LOCUS       NM_177551               2065 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens hydroxycarboxylic acid receptor 2 (HCAR2), mRNA.
ACCESSION   NM_177551 XM_290593
VERSION     NM_177551.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Sun,Y., Nie,Q., Zhang,S., He,H., Zuo,S., Chen,C., Yang,J., Chen,H.,
            Hu,J., Li,S., Cheng,J., Zhang,B., Zheng,Z., Pan,S., Huang,P.,
            Lian,L. and Nie,S.
  TITLE     Parabacteroides distasonis ameliorates insulin resistance via
            activation of intestinal GPR109a
  JOURNAL   Nat Commun 14 (1), 7740 (2023)
   PUBMED   38007572
  REMARK    GeneRIF: Parabacteroides distasonis ameliorates insulin resistance
            via activation of intestinal GPR109a.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Kuroda,M., Halfmann,P.J. and Kawaoka,Y.
  TITLE     Ebola Virus Infection Induces HCAR2 Expression Leading to Cell
            Death
  JOURNAL   J Infect Dis 228 (Suppl 7), S508-S513 (2023)
   PUBMED   37578011
  REMARK    GeneRIF: Ebola Virus Infection Induces HCAR2 Expression Leading to
            Cell Death.
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Park,J.H., Kawakami,K., Ishimoto,N., Ikuta,T., Ohki,M., Ekimoto,T.,
            Ikeguchi,M., Lee,D.S., Lee,Y.H., Tame,J.R.H., Inoue,A. and
            Park,S.Y.
  TITLE     Structural basis for ligand recognition and signaling of
            hydroxy-carboxylic acid receptor 2
  JOURNAL   Nat Commun 14 (1), 7150 (2023)
   PUBMED   37932263
  REMARK    GeneRIF: Structural basis for ligand recognition and signaling of
            hydroxy-carboxylic acid receptor 2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Huang,Y., Zhu,Y., Shi,J., Liu,R., Zeng,T. and Han,L.
  TITLE     [GPR109A partly mediates inhibitory effects of beta-hydroxybutyric
            acid on lung adenocarcinoma cell proliferation, migration and
            invasion]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (10), 1744-1751 (2023)
   PUBMED   37933650
  REMARK    GeneRIF: [GPR109A partly mediates inhibitory effects of
            beta-hydroxybutyric acid on lung adenocarcinoma cell proliferation,
            migration and invasion].
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   McGuire Sams,C., Shepp,K., Pugh,J., Bishop,M.R. and Merner,N.D.
  TITLE     Rare and potentially pathogenic variants in hydroxycarboxylic acid
            receptor genes identified in breast cancer cases
  JOURNAL   BMC Med Genomics 14 (1), 284 (2021)
   PUBMED   34852802
  REMARK    GeneRIF: Rare and potentially pathogenic variants in
            hydroxycarboxylic acid receptor genes identified in breast cancer
            cases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Zhang,Y., Schmidt,R.J., Foxworthy,P., Emkey,R., Oler,J.K.,
            Large,T.H., Wang,H., Su,E.W., Mosior,M.K., Eacho,P.I. and Cao,G.
  TITLE     Niacin mediates lipolysis in adipose tissue through its G-protein
            coupled receptor HM74A
  JOURNAL   Biochem Biophys Res Commun 334 (2), 729-732 (2005)
   PUBMED   16018973
  REMARK    GeneRIF: Our results provided direct evidence indicating that
            HM74A, but not HM74, was sufficient to mediate anti-lipolytic
            effect of niacin in adipose tissue.
REFERENCE   7  (bases 1 to 2065)
  AUTHORS   Soga,T., Kamohara,M., Takasaki,J., Matsumoto,S., Saito,T.,
            Ohishi,T., Hiyama,H., Matsuo,A., Matsushime,H. and Furuichi,K.
  TITLE     Molecular identification of nicotinic acid receptor
  JOURNAL   Biochem Biophys Res Commun 303 (1), 364-369 (2003)
   PUBMED   12646212
  REMARK    GeneRIF: HM74b has high similarity to HM74 is a receptor for
            nicotinic acid [HM74b]
REFERENCE   8  (bases 1 to 2065)
  AUTHORS   Wise,A., Foord,S.M., Fraser,N.J., Barnes,A.A., Elshourbagy,N.,
            Eilert,M., Ignar,D.M., Murdock,P.R., Steplewski,K., Green,A.,
            Brown,A.J., Dowell,S.J., Szekeres,P.G., Hassall,D.G.,
            Marshall,F.H., Wilson,S. and Pike,N.B.
  TITLE     Molecular identification of high and low affinity receptors for
            nicotinic acid
  JOURNAL   J Biol Chem 278 (11), 9869-9874 (2003)
   PUBMED   12522134
REFERENCE   9  (bases 1 to 2065)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 2065)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL698846.1, BC027965.1, BC056419.1, AL572062.2 and CD364466.1.
            
            On May 17, 2019 this sequence version replaced NM_177551.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC027965.1, DRR138517.935822.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328880.6/ ENSP00000375066.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL698846.1         1-14
            15-130              BC027965.1         1-116
            131-1247            BC056419.1         103-1219
            1248-1547           AL572062.2         502-801             c
            1548-2063           BC056419.1         1520-2035
            2064-2065           CD364466.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2065
                     /gene="HCAR2"
                     /gene_synonym="GPR109A; HCA2; HM74a; HM74b; NIACR1;
                     Puma-g; PUMAG"
                     /note="hydroxycarboxylic acid receptor 2"
                     /db_xref="GeneID:338442"
                     /db_xref="HGNC:HGNC:24827"
                     /db_xref="MIM:609163"
     exon            1..2065
                     /gene="HCAR2"
                     /gene_synonym="GPR109A; HCA2; HM74a; HM74b; NIACR1;
                     Puma-g; PUMAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1166
                     /gene="HCAR2"
                     /gene_synonym="GPR109A; HCA2; HM74a; HM74b; NIACR1;
                     Puma-g; PUMAG"
                     /note="G protein-coupled receptor HM74a;
                     hydroxy-carboxylic acid receptor 2; niacin receptor 1;
                     G-protein coupled receptor 109A; nicotinic acid receptor;
                     G-protein coupled receptor HM74A"
                     /codon_start=1
                     /product="hydroxycarboxylic acid receptor 2"
                     /protein_id="NP_808219.1"
                     /db_xref="CCDS:CCDS9235.1"
                     /db_xref="GeneID:338442"
                     /db_xref="HGNC:HGNC:24827"
                     /db_xref="MIM:609163"
                     /translation="MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLG
                     NGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRL
                     MLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTV
                     HLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQR
                     QMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAF
                     FITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGD
                     PNKTRGAPEALMANSGEPWSPSYLGPTSP"
ORIGIN      
        1 accacacaga cacacacctc cttgctggag cattcactag gcgaggcgct ccatcggact
       61 cactagccgc actcatgaat cggcaccatc tgcaggatca ctttctggaa atagacaaga
      121 agaactgctg tgtgttccga gatgacttca ttgtcaaggt gttgccgccg gtgttggggc
      181 tggagtttat cttcgggctt ctgggcaatg gccttgccct gtggattttc tgtttccacc
      241 tcaagtcctg gaaatccagc cggattttcc tgttcaacct ggcagtggct gactttctac
      301 tgatcatctg cctgcccttc ctgatggaca actatgtgag gcgttgggac tggaagtttg
      361 gggacatccc ttgccggctg atgctcttca tgttggctat gaaccgccag ggcagcatca
      421 tcttcctcac ggtggtggcg gtagacaggt atttccgggt ggtccatccc caccacgccc
      481 tgaacaagat ctccaatcgg acagcagcca tcatctcttg ccttctgtgg ggcatcacta
      541 ttggcctgac agtccacctc ctgaagaaga agatgccgat ccagaatggc ggtgcaaatt
      601 tgtgcagcag cttcagcatc tgccatacct tccagtggca cgaagccatg ttcctcctgg
      661 agttcttcct gcccctgggc atcatcctgt tctgctcagc cagaattatc tggagcctgc
      721 ggcagagaca aatggaccgg catgccaaga tcaagagagc catcaccttc atcatggtgg
      781 tggccatcgt ctttgtcatc tgcttccttc ccagcgtggt tgtgcggatc cgcatcttct
      841 ggctcctgca cacttcgggc acgcagaatt gtgaagtgta ccgctcggtg gacctggcgt
      901 tctttatcac tctcagcttc acctacatga acagcatgct ggaccccgtg gtgtactact
      961 tctccagccc atcctttccc aacttcttct ccactttgat caaccgctgc ctccagagga
     1021 agatgacagg tgagccagat aataaccgca gcacgagcgt cgagctcaca ggggacccca
     1081 acaaaaccag aggcgctcca gaggcgttaa tggccaactc cggtgagcca tggagcccct
     1141 cttatctggg cccaacctct ccttaaataa ccatgccaag aagggacatt gtcaccaaga
     1201 accaggatct ctggagaaac agttgggctg ttgcatcgag taatgtcact ggactcggcc
     1261 taaggtttcc tggaacttcc agattcagag aatgcgattt agggaaacgg tggcagatga
     1321 gtgggagact ggttgcaagg tgtgaccgca ggaatcctgg aggaatagag agtaaagctt
     1381 ctaggcatct gaaacttttg cttcatctct gacgctcgca ggactgaaga tgggcaaatt
     1441 gtaggcattt ctgctgagca gagttggagc cagagatcta cttgtgactt gttggccttc
     1501 ttcccacatc tgcctcagac tggagggggc tcagctcctg gggtgatatc tagcctgctt
     1561 gtgagctcta gcagggataa ggagagctga gattggaggg aattgtgttg ctcctggagg
     1621 gagcccaggc atcattaaac aagccagtag gtcacctggc ttccgtggac caattcatct
     1681 ttcagacaag ctttagcaga aatggactca gggaagagac tcacacgctt tggttaatat
     1741 ctgtgtttcc ggtgggtgta ataggggatt agccccagaa gggactgagc taaacagtgt
     1801 tattatggga aaggaaatgg cattgctgct ttcaaccagc gactaatgca atccattcct
     1861 ctcttgttta tagtaatcta agggttgggc agttaaaacg gcttcaggat agaaagctgt
     1921 ttcccacctc tgtttgcttt taacattaaa agggaaatgt gcctctgccc cacagttaga
     1981 ggggtgcacg ttcctcctgg ttccttcgct tgtgtttctg tacttaccaa aaatctacca
     2041 tttcaataaa ttttgatagg agaca
//
