LOCUS       NM_001355041            1790 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 4,
            mRNA.
ACCESSION   NM_001355041 XM_011537697
VERSION     NM_001355041.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1790)
  AUTHORS   Yu,H., Liu,S., Wang,S. and Gu,X.
  TITLE     The involvement of HDAC3 in the pathogenesis of lung injury and
            pulmonary fibrosis
  JOURNAL   Front Immunol 15, 1392145 (2024)
   PUBMED   39391308
  REMARK    GeneRIF: The involvement of HDAC3 in the pathogenesis of lung
            injury and pulmonary fibrosis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1790)
  AUTHORS   Yoon,J.G., Lim,S.K., Seo,H., Lee,S., Cho,J., Kim,S.Y., Koh,H.Y.,
            Poduri,A.H., Ramakumaran,V., Vasudevan,P., de Groot,M.J., Ko,J.M.,
            Han,D., Chae,J.H. and Lee,C.H.
  TITLE     De novo missense variants in HDAC3 leading to epigenetic machinery
            dysfunction are associated with a variable neurodevelopmental
            disorder
  JOURNAL   Am J Hum Genet 111 (8), 1588-1604 (2024)
   PUBMED   39047730
  REMARK    GeneRIF: De novo missense variants in HDAC3 leading to epigenetic
            machinery dysfunction are associated with a variable
            neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 1790)
  AUTHORS   Chen,H., Li,Y., Li,H., Chen,X., Fu,H., Mao,D., Chen,W., Lan,L.,
            Wang,C., Hu,K., Li,J., Zhu,C., Evans,I., Cheung,E., Lu,D., He,Y.,
            Behrens,A., Yin,D. and Zhang,C.
  TITLE     NBS1 lactylation is required for efficient DNA repair and
            chemotherapy resistance
  JOURNAL   Nature 631 (8021), 663-669 (2024)
   PUBMED   38961290
REFERENCE   4  (bases 1 to 1790)
  AUTHORS   Bhattacharyya,S., O-Sullivan,I. and Tobacman,J.K.
  TITLE     N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1
            Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism
  JOURNAL   Int J Mol Sci 25 (11), 5851 (2024)
   PUBMED   38892038
  REMARK    GeneRIF: N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B)
            Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated
            Epigenetic Mechanism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1790)
  AUTHORS   Fu,B., Shen,J., Zou,X., Sun,N., Zhang,Z., Liu,Z., Zeng,C., Liu,H.
            and Huang,W.
  TITLE     Matrix stiffening promotes chondrocyte senescence and the
            osteoarthritis development through downregulating HDAC3
  JOURNAL   Bone Res 12 (1), 32 (2024)
   PUBMED   38789434
  REMARK    GeneRIF: Matrix stiffening promotes chondrocyte senescence and the
            osteoarthritis development through downregulating HDAC3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1790)
  AUTHORS   Randhawa,G.S., Bell,D.W., Testa,J.R. and Feinberg,A.P.
  TITLE     Identification and mapping of human histone acetylation modifier
            gene homologues
  JOURNAL   Genomics 51 (2), 262-269 (1998)
   PUBMED   9722949
REFERENCE   7  (bases 1 to 1790)
  AUTHORS   Emiliani,S., Fischle,W., Van Lint,C., Al-Abed,Y. and Verdin,E.
  TITLE     Characterization of a human RPD3 ortholog, HDAC3
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2795-2800 (1998)
   PUBMED   9501169
REFERENCE   8  (bases 1 to 1790)
  AUTHORS   Dangond,F., Hafler,D.A., Tong,J.K., Randall,J., Kojima,R., Utku,N.
            and Gullans,S.R.
  TITLE     Differential display cloning of a novel human histone deacetylase
            (HDAC3) cDNA from PHA-activated immune cells
  JOURNAL   Biochem Biophys Res Commun 242 (3), 648-652 (1998)
   PUBMED   9464271
REFERENCE   9  (bases 1 to 1790)
  AUTHORS   Lynch,E.D., Lee,M.K., Morrow,J.E., Welcsh,P.L., Leon,P.E. and
            King,M.C.
  TITLE     Nonsyndromic deafness DFNA1 associated with mutation of a human
            homolog of the Drosophila gene diaphanous
  JOURNAL   Science 278 (5341), 1315-1318 (1997)
   PUBMED   9360932
REFERENCE   10 (bases 1 to 1790)
  AUTHORS   Yang,W.M., Yao,Y.L., Sun,J.M., Davie,J.R. and Seto,E.
  TITLE     Isolation and characterization of cDNAs corresponding to an
            additional member of the human histone deacetylase gene family
  JOURNAL   J Biol Chem 272 (44), 28001-28007 (1997)
   PUBMED   9346952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008781.7 and KC877130.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001355041.1.
            
            Summary: Histones play a critical role in transcriptional
            regulation, cell cycle progression, and developmental events.
            Histone acetylation/deacetylation alters chromosome structure and
            affects transcription factor access to DNA. The protein encoded by
            this gene belongs to the histone deacetylase/acuc/apha family. It
            has histone deacetylase activity and represses transcription when
            tethered to a promoter. It may participate in the regulation of
            transcription through its binding with the zinc-finger
            transcription factor YY1. This protein can also down-regulate p53
            function and thus modulate cell growth and apoptosis. This gene is
            regarded as a potential tumor suppressor gene. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2863130.1,
                                           SRR11853566.23031.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC008781.7         14248-14268
            22-114              KC877130.1         300-392             c
            115-197             KC877130.1         112-194             c
            198-279             AC008781.7         20972-21053
            280-336             AC008781.7         21181-21237
            337-392             AC008781.7         21358-21413
            393-526             AC008781.7         21791-21924
            527-607             AC008781.7         22458-22538
            608-681             AC008781.7         22910-22983
            682-746             AC008781.7         23140-23204
            747-836             AC008781.7         24814-24903
            837-895             AC008781.7         25026-25084
            896-975             AC008781.7         25333-25412
            976-1133            AC008781.7         25732-25889
            1134-1790           AC008781.7         29560-30216
FEATURES             Location/Qualifiers
     source          1..1790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..1790
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /note="histone deacetylase 3"
                     /db_xref="GeneID:8841"
                     /db_xref="HGNC:HGNC:4854"
                     /db_xref="MIM:605166"
     exon            1..114
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            115..197
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..279
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..336
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..392
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..526
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..1203
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /EC_number="3.5.1.98"
                     /note="isoform 4 is encoded by transcript variant 4;
                     SMAP45; protein deacylase HDAC3; protein deacetylase
                     HDAC3"
                     /codon_start=1
                     /product="histone deacetylase 3 isoform 4"
                     /protein_id="NP_001341970.1"
                     /db_xref="GeneID:8841"
                     /db_xref="HGNC:HGNC:4854"
                     /db_xref="MIM:605166"
                     /translation="MTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQS
                     YKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIP
                     LLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIE
                     NQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYS
                     RPEAPNEFYDGDHDNDKESDVEI"
     exon            527..607
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..681
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..746
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..836
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            837..895
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..975
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1133
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1790
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1765..1770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /note="hexamer: AATAAA"
     polyA_site      1790
                     /gene="HDAC3"
                     /gene_synonym="HD3; KDAC3; RPD3; RPD3-2"
                     /note="major polyA site"
ORIGIN      
        1 gctggcggcg gccgcgggcg gcgggcggcg gaggtgcggg gcctgctccc gccggcacca
       61 tggccaagac cgtggcctat ttctacgacc ccgacgtggg caacttccac tacggagctg
      121 gacaccctat gaagccccat cgcctggcat tgacccatag cctggtcctg cattacggtc
      181 tctataagaa gatgatcccc agtgtttccc gggctctttg agttctgctc gcgttacaca
      241 ggcgcatctc tgcaaggagc aacccagctg aacaacaaga tctgtgatat tgccattaac
      301 tgggctggtg gtctgcacca tgccaagaag tttgaggcct ctggcttctg ctatgtcaac
      361 gacattgtga ttggcatcct ggagctgctc aagtaccacc ctcgggtgct ctacattgac
      421 attgacatcc accatggtga cggggttcaa gaagctttct acctcactga ccgggtcatg
      481 acggtgtcct tccacaaata cggaaattac ttcttccctg gcacaggtga catgtatgaa
      541 gtcggggcag agagtggccg ctactactgt ctgaacgtgc ccctgcggga tggcattgat
      601 gaccagagtt acaagcacct tttccagccg gttatcaacc aggtagtgga cttctaccaa
      661 cccacgtgca ttgtgctcca gtgtggagct gactctctgg gctgtgatcg attgggctgc
      721 tttaacctca gcatccgagg gcatggggaa tgcgttgaat atgtcaagag cttcaatatc
      781 cctctactcg tgctgggtgg tggtggttat actgtccgaa atgttgcccg ctgctggaca
      841 tatgagacat cgctgctggt agaagaggcc attagtgagg agcttcccta tagtgaatac
      901 ttcgagtact ttgccccaga cttcacactt catccagatg tcagcacccg catcgagaat
      961 cagaactcac gccagtatct ggaccagatc cgccagacaa tctttgaaaa cctgaagatg
     1021 ctgaaccatg cacctagtgt ccagattcat gacgtgcctg cagacctcct gacctatgac
     1081 aggactgatg aggctgatgc agaggagagg ggtcctgagg agaactatag caggccagag
     1141 gcacccaatg agttctatga tggagaccat gacaatgaca aggaaagcga tgtggagatt
     1201 taagagtggc ttgggatgct gtgtcccaag gaatttcttt tcacctcttg gttgggctgg
     1261 agggaaaagg agtggctcct agagtcctgg gggtcacccc agggcttttg ctgactctgg
     1321 gaaagagtct ggagaccaca tttggttctc gaaccatcta cctgcttttc ctctctctcc
     1381 caaggcctga caatggtacc tattagggat gagatacaga caaggatagc tatctgggac
     1441 attattggca gtgggccctg gaggccagtc cctagccccc cttgcccctt atttcttccc
     1501 tgcttccctc gaacccagag atttttgagg gatgaacggg tagacaagga ctgagattgc
     1561 ctctgacttc ctcctcccct gggttctgac ttcttcctcc ccttgcttcc agggaagatg
     1621 aagagagaga gatttggaag gggctctggc tccctaacac ctgaatccca gatgatggga
     1681 agtatgtttt caagtgtggg gaggatatga aaatgttctg ttctcacttt tggctttatg
     1741 tccattttac cactgttttt atccaataaa ctaagtcggt attttttgta
//
