LOCUS       NP_004955                482 aa            linear   PRI 12-FEB-2025
DEFINITION  histone deacetylase 1 [Homo sapiens].
ACCESSION   NP_004955
VERSION     NP_004955.2
DBSOURCE    REFSEQ: accession NM_004964.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 482)
  AUTHORS   Chen,W., Chu,J., Miao,Y., Jiang,W., Wang,F., Zhang,N., Jin,J. and
            Cai,Y.
  TITLE     MOF-mediated acetylation of CDK9 promotes global transcription by
            modulating P-TEFb complex formation
  JOURNAL   FEBS J 291 (21), 4796-4812 (2024)
   PUBMED   39250546
REFERENCE   2  (residues 1 to 482)
  AUTHORS   Kanojia,A., Roy,G., Madhubala,R. and Muthuswami,R.
  TITLE     Interplay between DOT1L and HDAC1 regulates Leishmania donovani
            infection in human THP-1 cells
  JOURNAL   Acta Trop 258, 107352 (2024)
   PUBMED   39103111
  REMARK    GeneRIF: Interplay between DOT1L and HDAC1 regulates Leishmania
            donovani infection in human THP-1 cells.
REFERENCE   3  (residues 1 to 482)
  AUTHORS   Di Giorgio,E., Dalla,E., Tolotto,V., D'Este,F., Paluvai,H.,
            Ranzino,L. and Brancolini,C.
  TITLE     HDAC4 influences the DNA damage response and counteracts senescence
            by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and
            homology-directed repair
  JOURNAL   Nucleic Acids Res 52 (14), 8218-8240 (2024)
   PUBMED   38874468
  REMARK    GeneRIF: HDAC4 influences the DNA damage response and counteracts
            senescence by assembling with HDAC1/HDAC2 to control H2BK120
            acetylation and homology-directed repair.
REFERENCE   4  (residues 1 to 482)
  AUTHORS   Kong,Y., Jiang,R., Zhou,H., Ge,M., Lin,H., Wang,Y., Yao,R.,
            Wang,Q., Liang,X., Li,J. and Zhou,X.
  TITLE     PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT
            signaling pathway in non-small cell lung cancer
  JOURNAL   J Transl Med 22 (1), 689 (2024)
   PUBMED   39075515
  REMARK    GeneRIF: PHF12 regulates HDAC1 to promote tumorigenesis via
            EGFR/AKT signaling pathway in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 482)
  AUTHORS   Xiong,F., Wang,D., Xiong,W., Wang,X., Huang,W.H., Wu,G.H.,
            Liu,W.Z., Wang,Q., Chen,J.S., Kuai,Y.Y., Wang,B. and Chen,Y.J.
  TITLE     Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic
            target for HP1alpha-positive intrahepatic cholangiocarcinoma
  JOURNAL   J Exp Clin Cancer Res 43 (1), 152 (2024)
   PUBMED   38812060
  REMARK    GeneRIF: Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a
            therapeutic target for HP1alpha-positive intrahepatic
            cholangiocarcinoma.
            Erratum:[J Exp Clin Cancer Res. 2024 Jul 5;43(1):186. doi:
            10.1186/s13046-024-03112-w.. PMID: 38965576]
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 482)
  AUTHORS   Taunton,J., Hassig,C.A. and Schreiber,S.L.
  TITLE     A mammalian histone deacetylase related to the yeast
            transcriptional regulator Rpd3p
  JOURNAL   Science 272 (5260), 408-411 (1996)
   PUBMED   8602529
REFERENCE   7  (residues 1 to 482)
  AUTHORS   Wolffe,A.P.
  TITLE     Histone deacetylase: a regulator of transcription
  JOURNAL   Science 272 (5260), 371-372 (1996)
   PUBMED   8602525
  REMARK    Review article
REFERENCE   8  (residues 1 to 482)
  AUTHORS   Furukawa,Y., Kawakami,T., Sudo,K., Inazawa,J., Matsumine,A.,
            Akiyama,T. and Nakamura,Y.
  TITLE     Isolation and mapping of a human gene (RPD3L1) that is homologous
            to RPD3, a transcription factor in Saccharomyces cerevisiae
  JOURNAL   Cytogenet Cell Genet 73 (1-2), 130-133 (1996)
   PUBMED   8646880
REFERENCE   9  (residues 1 to 482)
  AUTHORS   Hijmans,E.M., Voorhoeve,P.M., Beijersbergen,R.L., van 't Veer,L.J.
            and Bernards,R.
  TITLE     E2F-5, a new E2F family member that interacts with p130 in vivo
  JOURNAL   Mol Cell Biol 15 (6), 3082-3089 (1995)
   PUBMED   7760804
REFERENCE   10 (residues 1 to 482)
  AUTHORS   Margolis,D.M., Somasundaran,M. and Green,M.R.
  TITLE     Human transcription factor YY1 represses human immunodeficiency
            virus type 1 transcription and virion production
  JOURNAL   J Virol 68 (2), 905-910 (1994)
   PUBMED   8289393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109945.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 26, 2001 this sequence version replaced NP_004955.1.
            
            Summary: Histone acetylation and deacetylation, catalyzed by
            multisubunit complexes, play a key role in the regulation of
            eukaryotic gene expression. The protein encoded by this gene
            belongs to the histone deacetylase/acuc/apha family and is a
            component of the histone deacetylase complex. It also interacts
            with retinoblastoma tumor-suppressor protein and this complex is a
            key element in the control of cell proliferation and
            differentiation. Together with metastasis-associated protein-2, it
            deacetylates p53 and modulates its effect on cell growth and
            apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.10339.1,
                                           SRR1803611.177301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373548.8/ ENSP00000362649.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2-p35.1"
     Protein         1..482
                     /product="histone deacetylase 1"
                     /EC_number="3.5.1.98"
                     /note="reduced potassium dependency, yeast homolog-like 1;
                     protein deacetylase HDAC1; protein decrotonylase HDAC1;
                     protein deacylase HDAC1"
                     /calculated_mol_wt=54972
     Region          4..374
                     /region_name="HDAC1"
                     /note="Histone deacetylase 1 (HDAC1); cd10010"
                     /db_xref="CDD:212534"
     Region          9..321
                     /region_name="Histone deacetylase"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13547.1)"
     Site            74
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     Site            order(140..141,149..150,176,178,264,271,301,303)
                     /site_type="active"
                     /db_xref="CDD:212534"
     Site            220
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     Region          390..482
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q13547.1)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:17487921, ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     Site            406
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q92769; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     Site            421
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:11602581,
                     ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q13547.1)"
     Site            423
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by CK2.
                     /evidence=ECO:0000269|PubMed:11602581,
                     ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18318008,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     Site            432
                     /site_type="methylation"
                     /note="N6-methylated lysine, by EHMT2.
                     /evidence=ECO:0000269|PubMed:18438403; propagated from
                     UniProtKB/Swiss-Prot (Q13547.1)"
     CDS             1..482
                     /gene="HDAC1"
                     /gene_synonym="GON-10; HD1; KDAC1; RPD3; RPD3L1"
                     /coded_by="NM_004964.3:88..1536"
                     /db_xref="CCDS:CCDS360.1"
                     /db_xref="GeneID:3065"
                     /db_xref="HGNC:HGNC:4852"
                     /db_xref="MIM:601241"
ORIGIN      
        1 maqtqgtrrk vcyyydgdvg nyyygqghpm kphrirmthn lllnyglyrk meiyrphkan
       61 aeemtkyhsd dyikflrsir pdnmseyskq mqrfnvgedc pvfdglfefc qlstggsvas
      121 avklnkqqtd iavnwagglh hakkseasgf cyvndivlai lellkyhqrv lyididihhg
      181 dgveeafytt drvmtvsfhk ygeyfpgtgd lrdigagkgk yyavnyplrd giddesyeai
      241 fkpvmskvme mfqpsavvlq cgsdslsgdr lgcfnltikg hakcvefvks fnlpmlmlgg
      301 ggytirnvar cwtyetaval dteipnelpy ndyfeyfgpd fklhispsnm tnqntneyle
      361 kikqrlfenl rmlphapgvq mqaipedaip eesgdededd pdkrisicss dkriaceeef
      421 sdseeegegg rknssnfkka krvktedeke kdpeekkevt eeektkeekp eakgvkeevk
      481 la
//
