LOCUS       NM_001525               2307 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens hypocretin receptor 1 (HCRTR1), mRNA.
ACCESSION   NM_001525
VERSION     NM_001525.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2307)
  AUTHORS   Guo,X., Wen,J., Gao,Q., Zhao,Y., Zhao,Y., Wang,C., Xu,N., Shao,Y.
            and Chang,X.
  TITLE     Orexin-A/OX1R is involved in regulation of autophagy to promote
            cortisol secretion in adrenocortical cell
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (1), 166844 (2024)
   PUBMED   37572990
  REMARK    GeneRIF: Orexin-A/OX1R is involved in regulation of autophagy to
            promote cortisol secretion in adrenocortical cell.
REFERENCE   2  (bases 1 to 2307)
  AUTHORS   Maruyama,T. and Ueta,Y.
  TITLE     Internal and external modulation factors of the orexin system
            (REVIEW)
  JOURNAL   Peptides 165, 171009 (2023)
   PUBMED   37054895
  REMARK    GeneRIF: Internal and external modulation factors of the orexin
            system (REVIEW).
            Review article
REFERENCE   3  (bases 1 to 2307)
  AUTHORS   Goldstein,N., Tsuneki,H., Bhandarkar,N., Aimaretti,E., Haim,Y.,
            Kon,K., Sato,K., Wada,T., Liberty,I.F., Kirshtein,B., Dukhno,O.,
            Maixner,N., Gepner,Y., Sasaoka,T. and Rudich,A.
  TITLE     Human adipose tissue is a putative direct target of daytime orexin
            with favorable metabolic effects: A cross-sectional study
  JOURNAL   Obesity (Silver Spring) 29 (11), 1857-1867 (2021)
   PUBMED   34472713
  REMARK    GeneRIF: Human adipose tissue is a putative direct target of
            daytime orexin with favorable metabolic effects: A cross-sectional
            study.
REFERENCE   4  (bases 1 to 2307)
  AUTHORS   Vitale,R.M., Iannotti,F.A., Schiano Moriello,A., Tunisi,L.,
            Piscitelli,F., Savopoulos,R., Cristino,L., De Petrocellis,L.,
            Amodeo,P., Gray,R. and Di Marzo,V.
  TITLE     Identification and Characterization of Cannabidiol as an OX1R
            Antagonist by Computational and In Vitro Functional Validation
  JOURNAL   Biomolecules 11 (8), 1134 (2021)
   PUBMED   34439801
  REMARK    GeneRIF: Identification and Characterization of Cannabidiol as an
            OX1R Antagonist by Computational and In Vitro Functional
            Validation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2307)
  AUTHORS   Xu,D., Kong,T., Zhang,S., Cheng,B., Chen,J. and Wang,C.
  TITLE     Orexin-A protects against cerebral ischemia-reperfusion injury by
            inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR
            pathway
  JOURNAL   Cell Signal 79, 109839 (2021)
   PUBMED   33212156
  REMARK    GeneRIF: Orexin-A protects against cerebral ischemia-reperfusion
            injury by inhibiting excessive autophagy through OX1R-mediated
            MAPK/ERK/mTOR pathway.
REFERENCE   6  (bases 1 to 2307)
  AUTHORS   Peyron,C., Faraco,J., Rogers,W., Ripley,B., Overeem,S., Charnay,Y.,
            Nevsimalova,S., Aldrich,M., Reynolds,D., Albin,R., Li,R., Hungs,M.,
            Pedrazzoli,M., Padigaru,M., Kucherlapati,M., Fan,J., Maki,R.,
            Lammers,G.J., Bouras,C., Kucherlapati,R., Nishino,S. and Mignot,E.
  TITLE     A mutation in a case of early onset narcolepsy and a generalized
            absence of hypocretin peptides in human narcoleptic brains
  JOURNAL   Nat Med 6 (9), 991-997 (2000)
   PUBMED   10973318
REFERENCE   7  (bases 1 to 2307)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richarson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (5), 1pagefollowing696 (1998)
   PUBMED   9527442
REFERENCE   8  (bases 1 to 2307)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
REFERENCE   9  (bases 1 to 2307)
  AUTHORS   Flier,J.S. and Maratos-Flier,E.
  TITLE     Obesity and the hypothalamus: novel peptides for new pathways
  JOURNAL   Cell 92 (4), 437-440 (1998)
   PUBMED   9491885
  REMARK    Review article
REFERENCE   10 (bases 1 to 2307)
  AUTHORS   de Lecea,L., Kilduff,T.S., Peyron,C., Gao,X., Foye,P.E.,
            Danielson,P.E., Fukuhara,C., Battenberg,E.L., Gautvik,V.T.,
            Bartlett,F.S. 2nd, Frankel,W.N., van den Pol,A.N., Bloom,F.E.,
            Gautvik,K.M. and Sutcliffe,J.G.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114488.3.
            
            On Dec 17, 2019 this sequence version replaced NM_001525.2.
            
            Summary: The protein encoded by this gene is a G-protein coupled
            receptor involved in the regulation of feeding behavior. The
            encoded protein selectively binds the hypothalamic neuropeptide
            orexin A. A related gene (HCRTR2) encodes a G-protein coupled
            receptor that binds orexin A and orexin B. [provided by RefSeq, Jan
            2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403528.7/ ENSP00000384387.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC114488.3         52974-53166
            194-254             AC114488.3         54041-54101
            255-595             AC114488.3         54336-54676
            596-774             AC114488.3         54817-54995
            775-1018            AC114488.3         56128-56371
            1019-1134           AC114488.3         56762-56877
            1135-1361           AC114488.3         58808-59034
            1362-1483           AC114488.3         60282-60403
            1484-2307           AC114488.3         62075-62898
FEATURES             Location/Qualifiers
     source          1..2307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..2307
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /note="hypocretin receptor 1"
                     /db_xref="GeneID:3061"
                     /db_xref="HGNC:HGNC:4848"
                     /db_xref="MIM:602392"
     exon            1..193
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..254
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..595
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1674
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /note="orexin receptor type 1; orexin receptor 1;
                     hypocretin receptor type 1; hypocretin (orexin) receptor
                     1"
                     /codon_start=1
                     /product="orexin/Hypocretin receptor type 1"
                     /protein_id="NP_001516.2"
                     /db_xref="CCDS:CCDS344.1"
                     /db_xref="GeneID:3061"
                     /db_xref="HGNC:HGNC:4848"
                     /db_xref="MIM:602392"
                     /translation="MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQ
                     YEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPA
                     SLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARR
                     ARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSC
                     FFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEP
                     QPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDRE
                     AVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPR
                     SSASHKSLSLQSRCSISKISEHVVLTSVTTVLP"
     exon            596..774
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1018
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1134
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1361
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1483
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..2307
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2288..2293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2307
                     /gene="HCRTR1"
                     /gene_synonym="ORXR1; OX1R; OXR1"
                     /note="major polyA site"
ORIGIN      
        1 acagcccgcg cagttgccgc ggatcgtgct gagccccgcg agccgaggca gcgcagccta
       61 gggagggggc tgccccggcc ccctcctgca gtcccggccc ctagaggctc ggccttcctc
      121 gcaggaaggc gaagtccccg gtgccaggtc cggggaccag cagccgagaa cgcccgggtc
      181 ccggagccaa caggttcttg gtgaagcact tggcacgcat cggagctcat tactcctcat
      241 cgtggtcctg taaggaagtt tgaggctgag acccgaaaag acctgggtgc aagcctccag
      301 gcaccctgaa gggagtgggc tgagggctgg cccaagctcc ctcctctccc tctgtagagc
      361 ctaggatgcc cctctgctgc agcggctcct gagctcatgg agccctcagc caccccaggg
      421 gcccagatgg gggtcccccc tggcagcaga gagccgtccc ctgtgcctcc agactatgaa
      481 gatgagtttc tccgctatct gtggcgcgat tatctgtacc caaaacagta tgagtgggtc
      541 ctcatcgcag cctatgtggc tgtgttcgtc gtggccctgg tgggcaacac gctggtctgc
      601 ctggccgtgt ggcggaacca ccacatgagg acagtcacca actacttcat tgtcaacctg
      661 tccctggctg acgttctggt gactgctatc tgcctgccgg ccagcctgct ggtggacatc
      721 actgagtcct ggctgttcgg ccatgccctc tgcaaggtca tcccctatct acaggctgtg
      781 tccgtgtcag tggcagtgct aactctcagc ttcatcgccc tggaccgctg gtatgccatc
      841 tgccacccac tattgttcaa gagcacagcc cggcgggccc gtggctccat cctgggcatc
      901 tgggctgtgt cgctggccat catggtgccc caggctgcag tcatggaatg cagcagtgtg
      961 ctgcctgagc tagccaaccg cacacggctc ttctcagtct gtgatgaacg ctgggcagat
     1021 gacctctatc ccaagatcta ccacagttgc ttctttattg tcacctacct ggccccactg
     1081 ggcctcatgg ccatggccta tttccagata ttccgcaagc tctggggccg ccagatcccc
     1141 ggcaccacct cagcactggt gcggaactgg aagcgcccct cagaccagct gggggacctg
     1201 gagcagggcc tgagtggaga gccccagccc cgggcccgcg ccttcctggc tgaagtgaag
     1261 cagatgcgtg cacggaggaa gacagccaag atgctgatgg tggtgctgct ggtcttcgcc
     1321 ctctgctacc tgcccatcag cgtcctcaat gtccttaaga gggtgttcgg gatgttccgc
     1381 caagccagtg accgcgaagc tgtctacgcc tgcttcacct tctcccactg gctggtgtac
     1441 gccaacagcg ctgccaaccc catcatctac aacttcctca gtggcaaatt ccgggagcag
     1501 tttaaggctg ccttctcctg ctgcctgcct ggcctgggtc cctgcggctc tctgaaggcc
     1561 cctagtcccc gctcctctgc cagccacaag tccttgtcct tgcagagccg atgctccatc
     1621 tccaaaatct ctgagcatgt ggtgctcacc agcgtcacca cagtgctgcc ctgagcgagg
     1681 gctgccctgg aggctccggc tcgggggatc tgcccctacc cctcatggaa agacagctgg
     1741 atgtggtgaa aggctgtggc ttcagtcctg ggtttctgcc tgtgtgactc tggataagtc
     1801 acttcctctg tctgagcttg tgtcccctaa gcagggttga tgtgaggatt aagcatgctg
     1861 aagcaagtgg aaagctcctt gtaaactgtg aagtgttgtg gacatgatta ttgttgtact
     1921 tctctcattt ggccataccc cacagtataa tctgtcccca tcctccttcc agagcttggt
     1981 catcctccta aagacccctt tcctacccaa ttacaggcct tccctggagt ctgctctaaa
     2041 ggtcccaaca ggcatttcca tcttgttcca tggctccctg aagcccaggg ctgcacttgg
     2101 ccagctgttc tgatgcctgt gtgaactaat ctgggcccag cctttctcca gcgggccacg
     2161 agcacagccc caccctaacc aggtgccaag ggcacacacc acagacccga ccttgttggc
     2221 tttgtggtgt gataaaacac tctccatggc cacttggcag agaggccagc agcccgaagc
     2281 aactgtaatt aaaagcctgg cactgaa
//
