LOCUS       NM_032019               2567 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens histone deacetylase 10 (HDAC10), transcript variant 1,
            mRNA.
ACCESSION   NM_032019
VERSION     NM_032019.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Guo,H., Ren,H., Han,K., Li,J., Dong,Y., Zhao,X. and Li,C.
  TITLE     Knockdown of HDAC10 inhibits POLE2-mediated DNA damage repair in
            NSCLC cells by increasing SP1 acetylation levels
  JOURNAL   Pulm Pharmacol Ther 83, 102250 (2023)
   PUBMED   37657752
  REMARK    GeneRIF: Knockdown of HDAC10 inhibits POLE2-mediated DNA damage
            repair in NSCLC cells by increasing SP1 acetylation levels.
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Jiang,W., Block,M.E. and Boosani,C.S.
  TITLE     Short communication: TNF-alpha and IGF-1 regulates epigenetic
            mechanisms of HDAC2 and HDAC10
  JOURNAL   PLoS One 17 (2), e0263190 (2022)
   PUBMED   35143520
  REMARK    GeneRIF: Short communication: TNF-alpha and IGF-1 regulates
            epigenetic mechanisms of HDAC2 and HDAC10.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Yu,D.S., Song,X.L. and Yan,C.
  TITLE     Oncogenic miRNA-1908 targets HDAC10 and promotes the aggressive
            phenotype of cervical cancer cell
  JOURNAL   Kaohsiung J Med Sci 37 (5), 402-410 (2021)
   PUBMED   33493381
  REMARK    GeneRIF: Oncogenic miRNA-1908 targets HDAC10 and promotes the
            aggressive phenotype of cervical cancer cell.
REFERENCE   4  (bases 1 to 2567)
  AUTHORS   Zhu,J. and Han,S.
  TITLE     Histone deacetylase 10 exerts antitumor effects on cervical cancer
            via a novel microRNA-223/TXNIP/Wnt/beta-catenin pathway
  JOURNAL   IUBMB Life 73 (4), 690-704 (2021)
   PUBMED   33481334
  REMARK    GeneRIF: Histone deacetylase 10 exerts antitumor effects on
            cervical cancer via a novel microRNA-223/TXNIP/Wnt/beta-catenin
            pathway.
REFERENCE   5  (bases 1 to 2567)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2567)
  AUTHORS   Tong,J.J., Liu,J., Bertos,N.R. and Yang,X.J.
  TITLE     Identification of HDAC10, a novel class II human histone
            deacetylase containing a leucine-rich domain
  JOURNAL   Nucleic Acids Res 30 (5), 1114-1123 (2002)
   PUBMED   11861901
  REMARK    GeneRIF: molecular cloning and characterization of a novel class II
            histone deacetylase
REFERENCE   7  (bases 1 to 2567)
  AUTHORS   Fischer,D.D., Cai,R., Bhatia,U., Asselbergs,F.A., Song,C.,
            Terry,R., Trogani,N., Widmer,R., Atadja,P. and Cohen,D.
  TITLE     Isolation and characterization of a novel class II histone
            deacetylase, HDAC10
  JOURNAL   J Biol Chem 277 (8), 6656-6666 (2002)
   PUBMED   11739383
  REMARK    GeneRIF: another histone deacetylase
REFERENCE   8  (bases 1 to 2567)
  AUTHORS   Guardiola,A.R. and Yao,T.P.
  TITLE     Molecular cloning and characterization of a novel histone
            deacetylase HDAC10
  JOURNAL   J Biol Chem 277 (5), 3350-3356 (2002)
   PUBMED   11726666
REFERENCE   9  (bases 1 to 2567)
  AUTHORS   Kao,H.Y., Lee,C.H., Komarov,A., Han,C.C. and Evans,R.M.
  TITLE     Isolation and characterization of mammalian HDAC10, a novel histone
            deacetylase
  JOURNAL   J Biol Chem 277 (1), 187-193 (2002)
   PUBMED   11677242
REFERENCE   10 (bases 1 to 2567)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF426160.1 and BC094734.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_032019.5.
            
            Summary: The protein encoded by this gene belongs to the histone
            deacetylase family, members of which deacetylate lysine residues on
            the N-terminal part of the core histones. Histone deacetylation
            modulates chromatin structure, and plays an important role in
            transcriptional regulation, cell cycle progression, and
            developmental events. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1, also known as
            alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF426160.1, BC032049.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216271.10/ ENSP00000216271.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2300              AF426160.1         121-2420
            2301-2567           BC094734.1         2109-2375
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..2567
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /note="histone deacetylase 10"
                     /db_xref="GeneID:83933"
                     /db_xref="HGNC:HGNC:18128"
                     /db_xref="MIM:608544"
     exon            1..292
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2243
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /EC_number="3.5.1.48"
                     /EC_number="3.5.1.62"
                     /note="isoform 1 is encoded by transcript variant 1;
                     polyamine deacetylase HDAC10"
                     /codon_start=1
                     /product="polyamine deacetylase HDAC10 isoform 1"
                     /protein_id="NP_114408.3"
                     /db_xref="CCDS:CCDS14088.1"
                     /db_xref="GeneID:83933"
                     /db_xref="HGNC:HGNC:18128"
                     /db_xref="MIM:608544"
                     /translation="MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLE
                     QRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHC
                     ARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQK
                     HGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQ
                     GLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQ
                     ATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMA
                     PCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAA
                     SAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHES
                     LAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLC
                     VALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPL
                     AYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARV
                     LNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA"
     exon            293..427
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            428..524
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            525..622
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            623..727
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            728..796
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            797..923
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            924..989
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1049
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1139
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1246
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1314
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1570
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1655
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1747
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1804
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1883
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2066
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2219
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2567
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2546..2551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /note="hexamer: AGTAAA"
     polyA_site      2567
                     /gene="HDAC10"
                     /gene_synonym="HD10"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcgggg agcctccccc ttcgactgca gcctcgctcc gtgccttctg cgcgcctggg
       61 atcccggagc ctgcctaggt tctgtgcgct cccgcccagg ccggtgcccg ccgcccgcct
      121 gcgccccagg caggtcccag gcctccggct gctcccggcc gaaggtgggg acaggcagtg
      181 gcaggcacca ctagcgaggg cgtttgggaa cccagggtga ccacggcgca gccatgggga
      241 ccgcgcttgt gtaccatgag gacatgacgg ccacccggct gctctgggac gaccccgagt
      301 gcgagatcga gcgtcctgag cgcctgaccg cagccctgga tcgcctgcgg cagcgcggcc
      361 tggaacagag gtgtctgcgg ttgtcagccc gcgaggcctc ggaagaggag ctgggcctgg
      421 tgcacagccc agagtatgta tccctggtca gggagaccca ggtcctaggc aaggaggagc
      481 tgcaggcgct gtccggacag ttcgacgcca tctacttcca cccgagtacc tttcactgcg
      541 cgcggctggc cgcaggggct ggactgcagc tggtggacgc tgtgctcact ggagctgtgc
      601 aaaatgggct tgccctggtg aggcctcccg ggcaccatgg ccagagggcg gctgccaacg
      661 ggttctgtgt gttcaacaac gtggccatag cagctgcaca tgccaagcag aaacacgggc
      721 tacacaggat cctcgtcgtg gactgggatg tgcaccatgg ccaggggatc cagtatctct
      781 ttgaggatga ccccagcgtc ctttacttct cctggcaccg ctatgagcat gggcgcttct
      841 ggcctttcct gcgagagtca gatgcagacg cagtggggcg gggacagggc ctcggcttca
      901 ctgtcaacct gccctggaac caggttggga tgggaaacgc tgactacgtg gctgccttcc
      961 tgcacctgct gctcccactg gcctttgagt ttgaccctga gctggtgctg gtctcggcag
     1021 gatttgactc agccatcggg gaccctgagg ggcaaatgca ggccacgcca gagtgcttcg
     1081 cccacctcac acagctgctg caggtgctgg ccggcggccg ggtctgtgcc gtgctggagg
     1141 gcggctacca cctggagtca ctggcggagt cagtgtgcat gacagtacag acgctgctgg
     1201 gtgacccggc cccacccctg tcagggccaa tggcgccatg tcagagtgcc ctagagtcca
     1261 tccagagtgc ccgtgctgcc caggccccgc actggaagag cctccagcag caagatgtga
     1321 ccgctgtgcc gatgagcccc agcagccact ccccagaggg gaggcctcca cctctgctgc
     1381 ctgggggtcc agtgtgtaag gcagctgcat ctgcaccgag ctccctcctg gaccagccgt
     1441 gcctctgccc cgcaccctct gtccgcaccg ctgttgccct gacaacgccg gatatcacat
     1501 tggttctgcc ccctgacgtc atccaacagg aagcgtcagc cctgagggag gagacagaag
     1561 cctgggccag gccacacgag tccctggccc gggaggaggc cctcactgca cttgggaagc
     1621 tcctgtacct cttagatggg atgctggatg ggcaggtgaa cagtggtata gcagccactc
     1681 cagcctctgc tgcagcagcc accctggatg tggctgttcg gagaggcctg tcccacggag
     1741 cccagaggct gctgtgcgtg gccctgggac agctggaccg gcctccagac ctcgcccatg
     1801 acgggaggag tctgtggctg aacatcaggg gcaaggaggc ggctgcccta tccatgttcc
     1861 atgtctccac gccactgcca gtgatgaccg gtggtttcct gagctgcatc ttgggcttgg
     1921 tgctgcccct ggcctatggc ttccagcctg acctggtgct ggtggcgctg gggcctggcc
     1981 atggcctgca gggcccccac gctgcactcc tggctgcaat gcttcggggg ctggcagggg
     2041 gccgagtcct ggccctcctg gaggagaact ccacacccca gctagcaggg atcctggccc
     2101 gggtgctgaa tggagaggca cctcctagcc taggcccttc ctctgtggcc tccccagagg
     2161 acgtccaggc cctgatgtac ctgagagggc agctggagcc tcagtggaag atgttgcagt
     2221 gccatcctca cctggtggct tgaaatcggc caaggtggga gcatttacac cgcagaaatg
     2281 acaccgcacg ccagcgcccc gcggccgcga tccggacccc aagcccacgg ctccctcgac
     2341 tctggggcac ggaaccccgc ccactcccaa tccccgcgcc ccgccctctc ccacccgtgc
     2401 ttcccccgct ccacccctca cctcacctcg cccccgcccc acccatcgcg ccccggcccg
     2461 tcccatcgag gcccatgcaa cccacgctcg gtcccgttcc ggcccctgcg ccccgctgcg
     2521 cttcgctccc cgcccttgcg ccgttagtaa acatcgctca aacgaaa
//
