LOCUS       NM_001945               2358 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens heparin binding EGF like growth factor (HBEGF), mRNA.
ACCESSION   NM_001945
VERSION     NM_001945.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Zhang,Y., Tang,L., Liu,H. and Cheng,Y.
  TITLE     The Multiple Functions of HB-EGF in Female Reproduction and Related
            Cancer: Molecular Mechanisms and Targeting Strategies
  JOURNAL   Reprod Sci 31 (9), 2588-2603 (2024)
   PUBMED   38424408
  REMARK    GeneRIF: The Multiple Functions of HB-EGF in Female Reproduction
            and Related Cancer: Molecular Mechanisms and Targeting Strategies.
            Review article
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Linnerbauer,M., Losslein,L., Vandrey,O., Peter,A., Han,Y.,
            Tsaktanis,T., Wogram,E., Needhamsen,M., Kular,L., Nagel,L.,
            Zissler,J., Andert,M., Meszaros,L., Hanspach,J., Zuber,F.,
            Naumann,U.J., Diebold,M., Wheeler,M.A., Beyer,T., Nirschl,L.,
            Cirac,A., Laun,F.B., Gunther,C., Winkler,J., Bauerle,T.,
            Jagodic,M., Hemmer,B., Prinz,M., Quintana,F.J. and Rothhammer,V.
  TITLE     The astrocyte-produced growth factor HB-EGF limits autoimmune CNS
            pathology
  JOURNAL   Nat Immunol 25 (3), 432-447 (2024)
   PUBMED   38409259
  REMARK    GeneRIF: The astrocyte-produced growth factor HB-EGF limits
            autoimmune CNS pathology.
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Cigliola,V., Shoffner,A., Lee,N., Ou,J., Gonzalez,T.J., Hoque,J.,
            Becker,C.J., Han,Y., Shen,G., Faw,T.D., Abd-El-Barr,M.M.,
            Varghese,S., Asokan,A. and Poss,K.D.
  TITLE     Spinal cord repair is modulated by the neurogenic factor Hb-egf
            under direction of a regeneration-associated enhancer
  JOURNAL   Nat Commun 14 (1), 4857 (2023)
   PUBMED   37567873
  REMARK    GeneRIF: Spinal cord repair is modulated by the neurogenic factor
            Hb-egf under direction of a regeneration-associated enhancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2358)
  AUTHORS   Volkner,M., Wagner,F., Steinheuer,L.M., Carido,M., Kurth,T.,
            Yazbeck,A., Schor,J., Wieneke,S., Ebner,L.J.A., Del Toro Runzer,C.,
            Taborsky,D., Zoschke,K., Vogt,M., Canzler,S., Hermann,A.,
            Khattak,S., Hackermuller,J. and Karl,M.O.
  TITLE     HBEGF-TNF induce a complex outer retinal pathology with
            photoreceptor cell extrusion in human organoids
  JOURNAL   Nat Commun 13 (1), 6183 (2022)
   PUBMED   36261438
  REMARK    GeneRIF: HBEGF-TNF induce a complex outer retinal pathology with
            photoreceptor cell extrusion in human organoids.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2358)
  AUTHORS   Wu,Y.X., Lin,Y.S., Li,S.C., Yao,X., Cheng,M., Zhu,L. and Liu,H.Y.
  TITLE     microRNA-194 is increased in polycystic ovary syndrome granulosa
            cell and induce KGN cells apoptosis by direct targeting
            heparin-binding EGF-like growth factor
  JOURNAL   Reprod Biol Endocrinol 19 (1), 170 (2021)
   PUBMED   34814928
  REMARK    GeneRIF: microRNA-194 is increased in polycystic ovary syndrome
            granulosa cell and induce KGN cells apoptosis by direct targeting
            heparin-binding EGF-like growth factor.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2358)
  AUTHORS   Yoshizumi,M., Kourembanas,S., Temizer,D.H., Cambria,R.P.,
            Quertermous,T. and Lee,M.E.
  TITLE     Tumor necrosis factor increases transcription of the
            heparin-binding epidermal growth factor-like growth factor gene in
            vascular endothelial cells
  JOURNAL   J Biol Chem 267 (14), 9467-9469 (1992)
   PUBMED   1577791
REFERENCE   7  (bases 1 to 2358)
  AUTHORS   Higashiyama,S., Lau,K., Besner,G.E., Abraham,J.A. and Klagsbrun,M.
  TITLE     Structure of heparin-binding EGF-like growth factor. Multiple
            forms, primary structure, and glycosylation of the mature protein
  JOURNAL   J Biol Chem 267 (9), 6205-6212 (1992)
   PUBMED   1556128
REFERENCE   8  (bases 1 to 2358)
  AUTHORS   Iwamoto,R., Senoh,H., Okada,Y., Uchida,T. and Mekada,E.
  TITLE     An antibody that inhibits the binding of diphtheria toxin to cells
            revealed the association of a 27-kDa membrane protein with the
            diphtheria toxin receptor
  JOURNAL   J Biol Chem 266 (30), 20463-20469 (1991)
   PUBMED   1939101
REFERENCE   9  (bases 1 to 2358)
  AUTHORS   Higashiyama,S., Abraham,J.A., Miller,J., Fiddes,J.C. and
            Klagsbrun,M.
  TITLE     A heparin-binding growth factor secreted by macrophage-like cells
            that is related to EGF
  JOURNAL   Science 251 (4996), 936-939 (1991)
   PUBMED   1840698
REFERENCE   10 (bases 1 to 2358)
  AUTHORS   Hayes,H., Kaneda,Y., Uchida,T. and Okada,Y.
  TITLE     Regional assignment of the gene for diphtheria toxin sensitivity
            using subchromosomal fragments in microcell hybrids
  JOURNAL   Chromosoma 96 (1), 26-32 (1987)
   PUBMED   3436221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313202.1, BC033097.1 and D55114.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001945.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033097.1, M60278.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230990.7/ ENSP00000230990.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK313202.1         1-13
            14-2235             BC033097.1         1-2222
            2236-2357           D55114.1           140-261
            2358-2358           BC033097.1         2345-2345
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..2358
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /note="heparin binding EGF like growth factor"
                     /db_xref="GeneID:1839"
                     /db_xref="HGNC:HGNC:3059"
                     /db_xref="MIM:126150"
     exon            1..321
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..902
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /note="diphtheria toxin receptor (heparin-binding
                     epidermal growth factor-like growth factor);
                     proheparin-binding EGF-like growth factor; diphtheria
                     toxin receptor (heparin-binding EGF-like growth factor)"
                     /codon_start=1
                     /product="proheparin-binding EGF-like growth factor
                     precursor"
                     /protein_id="NP_001936.1"
                     /db_xref="CCDS:CCDS4223.1"
                     /db_xref="GeneID:1839"
                     /db_xref="HGNC:HGNC:3059"
                     /db_xref="MIM:126150"
                     /translation="MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPT
                     VSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLG
                     KKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHT
                     TILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVENEEKVKLGMTNSH"
     exon            322..495
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /inference="alignment:Splign:2.1.0"
     exon            496..673
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /inference="alignment:Splign:2.1.0"
     exon            674..829
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /inference="alignment:Splign:2.1.0"
     exon            830..920
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /inference="alignment:Splign:2.1.0"
     exon            921..2358
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2335..2340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /note="hexamer: AATAAA"
     polyA_site      2358
                     /gene="HBEGF"
                     /gene_synonym="DTR; DTS; DTSF; HEGFL"
                     /note="major polyA site"
ORIGIN      
        1 attcggccga aggagctacg cgggccacgc tgctggctgg cctgacctag gcgcgcgggg
       61 tcgggcggcc gcgcgggcgg gctgagtgag caagacaaga cactcaagaa gagcgagctg
      121 cgcctgggtc ccggccaggc ttgcacgcag aggcgggcgg cagacggtgc ccggcggaat
      181 ctcctgagct ccgccgccca gctctggtgc cagcgcccag tggccgccgc ttcgaaagtg
      241 actggtgcct cgccgcctcc tctcggtgcg ggaccatgaa gctgctgccg tcggtggtgc
      301 tgaagctctt tctggctgca gttctctcgg cactggtgac tggcgagagc ctggagcggc
      361 ttcggagagg gctagctgct ggaaccagca acccggaccc tcccactgta tccacggacc
      421 agctgctacc cctaggaggc ggccgggacc ggaaagtccg tgacttgcaa gaggcagatc
      481 tggacctttt gagagtcact ttatcctcca agccacaagc actggccaca ccaaacaagg
      541 aggagcacgg gaaaagaaag aagaaaggca aggggctagg gaagaagagg gacccatgtc
      601 ttcggaaata caaggacttc tgcatccatg gagaatgcaa atatgtgaag gagctccggg
      661 ctccctcctg catctgccac ccgggttacc atggagagag gtgtcatggg ctgagcctcc
      721 cagtggaaaa tcgcttatat acctatgacc acacaaccat cctggccgtg gtggctgtgg
      781 tgctgtcatc tgtctgtctg ctggtcatcg tggggcttct catgtttagg taccatagga
      841 gaggaggtta tgatgtggaa aatgaagaga aagtgaagtt gggcatgact aattcccact
      901 gagagagact tgtgctcaag gaatcggctg gggactgcta cctctgagaa gacacaaggt
      961 gatttcagac tgcagagggg aaagacttcc atctagtcac aaagactcct tcgtccccag
     1021 ttgccgtcta ggattgggcc tcccataatt gctttgccaa aataccagag ccttcaagtg
     1081 ccaaacagag tatgtccgat ggtatctggg taagaagaaa gcaaaagcaa gggaccttca
     1141 tgcccttctg attcccctcc accaaacccc acttcccctc ataagtttgt ttaaacactt
     1201 atcttctgga ttagaatgcc ggttaaattc catatgctcc aggatctttg actgaaaaaa
     1261 aaaaagaaga agaagaagga gagcaagaag gaaagatttg tgaactggaa gaaagcaaca
     1321 aagattgaga agccatgtac tcaagtacca ccaagggatc tgccattggg accctccagt
     1381 gctggatttg atgagttaac tgtgaaatac cacaagcctg agaactgaat tttgggactt
     1441 ctacccagat ggaaaaataa caactatttt tgttgttgtt gtttgtaaat gcctcttaaa
     1501 ttatatattt attttattct atgtatgtta atttatttag tttttaacaa tctaacaata
     1561 atatttcaag tgcctagact gttactttgg caatttcctg gccctccact cctcatcccc
     1621 acaatctggc ttagtgccac ccacctttgc cacaaagcta ggatggttct gtgacccatc
     1681 tgtagtaatt tattgtctgt ctacatttct gcagatcttc cgtggtcaga gtgccactgc
     1741 gggagctctg tatggtcagg atgtaggggt taacttggtc agagccactc tatgagttgg
     1801 acttcagtct tgcctaggcg attttgtcta ccatttgtgt tttgaaagcc caaggtgctg
     1861 atgtcaaagt gtaacagata tcagtgtctc cccgtgtcct ctccctgcca agtctcagaa
     1921 gaggttgggc ttccatgcct gtagctttcc tggtccctca cccccatggc cccaggccca
     1981 cagcgtggga actcactttc ccttgtgtca agacatttct ctaactcctg ccattcttct
     2041 ggtgctactc catgcagggg tcagtgcagc agaggacagt ctggagaagg tattagcaaa
     2101 gcaaaaggct gagaaggaac agggaacatt ggagctgact gttcttggta actgattacc
     2161 tgccaattgc taccgagaag gttggaggtg gggaaggctt tgtataatcc cacccacctc
     2221 accaaaacga tgaagttatg ctgtcatggt cctttctgga agtttctggt gccatttctg
     2281 aactgttaca acttgtattt ccaaacctgg ttcatattta tactttgcaa tccaaataaa
     2341 gataaccctt attccata
//
