LOCUS       NM_001384272            1571 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens hypocretin receptor 2 (HCRTR2), transcript variant 1,
            mRNA.
ACCESSION   NM_001384272
VERSION     NM_001384272.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Hamdan,S., Wasling,P. and Lind,A.
  TITLE     High-resolution HLA sequencing and hypocretin receptor 2
            autoantibodies in narcolepsy type 1 and type 2
  JOURNAL   Int J Immunogenet 51 (5), 310-318 (2024)
   PUBMED   38898624
  REMARK    GeneRIF: High-resolution HLA sequencing and hypocretin receptor 2
            autoantibodies in narcolepsy type 1 and type 2.
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Popescu,C.
  TITLE     Combined genotype of HCRTR2 and CLOCK variants in a large family of
            cluster headache with familial periodicity phenotype
  JOURNAL   J Neurol 270 (10), 5064-5070 (2023)
   PUBMED   37418013
  REMARK    GeneRIF: Combined genotype of HCRTR2 and CLOCK variants in a large
            family of cluster headache with familial periodicity phenotype.
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Maruyama,T. and Ueta,Y.
  TITLE     Internal and external modulation factors of the orexin system
            (REVIEW)
  JOURNAL   Peptides 165, 171009 (2023)
   PUBMED   37054895
  REMARK    GeneRIF: Internal and external modulation factors of the orexin
            system (REVIEW).
            Review article
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Lozano-Tovar,S., Rodriguez-Agudelo,Y., Davila-Ortiz de
            Montellano,D.J., Perez-Aldana,B.E., Ortega-Vazquez,A. and
            Monroy-Jaramillo,N.
  TITLE     Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and
            Neuropsychiatric Symptoms in Patients with Alzheimer's Disease
  JOURNAL   Int J Environ Res Public Health 20 (5), 4412 (2023)
   PUBMED   36901420
  REMARK    GeneRIF: Relationship between APOE, PER2, PER3 and OX2R Genetic
            Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's
            Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Goldstein,N., Tsuneki,H., Bhandarkar,N., Aimaretti,E., Haim,Y.,
            Kon,K., Sato,K., Wada,T., Liberty,I.F., Kirshtein,B., Dukhno,O.,
            Maixner,N., Gepner,Y., Sasaoka,T. and Rudich,A.
  TITLE     Human adipose tissue is a putative direct target of daytime orexin
            with favorable metabolic effects: A cross-sectional study
  JOURNAL   Obesity (Silver Spring) 29 (11), 1857-1867 (2021)
   PUBMED   34472713
  REMARK    GeneRIF: Human adipose tissue is a putative direct target of
            daytime orexin with favorable metabolic effects: A cross-sectional
            study.
REFERENCE   6  (bases 1 to 1571)
  AUTHORS   Peyron,C., Faraco,J., Rogers,W., Ripley,B., Overeem,S., Charnay,Y.,
            Nevsimalova,S., Aldrich,M., Reynolds,D., Albin,R., Li,R., Hungs,M.,
            Pedrazzoli,M., Padigaru,M., Kucherlapati,M., Fan,J., Maki,R.,
            Lammers,G.J., Bouras,C., Kucherlapati,R., Nishino,S. and Mignot,E.
  TITLE     A mutation in a case of early onset narcolepsy and a generalized
            absence of hypocretin peptides in human narcoleptic brains
  JOURNAL   Nat Med 6 (9), 991-997 (2000)
   PUBMED   10973318
REFERENCE   7  (bases 1 to 1571)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richarson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (5), 1pagefollowing696 (1998)
   PUBMED   9527442
REFERENCE   8  (bases 1 to 1571)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
REFERENCE   9  (bases 1 to 1571)
  AUTHORS   Flier,J.S. and Maratos-Flier,E.
  TITLE     Obesity and the hypothalamus: novel peptides for new pathways
  JOURNAL   Cell 92 (4), 437-440 (1998)
   PUBMED   9491885
  REMARK    Review article
REFERENCE   10 (bases 1 to 1571)
  AUTHORS   de Lecea,L., Kilduff,T.S., Peyron,C., Gao,X., Foye,P.E.,
            Danielson,P.E., Fukuhara,C., Battenberg,E.L., Gautvik,V.T.,
            Bartlett,F.S. 2nd, Frankel,W.N., van den Pol,A.N., Bloom,F.E.,
            Gautvik,K.M. and Sutcliffe,J.G.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591718.14 and AL449104.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The protein encoded by this gene is a G-protein coupled
            receptor involved in the regulation of feeding behavior. The
            encoded protein binds the hypothalamic neuropeptides orexin A and
            orexin B. A related gene (HCRTR1) encodes a G-protein coupled
            receptor that selectively binds orexin A. [provided by RefSeq, Jan
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041245.2, AK314279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267753, SAMN03267755
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370862.4/ ENSP00000359899.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AL591718.14        144210-144505
            297-475             AL449104.5         60636-60814
            476-719             AL449104.5         67133-67376
            720-835             AL449104.5         75704-75819
            836-1056            AL449104.5         89377-89597
            1057-1178           AL449104.5         92320-92441
            1179-1571           AL449104.5         94222-94614
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..1571
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /note="hypocretin receptor 2"
                     /db_xref="GeneID:3062"
                     /db_xref="HGNC:HGNC:4849"
                     /db_xref="MIM:602393"
     exon            1..296
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1408
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /note="hypocretin receptor type 2; hypocretin (orexin)
                     receptor 2; orexin type-2 receptor"
                     /codon_start=1
                     /product="orexin receptor type 2"
                     /protein_id="NP_001371201.1"
                     /db_xref="CCDS:CCDS4956.1"
                     /db_xref="GeneID:3062"
                     /db_xref="HGNC:HGNC:4849"
                     /db_xref="MIM:602393"
                     /translation="MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLW
                     REYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVL
                     VTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPL
                     MFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEI
                     YPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPR
                     GPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFA
                     HTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQED
                     RLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW"
     exon            297..475
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..719
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            720..835
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1056
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1178
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1571
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1548..1553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /note="hexamer: AATAAA"
     polyA_site      1571
                     /gene="HCRTR2"
                     /gene_synonym="ORXR2; OX2R; OXR2"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatcacc agtgctcatg gggcaggcgg agaggagctt gcagcattga gcggaaccgg
       61 acttgagccc gtgatgtccg gcaccaaatt ggaggactcc cccccttgtc gcaactggtc
      121 atctgcttcg gagctgaatg aaactcaaga gcccttttta aaccccaccg actatgacga
      181 cgaggaattc ctgcggtacc tgtggaggga atacctgcac ccgaaagaat atgagtgggt
      241 cctgatcgcc gggtacatca tcgtgttcgt cgtggctctc attgggaacg tcctggtttg
      301 tgtggcagtg tggaagaacc accacatgag gacggtaacc aactacttca tagtcaatct
      361 ttctctggct gatgtgctcg tgaccatcac ctgccttcca gccacactgg tcgtggatat
      421 cactgagacc tggttttttg gacagtccct ttgcaaagtg attccttatc tacagaccgt
      481 gtcggtgtct gtgtctgtcc tcacactgag ctgtatcgcc ttggatcggt ggtatgcaat
      541 ctgtcaccct ttgatgttta agagcacagc aaagcgggcc cgtaacagca ttgtcatcat
      601 ctggattgtc tcctgcatta taatgattcc tcaggccatc gtcatggagt gcagcaccgt
      661 gttcccaggc ttagccaata aaaccaccct ctttacggtg tgtgatgagc gctggggtgg
      721 tgaaatttat cccaagatgt accacatctg tttctttctg gtgacataca tggcaccact
      781 gtgtctcatg gtgttggctt atctgcaaat atttcgcaaa ctctggtgtc gacagatccc
      841 tggaacatca tctgtagttc agagaaaatg gaagcccctg cagcctgttt cacagcctcg
      901 agggccagga cagccaacga agtcccggat gagcgctgtg gcggctgaaa taaagcagat
      961 ccgagccaga aggaaaacag cccggatgtt gatgattgtg cttttggtat ttgcaatttg
     1021 ctatctacca attagcatcc tcaatgtgct aaagagagta tttgggatgt ttgcccatac
     1081 tgaagacaga gagactgtgt atgcctggtt taccttttca cactggcttg tatatgccaa
     1141 tagtgctgcg aatccaatta tttataattt tctcagtgga aaatttcgag aggaatttaa
     1201 agctgcgttt tcttgctgtt gccttggagt tcaccatcgc caggaggatc ggctcaccag
     1261 gggacgaact agcacagaga gccggaagtc cttgaccact caaatcagca actttgataa
     1321 catatcaaaa ctttctgagc aagttgtgct cactagcata agcacactcc cagcagccaa
     1381 tggagcagga ccacttcaaa actggtagaa tatttattca tatgacaagg atacctgagt
     1441 aaaactatcc tttttaaaat cactgggaac agaaatttta ttatcctatg atgtgaagct
     1501 aaaattactt gtggatcttt ttttttttta atctattgct ctttggaaat aaaaaaaaag
     1561 tcagtttaaa a
//
