LOCUS       NM_017645               6323 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens HAUS augmin like complex subunit 6 (HAUS6), transcript
            variant 1, mRNA.
ACCESSION   NM_017645 XM_935767
VERSION     NM_017645.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6323)
  AUTHORS   Yao,Z., Chen,J., Wang,Y. and Cao,L.
  TITLE     Bioinformatics analysis and validation of HAUS6 as a key prognostic
            gene in squamous cell carcinoma of the tongue
  JOURNAL   Arch Oral Biol 164, 106000 (2024)
   PUBMED   38759391
  REMARK    GeneRIF: Bioinformatics analysis and validation of HAUS6 as a key
            prognostic gene in squamous cell carcinoma of the tongue.
REFERENCE   2  (bases 1 to 6323)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6323)
  AUTHORS   David,A.F., Roudot,P., Legant,W.R., Betzig,E., Danuser,G. and
            Gerlich,D.W.
  TITLE     Augmin accumulation on long-lived microtubules drives amplification
            and kinetochore-directed growth
  JOURNAL   J Cell Biol 218 (7), 2150-2168 (2019)
   PUBMED   31113824
  REMARK    GeneRIF: Our work shows that noncentrosomal microtubules nucleation
            is the predominant source of spindle microtubules also in human
            somatic cells. Importantly, our analysis of HAUS6-depleted cells
            shows that the Augmin complex is responsible for this activity.
REFERENCE   4  (bases 1 to 6323)
  AUTHORS   Luo,J., Yang,B., Xin,G., Sun,M., Zhang,B., Guo,X., Jiang,Q. and
            Zhang,C.
  TITLE     The microtubule-associated protein EML3 regulates mitotic spindle
            assembly by recruiting the Augmin complex to spindle microtubules
  JOURNAL   J Biol Chem 294 (14), 5643-5656 (2019)
   PUBMED   30723163
REFERENCE   5  (bases 1 to 6323)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 6323)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   7  (bases 1 to 6323)
  AUTHORS   Lawo,S., Bashkurov,M., Mullin,M., Ferreria,M.G., Kittler,R.,
            Habermann,B., Tagliaferro,A., Poser,I., Hutchins,J.R., Hegemann,B.,
            Pinchev,D., Buchholz,F., Peters,J.M., Hyman,A.A., Gingras,A.C. and
            Pelletier,L.
  TITLE     HAUS, the 8-subunit human Augmin complex, regulates centrosome and
            spindle integrity
  JOURNAL   Curr Biol 19 (10), 816-826 (2009)
   PUBMED   19427217
REFERENCE   8  (bases 1 to 6323)
  AUTHORS   Uehara,R., Nozawa,R.S., Tomioka,A., Petry,S., Vale,R.D., Obuse,C.
            and Goshima,G.
  TITLE     The augmin complex plays a critical role in spindle microtubule
            generation for mitotic progression and cytokinesis in human cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (17), 6998-7003 (2009)
   PUBMED   19369198
REFERENCE   9  (bases 1 to 6323)
  AUTHORS   Zhu,H., Coppinger,J.A., Jang,C.Y., Yates,J.R. 3rd and Fang,G.
  TITLE     FAM29A promotes microtubule amplification via recruitment of the
            NEDD1-gamma-tubulin complex to the mitotic spindle
  JOURNAL   J Cell Biol 183 (5), 835-848 (2008)
   PUBMED   19029337
  REMARK    GeneRIF: FAM29A promotes microtubule amplification via recruitment
            of the NEDD1-gamma-tubulin complex to the mitotic spindle.
REFERENCE   10 (bases 1 to 6323)
  AUTHORS   Goshima,G., Mayer,M., Zhang,N., Stuurman,N. and Vale,R.D.
  TITLE     Augmin: a protein complex required for centrosome-independent
            microtubule generation within the spindle
  JOURNAL   J Cell Biol 181 (3), 421-429 (2008)
   PUBMED   18443220
  REMARK    GeneRIF: Results suggest that an important mitotic function for
            gamma-tubulin may lie within the spindle, where augmin (Dgt2-6;
            FAM29A) and gamma-tubulin function cooperatively to amplify the
            number of microtubules.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF537091.1, BC114492.1 and
            AL356000.13.
            
            On Nov 23, 2018 this sequence version replaced NM_017645.4.
            
            Summary: The protein encoded by this gene is a subunit of the
            augmin complex. The augmin complex plays a role in microtubule
            attachment to the kinetochore and central spindle formation. This
            protein may have a role in efficient chromosome congression and
            segregation by promoting microtubule-dependent microtubule
            amplification. Pseudogenes of this gene are located on chromosomes
            7 and 20. Alternative splicing results in multiple transcript
            variants that encode different protein isoforms. [provided by
            RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF537091.1, SRR1660803.137365.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380502.8/ ENSP00000369871.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1473              AF537091.1         1-1473
            1474-1780           BC114492.1         1309-1615
            1781-5040           AF537091.1         1781-5040
            5041-6323           AL356000.13        83813-85095         c
FEATURES             Location/Qualifiers
     source          1..6323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..6323
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="HAUS augmin like complex subunit 6"
                     /db_xref="GeneID:54801"
                     /db_xref="HGNC:HGNC:25948"
                     /db_xref="MIM:613433"
     exon            1..381
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..3121
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="isoform 1 is encoded by transcript variant 1; dim
                     gamma-tubulin homolog; family with sequence similarity 29,
                     member A"
                     /codon_start=1
                     /product="HAUS augmin-like complex subunit 6 isoform 1"
                     /protein_id="NP_060115.3"
                     /db_xref="CCDS:CCDS6489.1"
                     /db_xref="GeneID:54801"
                     /db_xref="HGNC:HGNC:25948"
                     /db_xref="MIM:613433"
                     /translation="MSSASVTAFEKEHLWMYLQALGFEPGPATIACGKIVSHTHLGVN
                     MFDKLNRDAFHIISYFLFQVLDQSLTKEVFKFCWPPFDQKSDTEFRKHCCEWIKRISG
                     ECGSSFPQVVGSLFLSPGGPKFIHLMYHFARFVAMKYIKSNSKNSSHHFVETFNIKPQ
                     DLHKCIARCHFARSRFLQILQRQDCVTQKYQENAQLSVKQVRNLRSECIGLENQIKKM
                     EPYDDHSNMEEKIQKVRSLWASVNETLMFLEKEREVVSSVLSLVNQYALDGTNVAINI
                     PRLLLDKIEKQMFQLHIGNVYEAGKLNLLTVIQLLNEVLKVMKYERCQADQARLTVDL
                     HYLEKETKFQKERLSDLKHMRYRIKDDLTTIRHSVVEKQGEWHKKWKEFLGLSPFSLI
                     KGWTPSVDLLPPMSPLSFDPASEEVYAKSILCQYPASLPDAHKQHNQENGCRGDSDTL
                     GALHDLANSPASFLSQSVSSSDRNSVTVLEKDTKMGTPKEKNEAISKKIPEFEVENSP
                     LSDVAKNTESSAFGGSLPAKKSDPFQKEQDHLVEEVARAVLSDSPQLSEGKEIKLEEL
                     IDSLGSNPFLTRNQIPRTPENLITEIRSSWRKAIEMEENRTKEPIQMDAEHREVLPES
                     LPVLHNQREFSMADFLLETTVSDFGQSHLTEEKVISDCECVPQKHVLTSHIDEPPTQN
                     QSDLLNKKVICKQDLECLAFTKLSETSRMETFSPAVGNRIDVMGGSEEEFMKILDHLE
                     VSCNKPSTNKTMLWNSFQISSGISSKSFKDNDFGILHETLPEEVGHLSFNSSSSSEAN
                     FKLEPNSPMHGGTLLEDVVGGRQTTPESDFNLQALRSRYEALKKSLSKKREESYLSNS
                     QTPERHKPELSPTPQNVQTDDTLNFLDTCDLHTEHIKPSLRTSIGERKRSLSPLIKFS
                     PVEQRLRTTIACSLGELPNLKEEDILNKSLDAKEPPSDLTR"
     exon            382..477
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            478..556
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            557..689
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            690..837
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            838..903
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            904..952
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1123
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1317
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1444
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1547
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1629
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1696
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1882
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2018
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..3059
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..6323
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3716..3721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="hexamer: AATAAA"
     polyA_site      3738
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="major polyA site"
     regulatory      5694..5699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="hexamer: AATAAA"
     polyA_site      5715
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
     regulatory      5921..5926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="hexamer: AATAAA"
     polyA_site      5942
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
     regulatory      6304..6309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
                     /note="hexamer: AATAAA"
     polyA_site      6323
                     /gene="HAUS6"
                     /gene_synonym="Dgt6; FAM29A"
ORIGIN      
        1 cttaagggcg ggagtctcgg tttgtggtgg cttcgctgag gcagtggtgg ccgcactata
       61 ccgttagaaa ctcaatttcc cggaggttgt gaggcccttt gaggcgaaat cgctctgggc
      121 gtgaaaggag caggcgttgg caatggaagg accaccgcga cctcaggctg accgtaggga
      181 gggatcttga gggccctccg agtcccctgg gcttgcgctt tctttctttg cagccaccgt
      241 gcctaccgcg aggatgagct cggcctcggt caccgctttc gagaaggagc atctctggat
      301 gtatctgcag gcgctcggct tcgagccagg cccggcaacc attgcctgcg gaaagatcgt
      361 gtcgcacacg cacctcggag tgaacatgtt tgacaagctg aaccgtgatg cctttcatat
      421 aatttcttat tttttgtttc aagttctgga ccagtctctc accaaagaag ttttcaaatt
      481 ttgttggccc ccatttgacc aaaaaagtga cactgaattc cgaaaacatt gctgtgaatg
      541 gataaaaagg atttctggtg aatgtggaag tagctttcct caagttgttg gttcactatt
      601 tctttctcct ggtggtccta agtttattca tctgatgtat cattttgcaa gatttgttgc
      661 aatgaaatat attaaatcca attctaaaaa ttcttctcat cattttgtag agacatttaa
      721 cataaaacca caggacttgc acaaatgcat tgccagatgc catttcgcac gtagcagatt
      781 tttacaaatt ttgcaaagac aagattgtgt tacccaaaaa tatcaggaaa atgcacaatt
      841 atcagttaag caggtacgaa acttgagatc tgaatgtata ggattggaaa accaaataaa
      901 gaaaatggaa ccctatgatg accacagtaa tatggaagaa aaaattcaaa aggttcggtc
      961 tttgtgggct tcagtgaatg aaacgctcat gtttttggaa aaagagagag aagttgttag
     1021 ttcggtcctt agtcttgtta accaatatgc tttagatgga actaatgttg ctattaatat
     1081 tccaaggctc ttacttgaca aaattgagaa acaaatgttt cagttgcaca taggaaatgt
     1141 ttatgaggct ggaaaactga acctcttaac agttattcag ttattaaatg aagtcttgaa
     1201 ggtgatgaaa tatgaacgtt gtcaggctga tcaagcaaga ttgacggtag accttcacta
     1261 ccttgaaaaa gagaccaaat ttcagaagga aagattatca gatctgaaac atatgaggta
     1321 tagaataaaa gatgatctca caactataag acattctgtt gttgaaaagc aaggagaatg
     1381 gcataaaaag tggaaagaat ttcttggttt gtctcctttc agtctaatta aaggttggac
     1441 tccatctgta gatcttttac caccaatgtc tcccctttcg tttgatcctg cctcagaaga
     1501 agtgtatgca aagagtattc tttgtcagta tcctgcttca cttccagatg cacataagca
     1561 acataaccaa gaaaatggtt gcagaggaga cagtgatacc ttgggagcgc tacatgatct
     1621 agccaacagc cctgcctctt tcttgtcgca gtcagtttca tcatcagata gaaacagtgt
     1681 tacagtactt gaaaaggaca caaagatggg aactcccaaa gaaaaaaatg aagcaatttc
     1741 taagaaaata ccagaatttg aagtggaaaa ttctccatta tcagatgttg caaagaatac
     1801 agagagtagt gcatttggag ggtctttgcc agctaaaaaa agtgatccat ttcaaaaaga
     1861 gcaagatcat ctggtagaag aggttgccag agcagtttta tctgattcac cacagctctc
     1921 tgaaggaaaa gaaataaaat tagaggaact aattgactct ctgggttcta accccttctt
     1981 aacaaggaat cagattcccc gtactccaga aaacttgata actgaaatta ggagctcatg
     2041 gagaaaagct attgaaatgg aagaaaacag aactaaagaa ccaattcaaa tggatgctga
     2101 acatagagaa gtattgccag aatcattacc tgtgttgcac aatcaaagag aatttagcat
     2161 ggctgatttt ctcttagaaa ccactgtatc agattttggc cagtctcatt tgactgaaga
     2221 gaaagttatt tcagattgcg agtgtgtgcc tcagaaacat gtgctgacca gtcacataga
     2281 tgaaccacca acacaaaatc agtcagattt gttaaataag aaagtaattt gcaagcaaga
     2341 tttggaatgt ttagccttca ccaagctttc agaaactagc cgaatggaga cattctcccc
     2401 tgctgtcggc aataggatag atgtgatggg tggcagtgaa gaggagttta tgaaaatatt
     2461 ggaccactta gaagtttctt gtaacaaacc ttccacaaat aaaactatgt tgtggaattc
     2521 ttttcagata tcaagtggaa ttagttctaa gagttttaaa gataatgatt ttggcatatt
     2581 acacgaaact ctcccggaag aagttggtca tctaagtttt aatagttcca gtagttcaga
     2641 ggccaatttt aaactggagc caaatagtcc tatgcatggt ggcactcttc tagaagatgt
     2701 tgtgggaggg agacagacta ctccagaatc agactttaat ttacaggctc ttcgcagtag
     2761 atacgaggct ctgaagaaat ctctttccaa gaaaagggaa gaatcttacc tctcgaattc
     2821 ccaaacaccc gaaagacaca aaccagaatt gagccctact ccccaaaatg tacaaacaga
     2881 tgatacgctt aactttttgg acacctgtga tttgcatact gagcatataa agccatcttt
     2941 acgcacgtcc atcggtgaaa gaaaacggtc tctttcacca ctaattaagt tttctccagt
     3001 ggaacaaaga ttgagaacca caatagcatg tagtcttgga gaactaccta atttaaagga
     3061 agaagacatt ttgaataaga gccttgatgc aaaagaacca ccgtctgact tgacaagatg
     3121 aagacgtacc catttaatat aactatgatg cacttaaatt gaagctatgc cacaggatag
     3181 aaaatgaatt acaacttaaa tacatgttgg aagtgtaaca ctgtttttca aggtttaaaa
     3241 aaattcctaa tgccttttag ccttctttaa tatttttagg taaggaaagt atgtttggat
     3301 tttttcctct ttgtaggtat atgagattga aatgtgaagt atttggacaa caaacgtcaa
     3361 gcaatgggaa gccattttga tttcttgagt aatcttgtaa gcattaagtg aatgacaaag
     3421 tagtagtgta acttatttct tatgttataa cttcagtcaa ttaatataag gatagttttt
     3481 gttgtatgtt cactaaatgg ttaatataat agccattgaa tatactaatc tttcatctta
     3541 gagaactata caacttttat tgtttcttaa tggaacattc tggctaacca gaaaaagtga
     3601 gaaaagtagt accttgggat gtgtagtcaa gatgacaaat tttaagactg gaaaagctct
     3661 aaacaggctt aatgattctt caggtagaat gatcctgaga agtgatgttt gatggaataa
     3721 agtgcatgtg atgattaagt gaagactggg gcagaatgat ttaaaaaaag gaaaaagatg
     3781 gaagatgagt agacacttgc aaggaacact gtcaaactat aaatccattc agtgggttgt
     3841 ataacattta tatttagtct aatttagact ttgataattt aatgctactt ttatatttta
     3901 acaaaaatat aaattaaaat tttcattagt ctgttttgtt gttgggtttt tttgtgaggt
     3961 actccctgtt gggggaaagg aacaaggaac aaccatcaga atcccccagt ccctacagaa
     4021 tagcctcaca gtaacttgag aaaactgaac ttggggttaa ataacttgtc acacttgcag
     4081 tctcctgcct cactccttca ggtgccctgc ctagaaaaag acttgtgtct agcatccaag
     4141 tgaacacata ctattgccct ctgtgaacca ggaggaatgg aacaggcaat ggaagggtga
     4201 tagtacctac aatacccttt gtagacccca tctcactacc atcaaaatct tgtccactag
     4261 cccccaaaaa actggcaagg aaagaaggtg gaggggaaat ttatggaagt agatggctta
     4321 atagttattt cttttatctt gggctgcctt tctctaagtt ggttgtcctg tcccagtgtg
     4381 aagacccatc tttttgtgag aaaagacaaa agaaagcaca tgtaactacc ttctttgcaa
     4441 tggaaaagga gaaagaaaaa atcttctcct aagttgctgt tttcttttat tagttaataa
     4501 aacaaatcag ggactatgca ggtctatggg gaaaccttta gtctgcttta agaaaactca
     4561 gtatctgaaa atcttaactt agcatgtgat actgtcttat cagcatctgc agaagtgcca
     4621 aagccactgc tagacactta atgtgtatta tttcatttaa ttatatttta aatgtgcttc
     4681 cttggtaatt cttaagctcg agaaagagtt tgagaactgc tgctaggaaa tagagattca
     4741 catttaaccc tgtggtactt ttaagaagca ggtacgttgt tgcatatata cttgggtaga
     4801 gattggtaac tatctgatag ggaagctcaa gttggccacc caagtctgag aaacccttaa
     4861 ttactgagaa tcaaaagagc agaatgtctg tagacatttt ggatttgtaa aaatcacatt
     4921 gttgagttat acctgtgatg ggctgaaagt ttttggcatt ctttcctgtt cttcatatgc
     4981 cagtaccata aacaaaaagt atctcagatc tgtcactttc ttctcctaaa ccaatgtgat
     5041 ggcagctttt tgccttcagc cttttcccta tccagtatct cctacatagt taccttttga
     5101 tcttaaggaa ctgttttgat tgggtcactt ccttgcctaa aattccattg attgttcatt
     5161 gttaattcta aaatagagtt caaatttaaa ggcatgtaag ttcccctgta acggatttcc
     5221 tctactcccc cttccgctgt aatctcccat ttttttactg aaatgcttca gtgagcatgg
     5281 gtctttagag gtcttgatat acaattttcc tgaagcagga ataccttgct ttcctctact
     5341 agtttaccac aattacagct ctcttttaag cctcagaaaa aaatctcact tccgtcttga
     5401 agtcttaatc cacgcttttt atatccatgt gcctactcct tctctgaaat ctcctatggt
     5461 ttatcttttt attcatttaa tatcccacga attgatttta ttatatattt tttatggttg
     5521 catgtggtct ttctagttat agcaatatac acatacatgc ataaatacat atacacctat
     5581 gtaaatgtgt gttgggagta tgtattcaca cacatacata taccccaagg ccatgtgtca
     5641 tctttatcaa tatttaagtt ttggaattgt tttgtttgcc tcctatatca tggaataaat
     5701 ggtaaagagg gctaatttat tactctaagt ggatttctta ttacattaat atcagacata
     5761 tagaatgtac tttgttttac tatttgtaag atacaaaggt atataaactg acatacatca
     5821 gcttgaaacc tgagataatg ctaaaatgtt ctaattattt taaatgttta aagaggacaa
     5881 ccatgtaatg ttgctaaaca tgaaaaatgt catcaagtgg aataaagaat agctgaagtt
     5941 aacatttggg ggaaattgag ctgaaaacaa aaatatgagt attttgatac cttttcttta
     6001 ccatgagact cttgactatg aagtcaaatt tatctaaagg aaaaacagga attctggaga
     6061 cctgtgtaaa agcagactat tatcttccta ctgtgagagt actaaaatta aaatacgttt
     6121 aatgacgttt tcctcaatgt aaaagcattg aagtaaatgt ttcttttatg ttgcagatac
     6181 atagttgctc tagagatcac ctttttcttt atgcattgtg aatagcagtc tgcatcctaa
     6241 gtttaaaata tttgagaatc ctctatggga ctctctgtaa atgttttaaa tactgttgtt
     6301 ttcaataaat attttatact atc
//
