LOCUS       NM_017885                656 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens host cell factor C1 regulator 1 (HCFC1R1), transcript
            variant 1, mRNA.
ACCESSION   NM_017885
VERSION     NM_017885.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 656)
  AUTHORS   Wang,Y., Li,M., Meng,F. and Lou,G.
  TITLE     HPIP expression predicts chemoresistance and poor clinical outcomes
            in patients with epithelial ovarian cancer
  JOURNAL   Hum Pathol 60, 114-120 (2017)
   PUBMED   27818289
  REMARK    GeneRIF: HPIP overexpression is an independent predictor of
            platinum-based chemotherapy resistance in epithelial ovarian
            neoplasms.
REFERENCE   2  (bases 1 to 656)
  AUTHORS   Wang,S.C., Chai,D.S., Chen,C.B., Wang,Z.Y. and Wang,L.
  TITLE     HPIP promotes thyroid cancer cell growth, migration and EMT through
            activating PI3K/AKT signaling pathway
  JOURNAL   Biomed Pharmacother 75, 33-39 (2015)
   PUBMED   26463629
  REMARK    GeneRIF: HPIP promotes thyroid cancer cell growth, migration and
            epithelial mesenchymal transformation through activating PI3K/AKT
            signaling pathway.
REFERENCE   3  (bases 1 to 656)
  AUTHORS   Feng,Y., Xu,X., Zhang,Y., Ding,J., Wang,Y., Zhang,X., Wu,Z.,
            Kang,L., Liang,Y., Zhou,L., Song,S., Zhao,K. and Ye,Q.
  TITLE     HPIP is upregulated in colorectal cancer and regulates colorectal
            cancer cell proliferation, apoptosis and invasion
  JOURNAL   Sci Rep 5, 9429 (2015)
   PUBMED   25800793
  REMARK    GeneRIF: HPIP is upregulated in colorectal cancer and regulates
            colorectal cancer cell proliferation, apoptosis and invasion
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 656)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 656)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 656)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 656)
  AUTHORS   Mahajan,S.S., Little,M.M., Vazquez,R. and Wilson,A.C.
  TITLE     Interaction of HCF-1 with a cellular nuclear export factor
  JOURNAL   J Biol Chem 277 (46), 44292-44299 (2002)
   PUBMED   12235138
  REMARK    GeneRIF: HPIP regulates HCF-1 activity by modulating its
            subcellular localization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108134.3.
            
            On Aug 15, 2019 this sequence version replaced NM_017885.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3, and 4 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064026.1, AK000575.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248089.8/ ENSP00000248089.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC108134.3         35371-35466         c
            97-153              AC108134.3         34998-35054         c
            154-282             AC108134.3         34757-34885         c
            283-656             AC108134.3         34149-34522         c
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..656
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /note="host cell factor C1 regulator 1"
                     /db_xref="GeneID:54985"
                     /db_xref="HGNC:HGNC:21198"
                     /db_xref="MIM:618818"
     exon            1..96
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..418
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /note="isoform 1 is encoded by transcript variant 1; HCF-1
                     beta-propeller-interacting protein; host cell factor C1
                     regulator 1 (XPO1 dependent)"
                     /codon_start=1
                     /product="host cell factor C1 regulator 1 isoform 1"
                     /protein_id="NP_060355.1"
                     /db_xref="CCDS:CCDS10490.1"
                     /db_xref="GeneID:54985"
                     /db_xref="HGNC:HGNC:21198"
                     /db_xref="MIM:618818"
                     /translation="MILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTK
                     RRLEEEQEPLRKQFLSEENMATHFSQLSLHNDHPYCSPPMTFSPALPPLRSPCSELLL
                     WRYPGSLIPEALRLLRLGDTPSPPYPATPAGDIMEL"
     exon            97..153
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            154..282
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            283..656
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      633..638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /note="hexamer: AATAAA"
     polyA_site      656
                     /gene="HCFC1R1"
                     /gene_synonym="HPIP"
                     /note="major polyA site"
ORIGIN      
        1 aatgatcctg cagcagccct tgcagcgagg cccccaggga ggggcccagc gcctcccgcg
       61 ggccgccttg ggggtgactt ggggcctgga cgccagctcc cctctccgag gagctgtgcc
      121 catgagcacc aagcggcgcc tggaggagga gcaggagcct ctgcgcaagc agtttctgtc
      181 tgaggagaac atggccaccc acttctctca actcagcctg cacaatgacc acccctactg
      241 cagccccccc atgaccttct ccccagccct gcccccactc aggagccctt gctctgagct
      301 gcttctctgg cgctatcctg gcagcctcat ccctgaggcc ctccgtctgc tgaggctggg
      361 ggacaccccc agtcccccct accctgcaac cccagctggg gacataatgg agctctgagt
      421 gctggtggac agtgcccctc ccaccttcct tcttccccac aacagaagag accagcgact
      481 cccgcaaagg gacaaggttc ctccctctcc tgcagagtag gcatctgggc accaagacct
      541 tccctcaaca gaggacactg agcccaacgg agttctggga tgggaggggt gggagcatgg
      601 gaagggaggc atcccacccc caagaagaac tgaataaaga ttgctgagca aaggaa
//
