LOCUS       NM_024827               2819 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens histone deacetylase 11 (HDAC11), transcript variant 1,
            mRNA.
ACCESSION   NM_024827
VERSION     NM_024827.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2819)
  AUTHORS   Shi,J.Q., Liu,X.F. and Wang,C.
  TITLE     [Progress on the involvement of HDAC11 in the regulation of
            mammalian oocyte maturation and early embryonic development]
  JOURNAL   Sheng Li Xue Bao 76 (3), 438-446 (2024)
   PUBMED   38939938
  REMARK    GeneRIF: [Progress on the involvement of HDAC11 in the regulation
            of mammalian oocyte maturation and early embryonic development].
            Review article
REFERENCE   2  (bases 1 to 2819)
  AUTHORS   Byeon,H.E., Choi,S.E., Kim,Y., Choi,S., Lee,S.J., Kim,D.H., Mo,J.S.
            and Jeon,J.Y.
  TITLE     HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome Activation by
            Inducing YAP Expression in THP-1 Cells and PBMCs
  JOURNAL   Endocrinology 165 (3) (2024)
   PUBMED   38366363
  REMARK    GeneRIF: HDAC11 Regulates Palmitate-induced NLRP3 Inflammasome
            Activation by Inducing YAP Expression in THP-1 Cells and PBMCs.
REFERENCE   3  (bases 1 to 2819)
  AUTHORS   Liu,Y., Tong,X., Hu,W. and Chen,D.
  TITLE     HDAC11: A novel target for improved cancer therapy
  JOURNAL   Biomed Pharmacother 166, 115418 (2023)
   PUBMED   37659201
  REMARK    GeneRIF: HDAC11: A novel target for improved cancer therapy.
            Review article
REFERENCE   4  (bases 1 to 2819)
  AUTHORS   Wu,H., Yin,X., Zhao,X., Wu,Z., Xiao,Y., Di,Q., Sun,P., Tang,H.,
            Quan,J. and Chen,W.
  TITLE     HDAC11 negatively regulates antifungal immunity by inhibiting Nos2
            expression via binding with transcriptional repressor STAT3
  JOURNAL   Redox Biol 56, 102461 (2022)
   PUBMED   36087429
  REMARK    GeneRIF: HDAC11 negatively regulates antifungal immunity by
            inhibiting Nos2 expression via binding with transcriptional
            repressor STAT3.
REFERENCE   5  (bases 1 to 2819)
  AUTHORS   Li,R., Wu,X., Zhao,P., Xue,K. and Li,J.
  TITLE     A pan-cancer analysis identifies HDAC11 as an immunological and
            prognostic biomarker
  JOURNAL   FASEB J 36 (7), e22326 (2022)
   PUBMED   35657209
  REMARK    GeneRIF: A pan-cancer analysis identifies HDAC11 as an
            immunological and prognostic biomarker.
REFERENCE   6  (bases 1 to 2819)
  AUTHORS   Feng,W., Lu,Z., Luo,R.Z., Zhang,X., Seto,E., Liao,W.S. and Yu,Y.
  TITLE     Multiple histone deacetylases repress tumor suppressor gene ARHI in
            breast cancer
  JOURNAL   Int J Cancer 120 (8), 1664-1668 (2007)
   PUBMED   17230502
REFERENCE   7  (bases 1 to 2819)
  AUTHORS   Lindberg,D., Akerstrom,G. and Westin,G.
  TITLE     Mutational analyses of WNT7A and HDAC11 as candidate tumour
            suppressor genes in sporadic malignant pancreatic endocrine tumours
  JOURNAL   Clin Endocrinol (Oxf) 66 (1), 110-114 (2007)
   PUBMED   17201809
  REMARK    GeneRIF: the absence of tumour-specific somatic events in WNT7A and
            HDAC11 suggests that these genes are unlikely to have a classical
            tumour suppressor gene role in sporadic malignant pancreatic
            endocrine tumours
REFERENCE   8  (bases 1 to 2819)
  AUTHORS   Voelter-Mahlknecht,S., Ho,A.D. and Mahlknecht,U.
  TITLE     Chromosomal organization and localization of the novel class IV
            human histone deacetylase 11 gene
  JOURNAL   Int J Mol Med 16 (4), 589-598 (2005)
   PUBMED   16142391
  REMARK    GeneRIF: Fluorescence in situ hybridization analysis localized
            HDAC11 gene to chromosome 3p25, a region characterized by frequent
            gains and losses of chromosomal material in a number of various
            types of cancer.
REFERENCE   9  (bases 1 to 2819)
  AUTHORS   Bradbury,C.A., Khanim,F.L., Hayden,R., Bunce,C.M., White,D.A.,
            Drayson,M.T., Craddock,C. and Turner,B.M.
  TITLE     Histone deacetylases in acute myeloid leukaemia show a distinctive
            pattern of expression that changes selectively in response to
            deacetylase inhibitors
  JOURNAL   Leukemia 19 (10), 1751-1759 (2005)
   PUBMED   16121216
REFERENCE   10 (bases 1 to 2819)
  AUTHORS   Gao,L., Cueto,M.A., Asselbergs,F. and Atadja,P.
  TITLE     Cloning and functional characterization of HDAC11, a novel member
            of the human histone deacetylase family
  JOURNAL   J Biol Chem 277 (28), 25748-25755 (2002)
   PUBMED   11948178
  REMARK    GeneRIF: cloning and functional characterization
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB025431.1, BC009676.1,
            AC027124.5 and AW291816.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024827.3.
            
            Summary: This gene encodes a class IV histone deacetylase. The
            encoded protein is localized to the nucleus and may be involved in
            regulating the expression of interleukin 10. Alternative splicing
            results in multiple transcript variants.[provided by RefSeq, Apr
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.648618.1,
                                           SRR1660807.265243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295757.8/ ENSP00000295757.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB025431.1         92-124
            34-1737             BC009676.1         1-1704
            1738-2585           AC027124.5         181648-182495
            2586-2819           AW291816.1         17-250              c
FEATURES             Location/Qualifiers
     source          1..2819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1"
     gene            1..2819
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /note="histone deacetylase 11"
                     /db_xref="GeneID:79885"
                     /db_xref="HGNC:HGNC:19086"
                     /db_xref="MIM:607226"
     exon            1..44
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1086
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /EC_number="3.5.1.98"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="histone deacetylase 11 isoform 1"
                     /protein_id="NP_079103.2"
                     /db_xref="CCDS:CCDS2615.1"
                     /db_xref="GeneID:79885"
                     /db_xref="HGNC:HGNC:19086"
                     /db_xref="MIM:607226"
                     /translation="MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGK
                     VINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLP
                     NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITL
                     AIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQA
                     IRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPA
                     GIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSA
                     QNSDTPLLPPAVP"
     exon            45..193
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            194..294
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            295..411
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            412..454
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            455..531
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            532..594
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            595..691
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            692..870
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     exon            871..2819
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /note="hexamer: AATAAA"
     polyA_site      1737
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /note="major polyA site"
     regulatory      2796..2801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /note="hexamer: AATAAA"
     polyA_site      2819
                     /gene="HDAC11"
                     /gene_synonym="HD11"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgcggag ctgcggccag ctttgggagg gccggccccg ggatgctaca cacaacccag
       61 ctgtaccagc atgtgccaga gacacgctgg ccaatcgtgt actcgccgcg ctacaacatc
      121 accttcatgg gcctggagaa gctgcatccc tttgatgccg gaaaatgggg caaagtgatc
      181 aatttcctaa aagaagagaa gcttctgtct gacagcatgc tggtggaggc gcgggaggcc
      241 tcggaggagg acctgctggt ggtgcacacg aggcgctatc ttaatgagct caagtggtcc
      301 tttgctgttg ctaccatcac agaaatcccc cccgttatct tcctccccaa cttccttgtg
      361 cagaggaagg tgctgaggcc ccttcggacc cagacaggag gaaccataat ggcggggaag
      421 ctggctgtgg agcgaggctg ggccatcaac gtggggggtg gcttccacca ctgctccagc
      481 gaccgtggcg ggggcttctg tgcctatgcg gacatcacgc tcgccatcaa gtttctgttt
      541 gagcgtgtgg agggcatctc cagggctacc atcattgatc ttgatgccca tcagggcaat
      601 gggcatgagc gagacttcat ggacgacaag cgtgtgtaca tcatggatgt ctacaaccgc
      661 cacatctacc caggggaccg ctttgccaag caggccatca ggcggaaggt ggagctggag
      721 tggggcacag aggatgatga gtacctggat aaggtggaga ggaacatcaa gaaatccctc
      781 caggagcacc tgcccgacgt ggtggtatac aatgcaggca ccgacatcct cgagggggac
      841 cgccttgggg ggctgtccat cagcccagcg ggcatcgtga agcgggatga gctggtgttc
      901 cggatggtcc gtggccgccg ggtgcccatc cttatggtga cctcaggcgg gtaccagaag
      961 cgcacagccc gcatcattgc tgactccata cttaatctgt ttggcctggg gctcattggg
     1021 cctgagtcac ccagcgtctc cgcacagaac tcagacacac cgctgcttcc ccctgcagtg
     1081 ccctgaccct tgctgccctg cctgtcacgt ggccctgcct atccgcccct tagtgctttt
     1141 tgttttctaa cctcatgggg tggtggaggc agccttcagt gagcatggag gggcagggcc
     1201 atccctggct ggggcctgga gctggccctt cctctacttt tccctgctgg aagccagaag
     1261 ggcttgaggc ctctatgggt gggggcagaa ggcagagcct gtgtcccagg gggacccaca
     1321 cgaagtcacc agcccatagg tccagggagg caggcagtta actgagaatt ggagaggaca
     1381 ggctaggtcc caggcacagc gagggccctg ggcttggggt gttctggttt tgagaacggc
     1441 agacccaggt cggagtgagg aagcttccac ctccatcctg actaggcctg catcctaact
     1501 gggcctccct ccctcccctt ggtcatggga tttgctgccc tctttgcccc agagctgaag
     1561 agctataggc actggtgtgg atggcccagg aggtgctgga gctaggtctc caggtgggcc
     1621 tggttcccag gcagcaggtg ggaaccctgg gcctggatgt gaggggcggt caggaagggg
     1681 tacaggtggg ttccctcatc tggagttccc cctcaataaa gcaaggtctg gacctgcctt
     1741 cccaggccct tctgtggggg tgaaggtggg gaaggcctgc ggcgcccaga tcactgcctt
     1801 agcagtagtc ttgcctgttc agtgcaaggg gcaggttttg gggggaggaa ttcttagcgc
     1861 aaggacgggc ctcagccctg tcgcctccag ggggccgctg acccaggtgg ggagagggca
     1921 gaagaagggt gggggacgtg ggcaggccag gctcacaggt ggaaatcagg gatgcagggt
     1981 ggtgcccaag ccaggtcctg caggaaccca ggcccaggga gggacccaga cactggtgag
     2041 gcggggcagg ggttcctgga gagagggcag cgaggatctc tatcctggcc tggggattat
     2101 gaacataggt agccggggca gggccctggg tgggactgtg gcctccactg gcctcaccaa
     2161 agtgcctggg ccccaatcct tctccatgcc caggggcccc aggtgggcca gacctctggc
     2221 ctgttcctca gccctactca tggggacatt cagggacctc caggaagtgg gcgggggagc
     2281 atccacccct gctagccggc agctgtggcc ctgatcaaat caggggctgg ggagggaaag
     2341 tgggtccatt gaggtggccc tgctccatca gccccctacg ggacttgtgt tcattacagt
     2401 gagggggtgc tcccactgtc tcccggcctc cctaatgctc cctctgctgc agggagaagg
     2461 gttccaagat cacaaaatgt caacaatgct ggcctcctgg accagacccc gaggctctaa
     2521 caatgcactc tgagatccct acccttgccg ttggtctctg tcgctgactc gaggcaccta
     2581 acatccattc acacccaaca caggccagcg acttctgggg ctcagccaca gacatggttt
     2641 gtcactgttg agcttctgtt cctagagaat cctagaggct tgattggccc aggctgctgt
     2701 gtgtgctgga ggcaaagaat ccctacctcc taggggtgaa aggaaatgaa aatggaaagt
     2761 tcttgtagcg caaggcctga catgggtagc tgctcaataa atgctagtgt gttatttca
//
