LOCUS       NM_005334               8876 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens host cell factor C1 (HCFC1), transcript variant 2,
            mRNA.
ACCESSION   NM_005334
VERSION     NM_005334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8876)
  AUTHORS   Hussain,S.I., Muhammad,N., Shah,S.A., Rehman,A.U., Khan,S.A.,
            Saleha,S., Khan,Y.M., Muhammad,N., Khan,S. and Wasif,N.
  TITLE     Variants in HCFC1 and MN1 genes causing intellectual disability in
            two Pakistani families
  JOURNAL   BMC Med Genomics 17 (1), 176 (2024)
   PUBMED   38956580
  REMARK    GeneRIF: Variants in HCFC1 and MN1 genes causing intellectual
            disability in two Pakistani families.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8876)
  AUTHORS   He,N., Guan,B.Z., Wang,J., Liu,H.K., Mao,Y., Liu,Z.G., Yin,F.,
            Peng,J., Xiao,B., Tang,B.S., Zhou,D., Huang,G., Dai,Q.L., Zeng,Y.,
            Han,H., Zhai,Q.X., Li,B., Tang,B., Li,W.B., Song,W., Liu,L.,
            Shi,Y.W., Li,B.M., Su,T., Zhou,P., Liu,X.R., Guo,L.W., Yi,Y.H. and
            Liao,W.P.
  TITLE     HCFC1 variants in the proteolysis domain are associated with
            X-linked idiopathic partial epilepsy: Exploring the underlying
            mechanism
  JOURNAL   Clin Transl Med 13 (6), e1289 (2023)
   PUBMED   37264743
  REMARK    GeneRIF: HCFC1 variants in the proteolysis domain are associated
            with X-linked idiopathic partial epilepsy: Exploring the underlying
            mechanism.
REFERENCE   3  (bases 1 to 8876)
  AUTHORS   Wongkittichote,P., Wegner,D.J. and Shinawi,M.S.
  TITLE     Novel exon-skipping variant disrupting the basic domain of HCFC1
            causes intellectual disability without metabolic abnormalities in
            both male and female patients
  JOURNAL   J Hum Genet 66 (7), 717-724 (2021)
   PUBMED   33517344
  REMARK    GeneRIF: Novel exon-skipping variant disrupting the basic domain of
            HCFC1 causes intellectual disability without metabolic
            abnormalities in both male and female patients.
REFERENCE   4  (bases 1 to 8876)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8876)
  AUTHORS   Xiang,P., Li,F., Ma,Z., Yue,J., Lu,C., You,Y., Hou,L., Yin,B.,
            Qiang,B., Shu,P. and Peng,X.
  TITLE     HCF-1 promotes cell cycle progression by regulating the expression
            of CDC42
  JOURNAL   Cell Death Dis 11 (10), 907 (2020)
   PUBMED   33097698
  REMARK    GeneRIF: HCF-1 promotes cell cycle progression by regulating the
            expression of CDC42.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8876)
  AUTHORS   Wilson,A.C., Peterson,M.G. and Herr,W.
  TITLE     The HCF repeat is an unusual proteolytic cleavage signal
  JOURNAL   Genes Dev 9 (20), 2445-2458 (1995)
   PUBMED   7590226
REFERENCE   7  (bases 1 to 8876)
  AUTHORS   Frattini,A., Faranda,S., Redolfi,E., Zucchi,I., Villa,A.,
            Patrosso,M.C., Strina,D., Susani,L. and Vezzoni,P.
  TITLE     Genomic organization of the human VP16 accessory protein, a
            housekeeping gene (HCFC1) mapping to Xq28
  JOURNAL   Genomics 23 (1), 30-35 (1994)
   PUBMED   7829097
REFERENCE   8  (bases 1 to 8876)
  AUTHORS   Sloan,J.L., Carrillo,N., Adams,D. and Venditti,C.P.
  TITLE     Disorders of Intracellular Cobalamin Metabolism
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301503
REFERENCE   9  (bases 1 to 8876)
  AUTHORS   Mulley,J.C., Kerr,B., Stevenson,R. and Lubs,H.
  TITLE     Nomenclature guidelines for X-linked mental retardation
  JOURNAL   Am J Med Genet 43 (1-2), 383-391 (1992)
   PUBMED   1605216
  REMARK    Review article
REFERENCE   10 (bases 1 to 8876)
  AUTHORS   Gedeon,A., Kerr,B., Mulley,J. and Turner,G.
  TITLE     Localisation of the MRX3 gene for non-specific X linked mental
            retardation
  JOURNAL   J Med Genet 28 (6), 372-377 (1991)
   PUBMED   1870093
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U52112.2, BC063435.1, L20010.1
            and BC010606.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005334.2.
            
            Summary: This gene is a member of the host cell factor family and
            encodes a protein with five Kelch repeats, a fibronectin-like
            motif, and six HCF repeats, each of which contains a highly
            specific cleavage signal. This nuclear coactivator is
            proteolytically cleaved at one of the six possible sites, resulting
            in the creation of an N-terminal chain and the corresponding
            C-terminal chain. The final form of this protein consists of
            noncovalently bound N- and C-terminal chains. The protein is
            involved in control of the cell cycle and transcriptional
            regulation during herpes simplex virus infection. Alternatively
            spliced variants which encode different protein isoforms have been
            described; however, not all variants have been fully characterized.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20010.1, SRR11853560.30529.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310441.12/ ENSP00000309555.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-450               U52112.2           124303-124752       c
            451-634             BC063435.1         12-195
            635-6836            L20010.1           1-6202
            6837-8876           BC010606.1         1111-3150
FEATURES             Location/Qualifiers
     source          1..8876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..8876
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /note="host cell factor C1"
                     /db_xref="GeneID:3054"
                     /db_xref="HGNC:HGNC:4839"
                     /db_xref="MIM:300019"
     exon            1..1171
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     CDS             979..7086
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /note="isoform 2 is encoded by transcript variant 2; host
                     cell factor 1; VP16-accessory protein; protein phosphatase
                     1, regulatory subunit 89"
                     /codon_start=1
                     /product="host cell factor 1 isoform 2"
                     /protein_id="NP_005325.2"
                     /db_xref="CCDS:CCDS44020.1"
                     /db_xref="GeneID:3054"
                     /db_xref="HGNC:HGNC:4839"
                     /db_xref="MIM:300019"
                     /translation="MASAVSPANLPAVLLQPRWKRVVGWSGPVPRPRHGHRAVAIKEL
                     IVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGCAAYGFVCDGTRLLVFGGMVE
                     YGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGNKCYLFGGLANDSE
                     DPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKL
                     VIYGGMSGCRLGDLWTLDIDTLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPL
                     VMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRL
                     YIWSGRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADS
                     YLLQLQKYDIPATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLLPQ
                     AAPAPPTTTTIQVLPTVPGSSISVPTAARTQGVPAVLKVTGPQATTGTPLVTMRPASQ
                     AGKAPVTVTSLPAGVRMVVPTQSAQGTVIGSSPQMSGMAALAAAAAATQKIPPSSAPT
                     VLSVPAGTTIVKTMAVTPGTTTLPATVKVASSPVMVSNPATRMLKTAAAQVGTSVSSA
                     TNTSTRPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPISVPGGSALISNLGK
                     VMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTTQ
                     ASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSSPGIKSPITI
                     ITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTVPMGGVRL
                     VTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGGHSTSASLATPITTLG
                     TIATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQ
                     PVHDLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTAT
                     TTVVANLGGHPQPTQVQFVCDRQEAAASLVTSTVGQQNGSVVRVCSNPPCETHETGTT
                     NTATTATSNMAGQHGCSNPPCETHETGTTNTATTAMSSVGANHQRDARRACAAGTPAV
                     IRISVATGALEAAQGSKSQCQTRQTSATSTTMTVMATGAPCSAGPLLGPSMAREPGGR
                     SPAFVQLAPLSSKVRLSSPSIKDLPAGRHSHAVSTAAMTRSSVGAGEPRMAPVCESLQ
                     GGSPSTTVTVTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQRVCSNP
                     PCETHETGTTHTATTATSNGGTGQPEGGQQPPAGRPCETHQTTSTGTTMSVSVGALLP
                     DATSSHRTVESGLEVAAAPSVTPQAGTALLAPFPTQRVCSNPPCETHETGTTHTATTV
                     TSNMSSNQDPPPAASDQGEVESTQGDSVNITSSSAITTTVSSTLTRAVTTVTQSTPVP
                     GPSVPPPEELQVSPGPRQQLPPRQLLQSASTALMGESAEVLSASQTPELPAAVDLSST
                     GEPSSGQESAGSAVVATVVVQPPPPTQSEVDQLSLPQELMAEAQAGTTTLMVTGLTPE
                     ELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMGTGEPMDTSEAAATVTQAELG
                     HLSAEGQEGQATTIPIVLTQQELAALVQQQQLQEAQAQQQHHHLPTEALAPADSLNDP
                     AIESNCLNELAGTVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKLQAAATLTEV
                     ANGIESLGVKPDLPPPPSKAPMKKENQWFDVGVIKGTNVMVTHYFLPPDDAVPSDDDL
                     GTVPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKIS
                     KSPDGAHLTWEPPSVTSGKIIEYSVYLAIQSSQAGGELKSSTPAQLAFMRVYCGPSPS
                     CLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPANKR
                     PMSSPEMKSAPKKSKADGQ"
     exon            1172..1320
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1481
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1690
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1775
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1882
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2062
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2422
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2583
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2781
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..3006
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..3111
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3331
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            3332..3474
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3613
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3834
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..5311
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            5312..5475
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            5476..5920
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            5921..6238
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            6239..6357
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            6358..6495
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            6496..6681
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            6682..6982
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            6983..7046
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     exon            7047..8876
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8853..8858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /note="hexamer: ATTAAA"
     polyA_site      8876
                     /gene="HCFC1"
                     /gene_synonym="CFF; HCF; HCF-1; HCF1; HFC1; MAHCX; MRX3;
                     PPP1R89; VCAF; XLID3"
                     /note="major polyA site"
ORIGIN      
        1 acacaagatg gcggctccca gggaggaggc atgagcgccc tgccgttacc gcttcttctg
       61 ccgtacagtt gccgcttcgg ggcctaactc tagctctttg aagcggctcc tgtgggaagg
      121 agtcataagg cgggaagtga ggatcggaca ccgccttgag tttggtgtgc agtggaagaa
      181 ctgacctagg aggaagagaa taggggggaa cggggagcta gtctcaagat ggcggctccc
      241 acggcggcag gcgcagcctg agcagcagag gcggactaag gggagaggcg cgagacttca
      301 caagccgtac ggcgcgagcc cccaaacggc cctcgagagc tcgagctggt tccaccggcc
      361 tccggcccgc ctccattcgt taggtgtgtc gaggctgttt cgggagcggc ggctgcacta
      421 aggcgctggg cggggaagcg ggacggtctc aagatggcgg ctcccacaat tgtggtctga
      481 gcgccggcgg ggctgcgacg accgcggcgc ttgtggctcc tttccacccg ccccggaagc
      541 cggccagtgc tggggacttg ggggtgtggg aaccgggccg gggctccgcc atttccggcg
      601 ggggagggct acgactgagg aagggaggag agagaggcgg ctcaagatgg cggctcccag
      661 ggcctcccgc ccgagcttgt aagcgggagc gcccggacaa gtagtcgggg cgacgggact
      721 cagcggcctc cagcttcttg agcctaggcg ctcgacagtt tcgggcggct cttgcggaga
      781 cggggtgagc gagaagaaag ggaagagcca aagggaagga gggcagttaa gatggcggcc
      841 tccatggagt cgtctaccgc tgtgtgagaa accgcttctc cgtgagagct gccttagacg
      901 aaagggggtg tgtgaaagga attgaggggc tcccttcccg cttgttgact tctccccacc
      961 gcaccctttc ccggaactat ggcttcggcc gtgtcgcccg ccaacttgcc agcggtgctt
     1021 ctgcagcccc gctggaagcg agtggtgggc tggtcgggtc cggtgccacg gccccgccac
     1081 ggccaccgcg ccgtggccat caaggagctc atcgtggtgt ttggcggcgg caacgaggga
     1141 atagtggacg aactgcacgt gtacaacacg gcaaccaacc agtggttcat cccagccgtg
     1201 aggggggaca ttccccctgg gtgtgcagcc tatggcttcg tgtgtgacgg gactcgcctc
     1261 ctggtgtttg gtgggatggt ggagtatggg aaatacagca atgacctcta cgaactccag
     1321 gcgagccggt gggagtggaa gagactcaaa gcaaagacgc ccaaaaacgg gccccctccg
     1381 tgtcctcgac tcgggcacag cttctccctt gtgggcaaca aatgctacct gtttgggggt
     1441 ctggccaatg atagcgagga cccaaagaac aacattccaa ggtacctgaa tgacttatat
     1501 atcctggaat tacggccagg ctctggagtg gtagcctggg acattcccat cacttacggg
     1561 gtcctaccac caccccggga gtcacatact gccgtggtct acaccgaaaa agacaataag
     1621 aagtccaagc tggtgatcta cggcgggatg agtggctgca ggctggggga cctgtggacc
     1681 ctagatattg acaccctgac gtggaataag cccagtctca gcggggtggc gcctcttcct
     1741 cgcagtctcc actcggcaac caccatcgga aataaaatgt acgtgtttgg tggctgggtg
     1801 cctctcgtca tggatgacgt caaagtggcc acacacgaga aggagtggaa gtgtaccaac
     1861 acgctggctt gtctcaacct ggataccatg gcctgggaga ccatcctgat ggatacactg
     1921 gaggacaaca tcccccgtgc tcgggctggc cactgcgcag tcgccatcaa cacccgcctg
     1981 tacatttgga gtgggcgtga cggctaccgc aaggcctgga acaaccaggt ctgctgcaag
     2041 gacctctggt acctagagac agaaaagcca ccacccccag cccgagtaca actggtacgc
     2101 gccaacacca actccctgga ggtgagctgg ggggcagtgg caacagccga cagctacctt
     2161 ctccagctcc agaaatatga cattcctgcc acggctgcta ctgccacctc ccctacaccc
     2221 aatccggtcc catctgtgcc tgccaaccct cccaagagcc ctgccccagc agcagccgca
     2281 cctgctgtgc agccgctgac ccaagtaggc atcacgctcc tgccccaggc tgcccccgca
     2341 cccccgacca ccaccaccat ccaggtcttg ccaacggtgc ctggcagctc catttctgtg
     2401 cccaccgcag ccaggactca aggtgtccct gctgttctca aagtgaccgg tcctcaggct
     2461 acaacaggaa ctccattggt caccatgcga cctgccagcc aggctgggaa agcccctgtc
     2521 accgtgacct cccttcccgc cggagtgcgg atggttgtgc caacacagag tgcccaggga
     2581 acggtgattg gcagtagccc acagatgagt gggatggccg cactggccgc tgcggccgct
     2641 gccacccaga agatcccccc ttcctcggca cccacggtgc tgagtgtccc agcgggtacc
     2701 accatcgtga agaccatggc tgtgacacct ggcactacca ccctcccagc cactgtgaag
     2761 gtggcctcct cgccagtcat ggtgagcaac cctgccactc gcatgctgaa gactgcagcc
     2821 gcccaggtgg ggacatcggt ttcctccgcc accaacacgt ctacccgccc tatcatcaca
     2881 gtgcacaagt caggcactgt gacagtggcc cagcaagccc aggtggtgac cacagttgtg
     2941 ggcggggtca ccaagaccat caccctggtg aagagcccca tctctgtccc aggaggcagt
     3001 gctctgattt ccaatctggg caaagtgatg tcggtggtcc agaccaaacc agttcagact
     3061 tcagcagtca caggccaggc gtccacgggt cctgtgactc agatcatcca gaccaaaggg
     3121 cccctgccag cgggaacaat cctgaagctg gtgacctcag cagatggcaa gcccaccacc
     3181 atcatcacta ccacgcaggc cagtggggcg gggaccaagc ccaccatcct gggcatcagc
     3241 agcgtctccc ccagtaccac caagcccggc acgaccacca tcatcaaaac catccccatg
     3301 tcggccatca tcacccaggc gggcgccacg ggtgtgacca gcagtcctgg catcaagtcc
     3361 cccatcacca tcatcaccac caaggtgatg acttcaggaa ctggagcacc tgcgaaaatc
     3421 atcactgctg tccccaaaat tgccactggc cacgggcagc agggagtgac ccaggtggtg
     3481 cttaaggggg ccccgggaca gccaggcacc atcctccgca ctgtgcccat ggggggtgtt
     3541 cgcctggtca cacccgtcac cgtctccgcc gtcaagccag ccgtcaccac gttggttgtg
     3601 aaaggcacca caggtgtcac gaccctaggc acagtgacag gcaccgtctc caccagcctt
     3661 gccggggcgg ggggccacag cactagtgct tccctggcca cgcccatcac caccttgggc
     3721 accattgcca ccctctcaag ccaggtgatc aaccccactg ccatcactgt gtcggccgca
     3781 cagaccacgc tgacagcggc aggcgggctc acaaccccaa ccatcaccat gcagcccgtg
     3841 tcccagccca cccaggtaac tctgatcacg gcacctagtg gggtggaggc ccagcctgtg
     3901 catgacctcc ctgtgtccat tctggcctcc ccgactacag aacagcccac cgccacagtt
     3961 accatcgccg actcaggcca gggtgatgtg cagcctggca ctgtcacctt ggtgtgctcc
     4021 aacccaccct gtgagaccca cgagactggc accaccaaca cggccaccac tactgttgtg
     4081 gctaaccttg ggggacaccc ccagcccacc caagtgcagt tcgtctgtga cagacaggag
     4141 gcagctgctt ctcttgtgac ctcgactgtg ggccagcaga atggtagcgt ggtccgagtc
     4201 tgttcgaacc cgccctgcga gacccacgag acgggcacca ccaacaccgc caccaccgcc
     4261 acctccaaca tggccgggca gcatggctgc tcaaacccac cctgcgagac ccacgagacg
     4321 ggcaccacca acactgccac tacagccatg tcgagcgtcg gcgccaacca ccagcgagat
     4381 gcccgtcggg cctgtgcagc tggcacccct gccgtgatcc ggatcagtgt ggccactggg
     4441 gcgctggagg cagcccaggg ctctaagtcc cagtgccaaa cccgccagac cagcgcgacc
     4501 agcaccacca tgactgtgat ggccaccggg gccccgtgct cggccggccc actccttggg
     4561 ccgagcatgg cacgggagcc cgggggccgc agccctgctt ttgtgcagtt ggcccctctg
     4621 agcagcaaag tcaggctgag cagcccaagc attaaggacc ttcctgcggg gcgccacagc
     4681 catgcggtca gcaccgctgc catgacccgt tccagcgtgg gtgctgggga gccccgcatg
     4741 gcacctgtgt gcgagagcct ccagggtggc tcgcccagca ccacagtgac tgtgacagcc
     4801 ctggaggcac tgctgtgccc ctcggccacc gtgacccaag tctgctccaa cccaccatgt
     4861 gagacccacg agacaggcac caccaacacc gccactacct cgaatgcagg cagcgcccag
     4921 agggtgtgct ccaacccgcc atgcgagacc cacgagacgg gcaccaccca cacggccacc
     4981 accgctactt caaacggggg cacgggccag cccgagggtg ggcagcagcc ccctgctggt
     5041 cgcccctgtg agacacacca gaccacttcc actggcacca ccatgtcggt cagcgtgggt
     5101 gccctgcttc ccgacgccac ttcttcccac aggaccgtgg agtctggcct agaggtggcg
     5161 gcggcaccca gcgtcacccc ccaggctggc accgcgctgc tggctccttt cccaacacag
     5221 agggtgtgct ccaacccccc ctgtgagacc cacgagacgg gcaccactca cacggccacc
     5281 actgtcactt ccaacatgag ttcaaaccaa gaccccccac ctgctgccag cgatcaggga
     5341 gaggtggaga gcacccaggg cgacagcgtg aacatcacca gctccagtgc catcacgaca
     5401 accgtgtcct ccacactgac gcgggctgtg accaccgtga cgcagtccac accggtcccg
     5461 ggcccctctg tgccgccccc agaggaactc caggtgtcgc caggtcctcg ccagcagctg
     5521 ccgccacggc agcttctgca gtcggcttcc acagccctga tgggggagtc cgccgaggtc
     5581 ctgtcagcct cccagacccc tgagctcccg gccgccgtgg atctgagcag cacaggggag
     5641 ccatcttcgg gccaggagtc tgccggctct gcggtggtgg ccactgtggt ggtccagcca
     5701 cccccaccca cacagtccga agtagaccag ttatcacttc cccaagagct aatggccgag
     5761 gcccaagctg gcaccaccac cctcatggta acggggctca cccccgagga gctggcagtg
     5821 acggctgctg cagaagcagc tgcccaggcc gcagccacgg aggaagccca ggccctggcc
     5881 atccaggcgg tgctccaggc cgcgcagcag gccgtcatgg gcaccggcga gcccatggac
     5941 acctccgagg cagcagcaac cgtgactcag gcggagctgg ggcacctgtc ggccgagggt
     6001 caggagggcc aggccaccac catacccatt gtgctgacac agcaggagct ggctgccctg
     6061 gtgcagcagc agcagctgca ggaggcccag gcccagcagc agcatcacca cctccccact
     6121 gaggccctgg cccctgccga cagtctcaac gacccagcca ttgagagcaa ttgcctcaat
     6181 gagctggccg gcacggtccc cagcactgtg gcgctgctgc cctcaacggc cactgagagc
     6241 ctggctccat ccaacacatt tgtggccccc cagccggttg tggtggccag cccagccaag
     6301 ctgcaggctg cagctaccct gaccgaagtg gccaatggca tcgagtccct gggtgtgaag
     6361 ccagacctgc cgcccccacc cagcaaagcc cccatgaaga aggaaaacca gtggtttgat
     6421 gtgggagtca ttaagggcac caatgtaatg gtgacacact atttcctgcc accagatgat
     6481 gctgtcccat cagacgatga tttgggcacc gtccctgact ataaccagct gaagaagcag
     6541 gagctgcagc caggcacagc ctataagttt cgtgttgccg gaatcaatgc ctgtggccgg
     6601 gggcccttca gcgaaatctc agcctttaag acgtgcctgc ctggtttccc aggggcccct
     6661 tgtgccatta aaatcagcaa aagtccggat ggtgctcacc tcacctggga gccaccctct
     6721 gtgacctccg gcaagattat cgagtactcc gtgtacctgg ccatccagag ctcacaggct
     6781 gggggcgagc tcaagagctc caccccggcc cagctggcct tcatgcgggt gtactgcggg
     6841 cccagcccct cctgcctggt gcagtcctcc agcctttcca acgcccacat cgactacacc
     6901 accaagcccg ccatcatctt ccgcatcgcc gcccgcaatg agaagggcta tggcccggcc
     6961 acacaagtga ggtggctgca ggaaaccagt aaagacagct ctggcaccaa gccagccaac
     7021 aagcggccca tgtcctctcc agaaatgaaa tctgctccaa agaaatctaa ggccgatggt
     7081 cagtgagagg aagctgacta gcccctggat tcttctccag acccccctgc ttcaggaaca
     7141 cccgccaggg cccacccctc ccaccccgtc ccagcattcg cacttcaccc tcgcgagccg
     7201 ctgttcactc ctctcccctt tctctttctc tctgttttta aaataatcta aagaaagcac
     7261 attttaccat tgctgttggg aggaagcaga ggcagatggg aaagcagaga gaggagcgcg
     7321 cttcctttcc tccccgctgc cgcccaccct ggggagagac ttttgcgggg agggaaggcg
     7381 gagctgagga cagccagctc cgccctccca aggctgtgcg ttcctgaggg ccaggtcggg
     7441 ggcaggcatg gaggggagga aaggcgtccc tcttggccct ccccagagtg gctttcctgg
     7501 caccctggcc tgggtgtctg gttctgtttt cttttcttcc ccttgtgttt ccagtcacct
     7561 aacttccctt cctcaggctc ccccggccca ccctgctcag tgaccccaca ggaagcttac
     7621 acattttctc agaggccttt gtgctcccac ctcttctacc ctccccctct tctttcccat
     7681 tttaaaaaag aaaagaagga aaaagaaaaa aggggcaagg agccccgcgg cggcctgggc
     7741 agcgcctgtg cagacctccc tgcaggccgc actgccaact gctgcatttg ttgtgttttt
     7801 taggttgcaa ttggtgaagt tcacactttc attgtaattt tagcgtgtgg ggttttgtcc
     7861 cttttttgtt gttgttagct gtgtacagaa tgtgtaatct tttttctttt ctcttttttt
     7921 tgttttgttt tgttttgttt ttgttttttt acttttttct tcttggctaa ttcttggcag
     7981 ggatctttct ggaggaaaag ctggggccag ccagggcagg agaggtgtga aatctgccac
     8041 gaggggcctg ctgtttgcca cccagcccaa cttcctgttg ctggcccctg ccctctgccc
     8101 ttttgcctgt cctcaggccg ctggaacaaa ggaaggacag ctcattcctc atgggcgatc
     8161 actccgcatc tatagggtcg agcctagggg agcttgaggg agggctgggg cctccttgtc
     8221 ctggatttcc agctctcccc atgccccctc cctgagcacc accggcaccg cctcccaaac
     8281 agggctgctg gtttccgcag ccactgctcc acctccccca aatcgtcatg gaaagggtgg
     8341 agaatggagg ggaaccaggc gtccttggag gcagcttggg agggtgactg tgtagtgtca
     8401 cccacaaggg aggctagggc aatggagcag gccaccagca gcagctgtgc agcatggaac
     8461 tcaggccagg ctccgaggct gggggatctg cttggagttt tctgcccccc accccaaact
     8521 tctgtcgagg agcaaggctt gccagcaagt cagaaggatt tgaaccgagc agccaatctt
     8581 tccagccctc ccctaccgac ctctgcctgg agacgcagca gcctgtgtcc tccagggcct
     8641 ctggtttgtt gtattatagt atatttcgct gtggaaaatg tcacgtttag tcaccttgga
     8701 gcccactcac ctggtcctgt tgttttaccc catcccttct ctcgcgcgcc tattgatttg
     8761 tttctgagga gagtacaccg ttcactattg tagagtaacc cctgtgactc aatattacca
     8821 tagtgcgatg tcgttttgtg ctattttgaa caattaaaag actttttttg aaataa
//
