LOCUS       NM_001244262            2676 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens HMG-box transcription factor 1 (HBP1), transcript
            variant 1, mRNA.
ACCESSION   NM_001244262
VERSION     NM_001244262.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2676)
  AUTHORS   Zhou,Y., Zhang,T., Wang,S., Yang,R., Jiao,Z., Lu,K., Li,H.,
            Jiang,W. and Zhang,X.
  TITLE     Targeting of HBP1/TIMP3 axis as a novel strategy against breast
            cancer
  JOURNAL   Pharmacol Res 194, 106846 (2023)
   PUBMED   37414199
  REMARK    GeneRIF: Targeting of HBP1/TIMP3 axis as a novel strategy against
            breast cancer.
REFERENCE   2  (bases 1 to 2676)
  AUTHORS   Yao,J., Luo,Y., Zeng,C., He,H. and Zhang,X.
  TITLE     UHRF1 regulates the transcriptional repressor HBP1 through MIF in T
            acute lymphoblastic leukemia
  JOURNAL   Oncol Rep 46 (1) (2021)
   PUBMED   34013373
  REMARK    GeneRIF: UHRF1 regulates the transcriptional repressor HBP1 through
            MIF in T acute lymphoblastic leukemia.
REFERENCE   3  (bases 1 to 2676)
  AUTHORS   Chan,C.Y., Chang,C.M., Chen,Y.H., Sheu,J.J., Lin,T.Y. and
            Huang,C.Y.
  TITLE     Regulatory role of transcription factor HBP1 in anticancer efficacy
            of EGFR inhibitor erlotinib in HNSCC
  JOURNAL   Head Neck 42 (10), 2958-2967 (2020)
   PUBMED   32677158
  REMARK    GeneRIF: Regulatory role of transcription factor HBP1 in anticancer
            efficacy of EGFR inhibitor erlotinib in HNSCC.
REFERENCE   4  (bases 1 to 2676)
  AUTHORS   Liu,W., Li,W.C., Pan,X.F., Sha,H., Gong,W.Q. and Yan,M.
  TITLE     HBP1 deficiency protects against stress-induced premature
            senescence of nucleus pulposus
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (17), 8685-8693 (2020)
   PUBMED   32964956
  REMARK    GeneRIF: HBP1 deficiency protects against stress-induced premature
            senescence of nucleus pulposus.
REFERENCE   5  (bases 1 to 2676)
  AUTHORS   Li,K., Zhou,Z., Li,J. and Xiang,R.
  TITLE     miR-146b Functions as an Oncogene in Oral Squamous Cell Carcinoma
            by Targeting HBP1
  JOURNAL   Technol Cancer Res Treat 19, 1533033820959404 (2020)
   PUBMED   33327874
  REMARK    GeneRIF: miR-146b Functions as an Oncogene in Oral Squamous Cell
            Carcinoma by Targeting HBP1.
REFERENCE   6  (bases 1 to 2676)
  AUTHORS   Shih,H.H., Xiu,M., Berasi,S.P., Sampson,E.M., Leiter,A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HMG box transcriptional repressor HBP1 maintains a proliferation
            barrier in differentiated liver tissue
  JOURNAL   Mol Cell Biol 21 (17), 5723-5732 (2001)
   PUBMED   11486012
  REMARK    GeneRIF: HBP1 regulates the cell cycle in liver regeneration and
            provides evidence for a role in tissue maintenance.
            Erratum:[Mol Cell Biol 2001 Nov;21(21):7535]
REFERENCE   7  (bases 1 to 2676)
  AUTHORS   Lemercier,C., Duncliffe,K., Boibessot,I., Zhang,H., Verdel,A.,
            Angelov,D. and Khochbin,S.
  TITLE     Involvement of retinoblastoma protein and HBP1 in histone H1(0)
            gene expression
  JOURNAL   Mol Cell Biol 20 (18), 6627-6637 (2000)
   PUBMED   10958660
REFERENCE   8  (bases 1 to 2676)
  AUTHORS   Zhuma,T., Tyrrell,R., Sekkali,B., Skavdis,G., Saveliev,A.,
            Tolaini,M., Roderick,K., Norton,T., Smerdon,S., Sedgwick,S.,
            Festenstein,R. and Kioussis,D.
  TITLE     Human HMG box transcription factor HBP1: a role in hCD2 LCR
            function
  JOURNAL   EMBO J 18 (22), 6396-6406 (1999)
   PUBMED   10562551
REFERENCE   9  (bases 1 to 2676)
  AUTHORS   Lavender,P., Vandel,L., Bannister,A.J. and Kouzarides,T.
  TITLE     The HMG-box transcription factor HBP1 is targeted by the pocket
            proteins and E1A
  JOURNAL   Oncogene 14 (22), 2721-2728 (1997)
   PUBMED   9178770
REFERENCE   10 (bases 1 to 2676)
  AUTHORS   Tevosian,S.G., Shih,H.H., Mendelson,K.G., Sheppard,K.A.,
            Paulson,K.E. and Yee,A.S.
  TITLE     HBP1: a HMG box transcriptional repressor that is targeted by the
            retinoblastoma family
  JOURNAL   Genes Dev 11 (3), 383-396 (1997)
   PUBMED   9030690
  REMARK    GeneRIF: HBP1 was isolated as a cell cycle inhibitor and HMG-box
            transcriptional repressor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295910.1 and BC017069.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001244262.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.25733.1,
                                           SRR11853558.22388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1634              AK295910.1         43-1676
            1635-2397           BC017069.1         1781-2543
            2398-2676           BC017069.1         2548-2826
FEATURES             Location/Qualifiers
     source          1..2676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.3"
     gene            1..2676
                     /gene="HBP1"
                     /note="HMG-box transcription factor 1"
                     /db_xref="GeneID:26959"
                     /db_xref="HGNC:HGNC:23200"
                     /db_xref="MIM:616714"
     exon            1..25
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1585
                     /gene="HBP1"
                     /note="isoform 1 is encoded by transcript variant 1; HMG
                     box-containing protein 1; high mobility group box
                     transcription factor 1"
                     /codon_start=1
                     /product="HMG box-containing protein 1 isoform 1"
                     /protein_id="NP_001231191.1"
                     /db_xref="GeneID:26959"
                     /db_xref="HGNC:HGNC:23200"
                     /db_xref="MIM:616714"
                     /translation="MATGLSEHHNMVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLEL
                     LQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWN
                     QNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYA
                     RPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWP
                     STVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLS
                     HEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIP
                     CCEVHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLS
                     CGGPGGQDFARSGFSKNCGSPGSSQLSSNSLYAKAVKNHSSGTVSATSPNKCKRPMNA
                     FMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLN
                     PDCWKRKRTNSGSQQH"
     exon            26..209
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..438
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..580
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..692
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..805
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..962
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1107
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1425
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1567
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..2676
                     /gene="HBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2652..2657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HBP1"
                     /note="hexamer: AATAAA"
     polyA_site      2653
                     /gene="HBP1"
                     /note="major polyA site"
     polyA_site      2676
                     /gene="HBP1"
                     /note="major polyA site"
ORIGIN      
        1 agacttggta atggcgacgg gtttgtcaga gcaccataac atggtgtggg aagtgaagac
       61 aaatcagatg cctaatgcag tacagaaact cctgttggtg atggacaaga gagcctcagg
      121 aatgaatgac tcattggagt tgctgcagtg taatgagaat ttgccatctt cacctggata
      181 taactcctgt gatgaacaca tggagcttga tgaccttcct gaacttcagg cagttcaaag
      241 tgatcctacc caatctggca tgtaccagct gagttcagat gtttcacatc aagaataccc
      301 aagatcatct tggaaccaaa atacctcaga cataccagaa actacttacc gtgaaaatga
      361 ggtggactgg ctaacagaat tggcaaatat cgcgaccagt ccacaaagtc cactgatgca
      421 gtgctcattt tacaatagat catctcctgt acacatcata gccactagca aaagtttaca
      481 ttcctatgca cgccctccac cagtgtcctc ttcttcgaag agtgaaccag ccttccctca
      541 tcaccattgg aaggaggaaa caccagtaag acacgaaagg gcaaatagtg agtcagaatc
      601 tggcattttc tgcatgtcct ccctgtcaga tgatgatgat ttgggatggt gcaattcctg
      661 gccttcaact gtctggcact gttttttgaa aggcacacga ctgtgctttc ataagggaag
      721 caataaggaa tggcaagatg ttgaagattt tgctagagct gaaggctgtg ataatgagga
      781 agatcttcaa atgggcattc acaagggcta tggttctgat ggtctaaagt tgttatcaca
      841 tgaagaaagt gtatcatttg gcgagtctgt actgaagttg acttttgatc ctggtacagt
      901 agaagatggt ttacttaccg tagagtgtaa gctggaccac cctttctatg ttaaaaataa
      961 aggttggtca tcattttatc caagcttgac tgtggtacag catggcattc catgttgtga
     1021 agttcatatt ggcgatgtat gtctacctcc tggacacccc gatgccatta attttgatga
     1081 ttcaggtgtt tttgatacat ttaaaagcta tgacttcaca cctatggatt cttctgcagt
     1141 ttatgtgtta agtagtatgg ctcgccagcg tcgtgcatct ttgtcttgtg gaggacctgg
     1201 tggtcaagac tttgcaagat ctggattcag taaaaactgt ggctcacctg gatcatcaca
     1261 gctctcttcc aattctttgt atgctaaagc tgtcaaaaac cacagctcag ggactgtgag
     1321 tgccacttct cctaataagt gcaaaagacc aatgaatgcc ttcatgcttt ttgccaaaaa
     1381 atacagagtt gaatatactc agatgtatcc agggaaagat aacagagcca taagtgtgat
     1441 ccttggtgac aggtggaaga aaatgaagaa tgaagagaga agaatgtaca cattagaagc
     1501 aaaggctttg gctgaagaac agaaacgttt aaatcctgac tgttggaaga ggaaaagaac
     1561 caattcaggc tcacaacaac attaaaccag gatgcttatg ttcttaagtc tatatttgca
     1621 tatacattga ctcttgatgg aaagacttaa gaagatcaag gtctcaccat ttgtcctcaa
     1681 ttcgtgtgac cataagatac tgatagcatt gagtcttgaa atgatttaat aatatgagtg
     1741 aggatttgct ttctccatta gagcattaag ctaaaactat caacatttta aaccaaattg
     1801 ccttattttt cttccaaact tcatatatgt ctatcaggta ataataggct tgaaaattga
     1861 tatcctgtgg tgctaaagta cagtagaaag agaggagaag tgtatacatg ttttatttta
     1921 aattgtacga aaggggaatt taaaaaatat gtaactgctg tttatacatt ggctccttac
     1981 tgcttattaa tctgtattgt acacatgatg aaatgaagca gaagctggga gtcggccttt
     2041 cctctagtaa ccaccacatg gctcagcatc tgtgccaaac ataggcgctc ctagtctggt
     2101 cagtgccaag aggctaccag aacatggggc aggtggctgg tgttggtgtc ccagcctaag
     2161 agccacctgc tgcagttacc atggcatgct gagttgatgc accaggtggc agcagccatc
     2221 cgttattatt tccaatggag acctagccca ggccaaggta aagttagtta atagcattgg
     2281 gatatagtca ctgtaatggt gctattaaca aacagtcaac accattgtat tttttaactt
     2341 cgtgttctgt atctcctcag ccatgtatct taaatatatt ttgtcatcat aatctttatg
     2401 gtgggggcag actttgcact tactgcagtg caacacttgc actttaattt tcctccaact
     2461 gtctaaaatt agagcaaata cattggcaat acagctgctt ttgctctgag ctacaatcat
     2521 ggcttttcat gttacttacc aagtggtgtt tctggttagg aatcacagct gtaaaattga
     2581 tttcagttca tcacacttct tcatgatgtt gcccctaaat tttgcacact atattcttgt
     2641 atattatttc aaataaatgg aaaaaaaagt tgctta
//
