LOCUS       NM_013320               5660 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens host cell factor C2 (HCFC2), mRNA.
ACCESSION   NM_013320
VERSION     NM_013320.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5660)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5660)
  AUTHORS   Park,S.H., Ayoub,A., Lee,Y.T., Xu,J., Kim,H., Zheng,W., Zhang,B.,
            Sha,L., An,S., Zhang,Y., Cianfrocco,M.A., Su,M., Dou,Y. and
            Cho,U.S.
  TITLE     Cryo-EM structure of the human MLL1 core complex bound to the
            nucleosome
  JOURNAL   Nat Commun 10 (1), 5540 (2019)
   PUBMED   31804488
  REMARK    Erratum:[Nat Commun. 2020 Feb 27;11(1):1165. doi:
            10.1038/s41467-020-14973-y.. PMID: 32109228]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5660)
  AUTHORS   Gudkova,D., Dergai,O., Praz,V. and Herr,W.
  TITLE     HCF-2 inhibits cell proliferation and activates
            differentiation-gene expression programs
  JOURNAL   Nucleic Acids Res 47 (11), 5792-5808 (2019)
   PUBMED   31049581
  REMARK    GeneRIF: HCF-2 is broadly present in human and mouse cells, and
            possesses activities distinct from HCF-1
REFERENCE   4  (bases 1 to 5660)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5660)
  AUTHORS   Li,Y., Han,J., Zhang,Y., Cao,F., Liu,Z., Li,S., Wu,J., Hu,C.,
            Wang,Y., Shuai,J., Chen,J., Cao,L., Li,D., Shi,P., Tian,C.,
            Zhang,J., Dou,Y., Li,G., Chen,Y. and Lei,M.
  TITLE     Structural basis for activity regulation of MLL family
            methyltransferases
  JOURNAL   Nature 530 (7591), 447-452 (2016)
   PUBMED   26886794
REFERENCE   6  (bases 1 to 5660)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   7  (bases 1 to 5660)
  AUTHORS   van Nuland,R., Smits,A.H., Pallaki,P., Jansen,P.W., Vermeulen,M.
            and Timmers,H.T.
  TITLE     Quantitative dissection and stoichiometry determination of the
            human SET1/MLL histone methyltransferase complexes
  JOURNAL   Mol Cell Biol 33 (10), 2067-2077 (2013)
   PUBMED   23508102
REFERENCE   8  (bases 1 to 5660)
  AUTHORS   Yokoyama,A., Wang,Z., Wysocka,J., Sanyal,M., Aufiero,D.J.,
            Kitabayashi,I., Herr,W. and Cleary,M.L.
  TITLE     Leukemia proto-oncoprotein MLL forms a SET1-like histone
            methyltransferase complex with menin to regulate Hox gene
            expression
  JOURNAL   Mol Cell Biol 24 (13), 5639-5649 (2004)
   PUBMED   15199122
REFERENCE   9  (bases 1 to 5660)
  AUTHORS   Johnson,K.M., Mahajan,S.S. and Wilson,A.C.
  TITLE     Herpes simplex virus transactivator VP16 discriminates between
            HCF-1 and a novel family member, HCF-2
  JOURNAL   J Virol 73 (5), 3930-3940 (1999)
   PUBMED   10196288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB030069.1, BC033799.1,
            AC089983.23 and AI247087.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013320.2.
            
            Summary: This gene encodes one of two proteins which interact with
            VP16, a herpes simplex virus protein that initiates virus
            infection. Both the encoded protein and the original Herpes host
            cell factor interact with VP16 through a beta-propeller domain. The
            original Herpes host cell factor, however, is effective at
            initiating viral infection while the encoded protein is not.
            Transcripts of varying length due to alternative polyadenylation
            signals have been described. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.206310.1,
                                           SRR1660803.229480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229330.9/ ENSP00000229330.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DB030069.1         74-98
            26-2602             BC033799.1         1-2577
            2603-5242           AC089983.23        6252-8891
            5243-5660           AI247087.1         11-428              c
FEATURES             Location/Qualifiers
     source          1..5660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..5660
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="host cell factor C2"
                     /db_xref="GeneID:29915"
                     /db_xref="HGNC:HGNC:24972"
                     /db_xref="MIM:607926"
     exon            1..193
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2409
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="C2 factor"
                     /codon_start=1
                     /product="host cell factor 2"
                     /protein_id="NP_037452.1"
                     /db_xref="CCDS:CCDS9097.1"
                     /db_xref="GeneID:29915"
                     /db_xref="HGNC:HGNC:24972"
                     /db_xref="MIM:607926"
                     /translation="MAAPSLLNWRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEG
                     IADELHVYNTATNQWFLPAVRGDIPPGCAAHGFVCDGTRILVFGGMVEYGRYSNELYE
                     LQASRWLWKKVKPHPPPSGLPPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYL
                     NDFYELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCGAR
                     LDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTETSPH
                     DCEWRCTSSFSYLNLDTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRD
                     GYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVSTVEGYLLQLST
                     DLPYQAASSDSSAAPNMQGVRMDPHRQGSNNIVPNSINDTINSTKTEQPATKETSMKN
                     KPDFKALTDSNAILYPSLASNASNHNSHVVDMLRKNEGPHTSANVGVLSSCLDVRTVI
                     PETSVSSTVSSTQTMVTQQTIKTESSSTNGAVVKDETSLTTFSTKSEVDETYALPATK
                     ISRVETHATATPFSKETPSNPVATVKAGERQWCDVGIFKNNTALVSQFYLLPKGKQSI
                     SKVGNADVPDYSLLKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKTCIPGFPGAPS
                     AVRISKNVEGIHLSWEPPTSPSGNILEYSAYLAIRTAQIQDNPSQLVFMRIYCGLKTS
                     CIVTAGQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQGNNKKAPLN"
     exon            194..342
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..503
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            504..712
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..797
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..904
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1093
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1261
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1314
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1492
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1696
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1770
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1908
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2094
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..5660
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2575..2580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="hexamer: AAGAAA"
     polyA_site      2602
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="major polyA site"
     regulatory      3966..3971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="hexamer: AATAAA"
     polyA_site      3997
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="major polyA site"
     regulatory      5633..5638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="hexamer: AATAAA"
     polyA_site      5660
                     /gene="HCFC2"
                     /gene_synonym="HCF-2; HCF2"
                     /note="major polyA site"
ORIGIN      
        1 attgtgggca gaggggcggg ggttgggaag atggcggctc ccagcctcct caactggagg
       61 cgagtttctt ccttcacggg gccggtcccc cgcgcccggc acggacaccg agcggtggcc
      121 atccgggagc tgatgatcat ctttggaggg ggaaatgagg gcatcgcgga tgagctgcac
      181 gtctacaaca cggctacgaa tcagtggttt ctgccagctg ttagaggaga tatccctcca
      241 ggctgtgctg cccatggatt tgtctgtgat ggtaccagaa tattagtatt tgggggaatg
      301 gttgaatatg gaagatacag caatgagtta tatgagttac aagcaagtcg ttggttatgg
      361 aaaaaagtga aaccccatcc ccctccttct ggtttacctc cttgtcctcg gcttggacat
      421 agcttctctt tatatggtaa caaatgctat ttgtttggtg gcctggcaaa cgaaagcgaa
      481 gattcaaaca ataatgttcc cagatattta aatgattttt atgagttgga gctacagcat
      541 ggctctggtg ttgtgggttg gagcattcca gtgactaaag gggttgtgcc ttctccaaga
      601 gaatcccaca cagctgttat atattgcaaa aaagattctg gaagtcctaa aatgtatgtt
      661 tttggtggaa tgtgtggtgc tcgcctggat gacctatggc agcttgactt agaaactatg
      721 tcatggtcaa aaccagaaac taaagggaca gtgccacttc cacgaagcct tcatacagcc
      781 agtgttatag gaaacaagat gtacattttt ggtggatggg tcccacataa gggggaaaat
      841 actgagactt cacctcatga ttgtgaatgg agatgtacca gttcattttc ttacctaaat
      901 ctggatacaa cagagtggac caccctagta tcagattctc aggaagataa aaaaaattca
      961 agaccaagac caagagctgg ccactgtgct gttgcaatcg gcactcgatt gtatttttgg
     1021 agtggaagag atggctacaa aaaagcactg aatagtcaag tttgctgcaa ggatctttgg
     1081 tatcttgata ctgagaaacc accggcacca tctcaagtac agctgatcaa agccactacc
     1141 aactcctttc atgtcaagtg ggatgaagtg tctacagttg agggctatct tttgcagttg
     1201 agtacagact tgccatacca agctgcatca tcagattctt cagcagcacc aaatatgcaa
     1261 ggagtcagga tggaccctca cagacaaggc agtaataaca tcgttcctaa cagtatcaat
     1321 gatacaataa acagcacaaa aactgaacag ccagccacaa aagaaacttc aatgaaaaac
     1381 aaaccagact ttaaagcact gacggattct aatgccattt tatatccatc tttggcatca
     1441 aatgcttcta atcataatag tcatgtggtg gatatgctaa ggaaaaatga aggtcctcac
     1501 acttcagcaa atgtaggtgt tctaagtagt tgcctggatg taagaacagt aattcctgaa
     1561 acatctgtat ccagtactgt ttccagcaca caaactatgg taacccagca gaccattaaa
     1621 actgaatcat ccagtacaaa tggggcagtt gttaaagatg aaacttcact aacaacattc
     1681 agtaccaaat ctgaagttga tgaaacatat gcactgcctg caacgaagat cagccgtgta
     1741 gagacacatg ctacagcaac gccgttttct aaagagactc cttcaaatcc agtggccaca
     1801 gtgaaagcgg gagaacgaca atggtgtgat gtgggaattt ttaaaaataa tacagctttg
     1861 gtgagccagt tttatttgct gccaaaaggg aagcaaagca tctcaaaggt aggaaatgca
     1921 gatgtacctg actacagctt gcttaagaaa caagatcttg ttccaggcac aggatacaga
     1981 ttcagggttg ctgcaatcaa tggttgtggg ataggtcctt tcagcaaaat cagtgaattt
     2041 aaaacttgta ttcctggttt tcctggagct ccttctgcag tcagaatttc aaagaatgtt
     2101 gaaggtatcc acctttcctg ggaacctcca acctcacctt ctggaaatat tttggaatat
     2161 tcagcctact tggctatccg cacagcacag atacaagata atccaagtca acttgtgttc
     2221 atgaggattt attgtggtct taagacatca tgtatagtaa ctgctgggca acttgcaaat
     2281 gcacatattg attatacatc caggcctgcc attgtgttca ggatatcagc aaagaatgaa
     2341 aagggatatg gaccagctac acaagttcgg tggcttcaag gtaacaataa gaaagcacct
     2401 ttaaattgaa ttggtttttt tactgaagct attgtgatga tgattattta ttagtaactg
     2461 gttatgaaga tttgtcattt aaaagagtat tctctggctg tatttccagc agttatgaac
     2521 ttgagtttgt aaattgttct taaaatgtat ttgctgaatt atagatccaa ataaaagaaa
     2581 agaagcaaag actctctgaa aattagtata tgagttcttc cttacagata tagctctttt
     2641 ataaagaaaa acagtgaaat taagataaaa gctagaaagc tttattaccc caatatcttt
     2701 tataagggct gtgtaaccca gtcatcctag agttattgag atgattctgg taactggctg
     2761 ttgtatacta tgctgtctta tatagtaaat gttctctaca ttgtaaatgt cctacctttg
     2821 agtactcctt ctatctttat tctatatgag cagtgttcct ctaacaactg tcttctattg
     2881 gataatatgt gtgatactat aataattcta atagttattt gattcctttc tttgtttaca
     2941 gttagcacag agcttaagaa attaaaaaag aggcaagttt agaaactgct tttgaacttt
     3001 tattattttc caagaatcat ggtaaaatac aacaagaaca atgagttttc ttgattctta
     3061 ccaggccaat atatttgaat atatttttgg ccaaagcact taacttatct ggccctcatt
     3121 ttcctcataa cagatgaggg agttaaagca gtttatcttt taggtccctt tcagcactaa
     3181 ggttttgtgt ttttagtaga agtgaagtat gtccctgaac attttcatct gtcttaatgg
     3241 ctctaatttt gcttttgcta aaattaaaat cttcataatt gaattcaaaa ttaaagtata
     3301 tgtcctccta ttggagaaaa aaacaagcac cttaacagga cacaagtttt aaaatagtgt
     3361 tttaaacatt tgtaagattt ttgtaaatgc tctaaatgtt ttatttttgc attgttttta
     3421 ccttgaaatt gtataaactt ttttactatg aaaatataag cattagacag ctaactcagg
     3481 ttccattaca accttaaaga tacagatagg cattataaac actctgctac aggtaacttg
     3541 ttttaaacct tttaggaatt tcatggttcc actgcctatt taaatctgga attaatatac
     3601 agagcaataa ttgcagaaaa gatatttcaa actaagagct tcaataactg caggggcaca
     3661 ggtctatctt tttttatacc acataacctt atgccagttt aggttgactg agtagctatg
     3721 tcctcaaatt tcatgtatga taccccccag caaagatgga tttaattgtg cagaattgat
     3781 atatatgtgt gttccagtta ctaatttaaa gtgtatagaa tattttaata tataattttt
     3841 gtaaagaact gggattttta tactacagta tttgtaatta atgtgtctca ctaattaagt
     3901 ttctcttgaa gaaaatatgc aaattgttag acacataatg agtggtttcc aaactctaaa
     3961 gataaaataa atgcactact atggtgttgt tagaatacct tttttgtggc tgtatgaatc
     4021 tttactcttt aaatgtgtac tttacaatgt ttacaaggag cttctctggt ttgttatccc
     4081 agcaatgccc ttggtgagag cttcattctg catttgttta attcatatgc tttgcttttg
     4141 gcatatgctt gctttttgca ctagtagaat tttaacttac ctcattatta tgtttgtaat
     4201 catttgtcta gcttctgtaa tgtatctgat ataggctaaa caaatactta accaaagtta
     4261 aaatacatgg taagcaattt tgcacatatt aaatattagg gtttgttgtg tatatgtgta
     4321 tacttaatta taaaagaata tgaatggaaa gttatactaa aagtatatgt ttcaagccca
     4381 gttattttaa agatctattg ctttaataga aaaagtttgg cttttaaccc tttcttctct
     4441 gcattaatta acaacgtgca tcttgaagcc cttctcctga taacaaggaa taagttgatt
     4501 ttaagcaaag gatagaatat ttgtttgagt gtgcacattt atacctgttt agtatttgat
     4561 tcagttaagc ctccactctt ctggatcagg aggtgattct gaacctgtgg ttctaacata
     4621 tgacttaact gtttagaggg aagagaagtc tttctatact gagggatttg ttaaaatcat
     4681 aaatgttttt gccctgagac ttagcccaga ttctattttt tttttttttt tggcatttgt
     4741 acattaagca ccagtcatat ttatctctgt gataagggat tgctgactaa aaaatgccat
     4801 taagaaatct ctgtggcttt gacattagta gttaataaga gatcttagag ctgtgtgctg
     4861 atgaatagaa tgaattggag caaatagcaa gagaagtgca tttagcttct tatgatttgc
     4921 acattttcta aatgaagatc cctttgtgta gcagtaggct gtatcatgca gatatttttc
     4981 ataggatttg cactgagtta aatgactttc tttactcttc ccagtcaggt aagcagttca
     5041 aatataacaa gactttgtgc cagtcctctt ctgtgttctg caactctggc tctcataagt
     5101 agtaaaaata tttttgatgt tgcatgctct cagaattatg ttttctaaaa tatcatattg
     5161 gcttcatttt agtttaataa acttctttgg caacttaatt agacataggg tatatataaa
     5221 ctcaatttta tctgcatttt ttaaaaaatt gaaataatct gattgcatgt atgaaggact
     5281 cctgcctcat tacccaatta cataaataca attatctata ggaaggtgaa attgttgatc
     5341 tattatttca aagacttgta gactagcaaa gattcattct gattagaaat aaggtctata
     5401 gctaaagata tttttatttt aaaaaattac agcccttgta acaaaaatca tttgtaacat
     5461 tggatatgaa gacattatta gtatttaaaa ttattgtagt catttgatca taaatgaagt
     5521 agcttgcaaa atagacttgg tctttgaccc tttaaggtgt aactgactga ctgttgtgtt
     5581 tttcaagact gattttaggc agttttatgt atcgtgtacc aatgatatgt aaaataaagc
     5641 accttttcta ctataaacaa
//
