LOCUS       NM_001524                577 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens hypocretin neuropeptide precursor (HCRT), mRNA.
ACCESSION   NM_001524
VERSION     NM_001524.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 577)
  AUTHORS   Nigro,E., D'Arco,D., Moscatelli,F., Pisani,A., Amicone,M.,
            Riccio,E., Capuano,I., Argentino,F., Monda,M., Messina,G.,
            Daniele,A. and Polito,R.
  TITLE     Increased Expression of Orexin-A in Patients Affected by Polycystic
            Kidney Disease
  JOURNAL   Int J Mol Sci 25 (11), 6243 (2024)
   PUBMED   38892431
  REMARK    GeneRIF: Increased Expression of Orexin-A in Patients Affected by
            Polycystic Kidney Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 577)
  AUTHORS   Huan,R., Zhang,J., Yue,J., Yang,S., Han,G., Cheng,Y. and Tan,Y.
  TITLE     Orexin-A mediates glioblastoma proliferation inhibition by
            increasing ferroptosis triggered by unstable iron pools and GPX4
            depletion
  JOURNAL   J Cell Mol Med 28 (9), e18318 (2024)
   PUBMED   38685674
  REMARK    GeneRIF: Orexin-A mediates glioblastoma proliferation inhibition by
            increasing ferroptosis triggered by unstable iron pools and GPX4
            depletion.
REFERENCE   3  (bases 1 to 577)
  AUTHORS   Hakami,W., Thabet,F., Alhashem,A., Alghamdi,A., Alshahwan,S.,
            Alkuraya,F.S. and Tabarki,B.
  TITLE     Bi-allelic variants in HCRT cause autosomal recessive narcolepsy
  JOURNAL   Neurogenetics 25 (2), 79-83 (2024)
   PUBMED   38240911
  REMARK    GeneRIF: Bi-allelic variants in HCRT cause autosomal recessive
            narcolepsy.
REFERENCE   4  (bases 1 to 577)
  AUTHORS   Sandikci,S.C., Gultuna,S., Ozisler,C. and Aydin,F.N.
  TITLE     The role of orexin in fatigue and sleep quality in patients with
            primary Sjogren's syndrome
  JOURNAL   Z Rheumatol 83 (Suppl 1), 242-247 (2024)
   PUBMED   38108866
  REMARK    GeneRIF: The role of orexin in fatigue and sleep quality in
            patients with primary Sjogren's syndrome.
REFERENCE   5  (bases 1 to 577)
  AUTHORS   Soejima,Y., Iwata,N., Nishioka,R., Honda,M., Nakano,Y.,
            Yamamoto,K., Suyama,A. and Otsuka,F.
  TITLE     Interaction of Orexin and Bone Morphogenetic Proteins in
            Steroidogenesis by Human Adrenocortical Cells
  JOURNAL   Int J Mol Sci 24 (16), 12559 (2023)
   PUBMED   37628739
  REMARK    GeneRIF: Interaction of Orexin and Bone Morphogenetic Proteins in
            Steroidogenesis by Human Adrenocortical Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 577)
  AUTHORS   Sakurai,T., Moriguchi,T., Furuya,K., Kajiwara,N., Nakamura,T.,
            Yanagisawa,M. and Goto,K.
  TITLE     Structure and function of human prepro-orexin gene
  JOURNAL   J Biol Chem 274 (25), 17771-17776 (1999)
   PUBMED   10364220
REFERENCE   7  (bases 1 to 577)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richarson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (5), 1pagefollowing696 (1998)
   PUBMED   9527442
REFERENCE   8  (bases 1 to 577)
  AUTHORS   Sakurai,T., Amemiya,A., Ishii,M., Matsuzaki,I., Chemelli,R.M.,
            Tanaka,H., Williams,S.C., Richardson,J.A., Kozlowski,G.P.,
            Wilson,S., Arch,J.R., Buckingham,R.E., Haynes,A.C., Carr,S.A.,
            Annan,R.S., McNulty,D.E., Liu,W.S., Terrett,J.A., Elshourbagy,N.A.,
            Bergsma,D.J. and Yanagisawa,M.
  TITLE     Orexins and orexin receptors: a family of hypothalamic
            neuropeptides and G protein-coupled receptors that regulate feeding
            behavior
  JOURNAL   Cell 92 (4), 573-585 (1998)
   PUBMED   9491897
REFERENCE   9  (bases 1 to 577)
  AUTHORS   Flier,J.S. and Maratos-Flier,E.
  TITLE     Obesity and the hypothalamus: novel peptides for new pathways
  JOURNAL   Cell 92 (4), 437-440 (1998)
   PUBMED   9491885
  REMARK    Review article
REFERENCE   10 (bases 1 to 577)
  AUTHORS   de Lecea,L., Kilduff,T.S., Peyron,C., Gao,X., Foye,P.E.,
            Danielson,P.E., Fukuhara,C., Battenberg,E.L., Gautvik,V.T.,
            Bartlett,F.S. 2nd, Frankel,W.N., van den Pol,A.N., Bloom,F.E.,
            Gautvik,K.M. and Sutcliffe,J.G.
  TITLE     The hypocretins: hypothalamus-specific peptides with
            neuroexcitatory activity
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 322-327 (1998)
   PUBMED   9419374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF041240.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a hypothalamic neuropeptide precursor
            protein that gives rise to two mature neuropeptides, orexin A and
            orexin B, by proteolytic processing. Orexin A and orexin B, which
            bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2,
            function in the regulation of sleep and arousal. This neuropeptide
            arrangement may also play a role in feeding behavior, metabolism,
            and homeostasis. [provided by RefSeq, Jan 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041240.1, AW163085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293330.1/ ENSP00000293330.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..577
                     /gene="HCRT"
                     /gene_synonym="NRCLP1; OX; PPOX"
                     /note="hypocretin neuropeptide precursor"
                     /db_xref="GeneID:3060"
                     /db_xref="HGNC:HGNC:4847"
                     /db_xref="MIM:602358"
     exon            1..108
                     /gene="HCRT"
                     /gene_synonym="NRCLP1; OX; PPOX"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..483
                     /gene="HCRT"
                     /gene_synonym="NRCLP1; OX; PPOX"
                     /note="orexin; prepro-orexin; hypocretin (orexin)
                     neuropeptide; preprohypocretin"
                     /codon_start=1
                     /product="hypocretin neuropeptide precursor precursor"
                     /protein_id="NP_001515.1"
                     /db_xref="CCDS:CCDS11421.1"
                     /db_xref="GeneID:3060"
                     /db_xref="HGNC:HGNC:4847"
                     /db_xref="MIM:602358"
                     /translation="MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKT
                     CSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAG
                     AEPAPRPCLGRRCSAPAAASVAPGGQSGI"
     exon            109..577
                     /gene="HCRT"
                     /gene_synonym="NRCLP1; OX; PPOX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      558..563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCRT"
                     /gene_synonym="NRCLP1; OX; PPOX"
                     /note="hexamer: AATAAA"
     polyA_site      577
                     /gene="HCRT"
                     /gene_synonym="NRCLP1; OX; PPOX"
                     /note="major polyA site"
ORIGIN      
        1 cacaattgac agcctcaagg ttcctggctt tttgaaccac cacagacatc tcctttcccg
       61 gctaccccac cctgagcgcc agacaccatg aaccttcctt ccacaaaggt ctcctgggcc
      121 gccgtgacgc tactgctgct gctgctgctg ctgccgcccg cgctgttgtc gtccggggcg
      181 gctgcacagc ccctgcccga ctgctgtcgt caaaagactt gctcttgccg cctctacgag
      241 ctgctgcacg gcgcgggcaa tcacgcggcc ggcatcctca cgctgggcaa gcggaggtcc
      301 gggcccccgg gcctccaggg tcggctgcag cgcctcctgc aggccagcgg caaccacgcc
      361 gcgggcatcc tgaccatggg ccgccgcgca ggcgcagagc cagcgccgcg cccctgcctc
      421 gggcgccgct gttccgcccc ggccgccgcc tccgtcgcgc ccggaggaca gtccgggatc
      481 tgagtcgttc ttcgggccct gtcctggccc aggcctctgc cctctgccca cccagcgtca
      541 gcccccagaa aaaaggcaat aaagacgagt ctccatt
//
