"
                     /codon_start=1
                     /product="histone deacetylase 4 isoform 1"
                     /protein_id="NP_001365343.1"
                     /db_xref="CCDS:CCDS92981.1"
                     /db_xref="GeneID:9759"
                     /db_xref="HGNC:HGNC:14063"
                     /db_xref="MIM:605314"
                     /translation="MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAP
                     SAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSR
                     QHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEK
                     GKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQ
                     SGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPV
                     VTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLV
                     AREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTH
                     LTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTDWYLSGLGALPLHAQSLVG
                     ADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQ
                     MNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQE
                     PIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPV
                     SFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPE
                     HAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDS
                     KKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNG
                     FAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAF
                     YSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLA
                     AFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGR
                     IVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHS
                     KYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPP
                     L"
     exon            285..356
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            357..601
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            602..752
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            753..873
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            874..995
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1127
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1240
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1357
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1556
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1795
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2053
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2240
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2374
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2495
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2542
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2650
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2706
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2794
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2914
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3012
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3131
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3265
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3350
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3351..3492
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..8461
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7916..7921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="hexamer: ATTAAA"
     polyA_site      7942
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="major polyA site"
     regulatory      8434..8439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="hexamer: AATAAA"
     polyA_site      8461
                     /gene="HDAC4"
                     /gene_synonym="AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A;
                     HDACA; NEDCHF; NEDCHID"
                     /note="major polyA site"
ORIGIN      
        1 gcctggctcg acgctggagt ggggagaagc atcatggttc aacgttcatc tgcagaagcc
       61 agcggacgcc tctgttcaac ttgtgggtta cctggctcat gagaccttgc cggcgaggct
      121 cggcgcttga acgtctgtga cccagccctc accgtcccgg tacttgtatg tgttggtggg
      181 agtttggagc tcgttggagc tatcgtttcc gtggaaattt tgagccattt cgaatcactt
      241 aaaggagtgg acattgctag caatgagctc ccaaagccat ccagatggac tttctggccg
      301 agaccagcca gtggagctgc tgaatcctgc ccgcgtgaac cacatgccca gcacggtgga
      361 tgtggccacg gcgctgcctc tgcaagtggc cccctcggca gtgcccatgg acctgcgcct
      421 ggaccaccag ttctcactgc ctgtggcaga gccggccctg cgggagcagc agctgcagca
      481 ggagctcctg gcgctcaagc agaagcagca gatccagagg cagatcctca tcgctgagtt
      541 ccagaggcag cacgagcagc tctcccggca gcacgaggcg cagctccacg agcacatcaa
      601 gcaacaacag gagatgctgg ccatgaagca ccagcaggag ctgctggaac accagcggaa
      661 gctggagagg caccgccagg agcaggagct ggagaagcag caccgggagc agaagctgca
      721 gcagctcaag aacaaggaga agggcaaaga gagtgccgtg gccagcacag aagtgaagat
      781 gaagttacaa gaatttgtcc tcaataaaaa gaaggcgctg gcccaccgga atctgaacca
      841 ctgcatttcc agcgaccctc gctactggta cgggaaaacg cagcacagtt cccttgacca
      901 gagttctcca ccccagagcg gagtgtcgac ctcctataac cacccggtcc tgggaatgta
      961 cgacgccaaa gatgacttcc ctcttaggaa aacagcttct gaaccgaatc tgaaattacg
     1021 gtccaggcta aagcagaaag tggccgaaag acggagcagc cccctgttac gcaggaaaga
     1081 cgggccagtg gtcactgctc taaaaaagcg tccgttggat gtcacagact ccgcgtgcag
     1141 cagcgcccca ggctccggac ccagctcacc caacaacagc tccgggagcg tcagcgcgga
     1201 gaacggtatc gcgcccgccg tccccagcat cccggcggag acgagtttgg cgcacagact
     1261 tgtggcacga gaaggctcgg ccgctccact tcccctctac acatcgccat ccttgcccaa
     1321 catcacgctg ggcctgcctg ccaccggccc ctctgcgggc acggcgggcc agcaggacgc
     1381 cgagagactc acccttcccg ccctccagca gaggctctcc cttttccccg gcacccacct
     1441 cactccctac ctgagcacct cgcccttgga gcgggacgga ggggcagcgc acagccctct
     1501 tctgcagcac atggtcttac tggagcagcc gccggcacaa gcacccctcg tcacagactg
     1561 gtatctttca ggcctgggag cactgcccct ccacgcacag tccttggttg gtgcagaccg
     1621 ggtgtccccc tccatccaca agctgcggca gcaccgccca ctggggcgga cccagtcggc
     1681 cccgctgccc cagaacgccc aggctctgca gcacctggtc atccagcagc agcatcagca
     1741 gtttctggag aaacacaagc agcagttcca gcagcagcaa ctgcagatga acaagatcat
     1801 ccccaagcca agcgagccag cccggcagcc ggagagccac ccggaggaga cggaggagga
     1861 gctccgtgag caccaggctc tgctggacga gccctacctg gaccggctgc cggggcagaa
     1921 ggaggcgcac gcacaggccg gcgtgcaggt gaagcaggag cccattgaga gcgatgagga
     1981 agaggcagag cccccacggg aggtggagcc gggccagcgc cagcccagtg agcaggagct
     2041 gctcttcaga cagcaagccc tcctgctgga gcagcagcgg atccaccagc tgaggaacta
     2101 ccaggcgtcc atggaggccg ccggcatccc cgtgtccttc ggcggccaca ggcctctgtc
     2161 ccgggcgcag tcctcacccg cgtctgccac cttccccgtg tctgtgcagg agccccccac
     2221 caagccgagg ttcacgacag gcctcgtgta tgacacgctg atgctgaagc accagtgcac
     2281 ctgcgggagt agcagcagcc accccgagca cgccgggagg atccagagca tctggtcccg
     2341 cctgcaggag acgggcctcc ggggcaaatg cgagtgcatc cgcggacgca aggccaccct
     2401 ggaggagcta cagacggtgc actcggaagc ccacaccctc ctgtatggca cgaaccccct
     2461 caaccggcag aaactggaca gtaagaaact tctaggctcg ctcgcctccg tgttcgtccg
     2521 gctcccttgc ggtggtgttg gggtggacag tgacaccata tggaacgagg tgcactcggc
     2581 gggggcagcc cgcctggctg tgggctgcgt ggtagagctg gtcttcaagg tggccacagg
     2641 ggagctgaag aatggctttg ctgtggtccg cccccctgga caccatgcgg aggagagcac
     2701 gcccatgggc ttttgctact tcaactccgt ggccgtggca gccaagcttc tgcagcagag
     2761 gttgagcgtg agcaagatcc tcatcgtgga ctgggacgtg caccatggaa acgggaccca
     2821 gcaggctttc tacagcgacc ccagcgtcct gtacatgtcc ctccaccgct acgacgatgg
     2881 gaacttcttc ccaggcagcg gggctcctga tgaggtgggc acagggcccg gcgtgggttt
     2941 caacgtcaac atggctttca ccggcggcct ggaccccccc atgggagacg ctgagtactt
     3001 ggcggccttc agaacggtgg tcatgccgat cgccagcgag tttgccccgg atgtggtgct
     3061 ggtgtcatca ggcttcgatg ccgtggaggg ccaccccacc cctcttgggg gctacaacct
     3121 ctccgccaga tgcttcgggt acctgacgaa gcagctgatg ggcctggctg gcggccggat
     3181 tgtcctggcc ctcgagggag gccacgacct gaccgccatt tgcgacgcct cggaagcatg
     3241 tgtttctgcc ttgctgggaa acgagcttga tcctctccca gaaaaggttt tacagcaaag
     3301 acccaatgca aacgctgtcc gttccatgga gaaagtcatg gagatccaca gcaagtactg
     3361 gcgctgcctg cagcgcacaa cctccacagc ggggcgttct ctgatcgagg ctcagacttg
     3421 cgagaacgaa gaagccgaga cggtcaccgc catggcctcg ctgtccgtgg gcgtgaagcc
     3481 cgccgaaaag agaccagatg aggagcccat ggaagaggag ccgcccctgt agcactccct
     3541 cgaagctgct gttctcttgt ctgtctgtct ctgtcttgaa gctcagccaa gaaactttcc
     3601 cgtgtcacgc ctgcgtccca ccgtggggct ctcttggagc acccagggac acccagcgtg
     3661 caacagccac gggaagcctt tctgccgccc aggcccacag gtctcgagac gcacatgcac
     3721 gcctgggcgt ggcagcctca cagggaacac gggacagacg ccggcgacgc gcagacacac
     3781 ggacacgcgg aagccaagca cactctggcg ggtcccgcaa gggacgccgt ggaagaaagg
     3841 agcctgtggc aacaggcggc cgagctgccg aattcagttg acacgaggca cagaaaacaa
     3901 atatcaaaga tctaataata caaaacaaac ttgattaaaa ctggtgctta aagtttatta
     3961 cccacaactc cacagtctct gtgtaaacca ctcgactcat cttgtagctt attttttttt
     4021 aaagaggacg ttttctacgg ctgtggcccg cctctgtgaa ccatagcggt gtgcggcggg
     4081 gggtctgcac ccgggtgggg gacagaggga cctttaaaga aaacaaaact ggacagaaac
     4141 aggaatgtga gctgggggag ctggcttgag tttctcaaaa gccatcggaa gatgcgagtt
     4201 tgtgcctttt tttttattgc tctggtggat ttttgtggct gggttttctg aagtctgagg
     4261 aacaatgcct taagaaaaaa caaacagcag gaatcggtgg gacagtttcc tgtggccagc
     4321 cgagcctggc agtgctggca ccgcgagctg gcctgacgcc tcaagcacgg gcaccagccg
     4381 tcatctccgg ggccaggggc tgcagcccgg cggtccctgt tttgctttat tgctgtttaa
     4441 gaaaaatgga ggtagttcca aaaaagtggc aaatcccgtt ggaggttttg aagtccaaca
     4501 aattttaaac gaatccaaag tgttctcaca cgtcacatac gattgagcat ctccatctgg
     4561 tcgtgaagca tgtggtaggc acacttgcag tgttacgatc ggaatgcttt ttattaaaag
     4621 caagtagcat gaagtattgc ttaaatttta ggtataaata aatatatata tgtataatat
     4681 atattccaat gtattccaag ctaagaaact tacttgattc ttatgaaatc ttgataaaat
     4741 atttataatg catttataga aaaagtatat atatatatat aaaatgaatg cagattgcga
     4801 aggtccctgc aaatggatgg cttgtgaatt tgctctcaag gtgcttatgg aaagggatcc
     4861 tgattgattg aaattcatgt tttctcaagc tccagattgg ctagatttca gatcgccaac
     4921 acattcgcca ctgggcaact accctacaag tttgtacttt cattttaatt attttctaac
     4981 agaaccgctc ccgtctccaa gccttcatgc acatatgtac ctaatgagtt tttatagcaa
     5041 agaatataaa tttgctgttg atttttgtat gaattttttc acaaaaagat cctgaataag
     5101 cattgtttta tgaattttac atttttcctc accatttagc aattttctga atggtaataa
     5161 tgtctaaatc tttttccttt ctgaattctt gcttgtacat ttttttttac ctttcaaagg
     5221 tttttaatta tttttgtttt tatttttgta cgatgagttt tctgcagcgt acagaattgt
     5281 tgctgtcaga ttctattttc agaaagtgag aggagggacc gtaggtcttt tcggagtgac
     5341 accaacgatt gtgtctttcc tggtctgtcc taggagctgt ataaagaagc ccaggggctc
     5401 tttttaactt tcaacactag tagtattacg aggggtggtg tgtttttccc ctccgtggca
     5461 agggcaggga gggttgctta ggatgcccgg ccaccctggg aggcttgcca gatgccgggg
     5521 gcagtcagca ttaatgaaac tcatgtttaa acttctctga ccacatcgtc aggatagaat
     5581 tctaacttga gttttccaaa gaccttttga gcatgtcagc aatgcatggg gcacacgtgg
     5641 ggctctttac ccacttgggt ttttccactg cagccacgtg gccagccctg gattttggag
     5701 cctgtggctg caaggaaccc agggaccctt gttgcctggt gaacctgcag ggagggtatg
     5761 attgcctgac caggacagcc agtctttact ctttttctct tcaacagtaa ctgacagtca
     5821 cgttttactg gtaacttatt ttccagcaca tgaagccacc agtttcattc caaagtgtat
     5881 attgggttca gacttggggg cagaagttca gacacaccgt gctcaggagg gacccagagc
     5941 cgagtttcgg agtttggtaa agtttacagg gtagcttctg aaattaactc aaacttttga
     6001 ccaaatgagt gcagattctt ggattcactt ggtcactggg ctgctgatgg tcagctctga
     6061 gacagtggtt tgagagcagg cagaacggtc ttgggacttg tttgactttc ccctccctgg
     6121 tggccactct ttgctctgaa gcccagattg gcaagaggag ctggtccatt ccccattcat
     6181 ggcacagagc agtggcaggg cccagctagc aggctcttct ggcctccttg gcctcattct
     6241 ctgcatagcc ctctggggat cctgccacct gccctcttac cccgccgtgg cttatgggga
     6301 ggaatgcatc atctcacttt ttttttttaa gcagatgatg ggataacatg gactgctcag
     6361 tggccaggtt atcagtgggg ggacttaatt ctaatctcat tcaaatggag acgccctctg
     6421 caaaggcctg gcagggggag gcacgtttca tctgtcagct cactccagct tcacaaatgt
     6481 gctgagagca ttactgtgta gccttttctt tgaagacaca ctcggctctt ctccacagca
     6541 agcgtccagg gcagatggca gaggatctgc ctcggcgtct gcaggcggga ccacgtcagg
     6601 gagggttcct tcatgtgttc tccctgtggg tccttggacc tttagccttt ttcttccttt
     6661 gcaaaggcct tgggggcact ggctgggagt cagcaagcga gcactttata tccctttgag
     6721 ggaaaccctg atgacgccac tgggcctctt ggcgtctgcc ctgccctcgc ggcttcccgc
     6781 cgtgccgcag cgtgcccacg tgcccacgcc ccaccagcag gcggctgtcc cggaggccgt
     6841 ggcccgctgg gactggccgc ccctccccag cgtcccaggg ctctggttct ggagggccac
     6901 tttgtcaagg tgtttcagtt tttctttact tcttttgaaa atctgtttgc aaggggaagg
     6961 accatttcgt aatggtctga cacaaaagca agtttgattt ttgcagcact agcaatggac
     7021 tttgttgttt ttctttttga tcagaacatt ccttctttac tggtcacagc cacgtgctca
     7081 ttccattctt ctttttgtag actttgggcc cacgtgtttt atgggcattg atacatatat
     7141 aaatatatag atataaatat atatgaatat atttttttaa gtttcctaca cctggaggtt
     7201 gcatggactg tacgaccggc atgactttat attgtataca gattttgcac gccaaactcg
     7261 gcagctttgg ggaagaagaa aaatgccttt ctgttcccct ctcatgacat ttgcagatac
     7321 aaaagatgga aatttttctg taaaacaaaa ccttgaagga gaggagggcg gggaagtttg
     7381 cgtcttattg aacttattct taagaaattg tactttttat tgtaagaaaa ataaaaagga
     7441 ctacttaaac atttgtcata ttaagaaaaa aagtttatct agcacttgtg acataccaat
     7501 aatagagttt attgtattta tgtggaaaca gtgttttagg gaaactactc agaattcaca
     7561 gtgaactgcc tgtctctctc gagttgattt ggaggaattt tgttttgttt tgttttgttt
     7621 gtttcctttt atctccttcc acgggccagg cgagcgccgc ccgccctcac tggccttgtg
     7681 acggtttatt ctgattgaga actgggcgga ctcgaaagag tccccttttc cgcacagctg
     7741 tgttgacttt ttaattactt ttaggtgatg tatggctaag atttcacttt aagcagtcgt
     7801 gaactgtgcg agcactgtgg tttacaatta tactttgcat cgaaaggaaa ccatttcttc
     7861 attgtaacga agctgagcgt gttcttagct cggcctcact ttgtctctgg cattgattaa
     7921 aagtctgcta ttgaaagaaa aagaaagcga acagtttttg tttgtttttt ttgccgtgtg
     7981 tgctccatag tggaggcgct attttccaat tgatgagaat gacaaacata tataatctat
     8041 ctatctatct atctatctat ctatctatac agggggcttg aaccttactc acccaagagc
     8101 ttcttacgga atgtggtaga aaaccaagtt gtaacgacac tgtaacctac ctgatgcctg
     8161 ttcgcgcccg ccgtgagctg cgcactggcc gtggccacca ttcacctctg taatttaatc
     8221 cgtttctctt ggattgtctg gacgtgcccg atggttcttt cttttgctca gtggagttgg
     8281 aggttttgtg tttggttttc tcattcttgt cttgttttgt gtgggtggat tttcaccgac
     8341 caatgatatc ctcttctgac ggtcaccttc tttccacttc actggagtcc agtattctgt
     8401 accacatcac gcaacgtgtt atcttgtggt gtaaataaag actgcgttac ttgccctccc
     8461 a
//
