LOCUS       NM_003883               1933 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2,
            mRNA.
ACCESSION   NM_003883
VERSION     NM_003883.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1933)
  AUTHORS   Yu,H., Liu,S., Wang,S. and Gu,X.
  TITLE     The involvement of HDAC3 in the pathogenesis of lung injury and
            pulmonary fibrosis
  JOURNAL   Front Immunol 15, 1392145 (2024)
   PUBMED   39391308
  REMARK    GeneRIF: The involvement of HDAC3 in the pathogenesis of lung
            injury and pulmonary fibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1933)
  AUTHORS   Yoon,J.G., Lim,S.K., Seo,H., Lee,S., Cho,J., Kim,S.Y., Koh,H.Y.,
            Poduri,A.H., Ramakumaran,V., Vasudevan,P., de Groot,M.J., Ko,J.M.,
            Han,D., Chae,J.H. and Lee,C.H.
  TITLE     De novo missense variants in HDAC3 leading to epigenetic machinery
            dysfunction are associated with a variable neurodevelopmental
            disorder
  JOURNAL   Am J Hum Genet 111 (8), 1588-1604 (2024)
   PUBMED   39047730
  REMARK    GeneRIF: De novo missense variants in HDAC3 leading to epigenetic
            machinery dysfunction are associated with a variable
            neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 1933)
  AUTHORS   Chen,H., Li,Y., Li,H., Chen,X., Fu,H., Mao,D., Chen,W., Lan,L.,
            Wang,C., Hu,K., Li,J., Zhu,C., Evans,I., Cheung,E., Lu,D., He,Y.,
            Behrens,A., Yin,D. and Zhang,C.
  TITLE     NBS1 lactylation is required for efficient DNA repair and
            chemotherapy resistance
  JOURNAL   Nature 631 (8021), 663-669 (2024)
   PUBMED   38961290
REFERENCE   4  (bases 1 to 1933)
  AUTHORS   Bhattacharyya,S., O-Sullivan,I. and Tobacman,J.K.
  TITLE     N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1
            Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism
  JOURNAL   Int J Mol Sci 25 (11), 5851 (2024)
   PUBMED   38892038
  REMARK    GeneRIF: N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B)
            Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated
            Epigenetic Mechanism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1933)
  AUTHORS   Fu,B., Shen,J., Zou,X., Sun,N., Zhang,Z., Liu,Z., Zeng,C., Liu,H.
            and Huang,W.
  TITLE     Matrix stiffening promotes chondrocyte senescence and the
            osteoarthritis development through downregulating HDAC3
  JOURNAL   Bone Res 12 (1), 32 (2024)
   PUBMED   38789434
  REMARK    GeneRIF: Matrix stiffening promotes chondrocyte senescence and the
            osteoarthritis development through downregulating HDAC3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1933)
  AUTHORS   Randhawa,G.S., Bell,D.W., Testa,J.R. and Feinberg,A.P.
  TITLE     Identification and mapping of human histone acetylation modifier
            gene homologues
  JOURNAL   Genomics 51 (2), 262-269 (1998)
   PUBMED   9722949
REFERENCE   7  (bases 1 to 1933)
  AUTHORS   Emiliani,S., Fischle,W., Van Lint,C., Al-Abed,Y. and Verdin,E.
  TITLE     Characterization of a human RPD3 ortholog, HDAC3
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2795-2800 (1998)
   PUBMED   9501169
REFERENCE   8  (bases 1 to 1933)
  AUTHORS   Dangond,F., Hafler,D.A., Tong,J.K., Randall,J., Kojima,R., Utku,N.
            and Gullans,S.R.
  TITLE     Differential display cloning of a novel human histone deacetylase
            (HDAC3) cDNA from PHA-activated immune cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 648-652 (1998)
   PUBMED   9464271
REFERENCE   9  (bases 1 to 1933)
  AUTHORS   Lynch,E.D., Lee,M.K., Morrow,J.E., Welcsh,P.L., Leon,P.E. and
            King,M.C.
  TITLE     Nonsyndromic deafness DFNA1 associated with mutation of a human
            homolog of the Drosophila gene diaphanous
  JOURNAL   Science 278 (5341), 1315-1318 (1997)
   PUBMED   9360932
REFERENCE   10 (bases 1 to 1933)
  AUTHORS   Yang,W.M., Yao,Y.L., Sun,J.M., Davie,J.R. and Seto,E.
  TITLE     Isolation and characterization of cDNAs corresponding to an
            additional member of the human histone deacetylase gene family
  JOURNAL   J Biol Chem 272 (44), 28001-28007 (1997)
   PUBMED   9346952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB456387.1, BM461585.1 and
            BC000614.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003883.3.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to the histone deacetylase/acuc/apha family. It
            has histone deacetylase activity and represses transcription when
            tethered to a promoter. It may participate in the regulation of
            transcription through its binding with the zinc-finger
            transcription factor YY1. This protein can also down-regulate p53
            function and thus modulate cell growth and apoptosis. This gene is
            regarded as a potential tumor suppressor gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000614.1, AF039703.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305264.8/ ENSP00000302967.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                DB456387.1         22-113
            93-224              BM461585.1         90-221
            225-1933            BC000614.1         221-1929
FEATURES             Location/Qualifiers
     source          1..1933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1933
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /note="histone deacetylase 3"
                     /db_xref="GeneID:8841"
                     /db_xref="HGNC:HGNC:4854"
                     /db_xref="MIM:605166"
     exon            1..114
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1346
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /EC_number="3.5.1.98"
                     /note="isoform 2 is encoded by transcript variant 2;
                     SMAP45; protein deacylase HDAC3; protein deacetylase
                     HDAC3"
                     /codon_start=1
                     /product="histone deacetylase 3 isoform 2"
                     /protein_id="NP_003874.2"
                     /db_xref="CCDS:CCDS4264.1"
                     /db_xref="GeneID:8841"
                     /db_xref="HGNC:HGNC:4854"
                     /db_xref="MIM:605166"
                     /translation="MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKK
                     MIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFE
                     FCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKY
                     HPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYC
                     LNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGH
                     GECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAP
                     DFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE
                     ADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI"
     exon            115..197
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..340
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..422
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            423..479
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..535
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..669
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..750
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..824
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..889
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            890..979
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1038
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1118
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1276
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1933
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1908..1913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /note="hexamer: AATAAA"
     polyA_site      1933
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /note="major polyA site"
ORIGIN      
        1 gctggcggcg gccgcgggcg gcgggcggcg gaggtgcggg gcctgctccc gccggcacca
       61 tggccaagac cgtggcctat ttctacgacc ccgacgtggg caacttccac tacggagctg
      121 gacaccctat gaagccccat cgcctggcat tgacccatag cctggtcctg cattacggtc
      181 tctataagaa gatgatcgtc ttcaagccat accaggcctc ccaacatgac atgtgccgct
      241 tccactccga ggactacatt gacttcctgc agagagtcag ccccaccaat atgcaaggct
      301 tcaccaagag tcttaatgcc ttcaacgtag gcgatgactg cccagtgttt cccgggctct
      361 ttgagttctg ctcgcgttac acaggcgcat ctctgcaagg agcaacccag ctgaacaaca
      421 agatctgtga tattgccatt aactgggctg gtggtctgca ccatgccaag aagtttgagg
      481 cctctggctt ctgctatgtc aacgacattg tgattggcat cctggagctg ctcaagtacc
      541 accctcgggt gctctacatt gacattgaca tccaccatgg tgacggggtt caagaagctt
      601 tctacctcac tgaccgggtc atgacggtgt ccttccacaa atacggaaat tacttcttcc
      661 ctggcacagg tgacatgtat gaagtcgggg cagagagtgg ccgctactac tgtctgaacg
      721 tgcccctgcg ggatggcatt gatgaccaga gttacaagca ccttttccag ccggttatca
      781 accaggtagt ggacttctac caacccacgt gcattgtgct ccagtgtgga gctgactctc
      841 tgggctgtga tcgattgggc tgctttaacc tcagcatccg agggcatggg gaatgcgttg
      901 aatatgtcaa gagcttcaat atccctctac tcgtgctggg tggtggtggt tatactgtcc
      961 gaaatgttgc ccgctgctgg acatatgaga catcgctgct ggtagaagag gccattagtg
     1021 aggagcttcc ctatagtgaa tacttcgagt actttgcccc agacttcaca cttcatccag
     1081 atgtcagcac ccgcatcgag aatcagaact cacgccagta tctggaccag atccgccaga
     1141 caatctttga aaacctgaag atgctgaacc atgcacctag tgtccagatt catgacgtgc
     1201 ctgcagacct cctgacctat gacaggactg atgaggctga tgcagaggag aggggtcctg
     1261 aggagaacta tagcaggcca gaggcaccca atgagttcta tgatggagac catgacaatg
     1321 acaaggaaag cgatgtggag atttaagagt ggcttgggat gctgtgtccc aaggaatttc
     1381 ttttcacctc ttggttgggc tggagggaaa aggagtggct cctagagtcc tgggggtcac
     1441 cccagggctt ttgctgactc tgggaaagag tctggagacc acatttggtt ctcgaaccat
     1501 ctacctgctt ttcctctctc tcccaaggcc tgacaatggt acctattagg gatgagatac
     1561 agacaaggat agctatctgg gacattattg gcagtgggcc ctggaggcca gtccctagcc
     1621 ccccttgccc cttatttctt ccctgcttcc ctcgaaccca gagatttttg agggatgaac
     1681 gggtagacaa ggactgagat tgcctctgac ttcctcctcc cctgggttct gacttcttcc
     1741 tccccttgct tccagggaag atgaagagag agagatttgg aaggggctct ggctccctaa
     1801 cacctgaatc ccagatgatg ggaagtatgt tttcaagtgt ggggaggata tgaaaatgtt
     1861 ctgttctcac ttttggcttt atgtccattt taccactgtt tttatccaat aaactaagtc
     1921 ggtatttttt gta
//
