LOCUS       NM_012257               2834 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens HMG-box transcription factor 1 (HBP1), transcript
            variant 2, mRNA.
ACCESSION   NM_012257
VERSION     NM_012257.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2834)
  AUTHORS   Zhou,Y., Zhang,T., Wang,S., Yang,R., Jiao,Z., Lu,K., Li,H.,
            Jiang,W. and Zhang,X.
  TITLE     Targeting of HBP1/TIMP3 axis as a novel strategy against breast
            cancer
  JOURNAL   Pharmacol Res 194, 106846 (2023)
   PUBMED   37414199
  REMARK    GeneRIF: Targeting of HBP1/TIMP3 axis as a novel strategy against
            breast cancer.
REFERENCE   2  (bases 1 to 2834)
  AUTHORS   Yao,J., Luo,Y., Zeng,C., He,H. and Zhang,X.
  TITLE     UHRF1 regulates the transcriptional repressor HBP1 through MIF in T
            acute lymphoblastic leukemia
  JOURNAL   Oncol Rep 46 (1) (2021)
   PUBMED   34013373
  REMARK    GeneRIF: UHRF1 regulates the transcriptional repressor HBP1 through
            MIF in T acute lymphoblastic leukemia.
REFERENCE   3  (bases 1 to 2834)
  AUTHORS   Chan,C.Y., Chang,C.M., Chen,Y.H., Sheu,J.J., Lin,T.Y. and
            Huang,C.Y.
  TITLE     Regulatory role of transcription factor HBP1 in anticancer efficacy
            of EGFR inhibitor erlotinib in HNSCC
  JOURNAL   Head Neck 42 (10), 2958-2967 (2020)
   PUBMED   32677158
  REMARK    GeneRIF: Regulatory role of transcription factor HBP1 in anticancer
            efficacy of EGFR inhibitor erlotinib in HNSCC.
REFERENCE   4  (bases 1 to 2834)
  AUTHORS   Liu,W., Li,W.C., Pan,X.F., Sha,H., Gong,W.Q. and Yan,M.
  TITLE     HBP1 deficiency protects against stress-induced premature
            senescence of nucleus pulposus
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (17), 8685-8693 (2020)
   PUBMED   32964956
  REMARK    GeneRIF: HBP1 deficiency protects against stress-induced premature
            senescence of nucleus pulposus.
REFERENCE   5  (bases 1 to 2834)
  AUTHORS   Li,K., Zhou,Z., Li,J. and Xiang,R.
  TITLE     miR-146b Functions as an Oncogene in Oral Squamous Cell Carcinoma
            by Targeting HBP1
  JOURNAL   Technol Cancer Res Treat 19, 1533033820959404 (2020)
   PUBMED   33327874
  REMARK    GeneRIF: miR-146b Functions as an Oncogene in Oral Squamous Cell
            Carcinoma by Targeting HBP1.
REFERENCE   6  (bases 1 to 2834)
  AUTHORS   Shih,H.H., Xiu,M., Berasi,S.P., Sampson,E.M., Leiter,A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HMG box transcriptional repressor HBP1 maintains a proliferation
            barrier in differentiated liver tissue
  JOURNAL   Mol Cell Biol 21 (17), 5723-5732 (2001)
   PUBMED   11486012
  REMARK    GeneRIF: HBP1 regulates the cell cycle in liver regeneration and
            provides evidence for a role in tissue maintenance.
            Erratum:[Mol Cell Biol 2001 Nov;21(21):7535]
REFERENCE   7  (bases 1 to 2834)
  AUTHORS   Lemercier,C., Duncliffe,K., Boibessot,I., Zhang,H., Verdel,A.,
            Angelov,D. and Khochbin,S.
  TITLE     Involvement of retinoblastoma protein and HBP1 in histone H1(0)
            gene expression
  JOURNAL   Mol Cell Biol 20 (18), 6627-6637 (2000)
   PUBMED   10958660
REFERENCE   8  (bases 1 to 2834)
  AUTHORS   Zhuma,T., Tyrrell,R., Sekkali,B., Skavdis,G., Saveliev,A.,
            Tolaini,M., Roderick,K., Norton,T., Smerdon,S., Sedgwick,S.,
            Festenstein,R. and Kioussis,D.
  TITLE     Human HMG box transcription factor HBP1: a role in hCD2 LCR
            function
  JOURNAL   EMBO J 18 (22), 6396-6406 (1999)
   PUBMED   10562551
REFERENCE   9  (bases 1 to 2834)
  AUTHORS   Lavender,P., Vandel,L., Bannister,A.J. and Kouzarides,T.
  TITLE     The HMG-box transcription factor HBP1 is targeted by the pocket
            proteins and E1A
  JOURNAL   Oncogene 14 (22), 2721-2728 (1997)
   PUBMED   9178770
REFERENCE   10 (bases 1 to 2834)
  AUTHORS   Tevosian,S.G., Shih,H.H., Mendelson,K.G., Sheppard,K.A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HBP1: a HMG box transcriptional repressor that is targeted by the
            retinoblastoma family
  JOURNAL   Genes Dev 11 (3), 383-396 (1997)
   PUBMED   9030690
  REMARK    GeneRIF: HBP1 was isolated as a cell cycle inhibitor and HMG-box
            transcriptional repressor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004492.1, BC017069.1 and AF182038.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012257.3.
            
            Transcript Variant: This variant (2) contains an alternate 5' exon
            and uses a downstream start codon, compared to variant 1. Isoform 2
            has a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.145089.1,
                                           SRR1803613.189398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222574.9/ ENSP00000222574.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC004492.1         14525-14536
            13-731              BC017069.1         1-719
            732-1583            AF182038.1         557-1408
            1584-2550           BC017069.1         1572-2538
            2551-2834           BC017069.1         2543-2826
FEATURES             Location/Qualifiers
     source          1..2834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2834
                     /gene="HBP1"
                     /note="HMG-box transcription factor 1"
                     /db_xref="GeneID:26959"
                     /db_xref="HGNC:HGNC:23200"
                     /db_xref="MIM:616714"
     exon            1..183
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..367
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1743
                     /gene="HBP1"
                     /note="isoform 2 is encoded by transcript variant 2; HMG
                     box-containing protein 1; high mobility group box
                     transcription factor 1"
                     /codon_start=1
                     /product="HMG box-containing protein 1 isoform 2"
                     /protein_id="NP_036389.2"
                     /db_xref="CCDS:CCDS5741.1"
                     /db_xref="GeneID:26959"
                     /db_xref="HGNC:HGNC:23200"
                     /db_xref="MIM:616714"
                     /translation="MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSS
                     PGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETT
                     YRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSK
                     SEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKG
                     TRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGES
                     VLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEVHIGDVC
                     LPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGGQDFA
                     RSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNAFMLFAKKYRV
                     EYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTN
                     SGSQQH"
     exon            368..596
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..738
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..850
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..963
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1120
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1265
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1583
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1725
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..2834
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2810..2815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HBP1"
                     /note="hexamer: AATAAA"
     polyA_site      2811
                     /gene="HBP1"
                     /note="major polyA site"
     polyA_site      2834
                     /gene="HBP1"
                     /note="major polyA site"
ORIGIN      
        1 agacttggta atggcgacgg gtttggtaag taggaaagtt tcggttgagg agtaagagct
       61 gccgcgggag cagtaacccg cgcgggggag gccgacgtcg gtcggagagg gggtacgaga
      121 gctgctggtg gtgttgtcgt ggccggagcg gcccgcgcct gggctgccgg cacttcgcgg
      181 cagtcagagc accataacat ggtgtgggaa gtgaagacaa atcagatgcc taatgcagta
      241 cagaaactcc tgttggtgat ggacaagaga gcctcaggaa tgaatgactc attggagttg
      301 ctgcagtgta atgagaattt gccatcttca cctggatata actcctgtga tgaacacatg
      361 gagcttgatg accttcctga acttcaggca gttcaaagtg atcctaccca atctggcatg
      421 taccagctga gttcagatgt ttcacatcaa gaatacccaa gatcatcttg gaaccaaaat
      481 acctcagaca taccagaaac tacttaccgt gaaaatgagg tggactggct aacagaattg
      541 gcaaatatcg cgaccagtcc acaaagtcca ctgatgcagt gctcatttta caatagatca
      601 tctcctgtac acatcatagc cactagcaaa agtttacatt cctatgcacg ccctccacca
      661 gtgtcctctt cttcgaagag tgaaccagcc ttccctcatc accattggaa ggaggaaaca
      721 ccagtaagac acgaaagggc aaatagtgag tcagaatctg gcattttctg catgtcctcc
      781 ctgtcagatg atgatgattt gggatggtgc aattcctggc cttcaactgt ctggcactgt
      841 tttttgaaag gcacacgact gtgctttcat aagggaagca ataaggaatg gcaagatgtt
      901 gaagattttg ctagagctga aggctgtgat aatgaggaag atcttcaaat gggcattcac
      961 aagggctatg gttctgatgg tctaaagttg ttatcacatg aagaaagtgt atcatttggc
     1021 gagtctgtac tgaagttgac ttttgatcct ggtacagtag aagatggttt acttaccgta
     1081 gagtgtaagc tggaccaccc tttctatgtt aaaaataaag gttggtcatc attttatcca
     1141 agcttgactg tggtacagca tggcattcca tgttgtgaag ttcatattgg cgatgtatgt
     1201 ctacctcctg gacaccccga tgccattaat tttgatgatt caggtgtttt tgatacattt
     1261 aaaagctatg acttcacacc tatggattct tctgcagttt atgtgttaag tagtatggct
     1321 cgccagcgtc gtgcatcttt gtcttgtgga ggacctggtg gtcaagactt tgcaagatct
     1381 ggattcagta aaaactgtgg ctcacctgga tcatcacagc tctcttccaa ttctttgtat
     1441 gctaaagctg tcaaaaacca cagctcaggg actgtgagtg ccacttctcc taataagtgc
     1501 aaaagaccaa tgaatgcctt catgcttttt gccaaaaaat acagagttga atatactcag
     1561 atgtatccag ggaaagataa cagagccata agtgtgatcc ttggtgacag gtggaagaaa
     1621 atgaagaatg aagagagaag aatgtacaca ttagaagcaa aggctttggc tgaagaacag
     1681 aaacgtttaa atcctgactg ttggaagagg aaaagaacca attcaggctc acaacaacat
     1741 taaaccagga tgcttatgtt cttaagtcta tatttgcata tacattgact cttgatggaa
     1801 agacttaaga agatcaaggt ctcaccattt gtcctcaatt cgtgtgacca taagatactg
     1861 atagcattga gtcttgaaat gatttaataa tatgagtgag gatttgcttt ctccattaga
     1921 gcattaagct aaaactatca acattttaaa ccaaattgcc ttatttttct tccaaacttc
     1981 atatatgtct atcaggtaat aataggcttg aaaattgata tcctgtggtg ctaaagtaca
     2041 gtagaaagag aggagaagtg tatacatgtt ttattttaaa ttgtacgaaa ggggaattta
     2101 aaaaatatgt aactgctgtt tatacattgg ctccttactg cttattaatc tgtattgtac
     2161 acatgatgaa atgaagcaga agctgggagt cggcctttcc tctagtaacc accacatggc
     2221 tcagcatctg tgccaaacat aggcgctcct agtctggtca gtgccaagag gctaccagaa
     2281 catggggcag gtggctggtg ttggtgtccc agcctaagag ccacctgctg cagttaccat
     2341 ggcatgctga gttgatgcac caggtggcag cagccatccg ttattatttc caatggagac
     2401 ctagcccagg ccaaggtaaa gttagttaat agcattggga tatagtcact gtaatggtgc
     2461 tattaacaaa cagtcaacac cattgtattt tttaacttcg tgttctgtat ctcctcagcc
     2521 atgtatctta aatatatttt gtcatcataa tctttatggt gggggcagac tttgcactta
     2581 ctgcagtgca acacttgcac tttaattttc ctccaactgt ctaaaattag agcaaataca
     2641 ttggcaatac agctgctttt gctctgagct acaatcatgg cttttcatgt tacttaccaa
     2701 gtggtgtttc tggttaggaa tcacagctgt aaaattgatt tcagttcatc acacttcttc
     2761 atgatgttgc ccctaaattt tgcacactat attcttgtat attatttcaa ataaatggaa
     2821 aaaaaagttg ctta
//
