LOCUS       NM_004964               2118 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens histone deacetylase 1 (HDAC1), mRNA.
ACCESSION   NM_004964
VERSION     NM_004964.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2118)
  AUTHORS   Chen,W., Chu,J., Miao,Y., Jiang,W., Wang,F., Zhang,N., Jin,J. and
            Cai,Y.
  TITLE     MOF-mediated acetylation of CDK9 promotes global transcription by
            modulating P-TEFb complex formation
  JOURNAL   FEBS J 291 (21), 4796-4812 (2024)
   PUBMED   39250546
REFERENCE   2  (bases 1 to 2118)
  AUTHORS   Kanojia,A., Roy,G., Madhubala,R. and Muthuswami,R.
  TITLE     Interplay between DOT1L and HDAC1 regulates Leishmania donovani
            infection in human THP-1 cells
  JOURNAL   Acta Trop 258, 107352 (2024)
   PUBMED   39103111
  REMARK    GeneRIF: Interplay between DOT1L and HDAC1 regulates Leishmania
            donovani infection in human THP-1 cells.
REFERENCE   3  (bases 1 to 2118)
  AUTHORS   Di Giorgio,E., Dalla,E., Tolotto,V., D'Este,F., Paluvai,H.,
            Ranzino,L. and Brancolini,C.
  TITLE     HDAC4 influences the DNA damage response and counteracts senescence
            by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and
            homology-directed repair
  JOURNAL   Nucleic Acids Res 52 (14), 8218-8240 (2024)
   PUBMED   38874468
  REMARK    GeneRIF: HDAC4 influences the DNA damage response and counteracts
            senescence by assembling with HDAC1/HDAC2 to control H2BK120
            acetylation and homology-directed repair.
REFERENCE   4  (bases 1 to 2118)
  AUTHORS   Kong,Y., Jiang,R., Zhou,H., Ge,M., Lin,H., Wang,Y., Yao,R.,
            Wang,Q., Liang,X., Li,J. and Zhou,X.
  TITLE     PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT
            signaling pathway in non-small cell lung cancer
  JOURNAL   J Transl Med 22 (1), 689 (2024)
   PUBMED   39075515
  REMARK    GeneRIF: PHF12 regulates HDAC1 to promote tumorigenesis via
            EGFR/AKT signaling pathway in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2118)
  AUTHORS   Xiong,F., Wang,D., Xiong,W., Wang,X., Huang,W.H., Wu,G.H.,
            Liu,W.Z., Wang,Q., Chen,J.S., Kuai,Y.Y., Wang,B. and Chen,Y.J.
  TITLE     Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic
            target for HP1alpha-positive intrahepatic cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 152 (2024)
   PUBMED   38812060
  REMARK    GeneRIF: Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a
            therapeutic target for HP1alpha-positive intrahepatic
            cholangiocarcinoma.
            Erratum:[J Exp Clin Cancer Res. 2024 Jul 5;43(1):186. doi:
            10.1186/s13046-024-03112-w.. PMID: 38965576]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2118)
  AUTHORS   Taunton,J., Hassig,C.A. and Schreiber,S.L.
  TITLE     A mammalian histone deacetylase related to the yeast
            transcriptional regulator Rpd3p
  JOURNAL   Science 272 (5260), 408-411 (1996)
   PUBMED   8602529
REFERENCE   7  (bases 1 to 2118)
  AUTHORS   Wolffe,A.P.
  TITLE     Histone deacetylase: a regulator of transcription
  JOURNAL   Science 272 (5260), 371-372 (1996)
   PUBMED   8602525
  REMARK    Review article
REFERENCE   8  (bases 1 to 2118)
  AUTHORS   Furukawa,Y., Kawakami,T., Sudo,K., Inazawa,J., Matsumine,A.,
            Akiyama,T. and Nakamura,Y.
  TITLE     Isolation and mapping of a human gene (RPD3L1) that is homologous
            to RPD3, a transcription factor in Saccharomyces cerevisiae
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 130-133 (1996)
   PUBMED   8646880
REFERENCE   9  (bases 1 to 2118)
  AUTHORS   Hijmans,E.M., Voorhoeve,P.M., Beijersbergen,R.L., van 't Veer,L.J.
            and Bernards,R.
  TITLE     E2F-5, a new E2F family member that interacts with p130 in vivo
  JOURNAL   Mol Cell Biol 15 (6), 3082-3089 (1995)
   PUBMED   7760804
REFERENCE   10 (bases 1 to 2118)
  AUTHORS   Margolis,D.M., Somasundaran,M. and Green,M.R.
  TITLE     Human transcription factor YY1 represses human immunodeficiency
            virus type 1 transcription and virion production
  JOURNAL   J Virol 68 (2), 905-910 (1994)
   PUBMED   8289393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109945.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 25, 2018 this sequence version replaced NM_004964.2.
            
            Summary: Histone acetylation and deacetylation, catalyzed by
            multisubunit complexes, play a key role in the regulation of
            eukaryotic gene expression. The protein encoded by this gene
            belongs to the histone deacetylase/acuc/apha family and is a
            component of the histone deacetylase complex. It also interacts
            with retinoblastoma tumor-suppressor protein and this complex is a
            key element in the control of cell proliferation and
            differentiation. Together with metastasis-associated protein-2, it
            deacetylates p53 and modulates its effect on cell growth and
            apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.10339.1,
                                           SRR1803611.177301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373548.8/ ENSP00000362649.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL109945.15        8140-8275
            137-249             AL109945.15        18678-18790
            250-367             AL109945.15        32722-32839
            368-442             AL109945.15        40536-40610
            443-581             AL109945.15        42996-43134
            582-723             AL109945.15        43593-43734
            724-816             AL109945.15        45125-45217
            817-925             AL109945.15        46635-46743
            926-1066            AL109945.15        46825-46965
            1067-1175           AL109945.15        47531-47639
            1176-1306           AL109945.15        47733-47863
            1307-1459           AL109945.15        48147-48299
            1460-1508           AL109945.15        48758-48806
            1509-2118           AL109945.15        49074-49683
FEATURES             Location/Qualifiers
     source          1..2118
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2-p35.1"
     gene            1..2118
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /note="histone deacetylase 1"
                     /db_xref="GeneID:3065"
                     /db_xref="HGNC:HGNC:4852"
                     /db_xref="MIM:601241"
     exon            1..136
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1536
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /EC_number="3.5.1.98"
                     /note="reduced potassium dependency, yeast homolog-like 1;
                     protein deacetylase HDAC1; protein decrotonylase HDAC1;
                     protein deacylase HDAC1"
                     /codon_start=1
                     /product="histone deacetylase 1"
                     /protein_id="NP_004955.2"
                     /db_xref="CCDS:CCDS360.1"
                     /db_xref="GeneID:3065"
                     /db_xref="HGNC:HGNC:4852"
                     /db_xref="MIM:601241"
                     /translation="MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLN
                     YGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPV
                     FDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAI
                     LELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGK
                     GKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNL
                     TIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYF
                     EYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEE
                     SGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKE
                     KDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA"
     exon            137..249
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..367
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..442
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..581
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..723
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..816
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..925
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1066
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1175
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1306
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1459
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1508
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..2118
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2097..2102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /note="hexamer: AATAAA"
     polyA_site      2118
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /note="major polyA site"
ORIGIN      
        1 cccctccccc ctgggtcgga cgctgagcgg agccgcgggc gggagggcgg acggaccgac
       61 tgacggtagg gacgggaggc gagcaagatg gcgcagacgc agggcacccg gaggaaagtc
      121 tgttactact acgacgggga tgttggaaat tactattatg gacaaggcca cccaatgaag
      181 cctcaccgaa tccgcatgac tcataatttg ctgctcaact atggtctcta ccgaaaaatg
      241 gaaatctatc gccctcacaa agccaatgct gaggagatga ccaagtacca cagcgatgac
      301 tacattaaat tcttgcgctc catccgtcca gataacatgt cggagtacag caagcagatg
      361 cagagattca acgttggtga ggactgtcca gtattcgatg gcctgtttga gttctgtcag
      421 ttgtctactg gtggttctgt ggcaagtgct gtgaaactta ataagcagca gacggacatc
      481 gctgtgaatt gggctggggg cctgcaccat gcaaagaagt ccgaggcatc tggcttctgt
      541 tacgtcaatg atatcgtctt ggccatcctg gaactgctaa agtatcacca gagggtgctg
      601 tacattgaca ttgatattca ccatggtgac ggcgtggaag aggccttcta caccacggac
      661 cgggtcatga ctgtgtcctt tcataagtat ggagagtact tcccaggaac tggggaccta
      721 cgggatatcg gggctggcaa aggcaagtat tatgctgtta actacccgct ccgagacggg
      781 attgatgacg agtcctatga ggccattttc aagccggtca tgtccaaagt aatggagatg
      841 ttccagccta gtgcggtggt cttacagtgt ggctcagact ccctatctgg ggatcggtta
      901 ggttgcttca atctaactat caaaggacac gccaagtgtg tggaatttgt caagagcttt
      961 aacctgccta tgctgatgct gggaggcggt ggttacacca ttcgtaacgt tgcccggtgc
     1021 tggacatatg agacagctgt ggccctggat acggagatcc ctaatgagct tccatacaat
     1081 gactactttg aatactttgg accagatttc aagctccaca tcagtccttc caatatgact
     1141 aaccagaaca cgaatgagta cctggagaag atcaaacagc gactgtttga gaaccttaga
     1201 atgctgccgc acgcacctgg ggtccaaatg caggcgattc ctgaggacgc catccctgag
     1261 gagagtggcg atgaggacga agacgaccct gacaagcgca tctcgatctg ctcctctgac
     1321 aaacgaattg cctgtgagga agagttctcc gattctgaag aggagggaga ggggggccgc
     1381 aagaactctt ccaacttcaa aaaagccaag agagtcaaaa cagaggatga aaaagagaaa
     1441 gacccagagg agaagaaaga agtcaccgaa gaggagaaaa ccaaggagga gaagccagaa
     1501 gccaaagggg tcaaggagga ggtcaagttg gcctgaatgg acctctccag ctctggcttc
     1561 ctgctgagtc cctcacgttt cttccccaac ccctcagatt ttatattttc tatttctctg
     1621 tgtatttata taaaaattta ttaaatataa atatccccag ggacagaaac caaggccccg
     1681 agctcagggc agctgtgctg ggtgagctct tccaggagcc accttgccac ccattcttcc
     1741 cgttcttaac tttgaaccat aaagggtgcc aggtctgggt gaaagggata cttttatgca
     1801 accataagac aaactcctga aatgccaagt gcctgcttag tagctttgga aaggtgccct
     1861 tattgaacat tctagaaggg gtggctgggt cttcaaggat ctcctgtttt tttcaggctc
     1921 ctaaagtaac atcagccatt tttagattgg ttctgttttc gtaccttccc actggcctca
     1981 agtgagccaa gaaacactgc ctgccctctg tctgtcttct cctaattctg caggtggagg
     2041 ttgctagtct agtttccttt ttgagatact attttcattt ttgtgagcct ctttgtaata
     2101 aaatggtaca tttctata
//
