LOCUS       NM_006018               2056 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens hydroxycarboxylic acid receptor 3 (HCAR3), mRNA.
ACCESSION   NM_006018 XM_942699 XM_946266
VERSION     NM_006018.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Pedro,M.P., Lund,K., Kang,S.W.S., Chen,T., Stuelten,C.H.,
            Porat-Shliom,N. and Iglesias-Bartolome,R.
  TITLE     GPCR Screening Reveals that the Metabolite Receptor HCAR3 Regulates
            Epithelial Proliferation, Migration, and Cellular Respiration
  JOURNAL   J Invest Dermatol 144 (6), 1311-1321 (2024)
   PUBMED   38103827
  REMARK    GeneRIF: GPCR Screening Reveals that the Metabolite Receptor HCAR3
            Regulates Epithelial Proliferation, Migration, and Cellular
            Respiration.
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Peters,A., Rabe,P., Liebing,A.D., Krumbholz,P., Nordstrom,A.,
            Jager,E., Kraft,R. and Staubert,C.
  TITLE     Hydroxycarboxylic acid receptor 3 and GPR84 - Two
            metabolite-sensing G protein-coupled receptors with opposing
            functions in innate immune cells
  JOURNAL   Pharmacol Res 176, 106047 (2022)
   PUBMED   34968686
  REMARK    GeneRIF: Hydroxycarboxylic acid receptor 3 and GPR84 - Two
            metabolite-sensing G protein-coupled receptors with opposing
            functions in innate immune cells.
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Wnorowski,A., Wnorowska,S., Kurzepa,J. and Parada-Turska,J.
  TITLE     Alterations in Kynurenine and NAD+ Salvage Pathways during the
            Successful Treatment of Inflammatory Bowel Disease Suggest HCAR3
            and NNMT as Potential Drug Targets
  JOURNAL   Int J Mol Sci 22 (24), 13497 (2021)
   PUBMED   34948292
  REMARK    GeneRIF: Alterations in Kynurenine and NAD(+) Salvage Pathways
            during the Successful Treatment of Inflammatory Bowel Disease
            Suggest HCAR3 and NNMT as Potential Drug Targets.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   McGuire Sams,C., Shepp,K., Pugh,J., Bishop,M.R. and Merner,N.D.
  TITLE     Rare and potentially pathogenic variants in hydroxycarboxylic acid
            receptor genes identified in breast cancer cases
  JOURNAL   BMC Med Genomics 14 (1), 284 (2021)
   PUBMED   34852802
  REMARK    GeneRIF: Rare and potentially pathogenic variants in
            hydroxycarboxylic acid receptor genes identified in breast cancer
            cases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Peters,A., Rabe,P., Krumbholz,P., Kalwa,H., Kraft,R., Schoneberg,T.
            and Staubert,C.
  TITLE     Natural biased signaling of hydroxycarboxylic acid receptor 3 and G
            protein-coupled receptor 84
  JOURNAL   Cell Commun Signal 18 (1), 31 (2020)
   PUBMED   32102673
  REMARK    GeneRIF: Natural biased signaling of hydroxycarboxylic acid
            receptor 3 and G protein-coupled receptor 84.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2056)
  AUTHORS   Wise,A., Foord,S.M., Fraser,N.J., Barnes,A.A., Elshourbagy,N.,
            Eilert,M., Ignar,D.M., Murdock,P.R., Steplewski,K., Green,A.,
            Brown,A.J., Dowell,S.J., Szekeres,P.G., Hassall,D.G.,
            Marshall,F.H., Wilson,S. and Pike,N.B.
  TITLE     Molecular identification of high and low affinity receptors for
            nicotinic acid
  JOURNAL   J Biol Chem 278 (11), 9869-9874 (2003)
   PUBMED   12522134
REFERENCE   7  (bases 1 to 2056)
  AUTHORS   Tunaru,S., Kero,J., Schaub,A., Wufka,C., Blaukat,A., Pfeffer,K. and
            Offermanns,S.
  TITLE     PUMA-G and HM74 are receptors for nicotinic acid and mediate its
            anti-lipolytic effect
  JOURNAL   Nat Med 9 (3), 352-355 (2003)
   PUBMED   12563315
  REMARK    GeneRIF: HM74 is highly expressed in adipose tissue and is a
            nicotinic acid receptor
REFERENCE   8  (bases 1 to 2056)
  AUTHORS   Irobi,J., Nelis,E., Verhoeven,K., De Vriendt,E., Dierick,I., De
            Jonghe,P., Van Broeckhoven,C. and Timmerman,V.
  TITLE     Mutation analysis of 12 candidate genes for distal hereditary motor
            neuropathy type II (distal HMN II) linked to 12q24.3
  JOURNAL   J Peripher Nerv Syst 7 (2), 87-95 (2002)
   PUBMED   12090300
REFERENCE   9  (bases 1 to 2056)
  AUTHORS   Zingoni,A., Rocchi,M., Storlazzi,C.T., Bernardini,G., Santoni,A.
            and Napolitano,M.
  TITLE     Isolation and chromosomal localization of GPR31, a human gene
            encoding a putative G protein-coupled receptor
  JOURNAL   Genomics 42 (3), 519-523 (1997)
   PUBMED   9205127
REFERENCE   10 (bases 1 to 2056)
  AUTHORS   Nomura,H., Nielsen,B.W. and Matsushima,K.
  TITLE     Molecular cloning of cDNAs encoding a LD78 receptor and putative
            leukocyte chemotactic peptide receptors
  JOURNAL   Int Immunol 5 (10), 1239-1249 (1993)
   PUBMED   7505609
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA953971.1, BI908162.1, CU451507.1, DA948030.1, BC047891.1,
            CB529340.1 and CD366840.1.
            
            On May 17, 2019 this sequence version replaced NM_006018.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC047891.1, D10923.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528880.3/ ENSP00000436714.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               DA953971.1         1-559
            560-761             BI908162.1         533-734
            762-849             CU451507.1         385-472
            850-1385            DA948030.1         1-536               c
            1386-1516           BC047891.1         1372-1502
            1517-1955           CB529340.1         117-555             c
            1956-2056           CD366840.1         16-116              c
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2056
                     /gene="HCAR3"
                     /gene_synonym="GPR109B; HCA3; HM74; Puma-g; PUMAG"
                     /note="hydroxycarboxylic acid receptor 3"
                     /db_xref="GeneID:8843"
                     /db_xref="HGNC:HGNC:16824"
                     /db_xref="MIM:606039"
     exon            1..2056
                     /gene="HCAR3"
                     /gene_synonym="GPR109B; HCA3; HM74; Puma-g; PUMAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1238
                     /gene="HCAR3"
                     /gene_synonym="GPR109B; HCA3; HM74; Puma-g; PUMAG"
                     /note="putative chemokine receptor; hydroxy-carboxylic
                     acid receptor 3; G-protein coupled receptor 109B;
                     GTP-binding protein; niacin receptor 2; nicotinic acid
                     receptor 2; G-protein coupled receptor HM74; G-protein
                     coupled receptor HM74B"
                     /codon_start=1
                     /product="hydroxycarboxylic acid receptor 3"
                     /protein_id="NP_006009.2"
                     /db_xref="CCDS:CCDS53842.1"
                     /db_xref="GeneID:8843"
                     /db_xref="HGNC:HGNC:16824"
                     /db_xref="MIM:606039"
                     /translation="MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLG
                     NGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRL
                     VLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTV
                     HLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQR
                     QMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAF
                     FITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGD
                     PNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE"
ORIGIN      
        1 accatacaga cacacgccac tttgctggag cattcactag gcgaggcgct ccatcggact
       61 cactagctgc actcatgaat cggcaccatc tgcaggatca ctttctggaa atagacaaga
      121 agaactgctg tgtgttccga gatgacttca ttgccaaggt gttgccgccg gtgttggggc
      181 tggagtttat ctttgggctt ctgggcaatg gccttgccct gtggattttc tgtttccacc
      241 tcaagtcctg gaaatccagc cggattttcc tgttcaacct ggcagtagct gactttctac
      301 tgatcatctg cctgccgttc gtgatggact actatgtgcg gcgttcagac tggaagtttg
      361 gggacatccc ttgccggctg gtgctcttca tgtttgccat gaaccgccag ggcagcatca
      421 tattcctcac ggtggtggcg gtagacaggt atttccgggt ggtccatccc caccacgccc
      481 tgaacaagat ctccaattgg acagcagcca tcatctcttg ccttctgtgg ggcatcactg
      541 ttggcctaac agtccacctc ctgaagaaga agttgctgat ccagaatggc actgcaaatg
      601 tgtgcatcag cttcagcatc tgccatacct tccggtggca cgaagctatg ttcctcctgg
      661 agttcttcct gcccctgggc atcatcctgt tctgctcagc cagaattatc tggagcctgc
      721 ggcagagaca aatggaccgg catgccaaga tcaagagagc catcaccttc atcatggtgg
      781 tggccatcgt ctttgtcatc tgcttccttc ccagcgtggt tgtgcggatc cacatcttct
      841 ggctcctgca cacttcgggc acgcagaatt gtgaagtgta ccgctcggtg gacctggcgt
      901 tctttatcac tctcagcttc acctacatga acagcatgct ggaccccgtg gtgtactact
      961 tctccagccc atcctttccc aacttcttct ccactttgat caaccgctgc ctccagagga
     1021 agataacagg tgagccagat aataaccgca gcacgagcgt cgagctcaca ggggacccca
     1081 acaaaaccag aggcgctcca gaggcgttaa tcgccaactc cggtgagcca tggagcccct
     1141 cttatctggg cccaacctca aataaccatt ccaagaaggg acattgtcac caagaaccag
     1201 catctctgga gaaacagttg ggctgttgca tcgagtaatg tcactggact cggcctaaga
     1261 tttcctggaa cttccagatt cagagaatct gatttaggga aactgtggca gatgagtggg
     1321 agactggttg caaggtgtga ccgcaggaat cctggaggaa cagagagtaa agcttctagg
     1381 catctgaaac ttgcttcatc tctgacgctc gcaggactga agatgggcaa attgtaggcg
     1441 tttctgctga gcagagttgg agccagagat ctacttgtga cttgttggcc ttcttcccac
     1501 atctgcctca gactggaggg ggctcagctc ctggggtgat atctagcctg cttgtgagct
     1561 ctagcaggga taaggagagc tgagattgga gggaattgtg ttgttcctgg aggaagccca
     1621 ggcatcatta aacaagccag taggtcacct ggcttccgtg gaccaattca tctttcagac
     1681 aatctttagc agaaatggac tcagggaaga gactcacatg ctttggttag tatctgtgtt
     1741 tccggtgggt gtaatagggg attagcccca gaagggactg agctaaacag tgttattatg
     1801 ggaaaggaaa tggcattgct gctttcaacc agcgactaat gcaatccatt cctctcttgt
     1861 ttatagtaat ctaagggttg aacagttaaa acggcttcag gatagaaagc tgtttcccac
     1921 ctgtttgctt ttaccattaa aagggaaacg tgcctctgcc ccacgggtag aggggtgcac
     1981 gttcctcctg gttccttcgc ttgtgtttct gtacttacca aaaatctacc atttcaataa
     2041 attttgatag gagaca
//
