LOCUS       NM_001385482            1306 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens HAUS augmin like complex subunit 7 (HAUS7), transcript
            variant 1, mRNA.
ACCESSION   NM_001385482
VERSION     NM_001385482.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1306)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1306)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1306)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1306)
  AUTHORS   Luo,J., Yang,B., Xin,G., Sun,M., Zhang,B., Guo,X., Jiang,Q. and
            Zhang,C.
  TITLE     The microtubule-associated protein EML3 regulates mitotic spindle
            assembly by recruiting the Augmin complex to spindle microtubules
  JOURNAL   J Biol Chem 294 (14), 5643-5656 (2019)
   PUBMED   30723163
REFERENCE   5  (bases 1 to 1306)
  AUTHORS   Cunha-Ferreira,I., Chazeau,A., Buijs,R.R., Stucchi,R., Will,L.,
            Pan,X., Adolfs,Y., van der Meer,C., Wolthuis,J.C., Kahn,O.I.,
            Schatzle,P., Altelaar,M., Pasterkamp,R.J., Kapitein,L.C. and
            Hoogenraad,C.C.
  TITLE     The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule
            Organization during Neuronal Development
  JOURNAL   Cell Rep 24 (4), 791-800 (2018)
   PUBMED   30044976
REFERENCE   6  (bases 1 to 1306)
  AUTHORS   Uehara,R., Nozawa,R.S., Tomioka,A., Petry,S., Vale,R.D., Obuse,C.
            and Goshima,G.
  TITLE     The augmin complex plays a critical role in spindle microtubule
            generation for mitotic progression and cytokinesis in human cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 6998-7003 (2009)
   PUBMED   19369198
REFERENCE   7  (bases 1 to 1306)
  AUTHORS   Hahn,Y. and Lee,B.
  TITLE     Human-specific nonsense mutations identified by genome sequence
            comparisons
  JOURNAL   Hum Genet 119 (1-2), 169-178 (2006)
   PUBMED   16395595
REFERENCE   8  (bases 1 to 1306)
  AUTHORS   Mazur,D.J. and Perrino,F.W.
  TITLE     Structure and expression of the TREX1 and TREX2 3' --> 5'
            exonuclease genes
  JOURNAL   J Biol Chem 276 (18), 14718-14727 (2001)
   PUBMED   11278605
  REMARK    GeneRIF: Discusses transcript evidence for TREX1 and TREX2, as well
            as readthrough transcripts with upstream loci ATRIP and HAUS7.
REFERENCE   9  (bases 1 to 1306)
  AUTHORS   Li,T., Duan,W., Yang,H., Lee,M.K., Bte Mustafa,F., Lee,B.H. and
            Teo,T.S.
  TITLE     Identification of two proteins, S14 and UIP1, that interact with
            UCH37
  JOURNAL   FEBS Lett 488 (3), 201-205 (2001)
   PUBMED   11163772
REFERENCE   10 (bases 1 to 1306)
  AUTHORS   Esposito,T., Ciccodicola,A., Flagiello,L., Matarazzo,M.R.,
            Migliaccio,C., Cifarelli,R.A., Visone,R., Campanile,C.,
            Mazzarella,R., Schlessinger,D., D'Urso,M. and D'Esposito,M.
  TITLE     Expressed STSs and transcription of human Xq28
  JOURNAL   Gene 187 (2), 185-191 (1997)
   PUBMED   9099879
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U82695.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a subunit of the augmin complex, which
            regulates centrosome and mitotic spindle integrity, and is
            necessary for the completion of cytokinesis. The encoded protein
            was identified by interaction with ubiquitin C-terminal hydrolase
            37. Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF267739.1, BC008141.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370211.10/ ENSP00000359230.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               U82695.3           75187-75313         c
            128-243             U82695.3           73883-73998         c
            244-311             U82695.3           69725-69792         c
            312-373             U82695.3           67347-67408         c
            374-465             U82695.3           61874-61965         c
            466-624             U82695.3           61230-61388         c
            625-724             U82695.3           61002-61101         c
            725-949             U82695.3           60279-60503         c
            950-1064            U82695.3           59131-59245         c
            1065-1306           U82695.3           52405-52646         c
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1306
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /note="HAUS augmin like complex subunit 7"
                     /db_xref="GeneID:55559"
                     /db_xref="HGNC:HGNC:32979"
                     /db_xref="MIM:300540"
     exon            1..127
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1096
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-linked protein STS1769; 26S proteasome-associated
                     UCH37-interacting protein 1"
                     /codon_start=1
                     /product="HAUS augmin-like complex subunit 7 isoform 1"
                     /protein_id="NP_001372411.1"
                     /db_xref="CCDS:CCDS35438.2"
                     /db_xref="GeneID:55559"
                     /db_xref="HGNC:HGNC:32979"
                     /db_xref="MIM:300540"
                     /translation="MAGQDAGCGRGGDDYSEDEGDSSVSRAAVEVFGKLKDLNCPFLE
                     GLYITEPKTIQELLCSPSEYRLEILEWMCTRVWPSLQDRFSSLKGVPTEVKIQEMTKL
                     GHELMLCAPDDQELLKGCACAQKQLHFMDQLLDTIRSLTIGCSSCSSLMEHFEDTREK
                     NEALLGELFSSPHLQMLLNPECDPWPLDMQPLLNKQSDDWQWASASAKSEEEEKLAEL
                     ARQLQESAAKLHALRTEYFAQHEQGAAAGAADISTLDQKLRLVTSDFHQLILAFLQVY
                     DDELGECCQRPGPDLHPCGPIIQATHQNLTSYSQLLQVVMAVADTSAKAVETVKKQQG
                     EQICWGGSSSVMSLATKMNELMEK"
     exon            128..243
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..311
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            312..373
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..465
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            466..624
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..724
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..949
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1064
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1306
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1287..1292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /note="hexamer: AAGAAA"
     polyA_site      1306
                     /gene="HAUS7"
                     /gene_synonym="UCHL5IP; UIP1"
                     /note="major polyA site"
ORIGIN      
        1 gcggctcgga gcgcgaaaca tggcggggca ggacgctggc tgcggccgtg gcggcgacga
       61 ctactcagag gacgagggcg acagcagcgt gtccagggcg gctgtggagg tgttcgggaa
      121 gctgaaggac ctaaactgcc ccttcctcga gggtctgtat atcacagagc caaagacaat
      181 tcaggaactg ctgtgcagcc cctcagagta ccgcttggag atcctagagt ggatgtgtac
      241 ccgggtctgg ccctcactgc aggacaggtt cagctcactg aaaggggtcc caacagaggt
      301 gaagatccaa gaaatgacga agctgggcca cgagctgatg ctgtgtgcgc cagatgacca
      361 ggagctcctc aagggctgtg cctgcgccca gaagcagcta cacttcatgg accagttgct
      421 cgataccatc cggagcctga ccattgggtg ctccagttgc tcgagcctga tggagcactt
      481 cgaggacacc agggagaaga acgaggcctt gctgggggag ctcttctcta gcccccacct
      541 gcagatgctc ctgaatccag agtgcgaccc gtggcccctg gacatgcagc ccctcctcaa
      601 caagcagagt gatgactggc agtgggccag tgcctctgcc aagtccgagg aggaggagaa
      661 gctggcggag cttgccaggc agctgcagga gagtgctgcc aagttgcacg cgcttagaac
      721 ggagtacttt gcacagcatg agcaaggggc tgctgcgggc gcagccgaca tcagcaccct
      781 agaccagaag ctgcgtctgg tcacttccga cttccaccag ctaatcttgg cttttctcca
      841 agtctacgac gacgagctgg gcgagtgctg ccagcgccca ggccctgacc tccacccgtg
      901 cggccccatc atccaggcca cgcaccagaa tctgacttcc tacagccaac tgctgcaagt
      961 ggtcatggca gttgctgaca cctctgcgaa ggccgtggag accgtgaaga agcagcaagg
     1021 cgagcagatc tgctggggtg gcagcagctc cgtcatgagt ctagctacca agatgaatga
     1081 actaatggag aaatagaaag tcttcagtga tggcctacgc caaagcacag gatggggcgg
     1141 gcaggaagcc ctctcccaag atcgagttgg ccgaggatgg atgattgtgg cagcagaagc
     1201 cgttgcagcc ccacgttgtg ctctaggcag ggacctttgg cccctttggg gagggagaga
     1261 cagacgggcg gtttgacttg gacacaaaga aagccttggt ttctaa
//
