LOCUS       NM_032782               2237 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens hepatitis A virus cellular receptor 2 (HAVCR2), mRNA.
ACCESSION   NM_032782
VERSION     NM_032782.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Li,A., Zhang,J., Zhan,L., Liu,X., Zeng,X., Zhu,Q., Wang,Z. and
            Li,J.
  TITLE     TOX2 nuclear-cytosol translocation is linked to leukemogenesis of
            acute T-cell leukemia by repressing TIM3 transcription
  JOURNAL   Cell Death Differ 31 (11), 1506-1518 (2024)
   PUBMED   39080376
  REMARK    GeneRIF: TOX2 nuclear-cytosol translocation is linked to
            leukemogenesis of acute T-cell leukemia by repressing TIM3
            transcription.
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Basingab,F.S., Bashanfer,M., Alrofaidi,A.A., Barefah,A.S.,
            Hammad,R., Alahdal,H.M., Alrahimi,J.S., Zaher,K.A., Hassan,S.,
            Algiraigri,A.H., El-Daly,M.M., Alkarim,S.A. and Aldahlawi,A.M.
  TITLE     T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Gene Expression as
            a Negative Biomarker of B-Cell Acute Lymphoblastic Leukemia
  JOURNAL   Int J Mol Sci 25 (20), 11148 (2024)
   PUBMED   39456930
  REMARK    GeneRIF: T-Cell Immunoglobulin and Mucin Domain 3 (TIM-3) Gene
            Expression as a Negative Biomarker of B-Cell Acute Lymphoblastic
            Leukemia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Chang,X. and Miao,J.
  TITLE     Role of TIM-3 in ovarian cancer: the forsaken cop or a new noble
  JOURNAL   Front Immunol 15, 1407403 (2024)
   PUBMED   39206199
  REMARK    GeneRIF: Role of TIM-3 in ovarian cancer: the forsaken cop or a new
            noble.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Tyrinova,T.V. and Chernykh,E.R.
  TITLE     Inhibitory Checkpoint Receptor TIM-3 as a Regulator of the
            Functional Activity of Dendritic Cells
  JOURNAL   Bull Exp Biol Med 177 (3), 287-292 (2024)
   PUBMED   39123087
  REMARK    GeneRIF: Inhibitory Checkpoint Receptor TIM-3 as a Regulator of the
            Functional Activity of Dendritic Cells.
            Review article
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Chae,S.C., Park,Y.R., Shim,S.C., Yoon,K.S. and Chung,H.T.
  TITLE     The polymorphisms of Th1 cell surface gene Tim-3 are associated in
            a Korean population with rheumatoid arthritis
  JOURNAL   Immunol Lett 95 (1), 91-95 (2004)
   PUBMED   15325803
  REMARK    GeneRIF: Tim-3 gene associated with rheumatoid arthritis
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Khademi,M., Illes,Z., Gielen,A.W., Marta,M., Takazawa,N.,
            Baecher-Allan,C., Brundin,L., Hannerz,J., Martin,C., Harris,R.A.,
            Hafler,D.A., Kuchroo,V.K., Olsson,T., Piehl,F. and Wallstrom,E.
  TITLE     T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1
            molecules are differentially expressed on human Th1 and Th2 cells
            and in cerebrospinal fluid-derived mononuclear cells in multiple
            sclerosis
  JOURNAL   J Immunol 172 (11), 7169-7176 (2004)
   PUBMED   15153541
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Sabatos,C.A., Chakravarti,S., Cha,E., Schubart,A.,
            Sanchez-Fueyo,A., Zheng,X.X., Coyle,A.J., Strom,T.B., Freeman,G.J.
            and Kuchroo,V.K.
  TITLE     Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1
            responses and induction of peripheral tolerance
  JOURNAL   Nat Immunol 4 (11), 1102-1110 (2003)
   PUBMED   14556006
REFERENCE   8  (bases 1 to 2237)
  AUTHORS   Sanchez-Fueyo,A., Tian,J., Picarella,D., Domenig,C., Zheng,X.X.,
            Sabatos,C.A., Manlongat,N., Bender,O., Kamradt,T., Kuchroo,V.K.,
            Gutierrez-Ramos,J.C., Coyle,A.J. and Strom,T.B.
  TITLE     Tim-3 inhibits T helper type 1-mediated auto- and alloimmune
            responses and promotes immunological tolerance
  JOURNAL   Nat Immunol 4 (11), 1093-1101 (2003)
   PUBMED   14556005
REFERENCE   9  (bases 1 to 2237)
  AUTHORS   Monney,L., Sabatos,C.A., Gaglia,J.L., Ryu,A., Waldner,H.,
            Chernova,T., Manning,S., Greenfield,E.A., Coyle,A.J., Sobel,R.A.,
            Freeman,G.J. and Kuchroo,V.K.
  TITLE     Th1-specific cell surface protein Tim-3 regulates macrophage
            activation and severity of an autoimmune disease
  JOURNAL   Nature 415 (6871), 536-541 (2002)
   PUBMED   11823861
REFERENCE   10 (bases 1 to 2237)
  AUTHORS   McIntire,J.J., Umetsu,S.E., Akbari,O., Potter,M., Kuchroo,V.K.,
            Barsh,G.S., Freeman,G.J., Umetsu,D.T. and DeKruyff,R.H.
  TITLE     Identification of Tapr (an airway hyperreactivity regulatory locus)
            and the linked Tim gene family
  JOURNAL   Nat Immunol 2 (12), 1109-1116 (2001)
   PUBMED   11725301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP291914.1, AF450243.1,
            AF251707.1 and AC011377.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032782.4.
            
            Summary: The protein encoded by this gene belongs to the
            immunoglobulin superfamily, and TIM family of proteins.
            CD4-positive T helper lymphocytes can be divided into types 1 (Th1)
            and 2 (Th2) on the basis of their cytokine secretion patterns. Th1
            cells are involved in cell-mediated immunity to intracellular
            pathogens and delayed-type hypersensitivity reactions, whereas, Th2
            cells are involved in the control of extracellular helminthic
            infections and the promotion of atopic and allergic diseases. This
            protein is a Th1-specific cell surface protein that regulates
            macrophage activation, and inhibits Th1-mediated auto- and
            alloimmune responses, and promotes immunological tolerance.
            [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063431.1, AF251707.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307851.9/ ENSP00000312002.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BP291914.1         194-197
            5-1120              AF450243.1         1-1116
            1121-1735           AF251707.1         1186-1800
            1736-1898           AC011377.6         35401-35563
            1899-2194           AF251707.1         1964-2259
            2195-2195           AC011377.6         35860-35860
            2196-2237           AF251707.1         2261-2302
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..2237
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /note="hepatitis A virus cellular receptor 2"
                     /db_xref="GeneID:84868"
                     /db_xref="HGNC:HGNC:18437"
                     /db_xref="MIM:606652"
     exon            1..119
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..967
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /note="kidney injury molecule-3; T cell immunoglobulin
                     mucin 3; T-cell membrane protein 3; T-cell immunoglobulin
                     and mucin domain-containing protein 3; T-cell
                     immunoglobulin mucin receptor 3; T-cell immunoglobulin
                     mucin family member 3; T-cell immunoglobulin and mucin
                     domain 3"
                     /codon_start=1
                     /product="hepatitis A virus cellular receptor 2 precursor"
                     /protein_id="NP_116171.3"
                     /db_xref="CCDS:CCDS4333.1"
                     /db_xref="GeneID:84868"
                     /db_xref="HGNC:HGNC:18437"
                     /db_xref="MIM:606652"
                     /translation="MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAA
                     PGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTL
                     ADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPA
                     ETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIGIYIGAGICAGLALALI
                     FGALIFKWYSHSKEKIQNLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEVEE
                     PNEYYCYVSSRQQPSQPLGCRFAMP"
     exon            120..455
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..539
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            540..583
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..737
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..774
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            775..2237
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /note="hexamer: ACTAAA"
     polyA_site      2237
                     /gene="HAVCR2"
                     /gene_synonym="CD366; HAVcr-2; KIM-3; SPTCL; Tim-3; TIM3;
                     TIMD-3; TIMD3"
                     /note="major polyA site"
ORIGIN      
        1 atttggagag ttaaaactgt gcctaacaga ggtgtcctct gacttttctt ctgcaagctc
       61 catgttttca catcttccct ttgactgtgt cctgctgctg ctgctgctac tacttacaag
      121 gtcctcagaa gtggaataca gagcggaggt cggtcagaat gcctatctgc cctgcttcta
      181 caccccagcc gccccaggga acctcgtgcc cgtctgctgg ggcaaaggag cctgtcctgt
      241 gtttgaatgt ggcaacgtgg tgctcaggac tgatgaaagg gatgtgaatt attggacatc
      301 cagatactgg ctaaatgggg atttccgcaa aggagatgtg tccctgacca tagagaatgt
      361 gactctagca gacagtggga tctactgctg ccggatccaa atcccaggca taatgaatga
      421 tgaaaaattt aacctgaagt tggtcatcaa accagccaag gtcacccctg caccgactcg
      481 gcagagagac ttcactgcag cctttccaag gatgcttacc accaggggac atggcccagc
      541 agagacacag acactgggga gcctccctga tataaatcta acacaaatat ccacattggc
      601 caatgagtta cgggactcta gattggccaa tgacttacgg gactctggag caaccatcag
      661 aataggcatc tacatcggag cagggatctg tgctgggctg gctctggctc ttatcttcgg
      721 cgctttaatt ttcaaatggt attctcatag caaagagaag atacagaatt taagcctcat
      781 ctctttggcc aacctccctc cctcaggatt ggcaaatgca gtagcagagg gaattcgctc
      841 agaagaaaac atctatacca ttgaagagaa cgtatatgaa gtggaggagc ccaatgagta
      901 ttattgctat gtcagcagca ggcagcaacc ctcacaacct ttgggttgtc gctttgcaat
      961 gccatagatc caaccacctt atttttgagc ttggtgtttt gtctttttca gaaactatga
     1021 gctgtgtcac ctgactggtt ttggaggttc tgtccactgc tatggagcag agttttccca
     1081 ttttcagaag ataatgactc acatgggaat tgaactggga cctgcactga acttaaacag
     1141 gcatgtcatt gcctctgtat ttaagccaac agagttaccc aacccagaga ctgttaatca
     1201 tggatgttag agctcaaacg ggcttttata tacactagga attcttgacg tggggtctct
     1261 ggagctccag gaaattcggg cacatcatat gtccatgaaa cttcagataa actagggaaa
     1321 actgggtgct gaggtgaaag cataactttt ttggcacaga aagtctaaag gggccactga
     1381 ttttcaaaga gatctgtgat ccctttttgt tttttgtttt tgagatggag tcttgctctg
     1441 ttgcccaggc tggagtgcaa tggcacaatc tcggctcact gcaagctccg cctcctgggt
     1501 tcaagcgatt ctcctgcctc agcctcctga gtggctggga ttacaggcat gcaccaccat
     1561 gcccagctaa tttgttgtat ttttagtaga gacagggttt caccatgttg gccagtgtgg
     1621 tctcaaactc ctgacctcat gatttgcctg cctcggcctc ccaaagcact gggattacag
     1681 gcgtgagcca ccacatccag ccagtgatcc ttaaaagatt aagagatgac tggaccaggt
     1741 ctaccttgat cttgaagatt cccttggaat gttgagattt aggcttattt gagcactgcc
     1801 tgcccaactg tcagtgccag tgcatagccc ttcttttgtc tcccttatga agactgccct
     1861 gcagggctga gatgtggcag gagctcccag ggaaaaacga agtgcatttg attggtgtgt
     1921 attggccaag ttttgcttgt tgtgtgcttg aaagaaaata tctctgacca acttctgtat
     1981 tcgtggacca aactgaagct atatttttca cagaagaaga agcagtgacg gggacacaaa
     2041 ttctgttgcc tggtggaaag aaggcaaagg ccttcagcaa tctatattac cagcgctgga
     2101 tcctttgaca gagagtggtc cctaaactta aatttcaaga cggtataggc ttgatctgtc
     2161 ttgcttattg ttgccccctg cgcctagcac aattctgaca cacaattgga acttactaaa
     2221 aatttttttt tactgtt
//
